PPP2CA
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Official Full Name
protein phosphatase 2, catalytic subunit, alpha isozyme
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Overview
PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at Ser-259. -
Synonyms
PPP2CA; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2Calpha; protein phosphatase 2A catalytic su;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
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- Zebrafish
- E.coli
- HEK293
- HEK293T
- In Vitro Cell Free System
- Insect cell
- Insect Cell
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- Mammalian cells
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- Wheat Germ
- Flag
- GST
- His
- His (Fc)
- Avi
- Myc
- DDK
- Myc|DDK
- N/A
- N
- octahistidine
- streptactin
- Involved Pathway
- Protein Function
- Interacting Protein
PPP2CA involved in several pathways and played different roles in them. We selected most pathways PPP2CA participated on our site, such as mRNA surveillance pathway, Sphingolipid signaling pathway, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| mRNA surveillance pathway | pab1;PAPOLG;MAGOH2;SMG1;PABPC1B;SMG6;SRRM1;PPP2R5A;PABPN1 |
| Sphingolipid signaling pathway | FCER1G;PIK3CA;SGMS2;MAPK8;SGPL1;LASS2;SPTLC3;PLCB1;PRKCB |
| Oocyte meiosis | INSB;YWHAE2;CCNB1;MAPK1;CUL1;PPP3CB;SMC1B;YWHAZ;CAMK2D1 |
| PIK-Akt signaling pathway | G6PC;ITGA1;RPTOR;GNG7;FLT1;FGF19;Il4ra;FGF12;FIGF |
| AMPK signaling pathway | SREBF1;CREB3L1;IGF1R;ADRa1A;PFKP;PCK1;PIK3R5;PRKAB1;PRKAA2 |
| Adrenergic signaling in cardiomyocytes | TNNC1;CAMK2D2;ADRB3B;PPP2R5C;GNAS;CACNB4A;TPMA;ADRa1A;KCNQ1 |
| TGF-beta signaling pathway | ID1;BMP6;BAMBI;ROCK2B;PPP2CB;SMAD2;BMP2B;TGFB2;NOG3 |
| Hippo signaling pathway | AMH;ITGB2L;TEAD4;AXIN1;BMP2;PPP2R1A;BMP6;CTNNA2;SCRIB |
| Tight junction | LLGL1;CLDN7;CASK;SHROOM4;PPP2R2A;PARD6A;ASH1L;PRKCBA;CLDN8 |
| Dopaminergic synapse | KCNJ9;PRKCB;DRD4;MAOB;PPP2R3A;PRKCA;PPP1CC;GNG7;GNAI1 |
| Long-term depression | PLA2G4D;ITPR3;BRAF;MAPK1;MAP2K1;GNA13;PPP2R1A;ARAF;PPP2CA |
| Chagas disease (American trypanosomiasis) | GNAI3;TGFB3;IFNGR2;TICAM1;IRAK1;MYD88;GNAL;PPP2R2B;GNAI2 |
| Hepatitis C | CLDN7;PPP2R2A;PIAS1;MAPK3;MAPK12;IKBKG;IFNA8;CLDN9;CLDN6 |
PPP2CA has several biochemical functions, for example, GABA receptor binding, metal ion binding, phosphoprotein phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2CA itself. We selected most functions PPP2CA had, and list some proteins which have the same functions with PPP2CA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GABA receptor binding | ARFGEF2;PLCL2;PLCL1;GABRB1;TRAK1;GABARAPL2;GABARAP;AKAP5;GABRA5 |
| metal ion binding | TIMP2;NSF;HGS;ZYMND12;ZFP354C;CECR1A;PAK3;NUDT10;CHSY1 |
| phosphoprotein phosphatase activity | DUSP28;PPP4CA;PPP1R3B;DUSP10;PTPN11;PPP3CCB;PPM1BB;PPAP2B;PPP3CCA |
| protein C-terminus binding | VTA1;PDZD3;CACNA1B;DYNLL1;SIAH1A;RAD51;CTGF;HSPB7;NCL |
| protein binding | UBE2C;CLN3;APBA3;LRP5;GYPB;RPL36AL;ROS1;USP28;TRPC7 |
PPP2CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2CA.
PPP2R1A; IGBP1
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