ppp2ca

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ppp2ca

Official Full Name protein phosphatase 2, catalytic subunit, alpha isozyme
Background PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53. Dephosphorylates SV40 large T antigen, preferentially on serine residues 120, 123, 677, and perhaps 679. The C subunit was most active, followed by the AC form, which was more active than the ABC form, and activity of all three forms was strongly stimulated by manganese, and to a lesser extent by magnesium. Dephosphorylation by the AC form, but not C or ABC form is inhibited by small T antigen. Activates RAF1 by dephosphorylating it at Ser-259.
Synonyms PPP2CA; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2Calpha; protein phosphatase 2A catalytic su
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • octahistidine/streptactin
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PPP2CA-077H Recombinant Human PPP2CA Protein, octahistidine/streptactin-tagged Insect cell octahistidine/streptactin
    Human PPP2CA-15H Recombinant Human PPP2CA protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human PPP2CA-1913H Recombinant Human PPP2CA, His-tagged E.coli His
    Human PPP2CA-27617TH Recombinant Human PPP2CA protein, GST-tagged Wheat Germ GST
    Human PPP2CA-2929HCL Recombinant Human PPP2CA 293 Cell Lysate HEK293 N/A
    Human PPP2CA-33H Recombinant Human PPP2CA Protein, His-tagged Insect Cell His
    Human PPP2CA-571H Recombinant Human PPP2CA Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse PPP2CA-13249M Recombinant Mouse PPP2CA Protein Mammalian Cell His
    Mouse Ppp2ca-5077M Recombinant Mouse Ppp2ca Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat PPP2CA-4631R Recombinant Rat PPP2CA Protein Mammalian Cell His
    Chicken PPP2CA-1304C Recombinant Chicken PPP2CA Mammalian Cell His
    Zebrafish PPP2CA-2607Z Recombinant Zebrafish PPP2CA Mammalian Cell His

    ppp2ca involved in several pathways and played different roles in them. We selected most pathways ppp2ca participated on our site, such as mRNA surveillance pathway, Sphingolipid signaling pathway, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ppp2ca were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    mRNA surveillance pathway ETF1B; PPP2R5CB; PPP2R3A; PPP1CB; SYMPK; MAGOH2; CPSF7; MAGOHB; CPSF3; PELO
    Sphingolipid signaling pathway PLCB2; ACER1; SGPP1; BAX; PRKCE; S1PR4; FYN; TRADD; SGPP2; PRKCA
    Oocyte meiosis SMC3; CALM1A; CAMK2D2; CCNB1; FBXW11A; YWHAE; MOS; CDC25C; STAG3; CDC27
    PIK-Akt signaling pathway ITGA3; HSP90B1; LAMA4; FGFR1; OSM; LAMA1; NR4A1; FGF14; YWHAH; MLST8
    AMPK signaling pathway G6PC; PRKAA2; PPP2CA; LEP; CCNA1; RAB10; CREB5; CAMKK1; CPT1B; PPP2R5C
    Adrenergic signaling in cardiomyocytes CACNA1DA; Adcy4; AKT2L; PPP2R3A; TPMA; GNAIA; AGTR1A; ATP1B3B; GNAI3; PLCB3
    TGF-beta signaling pathway ROCK2B; TGFB1; ACVR1L; AMH; ZFYVE9; IFNG; SPAW; LFT2; CUL1; LEFTY2
    Hippo signaling pathway CRB2; FZD2; WNT8A; YWHAB; AXIN1; FZD6; TGFB1; WNT9B; FBXW11; LLGL2
    Tight junction OCLNA; HCLS1; CTTN; EPB41L3A; PRKCG; PPP2R2C; CLDN3; CLDN23; EXOC4; MYH6
    Dopaminergic synapse CALM1; PLCB2; GNGT2; ARRB2; GNG11; MAOA; MAPK9; KIF5C; CALM2; CREB3L1
    Long-term depression GNAI3; PRKCA; PRKCB; GNAS; GUCY1B3; RYR1; GNAO1; GNAI2; PLCB2; MAPK3
    Chagas disease (American trypanosomiasis) MAPK10; IL12A; BDKRB2; GNAI2; AKT2; PIK3CA; CCL5; IL1B2; MAPK3; SMAD3
    Hepatitis C IFNAR1; CLDN7; PPP2R2B; Ifna15; CLDN1; GSK3B; PPP2CA; MAPK1; OCLN; IRF3

    ppp2ca has several biochemical functions, for example, GABA receptor binding, metal ion binding, phosphoprotein phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ppp2ca itself. We selected most functions ppp2ca had, and list some proteins which have the same functions with ppp2ca. You can find most of the proteins on our site.

    Function Related Protein
    GABA receptor binding GABRB1; PPP2CA; GABRA5; PLCL1; AKAP5; GABARAPL1; ARFGEF2; GABRG1; GABARAPA; JAKMIP1
    metal ion binding ACSM2; HPD; ZFP106; ZFYVE21; TRIM35-24; ARHGAP29B; PRKCBB; DPYD; CYP2AD6; MORC4
    phosphoprotein phosphatase activity DLGAP5; PTPRQ; PTPN11A; PTPN23A; PPP1CAB; PPM1AA; CTDNEP1; PPM1LA; PPP4CA; PPM1DB
    protein C-terminus binding NEFL; VPS4B; PIAS4; PEX12; COIL; FOXN3; PLEKHB1; PIAS3; MIF4GD; XRCC6
    protein binding GNG10; cgr2b; SENP1; CCDC64B; SKIL; C2orf51; PDK1; Unc5b; PDS5B; LAT2

    ppp2ca has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ppp2ca here. Most of them are supplied by our site. Hope this information will be useful for your research of ppp2ca.

    PPP2R1A; IGBP1

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