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Official Full Name protein phosphatase 2, regulatory subunit A, alpha
Background This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described.
Synonyms PPP2R1A; protein phosphatase 2, regulatory subunit A, alpha; protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform , protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform; serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform; PP2A Aalpha; PR65A; protein phosphatase 2; 65kDa regulatory subunit A; protein phosphatase 2A; regulatory subunit A; alpha isoform; 6330556D22Rik; Alpha isoform of regulatory subunit A, protein phosphatase; DKFZp470L0914; Medium tumor antigen-associated 61 kDa protein; MGC128399; MGC786; MGC83000; MGC95083; PP2A; PP2A subunit A PR65-alpha isoform; PP2A subunit A R1 alpha isoform; PP2A, subunit A, PR65-alpha isoform; PP2A, subunit A, R1-alpha isoform; ppp2r1a-b; PR65; Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform; Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform, isoform CRA_a; Protein phosphatase 2 (formerly 2A), regulatory subunit A,; Protein phosphatase 2 regulatory subunit A alpha isoform; Protein phosphatase 2, 65-KD regulatory subunit A, alpha; Protein phosphatase 2, regulatory subunit A, alpha isoform; Protein phosphatase 2, structural/regulatory subunit A, alpha; Serine threonine protein phosphatase 65 kDa; Serine/threonine protein phosphatase 2A 65 KDA regulatory subunit A alpha isoform; PP2A subunit A isoform R1-alpha; PP2A subunit A isoform PR65-alpha; protein phosphatase 2 (formerly 2A), regulatory subunit A (P; PP2AAALPHA; PP2A-Aalpha
    • Species :
    • Human
    • Mouse
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Tag :
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human PPP2R1A-1914H Recombinant Human PPP2R1A, GST-tagged E.coli GST
    Human PPP2R1A-27571TH Recombinant Human PPP2R1A, His-tagged E.coli His
    Human PPP2R1A-2926HCL Recombinant Human PPP2R1A 293 Cell Lysate HEK293 N/A
    Human PPP2R1A-37H Recombinant Human PPP2R1A protein, His-tagged Insect Cell His
    Human PPP2R1A-43H Recombinant Human PPP2R1A protein, His-tagged E.coli His
    Human PPP2R1A-5688H Recombinant Human PPP2R1A Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse PPP2R1A-13251M Recombinant Mouse PPP2R1A Protein Mammalian Cell His
    Mouse Ppp2r1a-5078M Recombinant Mouse Ppp2r1a Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rhesus Macaque PPP2R1A-3571R Recombinant Rhesus monkey PPP2R1A Protein, His-tagged Mammalian Cell His
    Zebrafish PPP2R1A-12554Z Recombinant Zebrafish PPP2R1A Mammalian Cell His

    ppp2r1a involved in several pathways and played different roles in them. We selected most pathways ppp2r1a participated on our site, such as mRNA surveillance pathway, Sphingolipid signaling pathway, Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with ppp2r1a were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    mRNA surveillance pathway FIP1L1; PABPC5; ETF1; CSTF2T; HBS1L; MSI2A; PPP2CB; RNMT; PPP2R2BB; MAGOH
    Sphingolipid signaling pathway CERS2; SPTLC3; PIK3CG; RAC1; PLD2; PRKCA; GNAI1; SMPD1; MAPK9; RAC2
    PIK-Akt signaling pathway Il4ra; GNGT1; PDGFA; BAD; RXRA; PKN1; INS; LAMB2; IFNA8; PPP2R1A
    AMPK signaling pathway CRTC2; PFKFB3; ACACA; PIK3CB; PPARG; AKT3; SCD5; EEF2K; RAB14; ULK1
    Adrenergic signaling in cardiomyocytes ATP2B1; ADRB2A; CREB3; MYL2; PIK3CD; ADRB3B; CAMK2G1; CACNA1D; ATP1B1B; CALM2A
    TGF-beta signaling pathway BMP7B; CUL1A; BMP2; LEFTY2; GDF7; SMAD7B; TNF; ACVR1BA; ROCK2B; INHBA
    Hippo signaling pathway CRB1; CTNNA2; FZD7; LATS2; GSK3B; WNT5B; YWHAE; SAV1; WNT7B; TGFB2
    Tight junction PPP2R2D; SRC; F11R; MYH1E; EXOC4; VAPAL; CASKA; HRASB; F11R.1; PARD3
    Dopaminergic synapse DRD1; GNB1; FOS; PPP2R3A; CALM1; PLCB3; SCN1A; CLOCK; PPP3CC; GRIA3
    Long-term depression KRAS; PLCB2; PPP2R1B; LYN; GNA13; GNA12; CRH; NOS1; BRAF; RAF1
    Chagas disease (American trypanosomiasis) CXCL8; PLCB3; TLR2; GNA15; IFNB1; IL1B; PLCB1; IKBKG; LOC100033925; PPP2CB
    Hepatitis C CXCL8; MAPK12; EIF2AK3; TRAF6; CLDN1; IFNA16; MAPK1; TRAF2; SOCS3; LDLR

    ppp2r1a has several biochemical functions, for example, antigen binding, protein binding, protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by ppp2r1a itself. We selected most functions ppp2r1a had, and list some proteins which have the same functions with ppp2r1a. You can find most of the proteins on our site.

    Function Related Protein
    antigen binding TGFB1; FCN2; IGLC2; Ighg2a; LCK; LILRB4; IGKC; TSPAN4; IGKV1-5; LILRA3
    protein binding BNIPL; CHRAC1; DENR; DMKN; YWHAZ; EGLN1; CARD11; BTN3A1; EWSR1; TLX1
    protein heterodimerization activity ZHX1; HIST1H4I; SNX1; HIST1H2AI; BARD1; HIST1H2BL; PIK3R1; TBX18; GAD2; BCL2A1A
    protein phosphatase type 2A regulator activity PPP2R5EB; ENSAA; PPP2R1A; pab1; PPP2R2A; PPP2R5A; SET; PPP2R2B; PPP2R5CB; IGBP1
    protein serine/threonine phosphatase activity PPA2; PPM1L; PPM1AB; CDC14A; EPM2A; PDP1; PPP6C; PPP2R5D; PPM1K; DUSP23

    ppp2r1a has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ppp2r1a here. Most of them are supplied by our site. Hope this information will be useful for your research of ppp2r1a.


    Becsi, B; Dedinszki, D; et al. Identification of protein phosphatase interacting proteins from normal and UVA-irradiated HaCaT cell lysates by surface plasmon resonance based binding technique using biotin-microcystin-LR as phosphatase capturing molecule. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 138:240-248(2014).
    Yao, MY; Rogers, NM; et al. Thrombospondin-1 Activation of Signal-Regulatory Protein-alpha Stimulates Reactive Oxygen Species Production and Promotes Renal Ischemia Reperfusion Injury. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 25:1171-1186(2014).

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