PPP3R1
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Official Full Name
protein phosphatase 3, regulatory subunit B, alpha
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Overview
PPP3R1, also known as Calcineurin subunit B type 1, is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. Calcineurin is composed of two subunits; calcineurin A (CnA) and -
Synonyms
PPP3R1; protein phosphatase 3, regulatory subunit B, alpha; protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I) , protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) , protein phosphatase 3 (formerly 2B), reg; calcineurin subunit B type 1; calcineurin B; type I (19kDa); CALNB1; CNB; CNB1; protein phosphatase 2B regulatory subunit B alpha; CANB1_HUMAN; Cna2; PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform; Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1; OTTHUMP00000201952; OTTHUMP00000201960; OTTHUMP00000201961; calcineurin B, type I (19kDa); protein phosphatase 3 (formerly 2B), regulato;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- Insect Cell
- Insect Cells
- Mammalian Cell
- Sf21 Insect Cell
- GST
- His
- Fc
- Avi
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
PPP3R1 involved in several pathways and played different roles in them. We selected most pathways PPP3R1 participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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MAPK signaling pathway | MEF2CB;TRAF6;MAP3K13;Fgf15;AKT3A;TGFBR2;NTF3;IKBKG;PTPRR |
Calcium signaling pathway | CHRM3;HTR2A;ATP2B4;DRD1;CALM1B;CD38;SLC8A3;CACNA1DA;PHKA1 |
cGMP-PKG signaling pathway | MAP2K2;BNP;PDE5A;PDE3B;NPR2;MEF2B;GATA4;PPP3CC;RGS2 |
Oocyte meiosis | CALM1B;CDC25C;MAPK3;PRKACAA;PTTG2;CAMK2G;PKMYT1;Adcy4;PRKACG |
Apoptosis | AKT3A;HIST1H1C;AIFM1;MAP3K14;IRF6;TRADD;NFKBIAB;IRF4;PRKACA |
Wnt signaling pathway | WNT2BB;ROCK2;CTBP2A;WNT1;PRKACA;FZD1;FZD7B;SOST;GPC4 |
Axon guidance | RAC3;SEMA4A;SIAH2;PPP3CA;KRAS;RNF8;EPHA2A;CXCR4;RAC1 |
VEGF signaling pathway | PRKCBB;RAF1;RAC3A;AKT3A;PIK3CB;PPP3CCB;PPP3CA;PTK2AA;PTK2AB |
Osteoclast differentiation | SIRPB1;NCF4;MAP2K1;ITGB3;NFATC1;PPP3R2;TGFBR1;TREM2;IKBKG |
Natural killer cell mediated cytotoxicity | Fasl;PLCG1;BID;NFATC1;PRKCA;RAF1;MAP2K2;PIK3CG;PIK3R5 |
T cell receptor signaling pathway | HRAS;CD8A;PIK3R5;NCK2;Il2;MAP2K1;MAP3K7;MAP2K7;MAPK11 |
B cell receptor signaling pathway | DUSP6;CMTM3;PIK3R5;PIK3R1;ITPR2;AKT2;CDK7;CDK6;CRKL |
Long-term potentiation | PPP3CC;GRIA2;CAMK4;MAPK3;CALML5;PPP1CC;PPP3R1;RPS6KA6;CALM1 |
Glutamatergic synapse | PRKACB;SLC17A8;TRPC1;GRIK5;GNG8;GNAI2;PLA2G4D;HOMER3;PRKCA |
Oxytocin signaling pathway | PPP1CB;ROCK1;MYL6;PIK3R2;RAF1;CACNG6;MAP2K2;NPR2;TRPM2 |
Renin secretion | PRKACB;PLCB1;CLCA2;GNAI2;AQP1;NPR1;PLCB4;CALM2;PDE1B |
Alzheimers disease | IDE;NDUFC2;PPP3R1;NDUFA6;UQCRC1;PPP3CB;PPP3CA;MAPT;COX7A2 |
Amyotrophic lateral sclerosis (ALS) | MAPK14;SOD1;PPP3R1;PPP3CA;NEFM;GPX1;PPP3CC;DERL1;CAT |
Tuberculosis | MYD88;RFX5;TLR4;C3;PMAP-36;MAPK1;CAMP;RELA;CASP10 |
HTLV-I infection | ZFP36;ATM;KRAS;GSK3B;HLA-G;CCNB2;BUB3;TGFB3;GPS2 |
PPP3R1 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3R1 itself. We selected most functions PPP3R1 had, and list some proteins which have the same functions with PPP3R1. You can find most of the proteins on our site.
Function | Related Protein |
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calcium ion binding | JAG2;PVALB4;ASPH;PCDH1G29;PCDHB13;DNASE1L2;PKD1L2;PRF1;OC90 |
calcium-dependent protein serine/threonine phosphatase activity | CAMK2G;NETO2;PPP3R1;PPP3CB |
calmodulin binding | MIP;KCNN2;MAPKAPK2;CALD1;NOS1;EWSR1;ITPKB;MYH1E;UBR4 |
protein binding | CXorf48;TRIM71;PYGO1;TTC9C;COMMD2;DERL1;RNF19B;USP44;HM13 |
protein domain specific binding | ARFIP2;YWHABL;RXRA;CRB3;EZR;SCN5A;ACTN2;NLRP1;GNAI3 |
PPP3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3R1.
PPP3CA; BCL2; CALM1; MAP3K5; NAP1L2; USP14; IQCB1
Research Area
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