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PPP3R1

  • Official Full Name

    protein phosphatase 3, regulatory subunit B, alpha

  • Overview

    PPP3R1, also known as Calcineurin subunit B type 1, is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. Calcineurin is composed of two subunits; calcineurin A (CnA) and
  • Synonyms

    PPP3R1; protein phosphatase 3, regulatory subunit B, alpha; protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I) , protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) , protein phosphatase 3 (formerly 2B), reg; calcineurin subunit B type 1; calcineurin B; type I (19kDa); CALNB1; CNB; CNB1; protein phosphatase 2B regulatory subunit B alpha; CANB1_HUMAN; Cna2; PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform; Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1; OTTHUMP00000201952; OTTHUMP00000201960; OTTHUMP00000201961; calcineurin B, type I (19kDa); protein phosphatase 3 (formerly 2B), regulato;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Sf21 Insect Cell
  • GST
  • His
  • Fc
  • Avi
  • Non
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPP3CA&PPP3R1-626H Active Recombinant Human PPP3CA&PPP3R1 Sf21 Insect Cell Non
Human PPP3R1-1923H Recombinant Human PPP3R1, GST-tagged E.coli GST 1-170aa
Human PPP3R1-1119H Recombinant Human PPP3R1 protein, His & GST-tagged E.coli His&GST Gly2~Val170
Human PPP3R1-7366H Recombinant Human PPP3R1 protein(Gly2-Val170), His-tagged Insect Cells His Gly2-Val170
Human PPP3R1-3471H Recombinant Human PPP3R1, His-tagged E.coli His
Human PPP3R1-27208TH Recombinant Human PPP3R1, His-tagged E.coli His 170 amino acids
Human PPP3R1-001HCL Recombinant Human PPP3R1 cell lysate Insect Cell Non
Human PPP3R1-5969H Recombinant Human PPP3R1 Protein (Gly2-Val170), N-GST tagged E.coli GST Gly2-Val170
Human PPP3R1-2158H Recombinant Human PPP3R1 Protein (Met1-Val170), N-His tagged E.coli His Met1-Val170
Mouse PPP3R1-13269M Recombinant Mouse PPP3R1 Protein Mammalian Cell His
Mouse PPP3R1-7043M Recombinant Mouse PPP3R1 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Mouse PPP3R1-7043M-B Recombinant Mouse PPP3R1 Protein Pre-coupled Magnetic Beads HEK293
Rat PPP3R1-4641R Recombinant Rat PPP3R1 Protein Mammalian Cell His
Rat PPP3R1-4300R-B Recombinant Rat PPP3R1 Protein Pre-coupled Magnetic Beads HEK293
Rat PPP3R1-4300R Recombinant Rat PPP3R1 Protein, His (Fc)-Avi-tagged HEK293 His&Fc&Avi
Chicken PPP3R1-5946C Recombinant Chicken PPP3R1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PPP3R1 involved in several pathways and played different roles in them. We selected most pathways PPP3R1 participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
MAPK signaling pathwayMEF2CB;TRAF6;MAP3K13;Fgf15;AKT3A;TGFBR2;NTF3;IKBKG;PTPRR
Calcium signaling pathwayCHRM3;HTR2A;ATP2B4;DRD1;CALM1B;CD38;SLC8A3;CACNA1DA;PHKA1
cGMP-PKG signaling pathwayMAP2K2;BNP;PDE5A;PDE3B;NPR2;MEF2B;GATA4;PPP3CC;RGS2
Oocyte meiosisCALM1B;CDC25C;MAPK3;PRKACAA;PTTG2;CAMK2G;PKMYT1;Adcy4;PRKACG
ApoptosisAKT3A;HIST1H1C;AIFM1;MAP3K14;IRF6;TRADD;NFKBIAB;IRF4;PRKACA
Wnt signaling pathwayWNT2BB;ROCK2;CTBP2A;WNT1;PRKACA;FZD1;FZD7B;SOST;GPC4
Axon guidanceRAC3;SEMA4A;SIAH2;PPP3CA;KRAS;RNF8;EPHA2A;CXCR4;RAC1
VEGF signaling pathwayPRKCBB;RAF1;RAC3A;AKT3A;PIK3CB;PPP3CCB;PPP3CA;PTK2AA;PTK2AB
Osteoclast differentiationSIRPB1;NCF4;MAP2K1;ITGB3;NFATC1;PPP3R2;TGFBR1;TREM2;IKBKG
Natural killer cell mediated cytotoxicityFasl;PLCG1;BID;NFATC1;PRKCA;RAF1;MAP2K2;PIK3CG;PIK3R5
T cell receptor signaling pathwayHRAS;CD8A;PIK3R5;NCK2;Il2;MAP2K1;MAP3K7;MAP2K7;MAPK11
B cell receptor signaling pathwayDUSP6;CMTM3;PIK3R5;PIK3R1;ITPR2;AKT2;CDK7;CDK6;CRKL
Long-term potentiationPPP3CC;GRIA2;CAMK4;MAPK3;CALML5;PPP1CC;PPP3R1;RPS6KA6;CALM1
Glutamatergic synapsePRKACB;SLC17A8;TRPC1;GRIK5;GNG8;GNAI2;PLA2G4D;HOMER3;PRKCA
Oxytocin signaling pathwayPPP1CB;ROCK1;MYL6;PIK3R2;RAF1;CACNG6;MAP2K2;NPR2;TRPM2
Renin secretionPRKACB;PLCB1;CLCA2;GNAI2;AQP1;NPR1;PLCB4;CALM2;PDE1B
Alzheimers diseaseIDE;NDUFC2;PPP3R1;NDUFA6;UQCRC1;PPP3CB;PPP3CA;MAPT;COX7A2
Amyotrophic lateral sclerosis (ALS)MAPK14;SOD1;PPP3R1;PPP3CA;NEFM;GPX1;PPP3CC;DERL1;CAT
TuberculosisMYD88;RFX5;TLR4;C3;PMAP-36;MAPK1;CAMP;RELA;CASP10
HTLV-I infectionZFP36;ATM;KRAS;GSK3B;HLA-G;CCNB2;BUB3;TGFB3;GPS2

PPP3R1 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3R1 itself. We selected most functions PPP3R1 had, and list some proteins which have the same functions with PPP3R1. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingJAG2;PVALB4;ASPH;PCDH1G29;PCDHB13;DNASE1L2;PKD1L2;PRF1;OC90
calcium-dependent protein serine/threonine phosphatase activityCAMK2G;NETO2;PPP3R1;PPP3CB
calmodulin bindingMIP;KCNN2;MAPKAPK2;CALD1;NOS1;EWSR1;ITPKB;MYH1E;UBR4
protein bindingCXorf48;TRIM71;PYGO1;TTC9C;COMMD2;DERL1;RNF19B;USP44;HM13
protein domain specific bindingARFIP2;YWHABL;RXRA;CRB3;EZR;SCN5A;ACTN2;NLRP1;GNAI3

PPP3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3R1.

PPP3CA; BCL2; CALM1; MAP3K5; NAP1L2; USP14; IQCB1

Research Area

Related articles

Peng, HY; Chen, GD; et al. Spinal SIRP alpha 1-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats. PAIN 153:1042-1053(2012).
Pinheiro, CS; Staub, O; et al. Characterization and binding affinities of SmLANP: A new Schistosoma mansoni member of the ANP32 family of regulatory proteins. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 165:95-102(2009).
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