Creative BioMart to Present at AACR Annual Meeting|Apr. 5-10, 2024|Booth #2953 Learn More

PPP3R1

Official Full Name

protein phosphatase 3, regulatory subunit B, alpha
Overview

PPP3R1, also known as Calcineurin subunit B type 1, is a Ser/Thr-specific calcium and calmodulin-dependent protein phosphatase that plays an essential role in the T cell activation pathway. Calcineurin is composed of two subunits; calcineurin A (CnA) and
Synonyms

PPP3R1; protein phosphatase 3, regulatory subunit B, alpha; protein phosphatase 3 (formerly 2B), regulatory subunit B (19kD), alpha isoform (calcineurin B, type I) , protein phosphatase 3 (formerly 2B), regulatory subunit B, 19kDa, alpha isoform (calcineurin B, type I) , protein phosphatase 3 (formerly 2B), reg; calcineurin subunit B type 1; calcineurin B; type I (19kDa); CALNB1; CNB; CNB1; protein phosphatase 2B regulatory subunit B alpha; CANB1_HUMAN; Cna2; PPP3R1 protein phosphatase 3 (formerly 2B), regulatory subunit B, alpha isoform; Protein phosphatase 2B regulatory subunit 1; Protein phosphatase 3 regulatory subunit B alpha isoform 1; OTTHUMP00000201952; OTTHUMP00000201960; OTTHUMP00000201961; calcineurin B, type I (19kDa); protein phosphatase 3 (formerly 2B), regulato;

Type

Recombinant Proteins
Cell & Tissue Lysates
Protein Pre-coupled Magnetic Beads

Species

Chicken
Human
Mouse
Rat

Source

E.coli
HEK293
Insect Cell
Mammalian Cell
Sf21 Insect Cell

Tag

GST
His
His (Fc)
Avi
His|GST
N/A
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	PPP3CA&PPP3R1-626H	Active Recombinant Human PPP3CA&PPP3R1	Sf21 Insect Cell	N/A		Inquiry
Human	PPP3R1-1923H	Recombinant Human PPP3R1, GST-tagged	E.coli	GST	1-170aa	$319 / 25ug
Human	PPP3R1-1119H	Recombinant Human PPP3R1 protein, His & GST-tagged	E.coli	His/GST	Gly2~Val170 (Accession # P63098)	Inquiry
Human	PPP3R1-7366H	Recombinant Human PPP3R1, His tagged	Insect Cell	His		Inquiry
Human	PPP3R1-3471H	Recombinant Human PPP3R1, His-tagged	E.coli	His		Inquiry
Human	PPP3R1-27208TH	Recombinant Human PPP3R1, His-tagged	E.coli	His	170 amino acids	Inquiry
Human	PPP3R1-001HCL	Recombinant Human PPP3R1 cell lysate	Insect Cell	N/A		Inquiry
Human	PPP3R1-5969H	Recombinant Human PPP3R1 Protein (Gly2-Val170), N-GST tagged	E.coli	N-GST	Gly2-Val170	Inquiry
Human	PPP3R1-2158H	Recombinant Human PPP3R1 Protein (Met1-Val170), N-His tagged	E.coli	N-His	Met1-Val170	Inquiry
Mouse	PPP3R1-13269M	Recombinant Mouse PPP3R1 Protein	Mammalian Cell	His		Inquiry
Mouse	PPP3R1-7043M	Recombinant Mouse PPP3R1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Mouse	PPP3R1-7043M-B	Recombinant Mouse PPP3R1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	PPP3R1-4641R	Recombinant Rat PPP3R1 Protein	Mammalian Cell	His		Inquiry
Rat	PPP3R1-4300R-B	Recombinant Rat PPP3R1 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	PPP3R1-4300R	Recombinant Rat PPP3R1 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Chicken	PPP3R1-5946C	Recombinant Chicken PPP3R1	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
PPP3R1 Related Articles
PPP3R1 Related Research Area

PPP3R1 involved in several pathways and played different roles in them. We selected most pathways PPP3R1 participated on our site, such as MAPK signaling pathway, Calcium signaling pathway, cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
MAPK signaling pathway	RPS6KA4;HSPA2;HRAS;RELB;PRKACBA;FGF22;CACNG8;RPS6KA3B;MAP4K3
Calcium signaling pathway	AGTR1B;GNA11A;PDE1B;PRKCG;P2RX4;STIM1A;PRKACAB;HTR5AL;AGTR1A
cGMP-PKG signaling pathway	PLN;PIK3R3;ATP1A3;ROCK2;GNAI2;PPP3CB;PPP1CB;PPP3R1;IRS1
Oocyte meiosis	PRKACA;FBXO43;STAG3;PRKACAB;CUL1B;YWHAQB;MAD2L1;PLK1;MOS
Apoptosis	GZME;NMT1;PLECA;PIK3R5;PRKAR1A;PIK3CD;BNIP3L;AKT2;TNF
Wnt signaling pathway	PLCB3;BTRC;CAMK2G1;WNT7B;PRKACB;PRKACAA;FBXW11A;WNT11B;Fzd4
Axon guidance	FGF10B;COL9A1A;KALRNB;PAQR3A;LRRC4;PAK4;PLXNA3;Unc5b;CDK5R1B
VEGF signaling pathway	MAPK12;MAPK14B;AKT2L;RAC3B;RAC2;PTK2;NFATC2;MAPKAPK2A;RAC1A
Osteoclast differentiation	FOSL2;LILRB1;PIK3CB;IFNAR2;PPP3CC;NFKB1;CYBA;NFKBIA;LILRA3
Natural killer cell mediated cytotoxicity	ICAM2;IFNA4;PLCG1;IFNB1;CD247;ITGB2;SOS1;RAC2;GRB2
T cell receptor signaling pathway	PIK3CG;IL4;PTPN6;PPP3CB;DLG1;NFKBIE;PPP3R1;CD8B1;DBNLB
B cell receptor signaling pathway	DOK1B;STAP1;PRKCB;CDK2;NFATC3;IKBKG;CD79A;BANK1;PIK3R1
Long-term potentiation	GRIA1;PRKCG;GRIN2D;CALML3;GRIN2B;RPS6KA2;EP300;PPP3CA;KRAS
Glutamatergic synapse	HOMER1;GNG10;PLD1;GRIN2C;GRM4;GRM5;PLA2G4D;PRKACB;GNGT2
Oxytocin signaling pathway	MYLK4;CALML3;CACNB1;ITPR1;GNAQ;CALM2;CAMK1D;RCAN1;PLA2G4C
Renin secretion	ACE;PRKACG;PPP3CC;PPP3CA;PDE1A;PRKACB;ITPR1;GNAI3;NPR1
Alzheimers disease	COX6A1;APOE;MAPK1;ADAM10;NOS1;GRIN2D;NDUFA7;ITPR2;Casp3
Amyotrophic lateral sclerosis (ALS)	BAD;MAPK13;GRIN2A;TOMM40L;GRIA1;TP53;GRIA2;CASP9;BCL2
Tuberculosis	cgr2b;FCGR4;ATP6V1H;FCGR1;ATP6V0A4;IL12B;PPP3CC;NFYA;CALM4
HTLV-I infection	LTA;BUB3;KAT2A;RRAS2;AKT1;POLD4;LCK;NFKB2;NFKB1

PPP3R1 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein serine/threonine phosphatase activity, calmodulin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3R1 itself. We selected most functions PPP3R1 had, and list some proteins which have the same functions with PPP3R1. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	NCALD;CDHR3;PLCD4;CALML5;SPTA1;RASGRP2;SLC24A4;NKD2B;THBS3B
calcium-dependent protein serine/threonine phosphatase activity	PPP3CB;CAMK2G;NETO2;PPP3R1
calmodulin binding	TRPV4;MYO5C;REM1;TJP1;NRGN;TRPV6;ATP2B4;PHKA2;CTH
protein binding	CCDC101;SOX30;CDC37;SMOC1;MEPE;PIK3R4;PKN2;LZTS2;UXT
protein domain specific binding	CASP2;CALM3;KCNN2;VCP;SKIL;CACNB2;HMGB2;GABRR3;RXRA

PPP3R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3R1.

PPP3CA; BCL2; CALM1; MAP3K5; NAP1L2; USP14; IQCB1

Peng, HY; Chen, GD; et al. Spinal SIRP alpha 1-SHP2 interaction regulates spinal nerve ligation-induced neuropathic pain via PSD-95-dependent NR2B activation in rats. PAIN 153:1042-1053(2012).

Pinheiro, CS; Staub, O; et al. Characterization and binding affinities of SmLANP: A new Schistosoma mansoni member of the ANP32 family of regulatory proteins. MOLECULAR AND BIOCHEMICAL PARASITOLOGY 165:95-102(2009).

Calcium-binding Proteins and Related Molecules

Wnt Intracellular Signaling

C-type Lectin Receptors

Phosphatases in the Akt Pathway