PPP1CA

  • Official Full Name

    protein phosphatase 1, catalytic subunit, alpha isozyme

  • Overview

    The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
  • Synonyms

    PPP1CA; protein phosphatase 1, catalytic subunit, alpha isozyme; PPP1A, protein phosphatase 1, catalytic subunit, alpha isoform; serine/threonine-protein phosphatase PP1-alpha catalytic subunit; PP 1A; PP1alpha; protein phosphatase 1, catalytic subunit,;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Dog
  • Human
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • Human
  • Mammalian Cell
  • Mammalian cells
  • His
  • His (Fc)
  • Avi
  • His|Myc
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human PPP1CA-159HFL Recombinant Full Length Human PPP1CA Protein E.coli Full Length
Human PPP1CA-1015H Recombinant Human PPP1CA, His-tagged Human His
Human PPP1CA-27568TH Recombinant Human PPP1CA, His-tagged E.coli His
Human PPP1CA-31049TH Recombinant Human PPP1CA, His-tagged E.coli His 330 amino acids
Human PPP1CA-2952HCL Recombinant Human PPP1CA 293 Cell Lysate HEK293 N/A
Human PPP1CA-2951HCL Recombinant Human PPP1CA 293 Cell Lysate HEK293 N/A
Human PPP1CA-2953HCL Recombinant Human PPP1CA 293 Cell Lysate HEK293 N/A
Human PPP1CA-5958H Recombinant Human PPP1CA Protein (Met1-Lys330), N-His tagged Mammalian cells N-His Met1-Lys330
Human PPP1CA-5959H Recombinant Human PPP1CA Protein (Ser2-Lys330), N-His tagged E.coli N-His Ser2-Lys330
Mouse PPP1CA-13209M Recombinant Mouse PPP1CA Protein Mammalian Cell His
Mouse PPP1CA-6999M-B Recombinant Mouse PPP1CA Protein Pre-coupled Magnetic Beads HEK293
Mouse PPP1CA-6999M Recombinant Mouse PPP1CA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PPP1CA-4611R Recombinant Rat PPP1CA Protein Mammalian Cell His
Rat PPP1CA-4270R Recombinant Rat PPP1CA Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat PPP1CA-4270R-B Recombinant Rat PPP1CA Protein Pre-coupled Magnetic Beads HEK293
Dog PPP1CA-2523D Recombinant Dog PPP1CA Protein (2-330 aa), His-Myc-tagged E.coli His/Myc 2-330 aa
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

PPP1CA involved in several pathways and played different roles in them. We selected most pathways PPP1CA participated on our site, such as mRNA surveillance pathway, cGMP-PKG signaling pathway, cAMP signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP1CA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
mRNA surveillance pathwayPPP2R1B;CSTF2T;PPP1CAB;CPSF7;NXT1;CPSF2;PPP2R5C;CPSF1;MAGOHB
cGMP-PKG signaling pathwayPRKG1;NPPB;GNAI2;GTF2IRD1;MEF2D;IRS4;ATP1B1;CREB3L1;ITPR3
cAMP signaling pathwayHTR1F;GPR81;F2R;SLC9A1;ROCK1;NFKBIA;GPR119;MAPK9;GRIA4
Oocyte meiosisYWHAG1;PPP2CB;PKMYT1;CDC27;PPP2R1B;SGOL1;CALML5;PRKACBB;CAMK2D1
Adrenergic signaling in cardiomyocytesAKT1;CAMK2B;CACNG7A;AGTR2;SCN5A;ADRB2A;CACNA2D4;PRKACG;MAPK1
Vascular smooth muscle contractionGNA11B;CACNA1SA;PPP1R12C;PPP1R14AB;ADRA1BB;PLA2G3;PLA2G2D;PLA2G4C;KCNMB1
Hippo signaling pathwayPRKCZ;SMAD4;AXIN1;WWTR1;RASSF1;BBC3;BIRC5;WNT3A;GSK3B
Focal adhesionPAK1;VASP;COL6A3;PDGFRA;HRAS;PDGFB;PTK2AB;TNK2;COL6A5
Platelet activationMAPK1;GP1BB;FGB;GP1BA;STIM1;SRC;GNAI2;PTGIR;PPP1CC
Long-term potentiationMAP2K1;MAPK3;CALM2;ARAF;PPP3R2;GRIA2;CALM3;PLCB3;CAMK4
Dopaminergic synapseDRD5;TH;GNB3;GNG11;GNAL;PPP2R2D;MAOB;PLCB1;GSK3A
Inflammatory mediator regulation of TRP channelsITPR1;IL1R1;KLK1B4;TRPV3;MAPK13;GNAS;MAPK11;CAMK2G;ACCN4
Regulation of actin cytoskeletonGNA12A;ITGB8;CDC42L2;PDGFB;ROCK2B;Itga10&Itgb1;RRAS2;SCINLB;FGF1
Insulin signaling pathwayPDPK1B;PIK3CD;G6PC3;FLOT1B;FBP1A;AKT3A;INSB;PPP1CB;BAD
Oxytocin signaling pathwayCALM1;GUCY1A3;NFATC2;RYR2;MYLK2;PIK3R3;PRKCG;GNAI2;CACNA2D1
Insulin resistancePTEN;RPS6KB1B;OGT.1;GFPT2;CREB3L3A;MGEA5;PPARGC1B;PIK3R3;TNF
AlcoholismH3F3B;HIST1H2BJ;GNB5;HIST1H4M;HIST1H4F;GNG12;GM14477;GNGT1;SHC3
Herpes simplex infectionIFNA16;HLA-DRB4;C3;HLA-DMA;SRPK1;TAF6;IFNPHI3;FADD;HLA-DMB
Proteoglycans in cancerSMO;FZD3;CCND1;WNT3;FLNA;PLAU;PTPN6;RRAS;RHOA

PPP1CA has several biochemical functions, for example, ATP binding, GTP binding, butyrate-CoA ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP1CA itself. We selected most functions PPP1CA had, and list some proteins which have the same functions with PPP1CA. You can find most of the proteins on our site.

Function Related Protein
ATP bindingWRNIP1;MAT1A;ATP1A1A.5;PRKCH;LATS2;ERCC3;DDX27;ACSL1;SUCLG1
GTP bindingGNAT1;RAN;GIMAP1;RABL2B;RAB3D;SRPRB;GPN1;RRAS2;TUBA8L4
butyrate-CoA ligase activityACSM3;ACSM1;PPP1CA;ACSM5;Acsm2a;ACSM2B;ACSM2;ACSM4;AACS
metal ion bindingCYB561D1;ZNF572;RACGAP1;ZNF10;LFNG;PVALB6;ZNF239;MB21D1;ACY3.1

PPP1CA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP1CA here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP1CA.

TP53BP2; CSRNP2; RB1; PPP1R13B

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