PPP3CC
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Official Full Name
protein phosphatase 3, catalytic subunit, gamma isozyme -
Overview
Calcineurin is a calcium-dependent, calmodulin-stimulated protein phosphatase involved in the downstream regulation of dopaminergic signal transduction. Calcineurin is composed of a regulatory subunit and a catalytic subunit. The protein encoded by this gene represents one of the regulatory subunits that has been found for calcineurin. Three transcript variants encoding different isoforms have been found for this gene. -
Synonyms
PPP3CC;protein phosphatase 3, catalytic subunit, gamma isozyme;protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform , protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma);serine/threonine-protein
Recombinant Proteins
- Mouse
- Human
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- DDK
- Myc
- Avi
- Fc
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| PPP3CC-13268M | Recombinant Mouse PPP3CC Protein | Mammalian Cells | Mouse | His |
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| PPP3CC-2913HCL | Recombinant Human PPP3CC 293 Cell Lysate | HEK293 | Human | Non |
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| Ppp3cc-5082M | Recombinant Mouse Ppp3cc Protein, Myc/DDK-tagged | HEK293 | Mouse | DDK&Myc |
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| PPP3CC-5693H | Recombinant Human PPP3CC Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | DDK&Myc |
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| PPP3CC-7042M | Recombinant Mouse PPP3CC Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | Avi&Fc&His |
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| PPP3CC-7042M-B | Recombinant Mouse PPP3CC Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| PPP3CC-736H | Recombinant Human PPP3CC Protein (2-512 aa), His-tagged | E.coli | Human | His | 2-512 aa |
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Involved Pathway
PPP3CC involved in several pathways and played different roles in them. We selected most pathways PPP3CC participated on our site, such as MAPK signaling pathway,Calcium signaling pathway,cGMP-PKG signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP3CC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Osteoclast differentiation | LCK,SIRPA,LILRA5,STAT1,FHL2,TNFRSF11B,MITF,CYLD,CSF1R,TNFRSF11A |
| B Cell Receptor Signaling Pathway | AKT2,PIK3CD,PIK3R3,MAPK4,LCP2A,MAPK1,RASGRP3,PPP3R1,LAT2,NFATC2 |
| Natural killer cell mediated cytotoxicity | HLA-G,Raet1a,GM-CSF,NRAS,FCER1G,RAET1L,ZAP70,TNFSF10,HLA-A,KLRD1 |
| Tuberculosis | ATP6V0D1,PPP3R2,IL23,CASP8,IL6,FCGR2B,cgr2b,CALM1,MAPK9,CALML5 |
| VEGF signaling pathway | BADB,HSPB1,SPHK1,PIK3R1,AKT1,MAPK14A,CDC42L,SPHK2,PTGS2,PTGS2A |
| Apoptosis | HMGB2A,IL1B,IL1A,PIK3CB,BIRC5A,BAX,TRP53,CFLARA,HIST1H1B,BOK |
| Dopaminergic synapse | DRD1A,CREB3L2,ITPR3,GNAO1,DRD1,CALM4,MAPK10,MAPK12,GRIN2B,PLCB4 |
| Amyotrophic lateral sclerosis (ALS) | TRP53,BCL2L1,MAPK11,GRIN1,NEFL,NOS1,PPP3R1,CASP12,MAP2K3,NEFM |
| Glutamatergic synapse | GRM4,PPP3CA,GRIN2C,SHANK2,GNGT1,SLC1A2,PRKCB,PLD2,ITPR3,GNG13 |
Protein Function
PPP3CC has several biochemical functions, for example, calmodulin binding,metal ion binding,phosphoprotein phosphatase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP3CC itself. We selected most functions PPP3CC had, and list some proteins which have the same functions with PPP3CC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calmodulin binding | EPB41,SPA17,OBSCN,PHKB,KCNN1,IQGAP3,MARCKSL1B,DDX5,MYO1D,RIT1 |
| metal ion binding | DMRTA2,ZNF498,ATP1A3,ATP1A4,OAS2,NKD2A,ACVR2AA,HAGH,ZMYND17,ATP11A |
| phosphoprotein phosphatase activity | PTPRK,MTM1,CTDSPL2,PTPN11A,CTDSPL2B,DUSP10,PPAP2B,PPM1AB,PPP2CA,CTDNEP1A |
| protein binding | PPM1B,STX16,CFH,ANK2,DBNL,SMARCE1,RBFOX1,RPRD1A,FAM19A4,NUDT14 |
Interacting Protein
PPP3CC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP3CC here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP3CC.
AMPH;CSNK2B;HAX1;SDC2;ybfM;yaaO;ITPKC;THAP7
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