Active GMP Recombinant Mouse Cxcl12 Protein, His-Tagged

• Cat.No.: Cxcl12-01M
• Product Overview: GMP Recombinant Mouse Cxcl12 Protein, His-Tagged was expressed in Escherichia coli cell-derived in an animal component free process under cGMP guidelines.

Specification

• Description: This gene encodes a member of the alpha chemokine protein family. The encoded protein is secreted and functions as the ligand for the G-protein coupled receptor, chemokine (C-X-C motif) receptor 4. The encoded protein plays a role in many diverse cellular functions, including embryogenesis, immune surveillance, inflammation response, tissue homeostasis, and tumor growth and metastasis. Alternative splicing results in multiple transcript variants.
• Source: Escherichia coli
• Species: Mouse
• Tag: His
• Form: Lyophilized
• Bio-activity: Measure by its ability to chemoattract BaF3 cells transfected with human CXCR4. The ED50 for this effect is <0.5 ng/mL.
• AA Sequence: MGKPVSLSYRCPCRFFESHIARANV KHLKILNTPNCALQIVARLKNNNRQ VCIDPKLKWIQEYLEKALNK with polyhistidine tag at the C-terminus
• Endotoxin: <0.1 EU per 1 μg of the protein by the LAL method.
• Purity: >98% as determined by SDS-PAGE. Ni-NTA chromatography
• Notes: Please use within one month after protein reconstitution.
• Storage: Lyophilized protein should be stored at -20°C. Upon reconstitution, protein aliquots should be stored at -20°C or -80°C.
• Storage Buffer: The protein was lyophilized from a solution containing 1X PBS, pH 7.4.
• Reconstitution: It is recommended to reconstitute the lyophilized protein in sterile H2O to a concentration not less than 100 μg/mL and incubate the stock solution for at least 20 min to ensure sufficient re-dissolved.

Gene Information

• Gene Name: Cxcl12 chemokine (C-X-C motif) ligand 12 [ Mus musculus (house mouse) ]
• Official Symbol: Cxcl12
• Synonyms: Pbsf; Sdf1; Tlsf; Tpar1; Scyb12
• Gene ID: 20315
• mRNA Refseq: NM_001012477.2
• Protein Refseq: NP_001012495.1
• UniProt ID: A0A6P7RBN4

Reviews

06/15/2022

The CXCL12 protein is of exceptional quality, making it an ideal candidate to fulfill my experimental requirements.

01/08/2022

The manufacturer's commitment to providing excellent technical support is truly commendable, as they have proven to be readily available to assist in resolving any concerns or challenges I encountered while working with the protein.

04/26/2021

Its purity and integrity have consistently delivered reliable and robust results in my research.

Q&As

How are researchers using CXCL12 in neurodegenerative disease research?

CXCL12 is being investigated for its role in neuroprotection and neuroregeneration in conditions like Alzheimer's and Parkinson's disease.

Are there diagnostic tests that measure CXCL12 levels in patients?

Yes, ELISA and other assays can be used to measure CXCL12 levels, aiding in the diagnosis and monitoring of certain diseases.

Can CXCL12 be used as a biomarker for specific diseases?

CXCL12 levels can serve as a biomarker for various diseases, such as HIV, cancer, and inflammatory disorders.

How is CXCL12 being researched for cardiovascular therapies?

Scientists are exploring the potential of CXCL12-based therapies to promote vascular repair and treat heart diseases.

Can CXCL12-based therapies help in spinal cord injury treatment?

Researchers are studying CXCL12-based treatments to promote nerve regeneration and functional recovery after spinal cord injuries.