Cxcl10

  • Official Full Name

    chemokine (C-X-C motif) ligand 10

  • Overview

    This gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Jul 2008]
  • Synonyms

    CXCL10; chemokine (C-X-C motif) ligand 10; C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10; C-X-C motif chemokine 10; gamma IP10; gamma-IP10; small-inducible cytokine B10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Transfected Stable Cell Lines
  • Protein Pre-coupled Magnetic Beads
  • GMP Proteins
  • Bovine
  • Canine
  • Caprine
  • Cattle
  • Cotton Rat
  • Dog
  • Dolphin
  • Equine
  • Feline
  • Guinea
  • Guinea Pig
  • Hamster
  • Human
  • Mouse
  • Ovine
  • Pig
  • Porcine
  • Rat
  • Rhesus
  • Rhesus macaque
  • Rhesus Macaque
  • Rhesus monkey
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • Biotin
  • C
  • His
  • Fc
  • Myc
  • DDK
  • DYKDDDDK
  • Fc|His
  • Flag
  • GST
  • HIgG1 Fc
  • His (Fc)
  • Avi
  • Met
  • MYC
  • N/A
  • N
  • Strep II
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CXCL10-105H Active Human CXCL10 N/A
Human CXCL10-242H Active Recombinant Human Chemokine (C-X-C Motif) Ligand 10, HIgG1 Fc-tagged CHO Fc
Human CXCL10-211H Active Recombinant Human Chemokine (C-X-C Motif) Ligand 10, MIgG2a Fc-tagged CHO Fc
Human CXCL10-186H Active Recombinant Human CXCL10 Protein (Val22-Pro98), N-His tagged, Animal-free, Carrier-free E.coli N-His Val22-Pro98
Human CXCL10-08H Recombinant Human CXCL10 protein E.coli N/A 77
Human CXCL10-31H Recombinant Human CXCL10, His-tagged HEK293 His
Human CXCL10-212H Recombinant Human Chemokine (C-X-C Motif) Ligand 10, HIgG1 Fc-tagged, mutant CHO HIgG1 Fc Val22-Pro98
Human CXCL10-274H Recombinant Human CXCL10, StrepII-tagged Human Cell Strep II 22-98, 77 a.a.
Human CXCL10-70H Recombinant Human CXCL10 (IP-10) Yeast N/A
Human CXCL10-524H Recombinant Human CXCL10 Protein, His-tagged E.coli His Val22~Pro98
Human CXCL10-11716H Recombinant Human CXCL10, GST-tagged E.coli GST 1-98a.a.
Human CXCL10-025H Recombinant Human CXCL10 Protein, Fc/His-tagged HEK293 Fc/His
Human CXCL10-7172HCL Recombinant Human CXCL10 293 Cell Lysate HEK293 N/A
Human CXCL10-19H Recombinant Human CXCL10 Protein, Biotin-tagged E.coli Biotin
Human CXCL10-5387H Recombinant Human CXCL10 protein, His-tagged Yeast His 22-98aa
Human CXCL10-9H Active Human CXCL10 Reference Standard N/A
Human CXCL10-01H Recombinant Human CXCL10 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Human CXCL10-691H Recombinant Human CXCL10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CXCL10-2226HF Recombinant Full Length Human CXCL10 Protein, GST-tagged In Vitro Cell Free System GST 98 amino acids
Human CXCL10-050H Recombinant Human CXCL10 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human CXCL10-691H-B Recombinant Human CXCL10 Protein Pre-coupled Magnetic Beads HEK293
Human CXCL10-2111H Recombinant Human CXCL10 Protein (Val22-Pro98), C-His and Fc tagged Mammalian cells C-His and Fc Val22-Pro98
Human CXCL10-101H Recombinant Human CXCL10 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CXCL10-583HFL Recombinant Full Length Human CXCL10 Protein, C-Flag-tagged Mammalian cells Flag
Human CXCL10-5006H Recombinant Human CXCL10 protein, His-tagged HEK293 His 22-98aa
Human CXCL10-2996H Recombinant Human CXCL10 Protein (Val22-Pro98), His tagged E.coli His Val22-Pro98
Mouse Cxcl10-01M Active GMP Recombinant Mouse Cxcl10 Protein, His-Tagged E.coli His
Mouse Cxcl10-39M Recombinant Mouse Chemokine (C-X-C Motif) Ligand 10 E.coli N/A
Mouse CXCL10-71M Recombinant Mouse CXCL10 (IP-10) Yeast N/A
Mouse Cxcl10-525M Recombinant Mouse Cxcl10 Protein, His-tagged E.coli His Ile22~Pro98
Mouse Cxcl10-613M Recombinant Mouse Cxcl10 protein E.coli N/A 77
Mouse CXCL10-805M Recombinant Mouse CXCL10 Protein (Ile22-Pro98), His-tagged Yeast His Ile22-Pro98
Mouse Cxcl10-40M Active Recombinant Mouse Cxcl10 Protein (Pro23-Pro98), N-His tagged, Animal-free, Carrier-free E.coli N-His Pro23-Pro98
Mouse CXCL10-38M Recombinant Mouse CXCL10 Protein, Biotin-tagged E.coli Biotin
Mouse Cxcl10-076M Recombinant Mouse Cxcl10 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Mouse Cxcl10-2770M Recombinant Mouse Cxcl10 protein, GST-tagged E.coli GST 22-98aa
Rat CXCL10-86R Recombinant Rat CXCL10 Yeast N/A
Rat Cxcl10-631R Recombinant Rat Cxcl10 protein E.coli N/A 77
Rat Cxcl10-526R Recombinant Rat Cxcl10 Protein, His-tagged E.coli His Ile22~Pro98
Rat CXCL10-1346R-B Recombinant Rat CXCL10 Protein Pre-coupled Magnetic Beads HEK293
Rat CXCL10-1346R Recombinant Rat CXCL10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CXCL10-938R Recombinant Rat CXCL10 Protein (Ile22-Pro98), His-tagged Yeast His Ile22-Pro98
Rat Cxcl10-175C Active Recombinant Rat Cxcl10 Protein (77 aa) HEK293 77
Rhesus monkey CXCL10-1176R Active Recombinant Rhesus Monkey CXCL10 Protein E.coli N/A
Dog CXCL10-523D Recombinant Dog CXCL10 Protein, His-tagged E.coli His Ile22~Pro98
Bovine CXCL10-133B Recombinant Bovine Chemokine (C-X-C motif) Ligand 10 Yeast N/A
Canine CXCL10-65C Recombinant Canine CXCL10 (IP-10) Yeast N/A
Caprine CXCL10-4342C Recombinant Caprine CXCL10 Protein Yeast N/A 83aa
Cattle CXCL10-522C Recombinant Cattle CXCL10 Protein, His-tagged E.coli His Val20~Ala102
Cotton Rat Cxcl10-388C Active Recombinant Cotton Rat Cxcl10, Met-tagged E.coli Met
Dolphin CXCL10-4341D Recombinant Dolphin CXCL10 Protein Yeast N/A 82aa
Equine CXCL10-142E Recombinant Equine Chemokine (C-X-C motif) Ligand 10 Yeast N/A
Feline CXCL10-69F Recombinant Feline CXCL10 (IP-10) Yeast N/A
Guinea CXCL10-54G Recombinant Guinea Pig CXCL10 Protein E.coli
Guinea Pig Cxcl10-4347G Recombinant Guinea Pig Cxcl10 Protein Yeast N/A 76aa
Hamster Cxcl10-2774H Recombinant Hamster Cxcl10 Protein, His-tagged E.coli N-His Ile22-Ser98
Ovine CXCL10-50O Recombinant Ovine CXCL10 (IP-10) Yeast N/A
Porcine CXCL10-01P Active GMP Recombinant Porcine CXCL10 Protein, His-Tagged E.coli His
Rhesus CXCL10-65R Recombinant Rhesus CXCL10 protein E.coli N/A 77
Rhesus Macaque CXCL10-1105R Recombinant Rhesus monkey CXCL10 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CXCL10-930R Recombinant Rhesus Macaque CXCL10 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus macaque CXCL10-4648R Recombinant Rhesus macaque CXCL10 protein, His-tagged E.coli His 22-98aa
Rhesus Macaque CXCL10-930R-B Recombinant Rhesus Macaque CXCL10 Protein Pre-coupled Magnetic Beads HEK293
Pig CXCL10-148S Recombinant Swine Chemokine (C-X-C motif) Ligand 10 Yeast N/A
Pig CXCL10-237P Active Recombinant Pig CXCL10 Protein (Pro23-Ala104), N-His tagged, Animal-free, Carrier-free E.coli N-His Pro23-Ala104
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

What is CXCL10 protein?

CXCL10 (C-X-C motif chemokine ligand 10) gene is a protein coding gene which situated on the long arm of chromosome 4 at locus 4q21. This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. This gene may also be a key regulator of the 'cytokine storm' immune response to SARS-CoV-2 infection. The CXCL10 protein is consisted of 98 amino acids and its molecular mass is approximately 10.9 kDa.

What is the function of CXCL10 protein?

CXCL10 protein is an important cytokine with many biological functions. First, it can act as a chemokine to attract and activate immune cells, such as T cells and natural killer cells, promoting their movement to the site of inflammation and participating in the regulation of inflammatory response. Secondly, CXCL10 can induce endothelial cell proliferation and migration, promote angiogenesis, and thus play a role in tissue repair and regeneration. In addition, CXCL10 also has anti-tumor activity, which can inhibit the growth and spread of tumor cells.

Schematic of the signaling pathways involved in TNF-α augments CXCL10 axis.jpg

Fig1. Schematic of the signaling pathways involved in TNF-α augments CXCL10/CXCR3 axis to promote CC cell EMT, invasion and migration. (Zhengcheng Wang, 2021)

CXCL10 Related Signaling Pathway

CXCL10 protein is an important cytokine belonging to the C-X-C family. It is mainly involved in a variety of signaling pathways, the most important of which is the inflammatory response signaling pathway. CXCL10 can bind to its receptor CXCR3, activate downstream signaling pathways, and trigger chemotaxis and activation of inflammatory cells, such as T cells, natural killer cells and monocytes. In addition, CXCL10 is involved in biological processes such as angiogenesis, tumor metastasis, and neurodevelopment.

CXCL10 Related Diseases

The CXCL10 protein has been implicated in a variety of diseases, including infectious diseases, autoimmune diseases, and tumors. In infectious diseases, CXCL10 is involved in the migration of chemotactic immune cells to the site of infection and in regulating the inflammatory response. In autoimmune diseases, CXCL10 can cause autoimmune responses and tissue damage. In tumors, CXCL10 can promote tumor cell growth, invasion and metastasis.

Bioapplications of CXCL10

In terms of clinical diagnosis, levels of CXCL10 have been used to assess the activity of certain inflammatory diseases, such as rheumatoid arthritis (RA). In addition, CXCL10 mRNA release assay (IP-10.TB) has been developed as a novel Mycobacterium tuberculosis specific assay for the diagnosis of mycobacterium tuberculosis infection, showing diagnostic sensitivity and specificity comparable to the existing T-SPOT.TB assay. In particular, there is a higher positive detection rate in patients co-infected with HIV, which provides a new tool for screening and preventive treatment of tuberculosis infection in people with immune abnormalities.

High Purity

CXCL10-PAGE-1.JPG

Fig1. SDS-PAGE (CXCL10-08H)

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CXCL10-PAGE-2.JPG

Fig2. SDS-PAGE (CXCL10-524H)

Case Study 1: Tadaatsu Imaizumi, 2021

Various viruses including a novel coronavirus (SARS-CoV-2) can infect the kidney. When viruses invade the glomeruli from the bloodstream, glomerular endothelial cells (GECs) initiate the innate immune reactions. Role of IFIT1/2/3 in the expression of C-X-C motif chemokine ligand 10 (CXCL10) was also examined. Human GECs were cultured and stimulated with polyinosinic-polycytidylic acid (poly IC), a synthetic TLR3 agonist. Real-time qPCR, Western blotting, and ELISA were used to examine the expression of IFIT1/2/3, IFN-β, and CXCL10. RNA interference against IFN-β or IFIT1/2/3 was also performed. xpression of IFIT1/2/3 and CXCL10 was induced by poly IC in GECs. Knockdown of IFIT1/2/3 decreased the CXCL10 expression. Knockdown of IFIT3 decreased the expression of IFIT1 and IFIT2 proteins.

CXCL10 concentration in the medium was measured using an ELISA kit.JPG

Fig1. CXCL10 concentration in the medium was measured using an ELISA kit.

The expression of mRNA and protein for CXCL10.jpg

Fig2. The expression of mRNA and protein for IFIT1, IFIT2, IFIT3, and CXCL10 was analyzed using qRT-PCR.

Case Study 2: Michelle Silasi, 2020

The process of implantation, trophoblast invasion and placentation demand continuous adaptation and modifications between the trophoblast (embryonic) and the decidua (maternal). Human chorionic gonadotropin (hCG) is one of the earliest hormones produced by the blastocyst and has potent immune modulatory effects, especially in relation to T cells. This study hypothesized that trophoblast-derived hCG modulates the immune population present at the maternal fetal interface by modifying the cytokine profile produced by the stromal/decidual cells. Using in vitro models from decidual samples the researchers demonstrate that hCG inhibits CXCL10 expression by inducing H3K27me3 histone methylation, which binds to Region 4 of the CXCL10 promoter, thereby suppressing its expression. hCG-induced histone methylation is mediated through EZH2, a functional member of the PRC2 complex. Regulation of CXCL10 expression has a major impact on the capacity of endometrial stromal cells to recruit CD8 cells. Alterations in this immune regulatory function, such as during infection, will have detrimental effects on the success of the pregnancy.

Quantification of CXCL10 protein expression.jpg

Fig3. Quantification of CXCL10 protein expression in HESC treated with cAMP or decidualized with estrogen, progesterone and cAMP.

evaluation of CXCL10 protein expression by Luminex.jpg

Fig4. Human term decidua tissues were treated with LPS (100 ng/ml) for 24 followed by evaluation of CXCL10 protein expression by Luminex.

Cxcl10 involved in several pathways and played different roles in them. We selected most pathways Cxcl10 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cxcl10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIFNK;TNFRSF1A;VEGFC;IFNA12;IL22;CCL4L1;CXCL16;GM10591;NGFRB
Chemokine signaling pathwayPLCB4;MAPK3;GNG4;CCL4;VAV2;CCL21B;CXCR1;DOCK2;GNGT1
Toll-like receptor signaling pathwayTMED7-TICAM2;Ifna15;IRAK1;CXCL10;MAPK14B;STAT1;MAPK12B;IFNA21;RAC1A
RIG-I-like receptor signaling pathwayIL8L2;CXCL10;FADD;IFNE;MAPK13;CXCL8B.3;RNF125;TBK1;NFKB1
Cytosolic DNA-sensing pathwayRIPK3;CCL4L1;IFNA1;POLR1C;LOC100033925;TBK1;NFKBIAB;CCL5;IFI202B
TNF signaling pathwayIKBKG;MAP2K4;CCL20;Ccl12;ATF4;TRAF2;VEGFC;RPS6KA5;IKBKB
Influenza ANFKBIB;ACTG1;XPO1;NXF2;IL18;IFNB;RNASEL;Fasl;IFNA3

Cxcl10 has several biochemical functions, for example, CXCR3 chemokine receptor binding, cAMP-dependent protein kinase regulator activity, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cxcl10 itself. We selected most functions Cxcl10 had, and list some proteins which have the same functions with Cxcl10. You can find most of the proteins on our site.

Function Related Protein
CXCR3 chemokine receptor bindingCXCL13;PF4;CXCL11.8;CXCL9;CXCL10;CXCL11
cAMP-dependent protein kinase regulator activityPRKAG1;PRKAR2A;PRKAR1AA;PRKAR1AB;PRKAR1B;PRKAG2;PRKAR1A;PRKAR2AB;CXCL10
chemokine activityCXCL11.8;CCL6;PF4;CCL20;CXCL18B;CXCL32B.1;Ccl21a;CX3CL1;CCL39.1
heparin bindingTHBS3;FGF2;APOE;CCL7;CTGF;CCL5;FSTL1;SLIT1B;PLA2G5
protein bindingKIF9;DCUN1D4;ABHD14B;SNX31;STAG3;RRAS2;TMEM194;INPP4B;STOX1
receptor bindingWIPI1;NPY;SMARCD1;H2-Q10;GAS6;FGF24;SLC9A3R2;DHRS4;GSTM2

Cxcl10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cxcl10 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cxcl10.

DPP4; DPP8

Gene Family

Chemokines Cytokines

Research Area

Related articles

Ma, T; Xu, JC; et al. Combination of C-X-C motif chemokine 9 and C-X-C motif chemokine 10 antibodies with FTY720 prolongs the survival of cardiac retransplantation allografts in a mouse model. EXPERIMENTAL AND THERAPEUTIC MEDICINE 9:1006-1012(2015).
Asquith, DL; Bryce, SA; et al. Targeting cell migration in rheumatoid arthritis. CURRENT OPINION IN RHEUMATOLOGY 27:204-211(2015).
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Q&As (7)

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What are the mechanisms by which CXCL10 modulates the blood-brain barrier and affects neuroinflammatory diseases? 10/21/2022

CXCL10 affects the blood-brain barrier, playing a role in neuroinflammatory disorders.

What is the impact of CXCL10 on the pathogenesis of autoimmune diseases, like rheumatoid arthritis and lupus? 09/28/2021

CXCL10 plays a role in autoimmune diseases, exacerbating conditions like rheumatoid arthritis and lupus.

What role does CXCL10 play in the tumor microenvironment and cancer metastasis? 11/10/2020

In cancer, CXCL10 influences the tumor microenvironment and may contribute to tumor spread and metastasis.

How do alterations in CXCL10 expression or signaling affect the progression of chronic inflammatory conditions? 06/08/2020

Changes in CXCL10 expression influence chronic inflammatory diseases, potentially aggravating or modulating disease progression.

How does CXCL10 contribute to the antiviral immune response, particularly in viral hepatitis and HIV infections? 11/03/2019

CXCL10 is important in antiviral defense, enhancing immune responses against pathogens like hepatitis viruses and HIV.

How does CXCL10 influence angiogenesis and tissue repair processes? 09/09/2019

CXCL10 impacts angiogenesis and is involved in tissue repair and regeneration processes.

How does CXCL10 mediate immune cell recruitment and activation in inflammatory and infectious diseases? 07/30/2019

CXCL10 attracts and activates immune cells to sites of inflammation and infection, coordinating the immune response.

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07/18/2019

    Expertise in protein engineering, invaluable for our laboratory's needs.

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        High-quality protein-protein interaction assays, integral to our experiments.

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