Cxcl10
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Official Full Name
chemokine (C-X-C motif) ligand 10
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Background
This gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation of adhesion molecule expression. [provided by RefSeq, Jul 2008] -
Synonyms
CXCL10; chemokine (C-X-C motif) ligand 10; C7; IFI10; INP10; IP-10; crg-2; mob-1; SCYB10; gIP-10; C-X-C motif chemokine 10; gamma IP10; gamma-IP10; small-inducible cytokine B10; interferon-inducible cytokine IP-10; 10 kDa interferon gamma-induced protein; protein 10 from interferon (gamma)-induced cell line; small inducible cytokine subfamily B (Cys-X-Cys), member 10;
- Involved Pathway
- Protein Function
- Interacting Protein
- Cxcl10 Related Articles
- Cxcl10 Related Gene Family
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Cxcl10 involved in several pathways and played different roles in them. We selected most pathways Cxcl10 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cxcl10 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | LOC100033925;IL19;TNFRSF18;MET;Ifnlr1;Kitl;KIT;Ccl21c;TP-1 |
| Chemokine signaling pathway | CXCL16;GRK5;GNB1;RAC1;CCR8;CCL27;AMCF-II;GNB4;GNG12 |
| Toll-like receptor signaling pathway | TLR2-2;MAPK1;MAP2K7;LY96;IL8L1;MAPK8B;LBP;MYD88;MAP3K7 |
| RIG-I-like receptor signaling pathway | MAPK13;TRAF2;RIPK1L;TBKBP1;DHX58;TP-1;NFKBIAA;IFNA12;IFNA7 |
| Cytosolic DNA-sensing pathway | Ifna15;CCL4;IFNB1;AIM2;ADAR;TMEM173;TREX1;POLR2F;Ifna11 |
| TNF signaling pathway | BIRC3;BIRC2;IKBKB;MAPK11;Ccl12;FADD;CXCL3;SOCS3;NFKBIA |
| Influenza A | MX1;BCL2L2-PABPN1;CXCL10;IFNA13;IFNA10;PIK3R2;HSPA6;HSPA1A;IRAK4 |
Cxcl10 has several biochemical functions, for example, CXCR3 chemokine receptor binding, cAMP-dependent protein kinase regulator activity, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cxcl10 itself. We selected most functions Cxcl10 had, and list some proteins which have the same functions with Cxcl10. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| CXCR3 chemokine receptor binding | CXCL9;CXCL11;PF4;CXCL11.8;CXCL13;CXCL10 |
| cAMP-dependent protein kinase regulator activity | PRKAR1AB;PRKAG2;PRKAR2AB;CXCL10;PRKAR1AA;PRKAR2AA;PRKAR2B;PRKAR2A;PRKAR1A |
| chemokine activity | CXCL14;CCL33.2;CCL34B.1;IL8L2;CCL28;CXCL16;CCL20B;CCL11;AMCF-II |
| heparin binding | PF4;SERPINE2;WISP1;WISP1B;APOA5;COL20A1;CECR1;ELANE;APLP1 |
| protein binding | HSPA13;KIF1C;SETD7;ATP6V1F;AARSD1;GGA1;THEMIS;AGPAT4;PALB2 |
| receptor binding | TNFSF13;SNX17;ADIPOQ;FYNB;PVRL3B;HSD17B4;ENSA;DAO1;F2RL1 |
Cxcl10 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cxcl10 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cxcl10.
DPP4; DPP8
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