CXCL6 Protein


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Official Full Name Chemokine (C-X-C motif) ligand 6
Background Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes. It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2. The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.
Synonyms GCP2; Chemokine (C-X-C motif) ligand 6; CXCL6
    • Species :
    • Human
    • Source :
    • CHO
    • E.coli
    • HEK293
    • In Vitro Cell Free System
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CXCL6-123H Active Recombinant Human CXCL6, MIgG2a Fc-tagged CHO Fc Inquiry
    Human CXCL6-133H Active Recombinant Human CXCL6, HIgG1 Fc-tagged, mutant CHO Fc Inquiry
    Human CXCL6-143H Active Recombinant Human CXCL6, HIgG1 Fc-tagged CHO Fc Inquiry
    Human CXCL6-171H Active Recombinant Human CXCL6 protein CHO Inquiry
    Human CXCL6-2173H Recombinant Human CXCL6 Protein, GST-tagged Wheat Germ GST Inquiry
    Human CXCL6-27781TH Recombinant Human CXCL6 E.coli N/A Inquiry
    Human CXCL6-7130H Recombinant Human CXCL6 protein, His & T7-tagged E.coli His/T7 Inquiry
    Human CXCL6-75H Recombinant Human CXCL6 protein E.coli N/A Inquiry
    Human CXCL6-7166HCL Recombinant Human CXCL6 293 Cell Lysate HEK293 N/A Inquiry
    Human CXCL6-170H Recombinant Human CXCL6(Gly38-Asn114) Protein, C-6*His-tagged HEK293 His Inquiry
    Human CXCL6-2299HF Recombinant Full Length Human CXCL6 Protein, GST-tagged In Vitro Cell Free System GST Inquiry

    CXCL6 involved in several pathways and played different roles in them. We selected most pathways CXCL6 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CCL14; CSH; TNFRSF25; LTBR; TNFRSF11B; TNFRSF13C; BMPR1BB; IL18R1; ACVR1B; IL12RB2
    Chemokine signaling pathway CXCL3; PIK3R3; PTK2; GNAI1; Cxcl15; CXCR4; PRKCB; CCR3; MAPK1; GSK3A
    Pertussis MAPK13; CD14; TICAM2; PYCARD; CALM4; IRF8; IRAK1; ITGB2; CALML3; IRF3
    Rheumatoid arthritis CCL3L3; HLA-DOB; IFNG; ATP6V1H; ICAM1; CCL20; TGFB1; ATP6V1E1; CD28; ATP6V1G2

    CXCL6 has several biochemical functions, for example, CXCR chemokine receptor binding, chemokine activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL6 itself. We selected most functions CXCL6 had, and list some proteins which have the same functions with CXCL6. You can find most of the proteins on our site.

    Function Related Protein
    CXCR chemokine receptor binding CXCL5; CXCL20; CXCL1; PPBP; CXCL18B; AMCF-II; CXCL3; PF4V1; CXCL12; ITCH
    chemokine activity CCL3L3; Ccl21c; CCL26; CCL20B; CCL28; CCL15; CCL34A.3; CCL44; CCL27B; CXCL11.8
    heparin binding LIPC; FGFR1; NRP1; SLIT1B; RSPO4; LIPG; APP; PRELP; SLIT1; F11

    CXCL6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL6.


    Tian, H; Huang, PX; et al. HIF-1 alpha Plays a Role in the Chemotactic Migration of Hepatocarcinoma Cells Through the Modulation of CXCL6 Expression. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 34:1536-1546(2014).
    Besnard, AG; Struyf, S; et al. CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model. JOURNAL OF LEUKOCYTE BIOLOGY 94:1317-1323(2013).

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