• Official Full Name

    Chemokine (C-X-C motif) ligand 6

  • Background

    Chemokine (C-X-C motif) ligand 6 (CXCL6) is a small cytokine belonging to the CXC chemokine family that is also known as granulocyte chemotactic protein 2 (GCP-2). As its former name suggests, CXCL6 is a chemoattractant for neutrophilic granulocytes. It elicits its chemotactic effects by interacting with the chemokine receptors CXCR1 and CXCR2. The gene for CXCL6 is located on human chromosome 4 in a cluster with other CXC chemokine genes.
  • Synonyms

    GCP2; Chemokine (C-X-C motif) ligand 6; CXCL6;
    • Type:
    • Recombinant Proteins
    • Cell & Tissue Lysates
    • Species :
    • Human
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • C
    • His
    • Fc
    • GST
    • His|T7
    • N/A
    • N
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • CXCL6 Related Articles
    • CXCL6 Related Gene Family
    • CXCL6 Related Research Area

    CXCL6 involved in several pathways and played different roles in them. We selected most pathways CXCL6 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionCCL21;FLT3;IL3RA;RNF207B;TGFBR1;LEPA;IL10RB;IL2RB;ACVR1L
    Chemokine signaling pathwayPIK3CA;CXCL14;DOCK2;PRKCZ;FGR;Ccl21c;CXCL8;PRKCB;GNB4
    Rheumatoid arthritisCCL3;ATP6V1G1;ATP6V0E2;CCL3L1;IFNG;FLT1;HLA-DQA1;ITGB2L;CTLA4

    CXCL6 has several biochemical functions, for example, CXCR chemokine receptor binding, chemokine activity, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL6 itself. We selected most functions CXCL6 had, and list some proteins which have the same functions with CXCL6. You can find most of the proteins on our site.

    Function Related Protein
    CXCR chemokine receptor bindingPF4V1;IL8L2;CXCL5;CXCL1;CXCL2;CXCL12B;PPBP;CXCL3;CXCL12
    chemokine activityCcl21c;CCL7;CCL35.1;CCL1;CCL6;CCL21B;XCL2;CCL27;CCL34B.4

    CXCL6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL6 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL6.


    Tian, H; Huang, PX; et al. HIF-1 alpha Plays a Role in the Chemotactic Migration of Hepatocarcinoma Cells Through the Modulation of CXCL6 Expression. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 34:1536-1546(2014).
    Besnard, AG; Struyf, S; et al. CXCL6 antibody neutralization prevents lung inflammation and fibrosis in mice in the bleomycin model. JOURNAL OF LEUKOCYTE BIOLOGY 94:1317-1323(2013).
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