CXCL1

  • Official Full Name

    chemokine (C-X-C motif) ligand 1

  • Overview

    This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]
  • Synonyms

    CXCL1; chemokine (C-X-C motif) ligand 1; KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1; growth-regulated alpha protein; KC/GR)-alpha; KC/GRO-alpha; GRO1 oncogene; alpha-chemokine; secretory protein N51; C-X-C motif chemokine 1; platelet-derived growth factor-inducible protein KC;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cotton Rat
  • Cynomolgus Monkey
  • Human
  • Mouse
  • Pan troglodytes
  • Rat
  • Rhesus Macaque
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Biotin
  • C
  • His
  • DYKDDDDK
  • Fc
  • GST
  • His (Fc)
  • Avi
  • His|GST
  • His|MBP
  • His|SUMO
  • His|T7
  • MBP
  • N/A
  • N
  • NusA
  • Strep II
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CXCL1-244H Active Recombinant Human Chemokine (C-X-C Motif) Ligand 1, HIgG1 Fc-tagged CHO Fc
Human CXCL1-222H Active Recombinant Human Chemokine (C-X-C Motif) Ligand 1, MIgG2a Fc-tagged CHO Fc
Human CXCL1-233H Active Recombinant Human Chemokine (C-X-C Motif) Ligand 1,HIgG1 Fc-tagged, mutant CHO Fc
Human CXCL1-14H Recombinant Human CXCL1 protein E.coli N/A 73
Human CXCL1-62H Recombinant Human Chemokine (C-X-C motif) Ligand 1 / Growth-regulated Alpha Protein, His-tagged E.coli His
Human CXCL1-162H Recombinant Human Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), MBP-tagged E.coli MBP
Human CXCL1-11715H Recombinant Human CXCL1, His-tagged E.coli His 1-107a.a.
Human CXCL1-769H Recombinant Human CXCL1 protein, His & GST-tagged E.coli His/GST Ala35~Asn107 (Accession # P09341)
Human CXCL1-195H Recombinant Human CXCL1 protein(Ala35-Asn107), His&NusA-tagged E.coli N-His&NusA Ala35-Asn107
Human CXCL1-281H Recombinant Human CXCL1, StrepII-tagged Human Cell Strep II 35-107, 73 a.a.
Human CXCL1-425HCL Recombinant Human CXCL1 cell lysate N/A
Human CXCL1-982H Recombinant Human CXCL1 Protein, His-SUMO-tagged E.coli His/SUMO
Human CXCL1-2370H Recombinant Human CXCL1 protein(Ala35-Asn107) E. coli N/A Ala35-Asn107
Human CXCL1-001H Recombinant Human CXCL1 Protein, MBP-tagged E.coli MBP
Human CXCL1-27707TH Native Human CXCL1 E.coli N/A
Human CXCL1-151H Recombinant Human CXCL1 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CXCL1-031HG GMP Recombinant Human CXCL1 protein HEK293 DNA sequence encoding Human CXCL1(UniProtKB/Swiss-Prot: P09341-1) was expressed with His tag at the C-terminal.
Human CXCL1-2096H Recombinant Human CXCL1 Protein (Ala35-Asn107), C-His tagged Mammalian cells C-His Ala35-Asn107
Human CXCL1-13H Recombinant Human CXCL1 Protein, Biotin-tagged E.coli Biotin
Human CXCL1-2098H Recombinant Human CXCL1 Protein (Ala35-Asn107), N-GST tagged E.coli N-GST Ala35-Asn107
Human CXCL1-2225HF Recombinant Full Length Human CXCL1 Protein, GST-tagged In Vitro Cell Free System GST 107 amino acids
Human CXCL1-134H Active Recombinant Human CXCL1 Protein (Ala35-Asn107), N-His tagged, Animal-free, Carrier-free E.coli N-His Ala35-Asn107
Human CXCL1-272C Active Recombinant Human CXCL1 Protein CHO
Mouse Cxcl1-384M Active Recombinant Mouse Chemokine (C-X-C motif) Ligand 1 E.coli N/A
Mouse Cxcl1-01M Active GMP Recombinant Mouse Cxcl1 Protein E.coli
Mouse Cxcl1-771M Recombinant Mouse Cxcl1 protein, His & GST-tagged E.coli His/GST Ala25~Lys96 (Accession # P12850)
Mouse Cxcl1-529M Recombinant Mouse Cxcl1 protein, His-tagged HEK293F His
Mouse Cxcl1-772M Recombinant Mouse Cxcl1 protein, His & MBP-tagged E.coli His/MBP Ala25~Lys96 (Accession # P12850)
Mouse Cxcl1-770M Recombinant Mouse Cxcl1 protein, His & T7-tagged E.coli His/T7 Ala25~Lys96 (Accession # P12850)
Mouse Cxcl1-377M Recombinant Mouse Chemokine (C-X-C motif) ligand 1, His-tagged E.coli His
Mouse Cxcl1-96M Recombinant Mouse Cxcl1 protein E.coli N/A 72
Mouse Cxcl1-5248M Recombinant Mouse Cxcl1 protein, His-tagged E.coli His 29-96aa
Mouse Cxcl1-5680M Recombinant Mouse Cxcl1 Protein (Arg20-Lys96), C-His tagged Mammalian cells C-His Arg20-Lys96
Mouse Cxcl1-33M Active Recombinant Mouse Cxcl1 Protein (Asn29-Lys96), Animal-free, Carrier-free E.coli Tag Free Asn29-Lys96
Mouse Cxcl1-7216M Recombinant Mouse Cxcl1 Protein, His-tagged E.coli His 25-96
Mouse Cxcl1-271C Active Recombinant Mouse Cxcl1 Protein CHO
Rat CXCL1-1686R Recombinant Rat CXCL1 Protein Mammalian Cell His
Rat Cxcl1-773R Recombinant Rat Cxcl1 protein, His-tagged E.coli His Ala25~Lys96 (Accession # P14095)
Rat Cxcl1-1877R Recombinant Rattus Chemokine (C-X-C motif) Ligand 1 (melanoma growth stimulating activity, alpha) E.coli N/A
Rat Cxcl1-011C Active Recombinant Rat Cxcl1 Protein (72 aa) E.coli 72
Rat CXCL1-1345R Recombinant Rat CXCL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CXCL1-1345R-B Recombinant Rat CXCL1 Protein Pre-coupled Magnetic Beads HEK293
Rat Cxcl1-187C Active Recombinant Rat Cxcl1 Protein HEK293
Rat CXCL1-3224R Recombinant Rat CXCL1 protein(Ala25-Lys96) E.coli N/A Ala25-Lys96
Cotton Rat Cxcl1-387C Active Recombinant Cotton Rat Cxcl1 E.coli N/A
Cynomolgus Monkey CXCL1-431C Recombinant Cynomolgus CXCL1 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CXCL1-178C Recombinant Cynomolgus Monkey CXCL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cynomolgus Monkey CXCL1-178C-B Recombinant Cynomolgus Monkey CXCL1 Protein Pre-coupled Magnetic Beads HEK293
Pan troglodytes CXCL1-01P Recombinant Pan troglodytes CXCL1 Protein E.coli
Rhesus Macaque CXCL1-1104R Recombinant Rhesus monkey CXCL1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CXCL1-929R-B Recombinant Rhesus Macaque CXCL1 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CXCL1-929R Recombinant Rhesus Macaque CXCL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CXCL1 involved in several pathways and played different roles in them. We selected most pathways CXCL1 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionAMH;CCL8;TGFBR1A;IL4;TNFRSF11B;IL20RB;TNFSF4;CXCL5;Ccl21a
Chemokine signaling pathwayNFKBIB;ARRB1;FOXO3;CXCL10;CXCR3;GNG5;PIK3CG;CXCL11;RAP1A
NOD-like receptor signaling pathwayLOC100033925;BIRC3;MAPK12B;IL8L2;HSP90AB1;PSTPIP1;CXCL1;IL6;NFKB1
TNF signaling pathwayMAP3K5;PIK3R2;PIK3CA;IKBKB;BAG4;IL18R1;MAGI2;TNFRSF1A;MAPK3
Epithelial cell signaling in Helicobacter pylori infectionMAPK12;RAC1;ATP6V1G2;ATP6V1B1;GIT1;MAPK9;ADAM17;MAP3K14;ATP6V1B2
Salmonella infectionPKN2;PFN2L;IL18;KLC1A;KLC1B;NOS2A;MAPK14A;TLR5;CCL4
LegionellosisTLR5;HSPA1L;CASP1;IL12B;CLK1;HSPA8;RAB1A;CD14;Casp3
AmoebiasisSERPINB1A;LAMC2;PIK3CG;RAB5C;IL1R1;LAMC3;COL5A1;GNA15;COL4A3
Rheumatoid arthritisCXCL12;IL15;ATP6V0A2;H2-AB1;TNFSF13B;FOS;ATP6AP1;HLA-DQA2;ATP6V0A1

CXCL1 has several biochemical functions, for example, CXCR chemokine receptor binding, chemokine activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL1 itself. We selected most functions CXCL1 had, and list some proteins which have the same functions with CXCL1. You can find most of the proteins on our site.

Function Related Protein
CXCR chemokine receptor bindingITCH;CXCL18B;PF4V1;CXCL12B;CXCL2;IL8L2;CXCL5;CXCL6;CXCL20
chemokine activityCXCL13;CCL20;XCL2;AMCF-II;CXCL12A;CCL33.2;CXCL8B.3;CCL19B;CCL5
enzyme activator activityPRKCD;CTSA;APOA5;DBNL;MGST2;MMP15;TIMP2;ASAP2;HSPB2
growth factor activityFGF21;IL10;FGF10A;BTC;PDGFC;INHBC;CNTF;NDR2;FGF12A
receptor bindingNCR3;TAC3;GRIN2A;ACOX1;HLA-A;ADIPOQ;HLA-E;CTNND1;CCL17

CXCL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL1.

XRCC3; HRAS; ESR1; PTEN; purL

Gene Family

Chemokines Cytokines

Research Area

Related articles

McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).
Lee, YH; Shynlova, O; et al. Stretch-induced human myometrial cytokines enhance immune cell recruitment via endothelial activation. CELLULAR & MOLECULAR IMMUNOLOGY 12:231-242(2015).
  • Q&As
  • Reviews

Q&As (7)

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Are there any therapeutic strategies targeting CXCL1? 11/17/2022

Therapeutic strategies targeting CXCL1 aim to modulate its activity in diseases like cancer and chronic inflammation.

How does CXCL1 contribute to inflammation? 05/03/2022

It mediates inflammation by promoting leukocyte migration and activation.

What role does CXCL1 play in tumor progression? 09/30/2021

In cancer, CXCL1 can promote tumor growth, metastasis, and angiogenesis.

What is the relationship between CXCL1 and angiogenesis? 04/21/2021

CXCL1 contributes to angiogenesis, supporting new blood vessel formation.

What is the primary function of CXCL1 in the immune system? 11/15/2019

CXCL1 is a chemokine that attracts neutrophils to sites of infection or injury.

In which pathological conditions is CXCL1 found to be elevated? 08/05/2018

CXCL1 levels are elevated in conditions like cancer, inflammatory diseases, and infections.

How is the expression of CXCL1 regulated in cells? 02/06/2018

CXCL1 expression is regulated by various stimuli, including cytokines and growth factors.

Customer Reviews (3)

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Reviews
06/15/2020

    Efficient delivery, great service.

    01/01/2019

      Product as described, perfect.

      10/13/2018

        Reliable for protein work.

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