CXCL1 Protein


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Official Full Name chemokine (C-X-C motif) ligand 1
Background This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]
Synonyms CXCL1; chemokine (C-X-C motif) ligand 1; KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1; growth-regulated alpha protein; KC/GR)-alpha; KC/GRO-alpha; GRO1 oncogene; alpha-chemokine; secretory protein N51; C-X-C motif chemokine 1; platelet-derived growth factor-inducible protein KC;
    • Species :
    • Cotton Rat
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Pan troglodytes
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293F
    • Human
    • Human Cell
    • Human Cells
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Biotin
    • Fc
    • GST
    • His
    • His(N-ter)
    • MBP
    • NusA
    • SUMO
    • T7
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CXCL1-222H Recombinant Human Chemokine (C-X-C Motif) Ligand 1, MIgG2a Fc-tagged CHO Fc
    Human CXCL1-233H Recombinant Human Chemokine (C-X-C Motif) Ligand 1,HIgG1 Fc-tagged, mutant CHO Fc
    Human CXCL1-244H Recombinant Human Chemokine (C-X-C Motif) Ligand 1, HIgG1 Fc-tagged CHO Fc
    Mouse Cxcl1-384M Recombinant Mouse Chemokine (C-X-C motif) Ligand 1 E.coli N/A
    Cotton Rat Cxcl1-387C Recombinant Cotton Rat Cxcl1 E.coli N/A
    Human CXCL1-334H Recombinant Human Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) Human N/A
    Mouse Cxcl1-01M GMP Recombinant Mouse Cxcl1 Protein E.coli
    Human CXCL1-11715H Recombinant Human CXCL1, His-tagged E.coli His
    Human CXCL1-14H Recombinant Human CXCL1 protein E.coli N/A
    Human CXCL1-162H Recombinant Human Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), MBP-tagged E.coli MBP
    Human CXCL1-195H Recombinant Human CXCL1, His & NusA tagged E.coli His/NusA
    Human CXCL1-196H Recombinant Human Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha), His-tagged Human His
    Human CXCL1-2155H Recombinant Human CXCL1 Protein, GST-tagged Wheat Germ GST
    Human CXCL1-281H Recombinant Human CXCL1, StrepII-tagged Human Cell Strep II
    Human CXCL1-29095TH Recombinant Human CXCL1 E.coli N/A
    Human CXCL1-29096TH Recombinant Human CXCL1, MBP-tagged E.coli MBP
    Human CXCL1-62H Recombinant Human Chemokine (C-X-C motif) Ligand 1 / Growth-regulated Alpha Protein, His-tagged E.coli His
    Human CXCL1-769H Recombinant Human CXCL1 protein, His & GST-tagged E.coli His/GST
    Human CXCL1-88H Recombinant Human Chemokine (C-X-C Motif) Ligand 1, His-tagged E.coli His
    Mouse Cxcl1-15865M Recombinant Mouse Cxcl1, His-tagged E.coli His
    Mouse Cxcl1-377M Recombinant Mouse Chemokine (C-X-C motif) ligand 1, His-tagged E.coli His
    Mouse Cxcl1-529M Recombinant Mouse Cxcl1 protein, His-tagged HEK293F His
    Mouse Cxcl1-770M Recombinant Mouse Cxcl1 protein, His & T7-tagged E.coli His/T7
    Mouse Cxcl1-771M Recombinant Mouse Cxcl1 protein, His & GST-tagged E.coli His/GST
    Mouse Cxcl1-772M Recombinant Mouse Cxcl1 protein, His & MBP-tagged E.coli His/MBP
    Mouse Cxcl1-96M Recombinant Mouse Cxcl1 protein E.coli N/A
    Rat Cxcl1-1069R Recombinant Rat Cxcl1 Protein E.coli N/A
    Rat CXCL1-1686R Recombinant Rat CXCL1 Protein Mammalian Cell His
    Rat Cxcl1-1877R Recombinant Rattus Chemokine (C-X-C motif) Ligand 1 (melanoma growth stimulating activity, alpha) E.coli N/A
    Rat Cxcl1-773R Recombinant Rat Cxcl1 protein, His-tagged E.coli His
    Rat Cxcl1-94R Recombinant Rat Cxcl1 protein E.coli N/A
    Cynomolgus Monkey CXCL1-431C Recombinant Cynomolgus CXCL1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CXCL1-1104R Recombinant Rhesus monkey CXCL1 Protein, His-tagged Mammalian Cell His
    Human CXCL1-425HCL Recombinant Human CXCL1 cell lysate N/A
    Pan troglodytes CXCL1-01P Recombinant Pan troglodytes CXCL1 Protein E.coli
    Human CXCL1-02H Recombinant Human CXCL1 Protein E.coli
    Human CXCL1-13H Recombinant Human CXCL1 Protein, Biotin-tagged E.coli Biotin
    Human CXCL1-151H Recombinant Human CXCL1 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human CXCL1-2225HF Recombinant Full Length Human CXCL1 Protein, GST-tagged In Vitro Cell Free System GST
    Mouse Cxcl1-5248M Recombinant Mouse Cxcl1 protein, His-tagged E.coli His
    Human CXCL1-52H Recombinant Active Human CXCL1 Protein, His-tagged(N-ter) E.coli His(N-ter)
    Human CXCL1-001H Recombinant Human CXCL1 Protein, MBP-tagged E.coli MBP
    Human CXCL1-031HG GMP Recombinant Human CXCL1 protein, His-tagged HEK293 His
    Human CXCL1-27707TH Native Human CXCL1 E.coli N/A
    Human CXCL1-982H Recombinant Human CXCL1 Protein, His-SUMO-tagged E.coli His/SUMO
    Mouse Cxcl1-068M Recombinant Mouse Cxcl1 Protein E.coli
    Mouse Cxcl1-069M Recombinant Mouse Cxcl1 Protein E.coli
    Mouse Cxcl1-7216M Recombinant Mouse Cxcl1 Protein, His-tagged E.coli His

    CXCL1 involved in several pathways and played different roles in them. We selected most pathways CXCL1 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction VEGFC; TSLP; IFNGR1; BMPR1BA; IFNA4; XCR1; CXCL8B.3; IL22RA2; BMPR1AA; TNFRSF10D
    Chemokine signaling pathway CCL25; CCL5; WAS; HCK; ITK; CXCR6; GNGT1; PRKACB; CXCL5; Ccl12
    NOD-like receptor signaling pathway MAPK8B; PSTPIP1; HSP90AA1; MAPK8; PYDC1; TNFAIP3; MAPK3; TRAF6; CARD18; MAPK1
    TNF signaling pathway PIK3CG; CREB5; TNF; CCL2; PGAM5; IL6; IL1B; MAP2K7; Casp3; CASP10
    Epithelial cell signaling in Helicobacter pylori infection SRC; NFKB1; CXCR1; ATP6V1C1; LYN; PTPN11; MAP2K4; ATP6V1A; ATP6V0C; NFKBIA
    Salmonella infection TLR4; IL1B; ACTB2; ARPC5LA; IL1A; NOS2B; PFN2L; RHOG; PFN2; KLC1B
    Legionellosis SAR1B; CASP7; IL1B; SEC22B; NAIP6; PYCARD; HSPA1L; ITGAM; HBS1L; EEF1G
    Amoebiasis CD1d1; Casp3; COL4A6; NOS2; PLCB4; CTSG; CD1D; VCL; IFNG; LAMC2
    Rheumatoid arthritis ATP6V0D2; ATP6V1D; CCL5; LTB; ATP6AP1; IL11; HLA-DOA; HLA-DMB; HLA-DQA1; ICAM1

    CXCL1 has several biochemical functions, for example, CXCR chemokine receptor binding, chemokine activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL1 itself. We selected most functions CXCL1 had, and list some proteins which have the same functions with CXCL1. You can find most of the proteins on our site.

    Function Related Protein
    CXCR chemokine receptor binding CXCL18B; CXCL1; CXCL3; CXCL12B; CXCL20; CXCL2; IL8L2; PPBP; CXCL6; ITCH
    chemokine activity CXCL12; CCL25B; CCL21; CCL35.1; CXCL19; CCL5; CCL20; CXCL12A; CCL34A.4; Ccl12
    enzyme activator activity CLPS; HSPB2; GTF3C4; MMP17; SAE1; ALOX5AP; CTSA; PPP1R12B; ALDH1A2; DBF4
    growth factor activity IL10; FGF8B; VEGFAB; GDF5; Artn; BMP15; F2; AREG; GSDF; VHL
    receptor binding NSG1; LAMA1; HLA-B; ITGA1; PVRL4; EHHADH; Fert2; TNFSF14; APLN; FGF13B

    CXCL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL1.

    XRCC3; HRAS; ESR1; PTEN; purL

    McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).
    Lee, YH; Shynlova, O; et al. Stretch-induced human myometrial cytokines enhance immune cell recruitment via endothelial activation. CELLULAR & MOLECULAR IMMUNOLOGY 12:231-242(2015).

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