CXCL1

  • Official Full Name

    chemokine (C-X-C motif) ligand 1

  • Background

    This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This secretory protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils. In mouse, deficiency of this gene is associated with colitis and with defects in immune cell recruitment to the lung. [provided by RefSeq, Apr 2013]
  • Synonyms

    CXCL1; chemokine (C-X-C motif) ligand 1; KC; Fsp; N51; gro; Gro1; Mgsa; Scyb1; growth-regulated alpha protein; KC/GR)-alpha; KC/GRO-alpha; GRO1 oncogene; alpha-chemokine; secretory protein N51; C-X-C motif chemokine 1; platelet-derived growth factor-inducible protein KC;
    • Type:
    • Recombinant Proteins
    • Protein Pre-coupled Magnetic Beads
    • Native Proteins
    • Cell & Tissue Lysates
    • GMP Proteins
    • Species :
    • Cotton Rat
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Pan troglodytes
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • HEK293F
    • Human
    • Human Cell
    • Human Cells
    • Mammalian Cell
    • Mammalian cells
    • Wheat Germ
    • Tag :
    • Biotin
    • C
    • His
    • DYKDDDDK
    • Fc
    • GST
    • His (Fc)
    • Avi
    • His(N
    • ter)
    • His|GST
    • His|MBP
    • His|NusA
    • His|SUMO
    • His|T7
    • MBP
    • N/A
    • N
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Cotton Rat Cxcl1-387C Active Recombinant Cotton Rat Cxcl1 E.coli N/A
    Cynomolgus Monkey CXCL1-178C Recombinant Cynomolgus Monkey CXCL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Cynomolgus Monkey CXCL1-431C Recombinant Cynomolgus CXCL1 Protein, His-tagged Mammalian Cell His
    Cynomolgus Monkey CXCL1-178C-B Recombinant Cynomolgus Monkey CXCL1 Protein Pre-coupled Magnetic Beads HEK293
    Human CXCL1-14H Recombinant Human CXCL1 protein E.coli N/A
    Human CXCL1-244H Active Recombinant Human Chemokine (C-X-C Motif) Ligand 1, HIgG1 Fc-tagged CHO Fc
    Human CXCL1-769H Recombinant Human CXCL1 protein, His & GST-tagged E.coli His/GST
    Human CXCL1-2096H Recombinant Human CXCL1 Protein (Ala35-Asn107), C-His tagged Mammalian cells C-His
    Human CXCL1-29095TH Recombinant Human CXCL1 E.coli N/A
    Human CXCL1-88H Recombinant Human Chemokine (C-X-C Motif) Ligand 1, His-tagged E.coli His
    Human CXCL1-27707TH Native Human CXCL1 E.coli N/A
    Human CXCL1-2098H Recombinant Human CXCL1 Protein (Ala35-Asn107), N-GST tagged E.coli N-GST
    Human CXCL1-2155H Recombinant Human CXCL1 Protein, GST-tagged Wheat Germ GST
    Human CXCL1-222H Active Recombinant Human Chemokine (C-X-C Motif) Ligand 1, MIgG2a Fc-tagged CHO Fc
    Human CXCL1-334H Active Recombinant Human Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha) Human N/A
    Human CXCL1-982H Recombinant Human CXCL1 Protein, His-SUMO-tagged E.coli His/SUMO
    Human CXCL1-53H Recombinant Human CXCL1 Protein E.coli
    Human CXCL1-233H Active Recombinant Human Chemokine (C-X-C Motif) Ligand 1,HIgG1 Fc-tagged, mutant CHO Fc
    Human CXCL1-162H Recombinant Human Chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha), MBP-tagged E.coli MBP
    Human CXCL1-02H Recombinant Human CXCL1 Protein E.coli
    Human CXCL1-425HCL Recombinant Human CXCL1 cell lysate N/A
    Human CXCL1-11715H Recombinant Human CXCL1, His-tagged E.coli His
    Human CXCL1-115C Recombinant Human CXCL1 Protein (73 aa) E.coli
    Human CXCL1-151H Recombinant Human CXCL1 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human CXCL1-2097H Recombinant Human CXCL1 Protein (Ala35-Asn107), GST tagged E.coli GST
    Human CXCL1-29096TH Recombinant Human CXCL1, MBP-tagged E.coli MBP
    Human CXCL1-196H Recombinant Human Chemokine (C-X-C Motif) Ligand 1 (Melanoma Growth Stimulating Activity, Alpha), His-tagged Human His
    Human CXCL1-281H Recombinant Human CXCL1, StrepII-tagged Human Cell Strep II
    Human CXCL1-62H Recombinant Human Chemokine (C-X-C motif) Ligand 1 / Growth-regulated Alpha Protein, His-tagged E.coli His
    Human CXCL1-001H Recombinant Human CXCL1 Protein, MBP-tagged E.coli MBP
    Human CXCL1-195H Recombinant Human CXCL1, His & NusA tagged E.coli His/NusA
    Human CXCL1-031HG GMP Recombinant Human CXCL1 protein HEK293
    Human CXCL1-13H Recombinant Human CXCL1 Protein, Biotin-tagged E.coli Biotin
    Human CXCL1-52H Recombinant Active Human CXCL1 Protein, His-tagged(N-ter) E.coli His(N-ter)
    Human CXCL1-272C Recombinant Human CXCL1 Protein CHO
    Human CXCL1-389C Recombinant Human CXCL1 Protein (73 aa) E.coli
    Mouse Cxcl1-53M Recombinant Mouse CXCL1 Protein E.coli
    Mouse Cxcl1-529M Recombinant Mouse Cxcl1 protein, His-tagged HEK293F His
    Mouse Cxcl1-771M Recombinant Mouse Cxcl1 protein, His & GST-tagged E.coli His/GST
    Mouse Cxcl1-271C Recombinant Mouse Cxcl1 Protein CHO
    Mouse Cxcl1-5248M Recombinant Mouse Cxcl1 protein, His-tagged E.coli His
    Mouse Cxcl1-770M Recombinant Mouse Cxcl1 protein, His & T7-tagged E.coli His/T7
    Mouse Cxcl1-069M Recombinant Mouse Cxcl1 Protein E.coli
    Mouse Cxcl1-01M Active GMP Recombinant Mouse Cxcl1 Protein E.coli
    Mouse Cxcl1-032C Recombinant Mouse Cxcl1 Protein (72 aa) E.coli
    Mouse Cxcl1-7216M Recombinant Mouse Cxcl1 Protein, His-tagged E.coli His
    Mouse Cxcl1-068M Recombinant Mouse Cxcl1 Protein E.coli
    Mouse Cxcl1-772M Recombinant Mouse Cxcl1 protein, His & MBP-tagged E.coli His/MBP
    Mouse Cxcl1-384M Active Recombinant Mouse Chemokine (C-X-C motif) Ligand 1 E.coli N/A
    Mouse Cxcl1-377M Recombinant Mouse Chemokine (C-X-C motif) ligand 1, His-tagged E.coli His
    Mouse Cxcl1-15865M Recombinant Mouse Cxcl1, His-tagged E.coli His
    Mouse Cxcl1-96M Recombinant Mouse Cxcl1 protein E.coli N/A
    Pan troglodytes CXCL1-01P Recombinant Pan troglodytes CXCL1 Protein E.coli
    Rat CXCL1-1345R Recombinant Rat CXCL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rat CXCL1-1345R-B Recombinant Rat CXCL1 Protein Pre-coupled Magnetic Beads HEK293
    Rat Cxcl1-1877R Recombinant Rattus Chemokine (C-X-C motif) Ligand 1 (melanoma growth stimulating activity, alpha) E.coli N/A
    Rat Cxcl1-94R Recombinant Rat Cxcl1 protein E.coli N/A
    Rat Cxcl1-1069R Recombinant Rat Cxcl1 Protein E.coli N/A
    Rat CXCL1-1686R Recombinant Rat CXCL1 Protein Mammalian Cell His
    Rat Cxcl1-773R Recombinant Rat Cxcl1 protein, His-tagged E.coli His
    Rat Cxcl1-011C Recombinant Rat Cxcl1 Protein (72 aa) E.coli
    Rat Cxcl1-187C Recombinant Rat Cxcl1 Protein HEK293
    Rhesus Macaque CXCL1-1104R Recombinant Rhesus monkey CXCL1 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CXCL1-929R Recombinant Rhesus Macaque CXCL1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
    Rhesus Macaque CXCL1-929R-B Recombinant Rhesus Macaque CXCL1 Protein Pre-coupled Magnetic Beads HEK293
    • Involved Pathway
    • Protein Function
    • Interacting Protein
    • CXCL1 Related Articles
    • CXCL1 Related Gene Family
    • CXCL1 Related Research Area

    CXCL1 involved in several pathways and played different roles in them. We selected most pathways CXCL1 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NOD-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interactionGH1;IFNB1;TNFRSF14;IL5;IL1B;IL17RB;CRLF2;IL20RA;CXCR4
    Chemokine signaling pathwayPXN;CCR5;PRKCZ;CCL21;Ccl12;CDC42;GSK3A;ROCK2;GRK7
    NOD-like receptor signaling pathwayMAPK3;NFKBIB;NFKBIAB;RIPK2;MAPK9;NLRC4;MAPK11;TAB2;TAB3
    TNF signaling pathwayIL1B;VEGFC;RELA;CREB3L3;LTA;BIRC2;CCL2;PTGS2;CASP10
    Epithelial cell signaling in Helicobacter pylori infectionPLCG1;PAK1;ATP6V1G3;ATP6V1E1;CXCL1;MAPK12;IL-8;CCL5;ATP6V0B
    Salmonella infectionARPC5LA;IL8L1;MAPK10;WASF1;CDC42;RAB7B;ROCK1;RAB7A;CDC42L2
    LegionellosisCLK1;APAF1;VCP;HSPA2;NAIP6;BNIP3;BCL2L13;EEF1G;RAB1
    AmoebiasisVCL;COL3A1;TNF;GM-CSF;LAMA5;IL1R1;COL1A2;CXCL1;C8B
    Rheumatoid arthritisATP6V0A4;CCL3L3;ATP6V1C2;ATP6V1C1;IFNG;ATP6AP1;HLA-DRB5;CCL3L1;IL17A

    CXCL1 has several biochemical functions, for example, CXCR chemokine receptor binding, chemokine activity, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL1 itself. We selected most functions CXCL1 had, and list some proteins which have the same functions with CXCL1. You can find most of the proteins on our site.

    Function Related Protein
    CXCR chemokine receptor bindingCXCL6;CXCL12B;CXCL3;ITCH;CXCL1;CXCL18B;PF4V1;CXCL12A;IL8L2
    chemokine activityCXCL12;XCL1;CCL38A.4;AMCF-II;CXCL11.8;CCL34A.4;CCL38A.5;CCL22;CXL34B.11
    enzyme activator activityOGT;PSAP;DCP1A;UBA2;DNMT3L;APOA5;ARL1;HSPB2;RAB3GAP2
    growth factor activityMSTNB;IGF2;FGF2;FBRS;CECR1;Kitl;FGF12A;FGF24;Fgf15
    receptor bindingF2;WNT7AA;GAS6;P2RX4;TENC1;GLA;APLN;FGF13B;INSL4

    CXCL1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL1.

    XRCC3; HRAS; ESR1; PTEN; purL

    McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).
    Lee, YH; Shynlova, O; et al. Stretch-induced human myometrial cytokines enhance immune cell recruitment via endothelial activation. CELLULAR & MOLECULAR IMMUNOLOGY 12:231-242(2015).
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