Chemokine (C-X-C motif) ligand 16 (CXCL16), also known as SR-PSOX, is a transmembrane protein that facilitates uptake of low density lipoproteins by macrophages, resulting in foam cell formation. CXCL16 is found in liver tissue2 and influences the uptake, subcellular localization, and cytokine profile induced by D oligonucleotides. 3 CXCL16 may play a pro- inflammatory role in Inflammatory Bowel Disease (IBD), particularly Crohns disease.
Synonyms
chemokine (C-X-C motif) ligand 16; SRPSOX; CXCLG16; SR-PSOX; CXCL16; CXC chemokine ligand 16; Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; Small-inducible cytokine B16; Transmembrane chemokine CXCL16;
Cxcl16 involved in several pathways and played different roles in them. We selected most pathways Cxcl16 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cxcl16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Cxcl16 has several biochemical functions, for example, chemokine activity, low-density lipoprotein receptor activity, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cxcl16 itself. We selected most functions Cxcl16 had, and list some proteins which have the same functions with Cxcl16. You can find most of the proteins on our site.
Cxcl16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cxcl16 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cxcl16.
Wehr, A; Baeck, C; et al. Pharmacological Inhibition of the Chemokine CXCL16 Diminishes Liver Macrophage Infiltration and Steatohepatitis in Chronic Hepatic Injury. PLOS ONE 9:-(2014).
Wang, L; Sun, SZ; et al. oxLDL-Induced Lipid Accumulation in Glomerular Podocytes: Role of IFN-gamma, CXCL16, and ADAM10. CELL BIOCHEMISTRY AND BIOPHYSICS 70:529-538(2014).
