• Official Full Name

    chemokine (C-X-C motif) ligand 16

  • Overview

    Chemokine (C-X-C motif) ligand 16 (CXCL16), also known as SR-PSOX, is a transmembrane protein that facilitates uptake of low density lipoproteins by macrophages, resulting in foam cell formation. CXCL16 is found in liver tissue2 and influences the uptake, subcellular localization, and cytokine profile induced by D oligonucleotides. 3 CXCL16 may play a pro- inflammatory role in Inflammatory Bowel Disease (IBD), particularly Crohns disease.
  • Synonyms

    chemokine (C-X-C motif) ligand 16; SRPSOX; CXCLG16; SR-PSOX; CXCL16; CXC chemokine ligand 16; Scavenger receptor for phosphatidylserine and oxidized low density lipoprotein; Small-inducible cytokine B16; Transmembrane chemokine CXCL16;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cell & Tissue Lysates
  • Canine
  • Cynomolgus
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293F
  • Human Cell
  • Human cells
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • Biotin
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CXCL16-330H Active Recombinant Human CXCL16, His-tagged Mammalian cells His
Human CXCL16-82H Recombinant Human Chemokine (C-X-C motif) Ligand 16 E.coli N/A
Human CXCL16-7648H Recombinant Human CXCL16 protein, His & T7-tagged E.coli His/T7
Human CXCL16-11721H Recombinant Human CXCL16, GST-tagged E.coli GST
Human CXCL16-881H Recombinant Human CXCL16 Protein, His-tagged E.coli N-His
Human CXCL16-3096H Recombinant Human CXCL16 protein, His-tagged E.coli His
Human CXCL16-1108H Active Recombinant Human CXCL16 protein, His-tagged HEK293 His
Human CXCL16-27H Recombinant Human CXCL16 Protein E.coli
Human CXCL16-2286HF Recombinant Full Length Human CXCL16 Protein, GST-tagged In Vitro Cell Free System GST
Human CXCL16-34H Recombinant Human CXCL16 Protein, Biotin-tagged E.coli Biotin
Human CXCL16-162H Recombinant Human CXCL16 Protein, His-tagged Human cells His
Human CXCL16-2759H Recombinant Human CXCL16 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CXCL16-2957H Recombinant Human CXCL16 protein, Fc-tagged HEK293 Fc
Human CXCL16-882H Recombinant Human CXCL16 Protein, His-tagged HEK293F N-His
Human CXCL16-151H Recombinant Human CXCL16 Protein, His-tagged Human Cells His
Human CXCL16-2182H Recombinant Human CXCL16 Protein (Pro49-Pro137), N-GST tagged E.coli N-GST
Human CXCL16-2183H Recombinant Human CXCL16 Protein (Val52-Lys190), N-His tagged E.coli N-His
Human CXCL16-2759H-B Recombinant Human CXCL16 Protein Pre-coupled Magnetic Beads HEK293
Human CXCL16-2179H Recombinant Human CXCL16 Protein (Asn27-Trp201), C-His tagged Mammalian cells C-His
Mouse Cxcl16-484M Active Recombinant Mouse Chemokine (C-X-C motif) Ligand 16, His-tagged Mammalian cells His
Mouse Cxcl16-01M Active GMP Recombinant Mouse Cxcl16 Protein, His-Tagged E.coli His
Mouse Cxcl16-7649M Recombinant Mouse Cxcl16 protein, His & T7-tagged E.coli His/T7
Mouse Cxcl16-153M Recombinant Mouse Cxcl16 protein(Met1-Trp201), His-tagged HEK293 C-His
Mouse Cxcl16-85M Recombinant Mouse Cxcl16 protein E.coli N/A
Mouse CXCL16-2545MCL Recombinant Mouse CXCL16 cell lysate Human Cell N/A
Mouse Cxcl16-5253M Recombinant Mouse Cxcl16 protein, His-tagged E.coli His
Mouse Cxcl16-2095M Recombinant Mouse Cxcl16 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cxcl16-284M Active Recombinant Mouse Cxcl16 Protein (Asn27-Pro114), N-His tagged, Animal-free, Carrier-free E.coli N-His
Mouse Cxcl16-347M Recombinant Mouse Cxcl16 protein, His-tagged Yeast His
Mouse CXCL16-3385M Recombinant Mouse CXCL16 protein, His-tagged HEK293 His
Mouse Cxcl16-883M Recombinant Mouse Cxcl16 Protein, His-tagged E.coli N-His
Mouse Cxcl16-884M Recombinant Mouse Cxcl16 Protein, His-tagged E.coli N-His
Mouse Cxcl16-2095M-B Recombinant Mouse Cxcl16 Protein Pre-coupled Magnetic Beads HEK293
Rat Cxcl16-7650R Recombinant Rat Cxcl16 protein, His & T7-tagged E.coli His/T7
Rat CXCL16-1688R Recombinant Rat CXCL16 Protein Mammalian Cell His
Rat Cxcl16-7441R Recombinant Rat Cxcl16, Fc tagged Human Cell Fc
Rat CXCL16-1083R Recombinant Rat CXCL16 Protein, His-tagged HEK293 His
Rat CXCL16-1414RCL Recombinant Rat CXCL16 cell lysate Human Cell N/A
Rat CXCL16-1347R Recombinant Rat CXCL16 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CXCL16-1347R-B Recombinant Rat CXCL16 Protein Pre-coupled Magnetic Beads HEK293
Canine CXCL16-259C Recombinant Canine CXCL16, His tagged Human Cell Fc
Canine CXCL16-178C Recombinant Canine CXCL16, Fc tagged Human Cell Fc
Canine CXCL16-842CCL Recombinant Canine CXCL16 cell lysate Human Cell N/A
Cynomolgus CXCL16-253C Recombinant Cynomolgus CXCL16 Protein E.coli N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Cxcl16 Related Articles
  • Cxcl16 Related Gene Family
  • Cxcl16 Related Research Area

Cxcl16 involved in several pathways and played different roles in them. We selected most pathways Cxcl16 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cxcl16 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionCxcl15;IFNA8;GM13306;BMP7A;CXCL12B;IL28RA;NGFRB;GM13305;FLT4
Chemokine signaling pathwayGNB1;CXCL5;LYN;PARD3;STAT5B;CCL14;DOCK2;NFKBIA;RAC2

Cxcl16 has several biochemical functions, for example, chemokine activity, low-density lipoprotein receptor activity, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cxcl16 itself. We selected most functions Cxcl16 had, and list some proteins which have the same functions with Cxcl16. You can find most of the proteins on our site.

Function Related Protein
chemokine activityCXCL5;CCL38A.5;CCL33.2;CCL3L1;CCL14;CCL1;CCL16;PF4V1;CKLF
low-density lipoprotein receptor activityCXCL16;LDLR;LRP12;VLDLR;LRP6;OLR1
scavenger receptor activityTMPRSS2;ENPP2;TMPRSS5;VTNA;TMPRSS3;C8orf84;SCARA5;DMBT1;TINAGL1

Cxcl16 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cxcl16 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cxcl16.

Wehr, A; Baeck, C; et al. Pharmacological Inhibition of the Chemokine CXCL16 Diminishes Liver Macrophage Infiltration and Steatohepatitis in Chronic Hepatic Injury. PLOS ONE 9:-(2014).
Wang, L; Sun, SZ; et al. oxLDL-Induced Lipid Accumulation in Glomerular Podocytes: Role of IFN-gamma, CXCL16, and ADAM10. CELL BIOCHEMISTRY AND BIOPHYSICS 70:529-538(2014).
  • Q&As
  • Reviews

Q&As (7)

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How does CXCL16 function as both a chemokine and an adhesion molecule in immune cell recruitment and interaction? 08/28/2022

CXCL16 acts as both a chemokine and adhesion molecule, guiding immune cell recruitment and facilitating cell-cell interactions.

How does CXCL16 influence the progression of inflammatory and autoimmune diseases? 03/16/2022

CXCL16 influences inflammatory and autoimmune diseases, modulating immune cell recruitment and activation.

What is the impact of CXCL16 in tumor immunology, specifically in tumor infiltration by immune cells? 12/25/2021

In tumor immunology, CXCL16 facilitates the infiltration of immune cells into tumors, affecting tumor immunity.

How do alterations in CXCL16 expression or signaling affect renal function and the progression of kidney diseases? 04/21/2021

Changes in CXCL16 expression impact kidney function, potentially contributing to the development of renal diseases.

What role does CXCL16 play in the pathogenesis of atherosclerosis and cardiovascular diseases? 09/13/2019

CXCL16 plays a role in atherosclerosis by recruiting immune cells to arterial walls, influencing plaque formation.

What are the mechanisms by which CXCL16 modulates the migration and activation of T cells and dendritic cells? 06/05/2019

CXCL16 regulates T cell and dendritic cell migration and activation, playing a key role in immune responses.

How does CXCL16 contribute to the immune response against pathogens, particularly in viral infections? 11/05/2018

CXCL16 boosts the immune response to pathogens, especially in viral infections, by attracting immune cells.

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