Cxcl5

  • Official Full Name

    chemokine (C-X-C motif) ligand 5

  • Overview

    This gene encodes a protein that is a member of the CXC subfamily of chemokines. Chemokines, which recruit and activate leukocytes, are classified by function (inflammatory or homeostatic) or by structure. This protein is proposed to bind the G-protein coupled receptor chemokine (C-X-C motif) receptor 2 to recruit neutrophils, to promote angiogenesis and to remodel connective tissues. This protein is thought to play a role in cancer cell proliferation, migration, and invasion.
  • Synonyms

    CXCL5; chemokine (C-X-C motif) ligand 5; SCYB5; ENA-78;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • GMP Proteins
  • Bovine
  • Cattle
  • Cynomolgus
  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Yeast
  • Biotin
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CXCL5-151H Active Recombinant Human CXCL5 protein HEK293T
Human CXCL5-038H Recombinant Human CXCL5 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CXCL5-8540H Recombinant Human CXCL5, None tagged E.coli N/A
Human CXCL5-12H Recombinant Human CXCL5 protein E.coli N/A 74
Human CXCL5-7840H Recombinant Human CXCL5 protein, His & GST-tagged E.coli His/GST Gly38~Asn114
Human CXCL5-7167HCL Recombinant Human CXCL5 293 Cell Lysate HEK293 N/A
Human CXCL5-692H Recombinant Human CXCL5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human CXCL5-2772H Recombinant Human CXCL5 protein, His-tagged E.coli His 37-110aa
Human CXCL5-2773H Recombinant Human CXCL5 protein, GST-tagged E.coli GST 37-110aa
Human CXCL5-692H-B Recombinant Human CXCL5 Protein Pre-coupled Magnetic Beads HEK293
Human CXCL5-272H Active Recombinant Human CXCL5 Protein (Arg45-Asn114), N-His tagged, Animal-free, Carrier-free E.coli N-His Arg45-Asn114
Human CXCL5-2298HF Recombinant Full Length Human CXCL5 Protein, GST-tagged In Vitro Cell Free System GST 114 amino acids
Human CXCL5-05H Recombinant Human CXCL5 Protein E.coli 78 amino acid
Human CXCL5-3379H Recombinant Human CXCL5 protein, His-tagged HEK293 His Ala41~Asn114
Human CXCL5-16H Recombinant Human CXCL5 Protein, Biotin-tagged E.coli Biotin
Human CXCL5-2198H Recombinant Human CXCL5 Protein (Leu44-Asn114) E.coli Tag Free Leu44-Asn114
Human CXCL5-767HFL Recombinant Full Length Human CXCL5 Protein, C-Flag-tagged Mammalian cells Flag
Human CXCL5-131C Active Recombinant Human CXCL5 Protein (74 aa) E.coli 74
Human CXCL5-190C Active Recombinant Human CXCL5 Protein (78 aa) HEK293 78
Human CXCL5-424C Active Recombinant Human CXCL5 Protein (9-78, 70 aa) E.coli 70
Mouse Cxcl5-01M Active GMP Recombinant Mouse Cxcl5 Protein, His-Tagged E.coli His
Mouse Cxcl5-7841M Recombinant Mouse Cxcl5 protein, His-tagged E.coli His Val45~Ala118 (Accession # P50228)
Mouse Cxcl5-98M Recombinant Mouse Cxcl5 protein E.coli N/A 92
Mouse Cxcl5-97M Recombinant Mouse Cxcl5 protein E.coli N/A 70
Mouse CXCL5-4107M Recombinant Mouse CXCL5 Protein Mammalian Cell His
Mouse Cxcl5-79M Active Recombinant Mouse Cxcl5 Protein (Val1-Ala118), N-His tagged, Animal-free, Carrier-free E.coli N-His Val1-Ala118
Mouse CXCL5-2099M Recombinant Mouse CXCL5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Cxcl5-2774M Recombinant Mouse Cxcl5 protein, His-tagged E.coli His 46-117aa
Mouse CXCL5-3380M Recombinant Mouse CXCL5 protein, His-tagged HEK293 His Ala41~Gln132
Mouse Cxcl5-350M Recombinant Mouse Cxcl5 protein, His-tagged Yeast His Val45-Ala118
Mouse Cxcl5-2398M Active Recombinant Mouse Cxcl5 Protein E.coli Val45-Ala118
Mouse CXCL5-2099M-B Recombinant Mouse CXCL5 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cxcl5-228C Active Recombinant Mouse Cxcl5 Protein (74 aa) CHO 74
Rat Cxcl5-445R Active Recombinant Rat Chemokine (C-X-C motif) Ligand 5 E.coli N/A
Rat Cxcl5-629R Recombinant Rat Cxcl5 protein E.coli N/A 93
Rat CXCL5-1691R Recombinant Rat CXCL5 Protein Mammalian Cell His
Rat Cxcl5-227C Active Recombinant Rat Cxcl5 Protein (88 aa) CHO 88
Rat CXCL5-1350R-B Recombinant Rat CXCL5 Protein Pre-coupled Magnetic Beads HEK293
Rat CXCL5-1350R Recombinant Rat CXCL5 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Bovine CXCL5-42B Recombinant Bovine CXCL5 protein E.coli N/A 76
Cattle CXCL5-7131C Recombinant Cattle CXCL5 protein, His & GST-tagged E.coli His/GST Gly37~Asn112 (Accession# P80221)
Cynomolgus CXCL5-01C Recombinant Cynomolgus CXCL5 Protein E.coli N/A
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

What is cxcl5 protein?

CXCL5 has a small molecular weight (~8 kDa) and contains an ELR motif that is important for its neutrophil chemotactic activity. CXCL5 signals through the CXCR2 receptor on neutrophils. Binding to CXCR2 triggers neutrophil migration, degranulation, respiratory burst etc. It is expressed by epithelial and endothelial cells, fibroblasts, and keratinocytes, especially during inflammation.

What is the function of cxcl5 protein?

Neutrophil chemotaxis: As a potent chemoattractant, CXCL5 recruitment neutrophils to sites of infection/injury through concentration gradients.

Neutrophil activation: Binding of CXCL5 to CXCR2 on neutrophils induces cellular activation including respiratory burst, degranulation and production of reactive oxygen species.

Angiogenesis: CXCL5 stimulates endothelial cell migration and tube formation, promoting neovascularization important in wound healing.

Tissue remodeling: It stimulates secretion of matrix metalloproteinases from neutrophils and fibroblasts to facilitate extracellular matrix breakdown and remodeling.

Cxcl5 related signaling pathway

CXCR2 signaling pathway: CXCL5 binds to CXCR2 receptor on neutrophils and other cells. This activates G protein coupled signaling cascades like MAPK, PI3K/Akt which promote neutrophil activation, migration and survival.

NF-κB pathway: CXCL5 enhances NF-κB transcriptional activity which upregulates pro-inflammatory genes in neutrophils and other immune cells. This amplifies the immune response.

JAK/STAT pathway: CXCL5 induced CXCR2 signaling triggers JAK/STAT (mainly STAT3) phosphorylation and transcriptional regulation of target genes involved in proliferation and survival.

VEGF pathway: CXCL5 stimulates VEGF secretion which induces angiogenesis. It also enhances VEGFR expression on endothelial cells promoting migratory and tube formation responses.

CXCL5 Related Diseases

Cancers: Increased levels correlate with angiogenesis, metastasis and poor prognosis in breast, gastric, thyroid cancers etc.

Pulmonary diseases: Elevated in COPD, cystic fibrosis, idiopathic pulmonary fibrosis promoting neutrophil inflammation.

Cardiovascular diseases: Associated with atherosclerosis and abdominal aortic aneurysm pathogenesis.

Rheumatoid arthritis: Contributes to joint inflammation and cartilage destruction. A potential biomarker and drug target.

Biomedical Application of CXCL5 Protein

  •  Cancer immunotherapy - Targeting CXCL5/CXCR2 signaling to reduce tumor-promoting inflammation and angiogenesis.
  •  Anti-inflammatory drug development - Designing CXCL5 inhibitors as novel drugs for neutrophilic diseases like arthritis, IBD, vascular inflammation.
  •  Wound healing modulation - Studying CXCL5 role to develop therapies/dressings for improving cutaneous wound closure.
  •  Tissue engineering - Controlling CXCL5 gradients to guide neutrophil infiltration and vascularization of implants/grafts.
  •  Stem cell therapy - Understanding CXCL5 impact on stem cell homing, survival and tissue repair functions.

High Purity

SDS-PAGE Cxcl5-01M.jpg

Fig1. SDS-PAGE (Cat. No.: Cxcl5-01M)

Comparison of CXCL5 expression between patients.jpg

(Ronghua Zhang, 2020)

Fig2. Comparison of CXCL5 expression between patients in the "High Risk" group and those in the "Low Risk" group through the SurvExpress program (p=3.32e-32).

patients with late stage gastric cancer had significantly higher serum CXCL5 levels.jpg

(Jeong Youp Park, 2007)

Fig3. Compared to patients with benign conditions, patients with late stage gastric cancer had significantly higher serum CXCL5 levels. In contrast, patients with early stage gastric cancer did not.

Cxcl5 involved in several pathways and played different roles in them. We selected most pathways Cxcl5 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with Cxcl5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionEDAR;EDA;IFNA3;PDGFAB;IL17A;IL12A;IL15;TNFRSF6B;CSF1R
Chemokine signaling pathwayAdcy4;CXCL10;ARRB2;CCL4L1;WAS;CCL18;GNG11;BRAF;PTK2B
TNF signaling pathwayRPS6KA4;MAPK11;FOS;PIK3CA;MAPK9;ICAM1;CREB3L1;LTA;LIF
PertussisCXCL6;MAPK8;CALM1;FOS;IL-8;TLR4;GNAI1;RELA;IRAK4
Rheumatoid arthritisH2-AA;FOS;IL18;IL1B;ITGB2L;TNFSF13B;Il23a; Il12b;HLA-DPA1;ITGAL

Cxcl5 has several biochemical functions, for example, CXCR chemokine receptor binding, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Cxcl5 itself. We selected most functions Cxcl5 had, and list some proteins which have the same functions with Cxcl5. You can find most of the proteins on our site.

Function Related Protein
CXCR chemokine receptor bindingIL8L2;CXCL12;AMCF-II;CXCL12A;CXCL18B;CXCL2;CXCL3;CXCL20;CXCL12B
chemokine activityCCL25;PPBP;CCL3;CXCL5;CXCL12;CCL27;CCL8;CCL1;CXCL19

Cxcl5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Cxcl5 here. Most of them are supplied by our site. Hope this information will be useful for your research of Cxcl5.

Gene Family

Chemokines Cytokines

Research Area

Related articles

Xia, JL; Xu, XJ; et al. The potential of CXCL5 as a target for liver cancer - what do we know so far?. EXPERT OPINION ON THERAPEUTIC TARGETS 19:141-146(2015).
Zychowska, M; Rojewska, E; et al. The Role of Some Chemokines from the CXC Subfamily in a Mouse Model of Diabetic Neuropathy. JOURNAL OF DIABETES RESEARCH :-(2015).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does CXCL5 contribute to tumor progression and metastasis? 12/04/2021

CXCL5 is implicated in promoting tumor growth and metastasis by facilitating the migration of cancer cells and modulating the tumor microenvironment.

Are there any ongoing clinical trials targeting CXCL5 for therapeutic purposes? 05/15/2020

Several clinical trials are exploring the efficacy of drugs that modulate CXCL5 levels in various diseases, including cancer, autoimmune disorders, and inflammatory conditions.

In what ways does CXCL5 participate in the regulation of angiogenesis? 03/01/2019

CXCL5 has been identified as a regulator of angiogenesis, influencing the formation of new blood vessels, a process crucial for tumor growth and wound healing.

How can CXCL5 be harnessed for regenerative medicine purposes? 03/31/2018

CXCL5's role in recruiting cells to damaged tissues makes it a potential candidate for enhancing regenerative medicine approaches, such as tissue repair and wound healing.

In what ways can CXCL5 be used as a biomarker in clinical diagnostics? 03/19/2016

CXCL5 levels can be measured in blood or tissue samples to assess the extent of inflammation, aiding in the diagnosis and monitoring of various diseases.

Customer Reviews (3)

Write a review
Reviews
06/25/2021

    Its versatility and reliability make it an indispensable asset for scientists seeking to explore the complexities of various biological systems.

    01/13/2021

      Its stability and functional attributes ensure reliable imaging and facilitate the elucidation of complex protein structures.

      03/28/2018

        The CXCL5 protein is known for its exceptional quality, making it a highly suitable choice for meeting diverse experimental needs.

        Ask a Question for All Cxcl5 Products

        Required fields are marked with *

        My Review for All Cxcl5 Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends