CXCL3

  • Official Full Name

    chemokine (C-X-C motif) ligand 3

  • Overview

    Cytokine-induced neutrophil chemo attractant 1(CINC-1) was originally purified from media conditioned by IL-1βstimulated rat kidney epithelioid cells (NRK-52E). Amino acid sequence that encodes for rat CINC-1 was identified in 1989 by Watanabe's group at Toyama Medical and Pharmaceutical University. CINC-1 is a member of the alpha (CXC) subfamily of chemokines. Three additional rat CXC chemokines (CINC-2α, CINC-2β, CINC-3/MIP-2) have been identified. The protein sequence of CINC-1 is 63 - 67% identical to that of CINC-2α, CINC-2β, CINC-3/MIP-2. In addition, GROα, GROβ and GROγ is sharing 68%, 71% and 69%, identity with CINC-1. This has been suggested that CINCs are the rat counterpart of human GROs.
  • Synonyms

    Cxcl3; Cinc2; Cinc-2; Gm1960; chemokine (C-X-C motif) ligand 3; GRO-gamma; SCYB3; GRO-gamma(1-73); GRO3; MIP2-beta; CINC-2b; MIP2B; GROg; MIP-2b; C-X-C motif chemokine 3; GRO3 oncogene; melanoma growth stimulatory activity gamma; Growth-regulated protein gamma; MGSA gamma2; Macrophage inflammatory protein 2-beta; GROG; C-X-C motif chemokine 3; MIP2-alpha/beta; macrophage inflammatory protein 2-alpha/beta; cytokine-induced neutrophil chemoattractant 2; cytokine-induced neutrophil chemoattractant-2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • GMP Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • yeast
  • Yeast
  • Biotin
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • MBP
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CXCL3-18H Active Recombinant Human CXCL3 yeast N/A
Human CXCL3-236H Active Recombinant Mouse Chemokine (C-X-C motif) Ligand 3, HIgG1 Fc-tagged CHO Fc
Human CXCL3-235H Active Recombinant Mouse Chemokine (C-X-C motif) Ligand 3, MIgG2a Fc-tagged CHO Fc
Human CXCL3-234H Active Recombinant Mouse Chemokine (C-X-C motif) Ligand 3, HIgG1 Fc-tagged, mutant CHO Fc
Human CXCL3-16H Recombinant Human CXCL3 protein E.coli N/A 73
Human CXCL3-84H Recombinant Human Chemokine (C-X-C motif) Ligand 3, His-tagged E.coli His
Human CXCL3-163H Recombinant Human Chemokine (C-X-C motif) ligand 3, MBP-tagged E.coli MBP
Human CXCL3-29040TH Recombinant Human CXCL3, MBP-tagged E.coli MBP
Human CXCL3-207HCL Recombinant Human CXCL3 lysate HEK293 N/A
Human CXCL3-270C Active Recombinant Human CXCL3 Protein (73 aa) CHO 73
Human CXCL3-131H Recombinant Human CXCL3 Protein, His-tagged Human Cells His
Human CXCL3-32H Recombinant Human CXCL3 Protein, Biotin-tagged E.coli Biotin
Human CXCL3-2288HF Recombinant Full Length Human CXCL3 Protein, GST-tagged In Vitro Cell Free System GST 107 amino acids
Human CXCL3-001H Recombinant Human CXCL3 Protein, MBP-tagged E.coli MBP
Human CXCL3-136H Active Recombinant Human CXCL3 Protein (Ala35-Asn107), N-His tagged, Animal-free, Carrier-free E.coli N-His Ala35-Asn107
Human CXCL3-2102H Recombinant Human CXCL3 Protein (Ala35-Asn107), C-His tagged E.coli C-His Ala35-Asn107
Mouse Cxcl3-01M Active GMP Recombinant Mouse Cxcl3 Protein, His-Tagged E.coli His
Mouse Cxcl3-610M Recombinant Mouse Cxcl3 protein E.coli N/A 73
Mouse Cxcl3-624M Recombinant Mouse Chemokine (C-X-C motif) Ligand 3, His-tagged E.coli His 28-100aa
Mouse Cxcl3-373M Recombinant Mouse Chemokine (C-X-C motif) Ligand 3 E.coli N/A
Mouse CXCL3-4106M Recombinant Mouse CXCL3 Protein Mammalian Cell His
Mouse Cxcl3-349M Recombinant Mouse Cxcl3 protein, His-tagged Yeast His Ala28-Ser100
Mouse CXCL3-2098M-B Recombinant Mouse CXCL3 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cxcl3-151M Active Recombinant Mouse Cxcl3 Protein (Ala28-Gln87), N-His tagged, Animal-free, Carrier-free E.coli N-His Ala28-Gln87
Mouse Cxcl3-5250M Recombinant Mouse Cxcl3 protein, His-tagged E.coli His 32-100aa
Mouse Cxcl3-294C Active Recombinant Mouse Cxcl3 Protein (73 aa) CHO 73
Mouse Cxcl3-7390M Recombinant Mouse Cxcl3 Protein, His-tagged E.coli His 28-100
Mouse CXCL3-2098M Recombinant Mouse CXCL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat CXCL3-1690R Recombinant Rat CXCL3 Protein Mammalian Cell His
Rat Cxcl3-627R Recombinant Rat Cxcl3 protein E.coli N/A 68
Rat CXCL3-1349R-B Recombinant Rat CXCL3 Protein Pre-coupled Magnetic Beads HEK293
Rat CXCL3-1349R Recombinant Rat CXCL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Cxcl3-297C Active Recombinant Rat Cxcl3 Protein (68 aa) CHO 68
Cynomolgus CXCL3-434C Recombinant Cynomolgus CXCL3 protein, His-tagged HEK293 His
Cynomolgus CXCL3-432C Recombinant Cynomolgus CXCL3 Protein, His-tagged E.coli His
Rhesus Macaque CXCL3-1110R Recombinant Rhesus monkey CXCL3 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CXCL3-935R Recombinant Rhesus Macaque CXCL3 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque CXCL3-935R-B Recombinant Rhesus Macaque CXCL3 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CXCL3 involved in several pathways and played different roles in them. We selected most pathways CXCL3 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionTNFRSF6B;ACVR2A;CCL20;IL13RA1;VEGFC;LIF;IL11RA;LEP;TNFRSF13C
Chemokine signaling pathwayCRK;MAPK3;GNAI2;GNGT2;ELMO1;SHC2;CXCL10;VAV1;CCR5
TNF signaling pathwayBIRC2;LIF;PIK3CG;TRAF1;SOCS3;FOS;FADD;MMP9;NFKB1
Salmonella infectionCXCL1;TJP1;NFKB1;RAC1;FLNC;PYCARD;PFN1;ARPC5LA;MAPK10
LegionellosisNFKBIA;PYCARD;HSPA2;EEF1G;RELA;NAIP6;HSF1;VCP;IL6

CXCL3 has several biochemical functions, for example, CXCR chemokine receptor binding, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL3 itself. We selected most functions CXCL3 had, and list some proteins which have the same functions with CXCL3. You can find most of the proteins on our site.

Function Related Protein
CXCR chemokine receptor bindingCXCL5;CXCL1;CXCL12B;AMCF-II;CXCL20;ITCH;CXCL3;CXCL2;CXCL6
chemokine activityCXCL20;CCL18;CXCL12;CCL7;CX3CL1;CXCL16;Ccl9;CXCL11.8;CCL33.2

CXCL3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL3 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL3.

Gene Family

Chemokines Cytokines

Research Area

Related articles

See, ALP; Chong, PK; et al. CXCL3 is a Potential Target for Breast Cancer Metastasis. CURRENT CANCER DRUG TARGETS 14:294-309(2014).
Girolomoni, G; Mrowietz, U; et al. Psoriasis: rationale for targeting interleukin-17. BRITISH JOURNAL OF DERMATOLOGY 167:717-724(2012).
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