cxcl3

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cxcl3

Official Full Name chemokine (C-X-C motif) ligand 3
Background Cytokine-induced neutrophil chemo attractant 1(CINC-1) was originally purified from media conditioned by IL-1βstimulated rat kidney epithelioid cells (NRK-52E). Amino acid sequence that encodes for rat CINC-1 was identified in 1989 by Watanabe's group at Toyama Medical and Pharmaceutical University. CINC-1 is a member of the alpha (CXC) subfamily of chemokines. Three additional rat CXC chemokines (CINC-2α, CINC-2β, CINC-3/MIP-2) have been identified. The protein sequence of CINC-1 is 63 - 67% identical to that of CINC-2α, CINC-2β, CINC-3/MIP-2. In addition, GROα, GROβ and GROγ is sharing 68%, 71% and 69%, identity with CINC-1. This has been suggested that CINCs are the rat counterpart of human GROs.
Synonyms Cxcl3; Cinc2; Cinc-2; Gm1960; chemokine (C-X-C motif) ligand 3; GRO-gamma; SCYB3; GRO-gamma(1-73); GRO3; MIP2-beta; CINC-2b; MIP2B; GROg; MIP-2b; C-X-C motif chemokine 3; GRO3 oncogene; melanoma growth stimulatory activity gamma; Growth-regulated protein gamma; MGSA gamma2; Macrophage inflammatory protein 2-beta; GROG; C-X-C motif chemokine 3; MIP2-alpha/beta; macrophage inflammatory protein 2-alpha/beta; cytokine-induced neutrophil chemoattractant 2; cytokine-induced neutrophil chemoattractant-2
    • Species :
    • Cynomolgus
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • yeast
    • Tag :
    • Fc
    • GST
    • His
    • MBP
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CXCL3-001H Recombinant Human CXCL3 Protein, MBP-tagged E.coli MBP
    Mouse Cxcl3-349M Recombinant Mouse Cxcl3 Protein, His-tagged Yeast His
    Human CXCL3-163H Recombinant Human Chemokine (C-X-C motif) ligand 3, MBP-tagged E.coli MBP
    Human CXCL3-16H Recombinant Human CXCL3 protein E.coli N/A
    Human CXCL3-18H Recombinant Human CXCL3 yeast N/A
    Human CXCL3-207HCL Recombinant Human CXCL3 lysate HEK293 N/A
    Human CXCL3-2171H Recombinant Human CXCL3 Protein, GST-tagged Wheat Germ GST
    Human CXCL3-234H Recombinant Mouse Chemokine (C-X-C motif) Ligand 3, HIgG1 Fc-tagged, mutant CHO Fc
    Human CXCL3-235H Recombinant Mouse Chemokine (C-X-C motif) Ligand 3, MIgG2a Fc-tagged CHO Fc
    Human CXCL3-236H Recombinant Mouse Chemokine (C-X-C motif) Ligand 3, HIgG1 Fc-tagged CHO Fc
    Human CXCL3-29038TH Recombinant Human CXCL3 E.coli N/A
    Human CXCL3-29040TH Recombinant Human CXCL3, MBP-tagged E.coli MBP
    Human CXCL3-29041TH Recombinant Human CXCL3, His-tagged E.coli His
    Human CXCL3-84H Recombinant Human Chemokine (C-X-C motif) Ligand 3, His-tagged E.coli His
    Mouse Cxcl3-373M Recombinant Mouse Chemokine (C-X-C motif) Ligand 3 E.coli N/A
    Mouse CXCL3-4106M Recombinant Mouse CXCL3 Protein Mammalian Cell His
    Mouse Cxcl3-610M Recombinant Mouse Cxcl3 protein E.coli N/A
    Mouse Cxcl3-624M Recombinant Mouse Chemokine (C-X-C motif) Ligand 3, His-tagged E.coli His
    Rat CXCL3-1690R Recombinant Rat CXCL3 Protein Mammalian Cell His
    Rat Cxcl3-437R Recombinant Rat Cxcl3 E.coli N/A
    Rat Cxcl3-439R Recombinant Rat Chemokine (C-X-C motif) Ligand 3 E.coli N/A
    Rat Cxcl3-627R Recombinant Rat Cxcl3 protein E.coli N/A
    Cynomolgus CXCL3-432C Recombinant Cynomolgus CXCL3 Protein, His-tagged E.coli His
    Cynomolgus CXCL3-434C Recombinant Cynomolgus CXCL3 protein, His-tagged HEK293 His
    Rhesus Macaque CXCL3-1110R Recombinant Rhesus monkey CXCL3 Protein, His-tagged Mammalian Cell His

    cxcl3 involved in several pathways and played different roles in them. We selected most pathways cxcl3 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, TNF signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with cxcl3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction CCL27; CCR1; TNFB; IFNAR1; KITLGB; TNFSF8; ACKR3B; IL4R; IFNL3; LIF
    Chemokine signaling pathway JAK3; CCR3; GNG8; AKT1; GRB2; GNG3; SRC; CXCL13; CCL25; CDC42
    TNF signaling pathway MAP2K4; VCAM1; MAP2K1; TRAF5; PIK3CB; TNFRSF1B; MAGI2; CCL2; MMP9; LTA
    Salmonella infection FOS; RAC1; DYNC1I2A; CDC42L; FLNA; MAPK14A; ARPC5LA; IL6; CCL3L3; DYNC1LI2
    Legionellosis TLR5; HSPA8; EEF1A2; TLR2; APAF1; RAB1B; EEF1A1; IL12B; HSPA1A; HBS1L

    cxcl3 has several biochemical functions, for example, CXCR chemokine receptor binding, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cxcl3 itself. We selected most functions cxcl3 had, and list some proteins which have the same functions with cxcl3. You can find most of the proteins on our site.

    Function Related Protein
    CXCR chemokine receptor binding PF4V1; AMCF-II; CXCL1; CXCL5; CXCL6; CXCL18B; CXCL12B; CXCL2; CXCL20; PPBP
    chemokine activity CCL3L1; CCL33.3; CCL39.1; CCL35.1; CCL34A.3; IL8L2; CCL6; CXCL12; Ccl9; CXCL5

    cxcl3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cxcl3 here. Most of them are supplied by our site. Hope this information will be useful for your research of cxcl3.

    See, ALP; Chong, PK; et al. CXCL3 is a Potential Target for Breast Cancer Metastasis. CURRENT CANCER DRUG TARGETS 14:294-309(2014).
    Girolomoni, G; Mrowietz, U; et al. Psoriasis: rationale for targeting interleukin-17. BRITISH JOURNAL OF DERMATOLOGY 167:717-724(2012).

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