CXCL13 Protein


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Official Full Name chemokine (C-X-C motif) ligand 13
Background C-X-C motif chemokine 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) and B cell-attracting chemokine 1 (BCA-1), is a 109 amino acid secreted protein that belongs to the intercrine alpha (chemokine CxC) family. It functions as a chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. CXCL13 does not induce calcium release in B-lymphocytes. It binds to BLR1/CXCR5. The highest level of CXCL13 is found in the liver, followed by spleen, lymph node, appendix and stomach. Low level of CXC13 is found in salivary gland, mammary gland, and fetal spleen.
Synonyms ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; SCYB13; B-cell chemoattractant; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitts lymphoma receptor-1); B-lymphocyte chemoattractant; C-X-C motif chemokine 13; CXC chemokine BLC; b cell-attracting chemokine 1; b lymphocyte chemoattractant; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); small-inducible cytokine B13
    • Species :
    • Canine
    • Cynomolgus Monkey
    • Hamster
    • Human
    • Mouse
    • Porcine
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • Human Cells
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • GST
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CXCL13-024H Active Recombinant Human CXCL13 Protein E.coli N/A
    Human CXCL13-123H Active Recombinant Human Chemokine (C-X-C motif) Ligand 13, HIgG1 Fc-tagged CHO Fc
    Human CXCL13-124H Active Recombinant Human Chemokine (C-X-C motif) Ligand 13, MIgG2a Fc-tagged CHO Fc
    Human CXCL13-2161H Recombinant Human CXCL13 Protein, GST-tagged Wheat Germ GST
    Human CXCL13-2437H Recombinant human CXCL13, His-tagged E.coli His
    Human CXCL13-26649TH Recombinant Human CXCL13 protein E.coli N/A
    Mouse CXCL13-4101M Recombinant Mouse CXCL13 Protein Mammalian Cell His
    Mouse Cxcl13-7160M Recombinant Mouse Cxcl13 protein, His & GST-tagged E.coli His/GST
    Mouse Cxcl13-83M Recombinant Mouse Chemokine (C-X-C Motif) Ligand 13 E.coli N/A
    Rat Cxcl13-49R Recombinant Rat Cxcl13 protein, His/GST-tagged E.coli His/GST
    Rat Cxcl13-7161R Recombinant Rat Cxcl13 protein, His & GST-tagged E.coli His/GST
    Rat Cxcl13-79R Recombinant Rat Cxcl13 Protein, His-GST-tagged E.coli His/GST
    Cynomolgus Monkey CXCL13-1169C Recombinant Cynomolgus CXCL13 Protein, His-tagged E.coli His
    Cynomolgus Monkey CXCL13-432C Recombinant Cynomolgus CXCL13 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CXCL13-1108R Recombinant Rhesus monkey CXCL13 Protein, His-tagged Mammalian Cell His
    Canine CXCL13-299C Recombinant Canine CXCL13, His tagged E.coli Fc/His
    Human CXCL13-7170HCL Recombinant Human CXCL13 293 Cell Lysate HEK293 N/A
    Porcine CXCL13-01P GMP Recombinant Porcine CXCL13 Protein, His-Tagged E.coli His
    Human CXCL13-11H Recombinant Human CXCL13 Protein E.coli
    Human CXCL13-131H Recombinant Human CXCL13 Protein, His-tagged Human Cells His
    Human CXCL13-2284HF Recombinant Full Length Human CXCL13 Protein, GST-tagged In Vitro Cell Free System GST
    Human CXCL13-2771H Recombinant Human CXCL13 protein, His-tagged E.coli His
    Hamster Cxcl13-2772H Recombinant Hamster Cxcl13 Protein, His-tagged E.coli N-His
    Rat CXCL13-5240R Recombinant Rat CXCL13 protein, GST-tagged E.coli GST
    Human CXCL13-58H Recombinant Human CXCL13 Protein E.coli
    Mouse Cxcl13-149M Recombinant Mouse Cxcl13 Protein E.coli
    Mouse Cxcl13-2392M Recombinant Mouse Cxcl13 Protein E. coli
    Rhesus CXCL13-1322R Recombinant Rhesus CXCL13 protein E.coli N/A

    CXCL13 involved in several pathways and played different roles in them. We selected most pathways CXCL13 participated on our site, such as CXCR3-mediated signaling events, Chemokine receptors bind chemokines, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    CXCR3-mediated signaling events DNM1; CXCL13; MAPKAP1
    Chemokine receptors bind chemokines CCRL2; CCR6; CCR3; CCR5; CCL35.1; ACKR4; CCR1; CCR8; CXCR6; CCL19A.2
    Chemokine signaling pathway CXCL10; Ccl12; SRC; KRAS; SHC4; Adcy4; ELMO1; PIK3CA; IKBKG; RAP1B
    Class A/1 (Rhodopsin-like receptors) DRD2; GAL; RLN3; PYYA; RGR; HEBP1; SSTR5; QRFP; DRD5; CXCR6
    Cytokine-cytokine receptor interaction IFNA1; OSTN; ACVR2A; CCL19B; IFNA8; IL21R; CCL2; CXCL1; CCR10; FLT3
    G alpha (i) signalling events CNR1; OXGR1A.2; S1PR5B; OXGR1A.1; OPN1MW; HRH3; OXER1; FPR-RS4; TAS2R7; INSL5
    GPCR downstream signaling FFAR3; GPR55; TAE1; GNA13B; PROKR1; GPR18; ARHGEF25; NPB; NPFFR2; ARHGEF18

    CXCL13 has several biochemical functions, for example, CCR10 chemokine receptor binding, CXCR3 chemokine receptor binding, CXCR5 chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL13 itself. We selected most functions CXCL13 had, and list some proteins which have the same functions with CXCL13. You can find most of the proteins on our site.

    Function Related Protein
    CCR10 chemokine receptor binding CXCL13; CCL25; CCL19
    CXCR3 chemokine receptor binding CXCL13; CXCL11.8; CXCL11; CXCL10; PF4; CXCL9
    CXCR5 chemokine receptor binding CXCL13
    chemokine activity CXCL11.8; CCL3L3; CCL18; CCL13; CXCL14; CCL21; CCL15; Cxcl15; CCL39.1; CXCL12A
    fibroblast growth factor binding GLG1B; FGFR1A; CEP57; FIBP; TGFBR3; FIBPB; FGFR4; HSPA9; FGFR1; FGFR3
    heparin binding OVALX; CRISPLD2; ADAMTSL5; CCL8; LIPG; F11; SERPINC1; REG4; CTGFB; APLP1
    protein heterodimerization activity ADORA1; ROPN1B; UGT1A2; KCNH5; HIST1H3H; FLOT2; NKX2-5; INHA; GRIN2A; SOX4
    receptor agonist activity VEGFA; GAS6; SFRP2; GREM1; NODAL; WNT10B; WNT3; WNT4; WNT7A; WNT1

    CXCL13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL13 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL13.

    EEF1G; ftsK

    Asquith, DL; Bryce, SA; et al. Targeting cell migration in rheumatoid arthritis. CURRENT OPINION IN RHEUMATOLOGY 27:204-211(2015).
    Klimatcheva, E; Pandina, T; et al. CXCL13 antibody for the treatment of autoimmune disorders. BMC IMMUNOLOGY 16:-(2015).

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