cxcl13

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cxcl13

Official Full Name chemokine (C-X-C motif) ligand 13
Background C-X-C motif chemokine 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) and B cell-attracting chemokine 1 (BCA-1), is a 109 amino acid secreted protein that belongs to the intercrine alpha (chemokine CxC) family. It functions as a chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. CXCL13 does not induce calcium release in B-lymphocytes. It binds to BLR1/CXCR5. The highest level of CXCL13 is found in the liver, followed by spleen, lymph node, appendix and stomach. Low level of CXC13 is found in salivary gland, mammary gland, and fetal spleen.
Synonyms ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; SCYB13; B-cell chemoattractant; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitts lymphoma receptor-1); B-lymphocyte chemoattractant; C-X-C motif chemokine 13; CXC chemokine BLC; b cell-attracting chemokine 1; b lymphocyte chemoattractant; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); small-inducible cytokine B13
    • Species :
    • Canine
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Rhesus
    • Rhesus Macaque
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CXCL13-024H Recombinant Human CXCL13 Protein E.coli N/A
    Human CXCL13-123H Recombinant Human Chemokine (C-X-C motif) Ligand 13, HIgG1 Fc-tagged CHO Fc
    Human CXCL13-124H Recombinant Human Chemokine (C-X-C motif) Ligand 13, MIgG2a Fc-tagged CHO Fc
    Human CXCL13-2161H Recombinant Human CXCL13 Protein, GST-tagged Wheat Germ GST
    Human CXCL13-2437H Recombinant human CXCL13, His-tagged E.coli His
    Human CXCL13-26649TH Recombinant Human CXCL13 protein E.coli N/A
    Human CXCL13-7170HCL Recombinant Human CXCL13 293 Cell Lysate HEK293 N/A
    Mouse CXCL13-4101M Recombinant Mouse CXCL13 Protein Mammalian Cell His
    Mouse Cxcl13-7160M Recombinant Mouse Cxcl13 protein, His & GST-tagged E.coli His/GST
    Mouse Cxcl13-83M Recombinant Mouse Chemokine (C-X-C Motif) Ligand 13 E.coli N/A
    Rat Cxcl13-49R Recombinant Rat Cxcl13 protein, His/GST-tagged E.coli His/GST
    Rat Cxcl13-7161R Recombinant Rat Cxcl13 protein, His & GST-tagged E.coli His/GST
    Rat Cxcl13-79R Recombinant Rat Cxcl13 Protein, His-GST-tagged E.coli His/GST
    Cynomolgus Monkey CXCL13-1169C Recombinant Cynomolgus CXCL13 Protein, His-tagged E.coli His
    Cynomolgus Monkey CXCL13-432C Recombinant Cynomolgus CXCL13 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CXCL13-1108R Recombinant Rhesus monkey CXCL13 Protein, His-tagged Mammalian Cell His
    Rhesus CXCL13-1322R Recombinant Rhesus CXCL13 protein E.coli N/A
    Canine CXCL13-299C Recombinant Canine CXCL13, His tagged E.coli Fc/His

    cxcl13 involved in several pathways and played different roles in them. We selected most pathways cxcl13 participated on our site, such as CXCR3-mediated signaling events, Chemokine receptors bind chemokines, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with cxcl13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    CXCR3-mediated signaling events CXCL13; MAPKAP1; DNM1
    Chemokine receptors bind chemokines CCL19A.2; CXCR6; CCR7; CCR5; CXCL11.8; CCRL2; CXCL13; CXCR7B; CCR8; CCL27
    Chemokine signaling pathway CCR9; PIK3CA; Ccl21a; AKT1; RHOA; CCL17; FOXO3; RAP1A; SHC1; CCL4
    Class A/1 (Rhodopsin-like receptors) DRD1; CCRL2; CHRM4; OPN1SW1; HEBP1; ADRB3; NMUR1; OPN4B; NPFFR2; GPR39
    Cytokine-cytokine receptor interaction TNFB; TNFRSF9A; GDF5; TNFRSF14; IL2RB; IL23R; KITLG; TNFSF10; LOC100033925; IFNA6
    G alpha (i) signalling events OXGR1A.3; PYY; APLN; CCR6; SSTR4; SOUL4; AMCF-II; GPR55; RLN3A; CCR8
    GPCR downstream signaling ARHGEF1B; AMCF-II; OPN4A; PTHLH; CCR8; CHRM4; OPN1LW1; AGT; PENK; RLN3
    GPCR ligand binding ADORA2B; CRHR1; FZD10; GPR55; TAS2R3; RAMP2; GPR132; APLN; ZFPM2B; LPAR1

    cxcl13 has several biochemical functions, for example, CCR10 chemokine receptor binding, CXCR3 chemokine receptor binding, CXCR5 chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cxcl13 itself. We selected most functions cxcl13 had, and list some proteins which have the same functions with cxcl13. You can find most of the proteins on our site.

    Function Related Protein
    CCR10 chemokine receptor binding CCL25; CXCL13; CCL19
    CXCR3 chemokine receptor binding CXCL11; PF4; CXCL9; CXCL10; CXCL13; CXCL11.8
    CXCR5 chemokine receptor binding CXCL13
    chemokine activity CXCL14; CCL25B; CXCL11; CCL3; XCL2; CXCL8B.3; CXCL10; XCL1; Ccl9; PPBP
    fibroblast growth factor binding PTPRZ1; KLB; FIBPB; TGFBR3; FGFR2; RPS2; FGFRL1; CXCL13; FGFR3; Api5
    heparin binding FBLN7; ZNF207; APPA; FGFRL1; FGFR1; PDCD5; CCL15; CXCL10; OGN; FGF1A
    protein heterodimerization activity IKBKB; HIST1H2BF; IKZF2; MAP3K7; HYPM; TAP1; RELA; CHUK; HAND1; THRA
    receptor agonist activity GREM1; WNT1; WNT5A; CXCL13; WNT3; WNT8A; WNT7A; GAS6; VEGFA; WNT3A

    cxcl13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cxcl13 here. Most of them are supplied by our site. Hope this information will be useful for your research of cxcl13.

    EEF1G; ftsK

    Asquith, DL; Bryce, SA; et al. Targeting cell migration in rheumatoid arthritis. CURRENT OPINION IN RHEUMATOLOGY 27:204-211(2015).
    Klimatcheva, E; Pandina, T; et al. CXCL13 antibody for the treatment of autoimmune disorders. BMC IMMUNOLOGY 16:-(2015).

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