CXCL13

  • Official Full Name

    chemokine (C-X-C motif) ligand 13

  • Overview

    C-X-C motif chemokine 13 (CXCL13), also known as B lymphocyte chemoattractant (BLC) and B cell-attracting chemokine 1 (BCA-1), is a 109 amino acid secreted protein that belongs to the intercrine alpha (chemokine CxC) family. It functions as a chemotactic for B-lymphocytes but not for T-lymphocytes, monocytes and neutrophils. CXCL13 does not induce calcium release in B-lymphocytes. It binds to BLR1/CXCR5. The highest level of CXCL13 is found in the liver, followed by spleen, lymph node, appendix and stomach. Low level of CXC13 is found in salivary gland, mammary gland, and fetal spleen.
  • Synonyms

    ANGIE; ANGIE2; BCA-1; BCA1; BLC; BLR1L; SCYB13; B-cell chemoattractant; B-cell-attracting chemokine 1; B-cell-homing chemokine (ligand for Burkitts lymphoma receptor-1); B-lymphocyte chemoattractant; C-X-C motif chemokine 13; CXC chemokine BLC; b cell-attracting chemokine 1; b lymphocyte chemoattractant; chemokine (C-X-C motif) ligand 13 (B-cell chemoattractant); small inducible cytokine B subfamily (Cys-X-Cys motif), member 13 (B-cell chemoattractant); small-inducible cytokine B13;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • GMP Proteins
  • Canine
  • Cynomolgus
  • Cynomolgus Monkey
  • Hamster
  • Human
  • Mouse
  • Pig
  • Porcine
  • Rat
  • Rhesus
  • Rhesus Macaque
  • CHO
  • E.coli
  • HEK293
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Fc
  • Fc|His
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CXCL13-123H Active Recombinant Human Chemokine (C-X-C motif) Ligand 13, HIgG1 Fc-tagged CHO Fc
Human CXCL13-024H Active Recombinant Human CXCL13 Protein E.coli N/A
Human CXCL13-124H Active Recombinant Human Chemokine (C-X-C motif) Ligand 13, MIgG2a Fc-tagged CHO Fc
Human CXCL13-2161H Recombinant Human CXCL13 Protein, GST-tagged Wheat Germ GST
Human CXCL13-2437H Recombinant human CXCL13, His-tagged E.coli His
Human CXCL13-7170HCL Recombinant Human CXCL13 293 Cell Lysate HEK293 N/A
Human CXCL13-1695H Recombinant Human CXCL13 Protein (Val23-Arg94), N-His tagged E.coli N-His Val23-Arg94
Human CXCL13-131H Recombinant Human CXCL13 Protein, His-tagged Human Cells His
Human CXCL13-2771H Recombinant Human CXCL13 protein, His-tagged E.coli His 23-95aa
Human CXCL13-2284HF Recombinant Full Length Human CXCL13 Protein, GST-tagged In Vitro Cell Free System GST 109 amino acids
Human CXCL13-58H Recombinant Human CXCL13 Protein E.coli
Human CXCL13-132H Active Recombinant Human CXCL13 Protein E.coli 87 AA
Human CXCL13-08H Active Recombinant Human CXCL13 Protein (Val23-Arg94), N-His tagged, Animal-free, Carrier-free E.coli N-His Val23-Arg94
Mouse CXCL13-4101M Recombinant Mouse CXCL13 Protein Mammalian Cell His
Mouse Cxcl13-7160M Recombinant Mouse Cxcl13 protein, His & GST-tagged E.coli His/GST Ile22~Ala109 (Accession # O55038)
Mouse CXCL13-2094M Recombinant Mouse CXCL13 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse CXCL13-2094M-B Recombinant Mouse CXCL13 Protein Pre-coupled Magnetic Beads HEK293
Mouse Cxcl13-149M Active Recombinant Mouse Cxcl13 Protein E.coli
Rat Cxcl13-79R Recombinant Rat Cxcl13 Protein, His-GST-tagged E.coli His/GST
Rat Cxcl13-7161R Recombinant Rat Cxcl13 protein, His & GST-tagged E.coli His/GST Arg33~Ser101 (Accession# Q10746)
Rat CXCL13-5240R Recombinant Rat CXCL13 protein, GST-tagged E.coli GST 23-108
Canine CXCL13-299C Recombinant Canine CXCL13, His tagged E.coli Fc/His
Cynomolgus CXCL13-1169C Recombinant Cynomolgus CXCL13 protein, His-tagged E.coli His Val23-Pro109
Cynomolgus Monkey CXCL13-432C Recombinant Cynomolgus CXCL13 Protein, His-tagged Mammalian Cell His
Cynomolgus Monkey CXCL13-179C-B Recombinant Cynomolgus Monkey CXCL13 Protein Pre-coupled Magnetic Beads HEK293
Cynomolgus Monkey CXCL13-179C Recombinant Cynomolgus Monkey CXCL13 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Hamster Cxcl13-2772H Recombinant Hamster Cxcl13 Protein, His-tagged E.coli N-His Ile22-Ala111
Porcine CXCL13-01P GMP Recombinant Porcine CXCL13 Protein, His-Tagged E.coli His
Rhesus CXCL13-1322R Recombinant Rhesus CXCL13 protein E.coli N/A 87
Rhesus Macaque CXCL13-1108R Recombinant Rhesus monkey CXCL13 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CXCL13-933R-B Recombinant Rhesus Macaque CXCL13 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CXCL13-933R Recombinant Rhesus Macaque CXCL13 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Pig CXCL13-05P Recombinant Pig CXCL13 Protein (Val24-Ala111), N-His tagged, Animal-free, Carrier-free E.coli N-His Val24-Ala111
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

CXCL13 involved in several pathways and played different roles in them. We selected most pathways CXCL13 participated on our site, such as CXCR3-mediated signaling events, Chemokine receptors bind chemokines, Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
CXCR3-mediated signaling eventsMAPKAP1;CXCL13;DNM1
Chemokine receptors bind chemokinesCXCR6;CX3CR1;CCL35.2;CCBP2;CCL27;CCR9;CCL19A.2;CCR6;CCR7
Chemokine signaling pathwayXCR1;GNG3;PRKCB;PAK1;CCL24;GNG13;GNGT2;CCL25;RHOA
Class A/1 (Rhodopsin-like receptors)QRFP;CCL35.1;CXCL11.8;PENK;CHRM1;NPB;ZFPM2B;ADRA2B;HRH3
Cytokine-cytokine receptor interactionTNFRSF19;IL15RA;OSM;BMP7;IL22;CCR9A;KITLG;IL20RA;IL17B
G alpha (i) signalling eventsAGTR2;SOUL3;PENKA;SST1.1;PENKB;ADRA2C;SSTR3;PYYA;CCR3
GPCR downstream signalingOXGR1;OPN4;ARHGEF1B;SST1.1;PMCH;OXGR1A.2;NMB;CCL35.1;ARHGEF18
GPCR ligand bindingHCRT;NPS;RGS1;EDNRB;PTH;ZFPM2B;CCBP2;CASR;FPR-RS4

CXCL13 has several biochemical functions, for example, CCR10 chemokine receptor binding, CXCR3 chemokine receptor binding, CXCR5 chemokine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL13 itself. We selected most functions CXCL13 had, and list some proteins which have the same functions with CXCL13. You can find most of the proteins on our site.

Function Related Protein
CCR10 chemokine receptor bindingCCL25;CCL19;CXCL13
CXCR3 chemokine receptor bindingCXCL11.8;CXCL11;PF4;CXCL13;CXCL10;CXCL9
CXCR5 chemokine receptor binding
chemokine activityCXCL12A;CCL11;CCL14;CCL3L3;CCL34B.4;Ccl12;CCL27;CCL18;CCL25B
fibroblast growth factor bindingGPC1;FGFBP1;HSPA9;FGFRL1;FGFR4;SCN5A;CXCL13;GLG1B;FGFR1A
heparin bindingCTSG;COL25A1;MPO;PLA2G2D;REG4;ADAMTS1;THBS3;UBE4A;FGF2
protein heterodimerization activityBCL11A;BCL2A1;TGFB1;DRD1A;CASP8;SYCP3;NOTCH4;ADD2;IRAK2
receptor agonist activityWNT3;SFRP2;GREM1;GAS6;WNT4;VEGFA;WNT7A;WNT5A;WNT3A

CXCL13 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL13 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL13.

EEF1G; ftsK

Gene Family

GPCRs Chemokines Cytokines

Research Area

Related articles

Asquith, DL; Bryce, SA; et al. Targeting cell migration in rheumatoid arthritis. CURRENT OPINION IN RHEUMATOLOGY 27:204-211(2015).
Klimatcheva, E; Pandina, T; et al. CXCL13 antibody for the treatment of autoimmune disorders. BMC IMMUNOLOGY 16:-(2015).
  • Q&As
  • Reviews

Q&As (6)

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Is the expression pattern of CXCL13 protein related to the clinical prognosis of specific diseases? 11/28/2019

Expression pattern of CXCL13 protein may be related to the clinical prognosis of specific diseases, but the specific association needs further research and verification.

What are the expression characteristics of CXCL13 protein in immune cells? 10/23/2019

The protein is mainly expressed in immune cells by activated dendritic cells, macrophages and inflammatory cells.

Is there a regulatory mechanism for CXCL13 protein expression during inflammation? 04/12/2019

The expression of CXCL13 protein is regulated by a variety of signaling pathways, including NF-κB, AP-1, etc. Stimulation of inflammatory factors and cytokines may lead to upregulation of CXCL13 expression.

What is the role of CXCL13 protein in lymph node metastasis? 04/11/2019

In lymph node metastasis, the CXCL13 protein promotes the localization and metastasis of cancer cells by attracting CXCR5-positive cancer cells or immune cells.

What are the implications of CXCL13 protein research for new drug development? 02/27/2019

CXCL13 protein plays an important role in immune regulation and inflammatory response, and studying the function and regulatory mechanism of CXCL13 protein will help the development of new drugs, such as targeted drugs targeting CXCL13 and its related signaling pathways, which may be applied to the treatment of related diseases.

What are the potential applications of CXCL13 protein in immunotherapy? 02/17/2019

The CXCL13 protein is involved in immunomodulation, and its bound antibodies or specific receptor antagonists may contribute to the design and development of immunotherapy.

Customer Reviews (3)

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Reviews
07/10/2021

    Stability of CXCL13 was very good during long-term storage, and its properties remained unchanged after prolonged storage, indicating its excellent storage stability.

    06/21/2021

      The broad storage conditions of proteins make the experimental process more stable and reliable, which provides strong support for scientific research.

      08/14/2019

        In the process of CXCL13 production, it can be seen that it pays great attention to purity and biological activity, which makes its product extremely reliable.

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