|Official Full Name||chemokine (C-X-C motif) ligand 12|
|Background||SDF-1 (Stromal cell-derived factor-1), also known as PBSF (pre-B-cell growth-stimulating factor), is a recently discovered protein belonging to the alpha chemokine (CXC) family of cytokines. SDF-1α and SDF-1β are the first cytokines initially identified using the signal sequence trap cloning trategy from a human bone-marrow stromal cell line. SDF-1 has chemotactic activity on resting T lymphocytes and monocytes.|
|Synonyms||CXCL12; chemokine (C-X-C motif) ligand 12; SDF1, SDF1A, SDF1B, stromal cell derived factor 1; stromal cell-derived factor 1; PBSF; SCYB12; SDF 1a; SDF 1b; TLSF a; TLSF b; TPAR1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor; IRH; SDF1; TLSF; SDF1A; SDF1B|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
cxcl12 involved in several pathways and played different roles in them. We selected most pathways cxcl12 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with cxcl12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Cytokine-cytokine receptor interaction||PF4V1; IFNB1; CCL4; TNFRSF6B; IFNA14; Il2; CCL24; FIGF; LTA; INHBB|
|Chemokine signaling pathway||Adcy4; NFKB1; GRK1; CXCL12; GNGT1; XCL2; CCL25; CXCR5; BCAR1; Ccl9|
|NF-kappa B signaling pathway||Ccl21c; VCAM1; CCL21; TNFRSF11A; TRAF1; LBP; LY96; MAP3K7; TLR4; PIAS4|
|Axon guidance||EFNB1; COL4A4; ARPC5; PAQR3B; SEMA3B; DAB2IPB; ITSN1; SPTB; SLC14A2; EPHA6|
|Leukocyte transendothelial migration||ROCK1; CXCR4; CLDN4; PECAM1; Itgam&Itgb2; MSN; MYL7; ACTG1; CLDN15; ICAM1|
|Intestinal i||HLA-DQB1; HLA-DRB3; IL15RA; ITGB7; CCR9A; CCR10; CD80; HLA-DRB4; CCL25; TNFSF13|
|ne network for IgA production||CXCR4; TNFRSF13B; CD28; CXCL12B; MHC2A; BLB1; IL15RA; HLA-DRB5; IL4; TNFSF13|
|Pathways in cancer||FGF1; PTCH2; FGF12; FGF21; GNG4; F2R; WNT8B; FGF11; MMP2; ARNT2|
|Rheumatoid arthritis||CXCL6; MMP1A; ATP6V0E; IL-8; TNFSF11; ANGPT1; CXCL12; Il23a; TLR4; HLA-DOA|
cxcl12 has several biochemical functions, for example, CXCR chemokine receptor binding, chemoattractant activity, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cxcl12 itself. We selected most functions cxcl12 had, and list some proteins which have the same functions with cxcl12. You can find most of the proteins on our site.
|CXCR chemokine receptor binding||CXCL1; CXCL12B; CXCL12; CXCL18B; IL8L2; CXCL5; PPBP; PF4V1; ITCH; CXCL12A|
|chemoattractant activity||SCG2; SAA1; FGF8; HMGB1; PDGFB; BMP4; FIGF; NTF3; VHL; LGALS3|
|chemokine activity||CCL20A.3; CXL34B.11; IL-8; CXCL11.8; CCL44; Ccl21a; CXCL13; CCL20; CXCL9; CXCL32B.1|
|chemokine receptor binding||CCL25; CCL19; CCL5; CCL21; Ccl21c; CCRL2; XCL1; CCL21B; S100A14; CXCL12|
|growth factor activity||EGF; TGFB1; FGF13; OGN; LACRT; PGF; IL4; Kitl; PDGFAB; FGF12B|
|receptor binding||MAG; TNFSF4; RAB8B; MYO1C; UFD1L; TMED1; PLAT; HSPA1A; ARRB2; DPP4|
cxcl12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cxcl12 here. Most of them are supplied by our site. Hope this information will be useful for your research of cxcl12.