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Official Full Name chemokine (C-X-C motif) ligand 12
Background SDF-1 (Stromal cell-derived factor-1), also known as PBSF (pre-B-cell growth-stimulating factor), is a recently discovered protein belonging to the alpha chemokine (CXC) family of cytokines. SDF-1α and SDF-1β are the first cytokines initially identified using the signal sequence trap cloning trategy from a human bone-marrow stromal cell line. SDF-1 has chemotactic activity on resting T lymphocytes and monocytes.
Synonyms CXCL12; chemokine (C-X-C motif) ligand 12; SDF1, SDF1A, SDF1B, stromal cell derived factor 1; stromal cell-derived factor 1; PBSF; SCYB12; SDF 1a; SDF 1b; TLSF a; TLSF b; TPAR1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor; IRH; SDF1; TLSF; SDF1A; SDF1B
    • Species :
    • Canine
    • Chicken
    • Cynomolgus Monkey
    • Feline
    • Human
    • Human/Feline
    • Mouse
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Human Cells
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • Biotin
    • Fc
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CXCL12-191H Recombinant Human CXCL12 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human CXCL12-192H Recombinant Human CXCL12 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human CXCL12-01H Recombinant Human CXCL12 protein E.coli N/A
    Human CXCL12-105H Recombinant Human CXCL12 E.coli Biotin
    Human CXCL12-133H Recombinant Human CXCL12, biotinylated E.coli Biotin
    Human CXCL12-1566H Recombinant Human CXCL12 (isoform alpha) Protein E.coli N/A
    Human CXCL12-20H Recombinant Human CXCL12, Fc tagged Human Cell Fc
    Human CXCL12-2160H Recombinant Human CXCL12 Protein, GST-tagged Wheat Germ GST
    Human CXCL12-21H Recombinant Human CXCL12, His-tagged E.coli His
    Human CXCL12-3016HCL Recombinant Human CXCL12 cell lysate Human Cell N/A
    Human CXCL12-306H Recombinant Human CXCL12 protein E.coli N/A
    Human CXCL12-31388TH Recombinant Human CXCL12 E.coli N/A
    Human CXCL12-3387H Recombinant Human CXCL12 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human CXCL12-519H Recombinant Human CXCL12 protein, His & GST-tagged E.coli His/GST
    Human CXCL12-5382H Recombinant Human CXCL12 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human CXCL12-550H Recombinant Human Chemokine (C-X-C motif) Ligand 12, HIgG1 Fc-tagged, mutant CHO Fc
    Human CXCL12-551H Recombinant Human Chemokine (C-X-C motif) Ligand 12, MIgG2a Fc-tagged CHO Fc
    Human CXCL12-552H Recombinant Human Chemokine (C-X-C motif) Ligand 12, HIgG1 Fc-tagged CHO Fc
    Human CXCL12-57H Recombinant Human CXCL12 protein E.coli N/A
    Human CXCL12-629H Recombinant Human CXCL12, None tagged E.coli N/A
    Human CXCL12-64H Recombinant Human Stromal Cell-Dreived Factor 1, His-tagged E.coli His
    Mouse Cxcl12-11719M Recombinant mouse Cxcl12, GST-tagged E.coli GST
    Mouse CXCL12-21M Recombinant Mouse CXCL12 protein E.coli N/A
    Mouse Cxcl12-2387M Recombinant Mouse Cxcl12 Protein E. coli
    Mouse Cxcl12-2388M Recombinant Mouse Cxcl12 Protein E. coli
    Mouse Cxcl12-2389M Recombinant Mouse Cxcl12 Protein E. coli
    Mouse Cxcl12-2390M Recombinant Mouse Cxcl12 Protein E. coli
    Mouse Cxcl12-2391M Recombinant Mouse Cxcl12 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Cxcl12-371M Recombinant Mouse Chemokine (C-X-C motif) Ligand 12 E.coli N/A
    Mouse CXCL12-391M Recombinant Mouse Chemokine (C-X-C Motif) Ligand 12(SDF-1a) E.coli N/A
    Mouse Cxcl12-42M Recombinant Mouse Cxcl12 protein, His-tagged E.coli His
    Mouse Cxcl12-8661M Recombinant Mouse Cxcl12 E.coli N/A
    Rat Cxcl12-111R Recombinant Rat Cxcl12 protein E.coli N/A
    Rat Cxcl12-521R Recombinant Rat Cxcl12 protein, His & GST-tagged E.coli His/GST
    Rat Cxcl12-65R Recombinant Rat Cxcl12 protein E.coli N/A
    Cynomolgus Monkey CXCL12-1863CCL Recombinant Cynomolgus CXCL12 cell lysate Human Cell N/A
    Rhesus Macaque CXCL12-1107R Recombinant Rhesus monkey CXCL12 Protein, His-tagged Mammalian Cell His
    Rhesus Macaque CXCL12-1166R Recombinant Rhesus CXCL12 Protein, Fc-tagged HEK293 Fc
    Canine CXCL12-383C Recombinant Canine CXCL12 E.coli N/A
    Canine CXCL12-3920C Recombinant Canine CXCL12 Protein E.coli N/A
    Rabbit CXCL12-4351R Recombinant Rabbit CXCL12 Protein Yeast N/A
    Chicken CXCL12-6079C Recombinant Chicken CXCL12 Mammalian Cell His
    Feline CXCL12-110F Recombinant Feline Chemokine (C-X-C Motif) Ligand 12(SDF-1b) E.coli N/A
    Human/Feline CXCL12-442H Recombinant Human/Feline CXCL12 E.coli N/A

    cxcl12 involved in several pathways and played different roles in them. We selected most pathways cxcl12 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with cxcl12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction XCL2; OSTN; IL6R; CNTF; IL4R; CSF1R; IL12RB1; ACVR2B; CSF3; IL1R2
    Chemokine signaling pathway Ccl21a; CXCL2; CCR8; GNG11; SRC; GNG12; GNGT1; PIK3CB; PRKCZ; PRKCD
    NF-kappa B signaling pathway ZAP70; BCL10; LRDD; BCL2A1; IRAK1; TNFRSF13C; LTB; ATM; PRKCQ; XIAP
    Axon guidance DPYSL5; PPP3R2; DUSP9; SCN3A; COL4A3; AGRN; PEA15; COL9A1B; EPHA3; EPHB2
    Leukocyte transendothelial migration PIK3R1; PTPN11; MYL12B; RASSF5; PIK3R5; RAC1; OCLN; VASP; VCL; ACTN1
    Intestinal i CXCL12; HLA-DRB4; Icosl; CD86; CCL25B; IL5; HLA-DRA; CXCR4B; CXCL12B; ITGB7
    ne network for IgA production MHC2DEB; BMA1; HLA-DRB4; IL-15RA; BLB1; CCL25B; AICDA; PIGR; TNFRSF17; CD86
    Pathways in cancer FN1; CBLC; EP300; ZBTB16; PIK3R3; AGTR1A; MAX; SMAD2; FGF8; ITGAV
    Rheumatoid arthritis ATP6V1C1; H2-AB1; ATP6V1D; IL-8; TNFRSF11A; IL23; ATP6V0C; ATP6V0A4; ATP6V1B1; ITGB2

    cxcl12 has several biochemical functions, for example, CXCR chemokine receptor binding, chemoattractant activity, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by cxcl12 itself. We selected most functions cxcl12 had, and list some proteins which have the same functions with cxcl12. You can find most of the proteins on our site.

    Function Related Protein
    CXCR chemokine receptor binding CXCL3; CXCL12; CXCL6; IL8L2; ITCH; PF4V1; CXCL2; AMCF-II; PPBP; CXCL12A
    chemoattractant activity HMGB1; VHL; FGF2; CXCL12B; SAA1; HMGB2; MIF; CCL16; SCG2; CCL5
    chemokine activity CCL33.3; CCL3; CCL19; CXCL2; CCL3L3; CXCL11; CCL20A.3; CCL34B.1; IL8L2; CCL25
    chemokine receptor binding Ccl21c; CCL21; S100A14; CCL21B; Ccl21a; CCL5; XCL1; CCL25; CCRL2; CCL19
    growth factor activity GDF1; NDP; INHBAA; IL10; GRN; CLEC11A; MDK; GFER; AREG; NRG3
    receptor binding APOL2; LHB; SLC9A3R2; FGF24; MAP7; FZD1; APOF; FGF12B; SSTR3; DVL3

    cxcl12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cxcl12 here. Most of them are supplied by our site. Hope this information will be useful for your research of cxcl12.

    DPP4; DAZAP2

    Wirtz, TH; Tillmann, S; et al. Platelet-derived MIF: A novel platelet chemokine with distinct recruitment properties. ATHEROSCLEROSIS 239:1-10(2015).
    Asquith, DL; Bryce, SA; et al. Targeting cell migration in rheumatoid arthritis. CURRENT OPINION IN RHEUMATOLOGY 27:204-211(2015).

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