CXCL12

  • Official Full Name

    chemokine (C-X-C motif) ligand 12

  • Overview

    SDF-1 (Stromal cell-derived factor-1), also known as PBSF (pre-B-cell growth-stimulating factor), is a recently discovered protein belonging to the alpha chemokine (CXC) family of cytokines. SDF-1α and SDF-1β are the first cytokines initially identified using the signal sequence trap cloning trategy from a human bone-marrow stromal cell line. SDF-1 has chemotactic activity on resting T lymphocytes and monocytes.
  • Synonyms

    CXCL12; chemokine (C-X-C motif) ligand 12; SDF1, SDF1A, SDF1B, stromal cell derived factor 1; stromal cell-derived factor 1; PBSF; SCYB12; SDF 1a; SDF 1b; TLSF a; TLSF b; TPAR1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor; IRH; SDF1; TLSF; SDF1A; SDF1B;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Canine
  • Chicken
  • Cynomolgus Monkey
  • Feline
  • Hamster
  • Human
  • Human/Feline
  • Mouse
  • Rabbit
  • Rat
  • Rhesus Macaque
  • CHO
  • E. coli
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human Cell
  • Human Cells
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • Yeast
  • Biotin
  • C
  • His
  • DYKDDDDK
  • Fc
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|GST
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • Tag Free
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human CXCL12-550H Active Recombinant Human Chemokine (C-X-C motif) Ligand 12, HIgG1 Fc-tagged, mutant CHO Fc
Human CXCL12-21H Active Recombinant Human CXCL12, His-tagged E.coli His
Human CXCL12-133H Active Recombinant Human CXCL12, biotinylated E.coli Biotin
Human CXCL12-551H Active Recombinant Human Chemokine (C-X-C motif) Ligand 12, MIgG2a Fc-tagged CHO Fc
Human CXCL12-20H Active Recombinant Human CXCL12, Fc tagged HEK293 Fc Lys 22-Met 93
Human CXCL12-01H Recombinant Human CXCL12 Protein E.coli
Human CXCL12-629H Recombinant Human CXCL12 protein(Lys22-Lys89) E. coli N/A Lys22-Lys89
Human CXCL12-552H Recombinant Human Chemokine (C-X-C motif) Ligand 12, HIgG1 Fc-tagged CHO Fc
Human CXCL12-64H Recombinant Human Stromal Cell-Dreived Factor 1, His-tagged E.coli His
Human CXCL12-2160H Recombinant Human CXCL12 Protein, GST-tagged Wheat Germ GST
Human CXCL12-519H Recombinant Human CXCL12 protein, His & GST-tagged E.coli His/GST Pro23~Lys89 (Accession # P48061)
Human CXCL12-306H Recombinant Human CXCL12 protein E.coli N/A 72
Human CXCL12-3016HCL Recombinant Human CXCL12 cell lysate Human Cell N/A
Human CXCL12-192H Recombinant Human CXCL12 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CXCL12-3387H Recombinant Human CXCL12 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human CXCL12-2190H Recombinant Human CXCL12 protein, His-tagged HEK293 His Lys 22 - Lys 89
Human CXCL12-5382H Recombinant Human CXCL12 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human CXCL12-2167H Recombinant Human CXCL12 Protein, His-tagged E.coli N-His Pro23-Lys89
Human CXCL12-191H Recombinant Human CXCL12 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human CXCL12-031H Recombinant Human CXCL12 Protein 93
Human CXCL12-23H Recombinant Human CXCL12 Protein, Biotin-tagged E.coli Biotin
Human CXCL12-033H Recombinant Human CXCL12 Protein, Biotinylated 93
Human CXCL12-2279HF Recombinant Full Length Human CXCL12 Protein, GST-tagged In Vitro Cell Free System GST 89 amino acids
Human CXCL12-2202H Recombinant Human CXCL12 Protein (Ser19-Met93) E.coli Tag Free Ser19-Met93
Human CXCL12-273H Active Recombinant Human CXCL12 Protein (Val24-Asn88), C-His tagged, Animal-free, Carrier-free E.coli C-His Val24-Asn88
Human CXCL12-57H Recombinant Human CXCL12 protein E.coli N/A 99
Human CXCL12-13H Active Recombinant Human CXCL12 Protein E.coli 68 amino acids
Human CXCL12-1219H Recombinant Human CXCL12 Protein, His-tagged HEK293F N-His Pro23-Lys89
Mouse Cxcl12-01M Active GMP Recombinant Mouse Cxcl12 Protein, His-Tagged E.coli His
Mouse Cxcl12-371M Recombinant Mouse Chemokine (C-X-C motif) Ligand 12 E.coli N/A
Mouse Cxcl12-11719M Recombinant mouse Cxcl12, GST-tagged E.coli GST 1-89a.a.
Mouse CXCL12-391M Recombinant Mouse Chemokine (C-X-C Motif) Ligand 12(SDF-1a) E.coli N/A
Mouse Cxcl12-42M Recombinant Mouse Cxcl12 protein, His-tagged E.coli His
Mouse CXCL12-21M Recombinant Mouse CXCL12 protein E.coli N/A 72
Mouse Cxcl12-80M Active Recombinant Mouse Cxcl12 Protein (Gly21-Lys89), C-His tagged, Animal-free, Carrier-free E.coli C-His Gly21-Lys89
Mouse Cxcl12-2391M Recombinant Mouse Cxcl12 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Cxcl12-207C Active Recombinant Mouse Cxcl12 Protein (78 aa) CHO 78
Mouse Cxcl12-2510M Recombinant Mouse Cxcl12 protein, His-tagged E.coli His 1-89 aa
Mouse Cxcl12-55M Recombinant Active Mouse CXCL12 Protein, His-tagged(C-ter) E.coli His(C-ter)
Mouse Cxcl12-208C Active Recombinant Mouse Cxcl12 Protein (68 aa) CHO 68
Mouse CXCL12-24M Recombinant Mouse CXCL12 Protein E.coli 68 amino acid
Mouse CXCL16-35M Recombinant Mouse CXCL12 Protein, Biotin-tagged E.coli Biotin
Rat Cxcl12-521R Recombinant Rat Cxcl12 protein, His & GST-tagged E.coli His/GST Gly21~Lys89 (Accession # Q9QZD1)
Rat Cxcl12-111R Recombinant Rat Cxcl12 protein E.coli N/A 72
Rat Cxcl12-65R Recombinant Rat Cxcl12 protein E.coli N/A 68
Rabbit CXCL12-4351R Recombinant Rabbit CXCL12 Protein Yeast N/A 73aa
Canine CXCL12-383C Recombinant Canine CXCL12 protein(Lys22-Met93) E. coli N/A Lys22-Met93
Canine CXCL12-3920C Recombinant Canine CXCL12 Protein E.coli N/A
Cynomolgus Monkey CXCL12-1863CCL Recombinant Cynomolgus CXCL12 cell lysate Human Cell N/A
Feline CXCL12-110F Recombinant Feline Chemokine (C-X-C Motif) Ligand 12(SDF-1b) E.coli N/A
Hamster Cxcl12-1220H Recombinant Hamster Cxcl12 Protein, His-tagged E.coli N-His Lys22-Lys89
Human/Feline CXCL12-442H Active Recombinant Human/Feline CXCL12 E.coli N/A
Rhesus Macaque CXCL12-1166R Active Recombinant Rhesus CXCL12 Protein, Fc-tagged HEK293 Fc
Rhesus Macaque CXCL12-1107R Recombinant Rhesus monkey CXCL12 Protein, His-tagged Mammalian Cell His
Rhesus Macaque CXCL12-932R-B Recombinant Rhesus Macaque CXCL12 Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque CXCL12-932R Recombinant Rhesus Macaque CXCL12 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Chicken CXCL12-6079C Recombinant Chicken CXCL12 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • CXCL12 Related Articles
  • CXCL12 Related Gene Family
  • CXCL12 Related Research Area
  • CXCL12 Related Signal Pathway

CXCL12 involved in several pathways and played different roles in them. We selected most pathways CXCL12 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionLTA;CRFB2;IL1B;CXCL1;BMP7A;CCR8;TGFB3;NGFR;IFNPHI1
Chemokine signaling pathwayGNG7;IKBKB;GM1987;PF4;CRKL;PPBP;GSK3A;CCL24;GM2506
NF-kappa B signaling pathwayBCL2A1A;LBP;PLAU;BLNK;ICAM1;NFKB1;BCL2A1;TRADD;MYD88
Axon guidanceTRIO;ADAM10;GPC1A;EPHB3;SPRED2;ST8SIA2;DPYSL4;PTPRA;NCK1
Leukocyte transendothelial migrationVAV3;PIK3R1;ITGAM;MYLPF;CXCL12;CLDN11;CLDN8;MYL5;ITGA4
Intestinal iHLA-DMB;TGFB1A;BLB1;IL15RA;CXCL12A;TNFRSF13B;CXCL12B;IL6;TNFRSF17
ne network for IgA productionHLA-DQB1;HLA-DMA;MHC2DAB;CXCL12B;ITGA4;CXCL12;MHC2DCB;CD28;CD80
Pathways in cancerFZD2;MMP2;KIT;DAPK1;FZD8;GNB4;IGF1R;MAPK10;PLCG2
Rheumatoid arthritisCXCL6;HLA-DPA1;IL-8;MMP3;H2-AB1;TNFRSF11A;ATP6V0A1;TNFSF13B;ATP6V1D

CXCL12 has several biochemical functions, for example, CXCR chemokine receptor binding, chemoattractant activity, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL12 itself. We selected most functions CXCL12 had, and list some proteins which have the same functions with CXCL12. You can find most of the proteins on our site.

Function Related Protein
CXCR chemokine receptor bindingCXCL6;AMCF-II;ITCH;PPBP;CXCL1;CXCL12B;CXCL18B;PF4V1;CXCL12
chemoattractant activityFIGF;SAA1;VEGFA;FGF7;FGF2;VHL;LGALS3;PDGFB;HMGB1
chemokine activityCCL25B;CCL35.2;CCL35.1;CCL3L3;CCL19;Ccl21c;CXCL9;CCL17;CCL20
chemokine receptor bindingXCL1;Ccl21c;CXCL12;CCRL2;S100A14;CCL21B;CCL21;CCL19;CCL5
growth factor activityFGF12B;EGF;GDF5;GDF11;CECR1A;GDF3;CDNF;IL10;BMP15
receptor bindingSRMS;LAMA2;ANXA1;Fert2;FGF11A;PECR;WNT4B;HTT;AMH

CXCL12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL12.

DPP4; DAZAP2

Wirtz, TH; Tillmann, S; et al. Platelet-derived MIF: A novel platelet chemokine with distinct recruitment properties. ATHEROSCLEROSIS 239:1-10(2015).
Asquith, DL; Bryce, SA; et al. Targeting cell migration in rheumatoid arthritis. CURRENT OPINION IN RHEUMATOLOGY 27:204-211(2015).
  • Q&As
  • Reviews

Q&As (5)

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How are researchers using CXCL12 in neurodegenerative disease research? 08/27/2022

CXCL12 is being investigated for its role in neuroprotection and neuroregeneration in conditions like Alzheimer's and Parkinson's disease.

Are there diagnostic tests that measure CXCL12 levels in patients? 12/19/2021

Yes, ELISA and other assays can be used to measure CXCL12 levels, aiding in the diagnosis and monitoring of certain diseases.

Can CXCL12 be used as a biomarker for specific diseases? 02/03/2021

CXCL12 levels can serve as a biomarker for various diseases, such as HIV, cancer, and inflammatory disorders.

How is CXCL12 being researched for cardiovascular therapies? 06/16/2019

Scientists are exploring the potential of CXCL12-based therapies to promote vascular repair and treat heart diseases.

Can CXCL12-based therapies help in spinal cord injury treatment? 04/02/2019

Researchers are studying CXCL12-based treatments to promote nerve regeneration and functional recovery after spinal cord injuries.

Customer Reviews (3)

Write a review
Reviews
06/15/2022

    The CXCL12 protein is of exceptional quality, making it an ideal candidate to fulfill my experimental requirements.

    01/08/2022

      The manufacturer's commitment to providing excellent technical support is truly commendable, as they have proven to be readily available to assist in resolving any concerns or challenges I encountered while working with the protein.

      04/26/2021

        Its purity and integrity have consistently delivered reliable and robust results in my research.

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