cxcl12
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  • Official Full Name
  • chemokine (C-X-C motif) ligand 12
  • Background
  • SDF-1 (Stromal cell-derived factor-1), also known as PBSF (pre-B-cell growth-stimulating factor), is a recently discovered protein belonging to the alpha chemokine (CXC) family of cytokines. SDF-1α and SDF-1β are the first cytokines initially identified using the signal sequence trap cloning trategy from a human bone-marrow stromal cell line. SDF-1 has chemotactic activity on resting T lymphocytes and monocytes.
  • Synonyms
  • CXCL12; chemokine (C-X-C motif) ligand 12; SDF1, SDF1A, SDF1B, stromal cell derived factor 1; stromal cell-derived factor 1; PBSF; SCYB12; SDF 1a; SDF 1b; TLSF a; TLSF b; TPAR1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor; IRH; SDF1; TLSF; SDF1A; SDF1B
Cat.#:CXCL12-1566HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL12 (isoform alpha) Protein
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Cat.#:CXCL12-2160HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CXCL12 Protein, GST-tagged
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Cat.#:CXCL12-3387HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CXCL12 Protein, MYC/DDK-tagged
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Cat.#:CXCL12-3920CTag:
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine CXCL12 Protein
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Cat.#:CXCL12-4351RTag:
Source (Host):YeastSpecies:Rabbit
Product nameRecombinant Rabbit CXCL12 Protein
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Cat.#:CXCL12-306HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C motif) Ligand 12
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Cat.#:Cxcl12-371MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-X-C motif) Ligand 12
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Cat.#:CXCL12-01HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Stromal Cell-Dreived Factor 1α
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Cat.#:CXCL12-105HTag:Biotin
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL12
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Cat.#:CXCL12-133HTag:Biotin
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL12, biotinylated
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Cat.#:CXCL12-20HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CXCL12, Fc tagged
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Cat.#:CXCL12-21HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL12, His-tagged
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Cat.#:CXCL12-31388THTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL12
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Cat.#:CXCL12-519HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL12 protein, His & GST-tagged
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Cat.#:CXCL12-550HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C motif) Ligand 12, HIgG1 Fc-tagged, mutant
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Cat.#:CXCL12-551HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C motif) Ligand 12, MIgG2a Fc-tagged
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Cat.#:CXCL12-552HTag:Fc
Source (Host):CHOSpecies:Human
Product nameRecombinant Human Chemokine (C-X-C motif) Ligand 12, HIgG1 Fc-tagged
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Cat.#:CXCL12-629HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CXCL12, None tagged
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Cat.#:CXCL12-64HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Stromal Cell-Dreived Factor 1, His-tagged
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Cat.#:Cxcl12-11719MTag:GST
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant mouse Cxcl12, GST-tagged
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Cat.#:CXCL12-21MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Murine Chemokine (C-X-C Motif) Ligand 12(SDF1b)
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Cat.#:CXCL12-391MTag:N/A
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Chemokine (C-X-C Motif) Ligand 12(SDF-1a)
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Cat.#:Cxcl12-42MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cxcl12 protein, His-tagged
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Cat.#:Cxcl12-8661MTag:
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cxcl12
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Cat.#:Cxcl12-111RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cxcl12(SDF-1b)
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Cat.#:Cxcl12-521RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cxcl12 protein, His & GST-tagged
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Cat.#:Cxcl12-65RTag:N/A
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat SDF-1 alpha
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Cat.#:CXCL12-1107RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CXCL12 Protein, His-tagged
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Cat.#:CXCL12-1166RTag:Fc
Source (Host):HEK293Species:Rhesus Macaque
Product nameRecombinant Rhesus CXCL12 Protein, Fc-tagged
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Cat.#:CXCL12-383CTag:
Source (Host):E. coliSpecies:Canine
Product nameRecombinant Canine CXCL12
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Cat.#:CXCL12-6079CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CXCL12
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Cat.#:CXCL12-110FTag:N/A
Source (Host):E. coliSpecies:Feline
Product nameRecombinant Feline Chemokine (C-X-C Motif) Ligand 12(SDF-1b)
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Cat.#:CXCL12-442HTag:
Source (Host):E. coliSpecies:Human/Feline
Product nameRecombinant Human/Feline CXCL12
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Cat.#:CXCL12-3016HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CXCL12 cell lysate
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Cat.#:CXCL12-1863CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus CXCL12 cell lysate
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Involved Pathway

CXCL12 involved in several pathways and played different roles in them. We selected most pathways CXCL12 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
BMPR1B; IL23; TNFSF18; TNFRSF21; IFNB1; IFNA6; PPBP; IFNG; RELT; CCL17
Chemokine signaling pathway
GNGT1; RAF1; CCR1; CCL23; CCL21; CDC42; CCL7; GNG12; MAP2K1; PLCB1
NF-kappa B signaling pathway
IL1B; Ccl21c; NFKBIA; LAT; XIAP; Ccl21a; CCL4; PRKCB; CCL13; GM13304
Axon guidance
EPHA4; DUSP10; RND1; DUSP9; ABLIM3; UNC5D; CNTN1; EPHB3; EFNA2A; ITSN1
Leukocyte transendothelial migration
PIK3CB; PLCG2; GNAI1; CTNNA3; VCL; OCLN; MYL5; F11R; MYL9; ARHGAP5
Intestinal i
HLA-DRB1; HLA-DMB; MHC2DEB; PIGR; CCL25B; CCR9A; IL-15RA; TNFSF13; BMA2; HLA-DOB
ne network for IgA production
BLA; HLA-DRA; AICDA; HLA-DRB1; HLA-DRB5; TGFB1A; MADCAM1; ITGB7; BLB2; CCL28
Pathways in cancer
TCF7L2; FZD8; LPAR3; SLC2A1; XIAP; AXIN1; STK4; PTGS2; GNAQ; SOS1
Rheumatoid arthritis
HLA-DOA; HLA-DOB; TNFSF13; ATP6V0E; TGFB2; CD80; CCL2; ATP6V1A; MMP3; ATP6V0E1

Protein Function

CXCL12 has several biochemical functions, for example, CXCR chemokine receptor binding, chemoattractant activity, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL12 itself. We selected most functions CXCL12 had, and list some proteins which have the same functions with CXCL12. You can find most of the proteins on our site.
Function
Related Protein
Function CXCR chemokine receptor binding
Related Protein CXCL20; CXCL1; IL8L2; CXCL12B; CXCL12; CXCL6; CXCL5; CXCL2; CXCL3; ITCH
Function chemoattractant activity
Related Protein CCL5; FGF8; HMGB1; PDGFB; NTF3; VHL; CCL3; HMGB2; VEGFC; MIF
Function chemokine activity
Related Protein CCL20B; CXCL11.8; CCL16; CCL5; CCL27B; CCL20A.3; CCL19A.2; CXCL2; Ccl21a; CCL17
Function chemokine receptor binding
Related Protein Ccl21c; CCL21B; S100A14; CCL21; CCRL2; CCL19; XCL1; CCL5; CXCL12; Ccl21a
Function growth factor activity
Related Protein RABEP2; BMP10; BMP15; MDKB; DKK1; TGFB1; BMP4; EFEMP1; NRG1; GDF9
Function receptor binding
Related Protein STRAP; PLG; GRIN2A; DRD1A; DPP4; C5; HILPDA; FLT3LG; GLA; GDNF

Interacting Protein

CXCL12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL12.
DPP4; DAZAP2

CXCL12 Related Articles

Wirtz, TH; Tillmann, S; et al. Platelet-derived MIF: A novel platelet chemokine with distinct recruitment properties. ATHEROSCLEROSIS 239:1-10(2015).
Asquith, DL; Bryce, SA; et al. Targeting cell migration in rheumatoid arthritis. CURRENT OPINION IN RHEUMATOLOGY 27:204-211(2015).

CXCL12 Related Gene Family

Chemokines Cytokines