CXCL12 Protein

CXCL12

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CXCL12

Official Full Name chemokine (C-X-C motif) ligand 12
Background SDF-1 (Stromal cell-derived factor-1), also known as PBSF (pre-B-cell growth-stimulating factor), is a recently discovered protein belonging to the alpha chemokine (CXC) family of cytokines. SDF-1α and SDF-1β are the first cytokines initially identified using the signal sequence trap cloning trategy from a human bone-marrow stromal cell line. SDF-1 has chemotactic activity on resting T lymphocytes and monocytes.
Synonyms CXCL12; chemokine (C-X-C motif) ligand 12; SDF1, SDF1A, SDF1B, stromal cell derived factor 1; stromal cell-derived factor 1; PBSF; SCYB12; SDF 1a; SDF 1b; TLSF a; TLSF b; TPAR1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor; IRH; SDF1; TLSF; SDF1A; SDF1B
    • Species :
    • Canine
    • Chicken
    • Cynomolgus Monkey
    • Feline
    • Hamster
    • Human
    • Human/Feline
    • Mouse
    • Rabbit
    • Rat
    • Rhesus Macaque
    • Source :
    • CHO
    • E. coli
    • E.coli
    • HEK293
    • HEK293F
    • HEK293T
    • Human Cell
    • Human Cells
    • In Vitro Cell Free System
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • Biotin
    • DYKDDDDK
    • Fc
    • GST
    • His
    • His(C-ter)
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CXCL12-105H Active Recombinant Human CXCL12 E.coli Biotin Inquiry
    Human CXCL12-133H Active Recombinant Human CXCL12, biotinylated E.coli Biotin Inquiry
    Human CXCL12-21H Active Recombinant Human CXCL12, His-tagged E.coli His Inquiry
    Human CXCL12-550H Active Recombinant Human Chemokine (C-X-C motif) Ligand 12, HIgG1 Fc-tagged, mutant CHO Fc Inquiry
    Human CXCL12-551H Active Recombinant Human Chemokine (C-X-C motif) Ligand 12, MIgG2a Fc-tagged CHO Fc Inquiry
    Rhesus Macaque CXCL12-1166R Active Recombinant Rhesus CXCL12 Protein, Fc-tagged HEK293 Fc Inquiry
    Human/Feline CXCL12-442H Active Recombinant Human/Feline CXCL12 E.coli N/A Inquiry
    Mouse Cxcl12-01M Active GMP Recombinant Mouse Cxcl12 Protein, His-Tagged E.coli His Inquiry
    Human CXCL12-01H Recombinant Human CXCL12 Protein E.coli Inquiry
    Human CXCL12-20H Recombinant Human CXCL12, Fc tagged Human Cell Fc Inquiry
    Human CXCL12-2160H Recombinant Human CXCL12 Protein, GST-tagged Wheat Germ GST Inquiry
    Human CXCL12-306H Recombinant Human CXCL12 protein E.coli N/A Inquiry
    Human CXCL12-31388TH Recombinant Human CXCL12 E.coli N/A Inquiry
    Human CXCL12-519H Recombinant Human CXCL12 protein, His & GST-tagged E.coli His/GST Inquiry
    Human CXCL12-552H Recombinant Human Chemokine (C-X-C motif) Ligand 12, HIgG1 Fc-tagged CHO Fc Inquiry
    Human CXCL12-629H Recombinant Human CXCL12, None tagged E.coli N/A Inquiry
    Human CXCL12-64H Recombinant Human Stromal Cell-Dreived Factor 1, His-tagged E.coli His Inquiry
    Mouse Cxcl12-11719M Recombinant mouse Cxcl12, GST-tagged E.coli GST Inquiry
    Mouse CXCL12-21M Recombinant Mouse CXCL12 protein E.coli N/A Inquiry
    Mouse Cxcl12-371M Recombinant Mouse Chemokine (C-X-C motif) Ligand 12 E.coli N/A Inquiry
    Mouse CXCL12-391M Recombinant Mouse Chemokine (C-X-C Motif) Ligand 12(SDF-1a) E.coli N/A Inquiry
    Mouse Cxcl12-42M Recombinant Mouse Cxcl12 protein, His-tagged E.coli His Inquiry
    Mouse Cxcl12-8661M Recombinant Mouse Cxcl12 E.coli N/A Inquiry
    Rat Cxcl12-111R Recombinant Rat Cxcl12 protein E.coli N/A Inquiry
    Rat Cxcl12-521R Recombinant Rat Cxcl12 protein, His & GST-tagged E.coli His/GST Inquiry
    Rat Cxcl12-65R Recombinant Rat Cxcl12 protein E.coli N/A Inquiry
    Rhesus Macaque CXCL12-1107R Recombinant Rhesus monkey CXCL12 Protein, His-tagged Mammalian Cell His Inquiry
    Canine CXCL12-383C Recombinant Canine CXCL12 E.coli N/A Inquiry
    Chicken CXCL12-6079C Recombinant Chicken CXCL12 Mammalian Cell His Inquiry
    Feline CXCL12-110F Recombinant Feline Chemokine (C-X-C Motif) Ligand 12(SDF-1b) E.coli N/A Inquiry
    Human CXCL12-3016HCL Recombinant Human CXCL12 cell lysate Human Cell N/A Inquiry
    Cynomolgus Monkey CXCL12-1863CCL Recombinant Cynomolgus CXCL12 cell lysate Human Cell N/A Inquiry
    Human CXCL12-10H Recombinant Human CXCL12 Protein E.coli Inquiry
    Human CXCL12-1219H Recombinant Human CXCL12 Protein, His-tagged HEK293F N-His Inquiry
    Hamster Cxcl12-1220H Recombinant Hamster Cxcl12 Protein, His-tagged E.coli N-His Inquiry
    Human CXCL12-191H Recombinant Human CXCL12 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK Inquiry
    Human CXCL12-192H Recombinant Human CXCL12 Protein, DYKDDDDK-tagged Human Cells DYKDDDDK Inquiry
    Human CXCL12-2167H Recombinant Human CXCL12 Protein, His-tagged E.coli N-His Inquiry
    Human CXCL12-2190H Recombinant Human CXCL12 protein, His-tagged E.coli His Inquiry
    Human CXCL12-2279HF Recombinant Full Length Human CXCL12 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Human CXCL12-23H Recombinant Human CXCL12 Protein, Biotin-tagged E.coli Biotin Inquiry
    Mouse CXCL12-24M Recombinant Mouse CXCL12 Protein E.coli Inquiry
    Mouse Cxcl12-2510M Recombinant Mouse Cxcl12 protein, His-tagged E.coli His Inquiry
    Human CXCL12-54H Recombinant Active Human CXCL12 Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Mouse Cxcl12-55M Recombinant Active Mouse CXCL12 Protein, His-tagged(C-ter) E.coli His(C-ter) Inquiry
    Human/Feline CXCL12-59H Recombinant Human/Feline CXCL12 Protein E.coli Inquiry
    Human/Feline CXCL12-60H Recombinant Human/Feline CXCL12 Protein E.coli Inquiry
    Human CXCL12-61H Recombinant Human CXCL12 Protein E.coli Inquiry
    Mouse Cxcl12-62M Recombinant Mouse CXCL12 Protein E.coli Inquiry
    Mouse Cxcl12-63M Recombinant Mouse CXCL12 Protein E.coli Inquiry
    Mouse CXCL16-35M Recombinant Mouse CXCL12 Protein, Biotin-tagged E.coli Biotin Inquiry
    Human CXCL12-1566H Recombinant Human CXCL12 (isoform alpha) Protein E.coli N/A Inquiry
    Human CXCL12-3387H Recombinant Human CXCL12 Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human CXCL12-5382H Recombinant Human CXCL12 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human CXCL12-57H Recombinant Human CXCL12 protein E.coli N/A Inquiry
    Mouse Cxcl12-2387M Recombinant Mouse Cxcl12 Protein E. coli Inquiry
    Mouse Cxcl12-2388M Recombinant Mouse Cxcl12 Protein E. coli Inquiry
    Mouse Cxcl12-2389M Recombinant Mouse Cxcl12 Protein E. coli Inquiry
    Mouse Cxcl12-2390M Recombinant Mouse Cxcl12 Protein E. coli Inquiry
    Mouse Cxcl12-2391M Recombinant Mouse Cxcl12 Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry
    Canine CXCL12-3920C Recombinant Canine CXCL12 Protein E.coli N/A Inquiry
    Rabbit CXCL12-4351R Recombinant Rabbit CXCL12 Protein Yeast N/A Inquiry

    CXCL12 involved in several pathways and played different roles in them. We selected most pathways CXCL12 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction Ifna11; IL11; CXCL10; CXCL3; IL21; CXCL12A; OSMR; TNFSF9; CXCL2; Ccl12
    Chemokine signaling pathway PIK3R5; GM1987; RAP1A; RAP1B; ARRB1; CCL22; IKBKB; GNG3; CCL16; SHC4
    NF-kappa B signaling pathway LBP; PIDD1; NFKB2; BCL2; TNFRSF1A; CCL4L1; LTA; TRADD; UBE2I; LYN
    Axon guidance DPYSL5A; RHOD; EPHA8; SCN8A; RGS3; RHOGA; CREB1B; EPHB4; COL9A3; DPYSL3
    Leukocyte transendothelial migration ARHGAP5; AASS; PTK2B; CLDN8; CXCR4; CLDN11; GNAI3; OCLN; Itgam&Itgb2; MYL12B
    Intestinal i HLA-DRB4; Icosl; HLA-DOB; H2-AB1; HLA-DMA; CD86; MHC2DAB; CXCL12A; HLA-DQA1; MHC2DCB
    ne network for IgA production CCL25B; TNFRSF13B; HLA-DRB5; ICOS; HLA-DQA1; ITGA4; HLA-DRB4; ICOSLG; BLB2; LTBR
    Pathways in cancer WNT3A; ITGA6; MAPK1; FOS; Fasl; FZD9; GNB1; CXCL12; MSH3; PIAS2
    Rheumatoid arthritis CXCL1; ACP5; H2-AA; TNF; IL17A; CCL3; HLA-DOB; ATP6V1G1; ITGB2L; HLA-DRB3

    CXCL12 has several biochemical functions, for example, CXCR chemokine receptor binding, chemoattractant activity, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL12 itself. We selected most functions CXCL12 had, and list some proteins which have the same functions with CXCL12. You can find most of the proteins on our site.

    Function Related Protein
    CXCR chemokine receptor binding CXCL20; CXCL18B; IL8L2; CXCL3; CXCL12; ITCH; AMCF-II; CXCL6; CXCL1; CXCL2
    chemoattractant activity CXCL12; BMP4; PDGFB; SAA3; SAA1; SCG2; CCL15; FGF7; CXCL12B; CCL5
    chemokine activity C5; CCL3L3; CCL6; CXCL12A; CCL28; CXCL12; CXCL18B; CXCL20; CXCL32B.1; CCL11
    chemokine receptor binding CCRL2; Ccl21a; CXCL12; S100A14; CCL25; Ccl21c; CCL21; CCL21B; XCL1; CCL19
    growth factor activity Il2; FGF9; BDNF; PGF; GPI; PRL2C3; LACRT; NTF7; LEP; EREG
    receptor binding DAO1; FGF18B; ABL1; SERPINE2; EPHX2; BMP3; ADAM10; NCK1; ARPP19; FYB

    CXCL12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL12.

    DPP4; DAZAP2

    Wirtz, TH; Tillmann, S; et al. Platelet-derived MIF: A novel platelet chemokine with distinct recruitment properties. ATHEROSCLEROSIS 239:1-10(2015).
    Asquith, DL; Bryce, SA; et al. Targeting cell migration in rheumatoid arthritis. CURRENT OPINION IN RHEUMATOLOGY 27:204-211(2015).

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