CXCL12
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Official Full Name
chemokine (C-X-C motif) ligand 12
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Overview
SDF-1 (Stromal cell-derived factor-1), also known as PBSF (pre-B-cell growth-stimulating factor), is a recently discovered protein belonging to the alpha chemokine (CXC) family of cytokines. SDF-1α and SDF-1β are the first cytokines initially identified using the signal sequence trap cloning trategy from a human bone-marrow stromal cell line. SDF-1 has chemotactic activity on resting T lymphocytes and monocytes. -
Synonyms
CXCL12; chemokine (C-X-C motif) ligand 12; SDF1, SDF1A, SDF1B, stromal cell derived factor 1; stromal cell-derived factor 1; PBSF; SCYB12; SDF 1a; SDF 1b; TLSF a; TLSF b; TPAR1; intercrine reduced in hepatomas; pre-B cell growth-stimulating factor; IRH; SDF1; TLSF; SDF1A; SDF1B;
- Recombinant Proteins
- Cell & Tissue Lysates
- GMP Proteins
- Protein Pre-coupled Magnetic Beads
- Canine
- Chicken
- Cynomolgus Monkey
- Feline
- Hamster
- Human
- Human/Feline
- Mouse
- Rabbit
- Rat
- Rhesus Macaque
- CHO
- E. coli
- E.coli
- HEK293
- HEK293F
- HEK293T
- Human Cell
- Human Cells
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- Yeast
- Biotin
- C
- His
- DYKDDDDK
- Fc
- GST
- His (Fc)
- Avi
- His(C
- ter)
- His|GST
- Myc
- DDK
- Myc|DDK
- N/A
- N
- Tag Free
- Involved Pathway
- Protein Function
- Interacting Protein
- CXCL12 Related Articles
- CXCL12 Related Gene Family
- CXCL12 Related Research Area
- CXCL12 Related Signal Pathway
CXCL12 involved in several pathways and played different roles in them. We selected most pathways CXCL12 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CXCL12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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Cytokine-cytokine receptor interaction | PDGFA;IL21R;IL24;TNFRSF9;TNFSF18;INHBB;CXCR6;GH1;CCR1L1 |
Chemokine signaling pathway | VAV2;CXCL2;CCR7;PARD3;GM13306;CCL14;CCL26;BRAF;GSK3B |
NF-kappa B signaling pathway | TRAF6;ICAM1;CARD11;TNFSF14;TRAF5;PRKCQ;MYD88;IRAK1;CCL21B |
Axon guidance | NCAN;Ntng2;EZRA;RAC1;DPYSL5A;CSF2RB;SEMA6D;SRGAP3;PAK2 |
Leukocyte transendothelial migration | CYBA;PIK3CD;PRKCG;CLDN10;MYL12A;CD99;NIPAL1;ITGB2L;EZR |
Intestinal i | IL15RA;CD28;AICDA;TNFSF13;BLB2;CXCR4A;Icosl;CCL28;MHC2DEB |
ne network for IgA production | IL15RA;CXCL12A;MHC2DEB;HLA-DRB3;PIGR;CXCL12;CXCR4;LTBR;Il2 |
Pathways in cancer | PIK3R1;MAPK3;CASP8;BRCA2;GNAQ;TCF7L2;KITLG;CXCL12;GNG10 |
Rheumatoid arthritis | IL1B;CXCL12;ATP6V1B1;IL17A;ATP6V0D2;HLA-DQA1;HLA-DOB;TNFSF13B;ATP6V1C1 |
CXCL12 has several biochemical functions, for example, CXCR chemokine receptor binding, chemoattractant activity, chemokine activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CXCL12 itself. We selected most functions CXCL12 had, and list some proteins which have the same functions with CXCL12. You can find most of the proteins on our site.
Function | Related Protein |
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CXCR chemokine receptor binding | PPBP;CXCL20;CXCL3;IL8L2;CXCL5;CXCL12A;ITCH;CXCL12;CXCL6 |
chemoattractant activity | FGF7;BMP4;CXCL12;CXCL12B;SAA1;LGALS3;CCL3;VEGFC;CCL5 |
chemokine activity | CCL20;CXCL12A;CXCL13;CCL23;CXCL5;IL8L2;CCL38.1;CCL3L1;CCL34A.3 |
chemokine receptor binding | CXCL12;Ccl21a;CCL21;S100A14;CCRL2;XCL1;CCL25;CCL5;CCL21B |
growth factor activity | LFT1;IL4;PPBP;CSF2;CSPG5;NGF;GDF6B;FGF11A;BMP6 |
receptor binding | AMACR;P2RX7;F7;FGF6B;LRRC4B;CHRNA10;NRG1;STOML2;WNT5B |
CXCL12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CXCL12 here. Most of them are supplied by our site. Hope this information will be useful for your research of CXCL12.
DPP4; DAZAP2
- Q&As
- Reviews
Q&As (5)
Ask a questionCXCL12 is being investigated for its role in neuroprotection and neuroregeneration in conditions like Alzheimer's and Parkinson's disease.
Yes, ELISA and other assays can be used to measure CXCL12 levels, aiding in the diagnosis and monitoring of certain diseases.
CXCL12 levels can serve as a biomarker for various diseases, such as HIV, cancer, and inflammatory disorders.
Scientists are exploring the potential of CXCL12-based therapies to promote vascular repair and treat heart diseases.
Researchers are studying CXCL12-based treatments to promote nerve regeneration and functional recovery after spinal cord injuries.
Customer Reviews (3)
Write a reviewThe CXCL12 protein is of exceptional quality, making it an ideal candidate to fulfill my experimental requirements.
The manufacturer's commitment to providing excellent technical support is truly commendable, as they have proven to be readily available to assist in resolving any concerns or challenges I encountered while working with the protein.
Its purity and integrity have consistently delivered reliable and robust results in my research.
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