cxcl2

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cxcl2

Official Full Name chemokine (C-X-C motif) ligand 2
Background Chemokine (C-X-C motif) ligand 2 (CXCL2) is a small cytokine belonging to the CXC chemokine family that is also called macrophage inflammatory protein 2-alpha (MIP2-alpha), Growth-regulated protein beta (Gro-beta) and Gro oncogene-2 (Gro-2). CXCL2 is 90% identical in amino acid sequence as a related chemokine, CXCL1. This chemokine is secreted by monocytes and macrophages and is chemotactic for polymorphonuclear leukocytes and hematopoietic stem cells. The gene for CXCL2 is located on human chromosome 4 in a cluster of other CXC chemokines. CXCL2 mobilizes cells by interacting with a cell surface chemokine receptor called CXCR2.
Synonyms GROb; Gro2; Mip2; Scyb; MIP-2; Scyb2; MIP-2a; Mgsa-b; CINC-2a; Cxcl2; chemokine (C-X-C motif) ligand 2
    • Species :
    • Cotton Rat
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human
    • Human Cell
    • Human Pleural Fluid
    • Mammalian Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • Flag
    • StrepII
    • SUMO
    • Myc/DDK
    • N/A
    • Strep II
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CXCL2-3982H Recombinant Human CXCL2 Protein, MYC/DDK-tagged HEK293T Myc/DDK
    Human CXCL2-401H Recombinant Human CXCL2 Protein (Ala35-Asn107) E.coli N/A
    Human CKERS-CXCL2-019H Human CXCL2 ELISA Kit Human Pleural Fluid N/A
    Human CXCL2-17H Recombinant Human CXCL2 yeast N/A
    Human CXCL2-2165P Recombinant CXCL2 Protein, His-Flag-StrepII-tagged Human Cell His/Flag/StrepII
    Human CXCL2-2167H Recombinant Human CXCL2 Protein, GST-tagged Wheat Germ GST
    Human CXCL2-224H Recombinant Human chemokine (C-X-C motif) ligand 2, His-tagged Human His
    Human CXCL2-282H Recombinant Human CXCL2, StrepII-tagged Human Cell Strep II
    Human CXCL2-476H Recombinant Human CXCL2 protein E.coli N/A
    Human CXCL2-7168HCL Recombinant Human CXCL2 293 Cell Lysate HEK293 N/A
    Mouse Cxcl2-13M Recombinant Mouse Cxcl2 yeast N/A
    Mouse Cxcl2-200M Recombinant Mouse Cxcl2, His & SUMO tagged E.coli His/SUMO
    Mouse Cxcl2-2169M Recombinant Mouse Cxcl2 protein E.coli N/A
    Mouse Cxcl2-3390M Recombinant Mouse Cxcl2 Protein E.coli N/A
    Mouse Cxcl2-38M Recombinant Mouse Chemokine (C-X-C Motif) Ligand 2 E.coli His
    Mouse CXCL2-4105M Recombinant Mouse CXCL2 Protein Mammalian Cell His
    Mouse Cxcl2-428M Recombinant Mouse Cxcl2 protein, His-tagged Yeast His
    Rat Cxcl2-1070R Recombinant Rat Cxcl2 Protein E.coli N/A
    Rat CXCL2-1689R Recombinant Rat CXCL2 Protein Mammalian Cell His
    Rat Cxcl2-54R Recombinant Rat Cxcl2 protein E.coli N/A
    Rat Cxcl2-578R Recombinant Rat Cxcl2 protein, His & GST-tagged E.coli His/GST
    Rat Cxcl2-626R Recombinant Rat Cxcl2 E.coli N/A
    Cotton Rat Cxcl2-395C Recombinant Cotton Rat Cxcl2 E.coli N/A

    cxcl2 involved in several pathways and played different roles in them. We selected most pathways cxcl2 participated on our site, such as Cytokine-cytokine receptor interaction, Chemokine signaling pathway, NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with cxcl2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction IL5; Ifnlr1; CXCR3.2; VEGFC; TNFRSF13C; THPO; PLEKHO2; PRL2; IL28A; IRX1
    Chemokine signaling pathway GNB4; BRAF; FOXO3; PXN; CCL6; CCL5; CXCL16; CCL21; Ccl27a; MAPK1
    NF-kappa B signaling pathway NFKB2; GM13304; TNFSF11; TNF; BCL2A1A; IL1B; CCL4L1; TNFSF13B; PIDD1; XIAP
    NOD-like receptor signaling pathway IKBKB; CCL2; IL6; TRAF6; MAPK8A; CXCL1; MAPK1; CARD9; ERBB2IP; SUGT1
    TNF signaling pathway PGAM5; PIK3CA; RELA; MMP9; PIK3CB; VEGFC; IL6; SOCS3; MAPK9; CASP7
    Salmonella infection ARPC4L; MAPK3; DYNC1LI1; NOS2B; IL-8; RAB7B; MAPK12; IL1A; IL18; ARPC5B
    Legionellosis PYCARD; CASP7; HBS1L; IL-8; CXCL1; IL12A; VCP; RAB1; BNIP3; CASP8

    cxcl2 has several biochemical functions, for example, CXCR chemokine receptor binding, chemokine activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by cxcl2 itself. We selected most functions cxcl2 had, and list some proteins which have the same functions with cxcl2. You can find most of the proteins on our site.

    Function Related Protein
    CXCR chemokine receptor binding CXCL12B; CXCL12A; CXCL12; CXCL6; PPBP; CXCL2; AMCF-II; CXCL3; ITCH; CXCL18B
    chemokine activity XCL1; CCL21; CCL20A.3; CCL34A.3; CCL1; CXCL11.8; CCL34B.1; IL8L2; CXCL6; CCL20
    protein binding DYNC1I1; DEFB121; METTL21C; TLN1; ZNF317; C1QTNF3; RORA; INSIG2; SKI; IFIT1

    cxcl2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with cxcl2 here. Most of them are supplied by our site. Hope this information will be useful for your research of cxcl2.

    DPP4; EPS8; PIK3R5

    Maeda, A; Bandow, K; et al. Induction of CXCL2 and CCL2 by pressure force requires IL-1 beta-MyD88 axis in osteoblasts. BONE 74:76-82(2015).
    McDermott, AJ; Higdon, KE; et al. The role of Gr-1(+) cells and tumour necrosis factor-alpha signalling during Clostridium difficile colitis in mice. IMMUNOLOGY 144:704-716(2015).

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