Recombinant Human MMP3 Protein, Myc/DDK-tagged, C13 and N15-labeled

• Cat.No.: MMP3-780H
• Product Overview: MMP3 MS Standard C13 and N15-labeled recombinant protein (NP_002413) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells.

Specification

• Description: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.
• Source: HEK293
• Species: Human
• Tag: Myc/DDK
• Molecular Mass: 54 kDa
• AA Sequence: MKSLPILLLLCVAVCSAYPLDGAAR GEDTSMNLVQKYLENYYDLEKDVKQ FVRRKDSGPVVKKIREMQKFLGLEV TGKLDSDTLEVMRKPRCGVPDVGHF RTFPGIPKWRKTHLTYRIVNYTPDL PKDAVDSAVEKALKVWEEVTPLTFS RLYEGEADIMISFAVREHGDFYPFD GPGNVLAHAYAPGPGINGDAHFDDD EQWTKDTTGTNLFLVAAHEIGHSLG LFHSANTEALMYPLYHSLTDLTRFR LSQDDINGIQSLYGPPPDSPETPLV PTEPVPPEPGTPANCDPALSFDAVS TLRGEILIFKDRHFWRKSLRKLEPE LHLISSFWPSLPSGVDAAYEVTSKD LVFIFKGNQFWAIRGNEVRAGYPRG IHTLGFPPTVRKIDAAISDKEKNKT YFFVEDKYWRFDEKRNSMEPGFPKQ IAEDFPGIDSKIDAVFEEFGFFYFF TGSSQLEFDPNAKKVTHTLKSNSWL NCTRTRPLEQKLISEEDLAANDILD YKDDDDKV
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 3 months from receipt of products under proper storage and handling conditions.
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Concentration: 50 μg/mL as determined by BCA
• Storage Buffer: 100 mM glycine, 25 mM Tris-HCl, pH 7.3.

Gene Information

• Gene Name: MMP3 matrix metallopeptidase 3 [ Homo sapiens (human) ]
• Official Symbol: MMP3
• Synonyms: MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase); matrix metalloproteinase 3 (stromelysin 1, progelatinase), STMY, STMY1; stromelysin-1; transin-1; proteoglycanase; matrix metalloproteinase-3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); SL-1; STMY; STR1; CHDS6; MMP-3; STMY1; MGC126102; MGC126103; MGC126104
• Gene ID: 4314
• mRNA Refseq: NM_002422
• Protein Refseq: NP_002413
• MIM: 185250
• UniProt ID: P08254