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Official Full Name matrix metallopeptidase 8 (neutrophil collagenase)
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Synonyms MMP8; matrix metallopeptidase 8 (neutrophil collagenase); HNC; CLG1; MMP-8; PMNL-CL; neutrophil collagenase; PMNL collagenase; matrix metalloproteinase-8; matrix metalloproteinase 8 (neutrophil collagenase); BB138268
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E. coli
    • E.coli
    • Human Cell
    • Human Neutrophil
    • Mammalian Cell
    • NS0
    • NSO
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MMP8-1132H Recombinant Human MMP8, None tagged Human Cell N/A
    Human MMP8-1135H Recombinant Human MMP8 protein, His-tagged E.coli His
    Human MMP8-123H Recombinant Human MMP8 Protien, His-tagged E. coli His
    Human MMP8-154H Recombinant Human Matrix Metallopeptidase 8, Catalytic Domain E.coli N/A
    Human MMP8-1656H Recombinant Human Matrix Metallopeptidase 8 (Neutrophil Collagenase) Human Neutrophil N/A
    Human MMP8-2054HCL Recombinant Human MMP8 cell lysate Human Cell N/A
    Human MMP8-2529H Recombinant Human Matrix Metallopeptidase 8(neutrophil collagenase), His-tagged Human Cell His
    Human MMP8-409H Recombinant Human Matrix Metallopeptidase 8 (Neutrophil Collagenase) NSO N/A
    Human MMP8-41H Recombinant Human Matrix Metallopeptidase 8 E.coli N/A
    Human MMP8-423H Recombinant Human MMP8 NS0 N/A
    Human MMP8-446H Recombinant Human matrix metallopeptidase 8 (neutrophil collagenase), His-tagged E.coli His
    Human MMP8-5047H Recombinant Human MMP8, His-tagged E.coli His
    Human MMP8-5437H Recombinant Human MMP8 Protein, GST-tagged Wheat Germ GST
    Human MMP8-648H Recombinant Human MMP8, His tagged Human Cell His
    Human MMP8-89H Native Human Pro-MMP-8 Human Neutrophil N/A
    Mouse MMP8-001MCL Recombinant Mouse MMP8 cell lysate CHO N/A
    Mouse MmP8-1187M Recombinant Mouse MmP8, None tagged Human Cell N/A
    Mouse MMP8-2080MCL Recombinant Mouse MMP8 cell lysate Human Cell N/A
    Mouse Mmp8-523M Recombinant Mouse Mmp8, His-tagged CHO His
    Mouse Mmp8-610M Recombinant Mouse Mmp8 Protein, His-tagged CHO His
    Rat Mmp8-1055R Recombinant Rat Mmp8 Protein, His-tagged NS0 His
    Rat MMP8-3719R Recombinant Rat MMP8 Protein Mammalian Cell His
    Rat Mmp8-750R Recombinant Rat Mmp8 protein, His & T7-tagged E.coli His/T7

    mmp8 involved in several pathways and played different roles in them. We selected most pathways mmp8 participated on our site, such as Activation of Matrix Metalloproteinases, Collagen degradation, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with mmp8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of Matrix Metalloproteinases LOC100686744; CTSLL; MMP11; CTSL2; TIMP2; CTRB1; FURINA; MMP24; CMA1; TPSAB1
    Collagen degradation CTSK; MMP11; CTS7; COL13A1; COL9A3; MMP8; TLDC2; MMP20; MMP19; MMP13
    Degradation of the extracellular matrix CTRB1; CTSB; COL9A1; BMP1; ADAMTS8; FURINA; MMP11; ELANE; CTSG; TLDC2
    Extracellular matrix organization ADAMTS2; CMA1; CTS7; COL9A1A; EFEMP2; SERPINH1A; COL6A1; SERPINH1B; SPARC; BGNA
    Matrix Metalloproteinases TIMP4; MMP17; MMP24; MMP19; MMP8; MMP28; BSG; MMP20; TIMP2; MMP11

    mmp8 has several biochemical functions, for example, calcium ion binding, metalloendopeptidase activity, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by mmp8 itself. We selected most functions mmp8 had, and list some proteins which have the same functions with mmp8. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding KCNIP2; DGKG; SCUBE2; MYL12.2; PCDH2AB11; CRB2A; PCDHB13; PDCD6; CDH6; CABP5A
    metalloendopeptidase activity ADAMTS4; MMP17; MMP25; ADAM15; ADAM10; UQCRC1; ADAM25; MMP13; MBTPS2; ADAM22
    serine-type endopeptidase activity F7I; FURIN; CORIN; PRSS8; PRSS27; CTSG; PRSS28; LTF; CELA3B; PLG
    zinc ion binding ZMAT3; RNF148; ISL2A; AGBL3; BIRC7; RNF121; PDLIM3A; P2RX2; WT1; SH3RF2

    mmp8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mmp8 here. Most of them are supplied by our site. Hope this information will be useful for your research of mmp8.

    Oberkofler, CE; Limani, P; et al. Systemic Protection Through Remote Ischemic Preconditioning Is Spread by Platelet-Dependent Signaling in Mice. HEPATOLOGY 60:1409-1417(2014).
    Yeo, ASL; Azhar, NA; et al. Lack of Clinical Manifestations in Asymptomatic Dengue Infection Is Attributed to Broad Down-Regulation and Selective Up-Regulation of Host Defence Response Genes. PLOS ONE 9:-(2014).

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