MMP8

  • Official Full Name

    matrix metallopeptidase 8 (neutrophil collagenase)

  • Overview

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
  • Synonyms

    MMP8; matrix metallopeptidase 8 (neutrophil collagenase); HNC; CLG1; MMP-8; PMNL-CL; neutrophil collagenase; PMNL collagenase; matrix metalloproteinase-8; matrix metalloproteinase 8 (neutrophil collagenase); BB138268;

  • Recombinant Proteins
  • Native Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • Rat
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • Human Neutrophil
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Neutrophil granulocytes
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
  • C
  • Myc
  • SUMO
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MMP8-648H Active Recombinant Human MMP8, His tagged HEK293 His Met 1-Gly 467
Human MMP8-2529H Active Recombinant Human Matrix Metallopeptidase 8(neutrophil collagenase), His-tagged Human Cell His 458 amino acids
Human MMP8-423H Active Recombinant Human MMP8 Mammalian cells N/A
Human MMP8-1656H Active Native Human MMP8 Protein Neutrophil granulocytes
Human MMP8-154H Recombinant Human Matrix Metallopeptidase 8, Catalytic Domain E.coli N/A
Human MMP8-5047H Recombinant Human MMP8, His-tagged E.coli His
Human MMP8-1132H Active Recombinant Human MMP8 protein HEK293 N/A Phe 21-Gly 467
Human MMP8-446H Recombinant Human matrix metallopeptidase 8 (neutrophil collagenase), His-tagged E.coli His
Human MMP8-409H Recombinant Human Matrix Metallopeptidase 8 (Neutrophil Collagenase) Mammalian cells N/A
Human MMP8-41H Recombinant Human Matrix Metallopeptidase 8 E.coli N/A
Human MMP8-2054HCL Recombinant Human MMP8 cell lysate Human Cell N/A
Human MMP8-5437H Recombinant Human MMP8 Protein, GST-tagged Wheat Germ GST
Human MMP8-89H Native Human Pro-MMP-8 Human Neutrophil N/A
Human MMP8-4454H-B Recombinant Human MMP8 Protein Pre-coupled Magnetic Beads HEK293
Human MMP8-1135H Recombinant Human MMP8 protein, His-tagged E.coli His Leu101-Gly467
Human MMP8-123H Recombinant Human MMP8 Protein, His-tagged E.coli His 119-467 aa
Human MMP8-1243H Recombinant Human MMP8 protein, His&Myc-tagged E.coli N-His&C-Myc 101-467aa
Human MMP8-6281HF Recombinant Full Length Human MMP8 Protein, GST-tagged In Vitro Cell Free System GST 467 amino acids
Human MMP8-4454H Recombinant Human MMP8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Mmp8-610M Active Recombinant Mouse Mmp8 Protein, His-tagged CHO His Phe21-Ser465
Mouse Mmp8-523M Recombinant Mouse Mmp8, His-tagged CHO His Met1-Ser465
Mouse MmP8-1187M Recombinant Mouse MmP8 protein(Phe21-Ser465) HEK293 N/A Phe21-Ser465
Mouse MMP8-001MCL Recombinant Mouse MMP8 cell lysate CHO N/A
Mouse MMP8-2080MCL Recombinant Mouse MMP8 cell lysate Human Cell N/A
Mouse MMP8-1867M Active Recombinant Mouse MMP8 protein, His-tagged HEK293 His Phe 21 - Ser 465
Rat Mmp8-1055R Active Recombinant Rat Mmp8 Protein, His-tagged Mammalian cells His Leu21-Pro466
Rat Mmp8-750R Recombinant Rat Mmp8 protein, His & T7-tagged E.coli His/T7 Leu212~Arg451 (Accession # O88766)
Rat MMP8-3719R Recombinant Rat MMP8 Protein Mammalian Cell His
Rat MMP8-3376R Recombinant Rat MMP8 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Mmp8-1127R Recombinant Rat Mmp8 Protein, His&SUMO-tagged E.coli N-His&SUMO Leu102-Pro466
Rat MMP8-3376R-B Recombinant Rat MMP8 Protein Pre-coupled Magnetic Beads HEK293
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MMP8 involved in several pathways and played different roles in them. We selected most pathways MMP8 participated on our site, such as Activation of Matrix Metalloproteinases, Collagen degradation, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of Matrix MetalloproteinasesCTRB1;MMP8;CTSG;MMP17;FURINA;TIMP2A;CTSK;LOC100686744;MMP10
Collagen degradationCOL25A1;COL15A1B;CTSB;MMP12;ADAM9;CTSD;MMP8;CTSK;COL13A1
Degradation of the extracellular matrixCOL15A1B;CTS7;COL25A1;FURINB;COL17A1;MMP15;MGC174155;MMP8;BSG
Extracellular matrix organizationCOL4A4;LOXL4;CRTAP;CTSLL;PPIB;COL5A2;EMID2;MMP13;ABHD1
Matrix MetalloproteinasesMMP28;MMP24;MMP27;MMP19;TIMP2;MMP23B;MMP17;MMP26;MMP15

MMP8 has several biochemical functions, for example, calcium ion binding, metalloendopeptidase activity, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP8 itself. We selected most functions MMP8 had, and list some proteins which have the same functions with MMP8. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingF9;NCAN;MYL9A;TMEM8C;ENPP2;PCDH17;CAPNS1;S100A5;HPGDS
metalloendopeptidase activityADAM10A;ADAMTS3;BMP1B;ADAM10;ADAM2;MMP11;ADAMTS15;ASTL;ADAM22
serine-type endopeptidase activityKLK5;GZME;HGF;CFB;HTRA1A;KLK1B4;PARLA;C2;PRSS12
zinc ion bindingRBM14A;THRB;RNF34A;RNF38;VDR;BMI1B;ZFHX3;XIAP;TRIM64C

MMP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP8.

Gene Family

MMPs

Research Area

Related articles

Oberkofler, CE; Limani, P; et al. Systemic Protection Through Remote Ischemic Preconditioning Is Spread by Platelet-Dependent Signaling in Mice. HEPATOLOGY 60:1409-1417(2014).
Yeo, ASL; Azhar, NA; et al. Lack of Clinical Manifestations in Asymptomatic Dengue Infection Is Attributed to Broad Down-Regulation and Selective Up-Regulation of Host Defence Response Genes. PLOS ONE 9:-(2014).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
04/03/2022

    The use of MMP8 as a catalyst can significantly increase the rate and yield of chemical reactions with impressive high catalytic efficiency.

    09/14/2021

      MMP8 is really impressive, the results of every experiment are very consistent, you can see that its production process is very careful.

      03/20/2021

        MMP8 are inexpensive to prepare and cost-effective, making them ideal for our study.

        Q&As (6)

        Ask a question
        What signaling pathways does the MMP8 protein interact with? 11/16/2019

        The MMP8 protein interacts with a variety of signaling pathways, including TNF-α, TGF-β, Wnt, and NF-κB.

        What drugs interact with the MMP8 protein? 08/14/2019

        A number of inhibitors and modulators of MMP8 protein have been developed for the regulation of MMP8 activity and the treatment of related diseases.

        Why does MMP8 protein play a role in tissue repair? 04/18/2019

        The MMP8 protein is involved in the tissue repair and wound healing process, by degrading damaged tissue and supporting the formation of new tissue.

        What is the mechanism of action of MMP8 protein in inflammatory response? 03/08/2019

        MMP8 protein is involved in regulating the production of inflammation-related molecules and cell infiltration, promoting the occurrence and maintenance of inflammatory response.

        Does MMP8 have a role in post-traumatic recovery? 03/04/2019

        MMP8 protein is involved in the inflammatory and remodeling processes of post-traumatic wound healing, contributing to wound repair and tissue regeneration.

        Does the MMP8 protein study have implications for new drug development? 01/13/2019

        MMP8 protein plays an important role in the occurrence and progression of diseases, and studying the regulatory mechanism of MMP8 protein is helpful for the development of new drugs, such as inhibitors targeting MMP8 protein may be applied to the treatment of related diseases

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