mmp8
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  • Official Full Name
  • matrix metallopeptidase 8 (neutrophil collagenase)
  • Background
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MMP8; matrix metallopeptidase 8 (neutrophil collagenase); HNC; CLG1; MMP-8; PMNL-CL; neutrophil collagenase; PMNL collagenase; matrix metalloproteinase-8; matrix metalloproteinase 8 (neutrophil collagenase); BB138268
Cat.#:MMP8-5437HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MMP8 Protein, GST-tagged
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Cat.#:MMP8-1656HTag:N/A
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameRecombinant Human Matrix Metallopeptidase 8 (Neutrophil Collagenase)
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Cat.#:MMP8-2529HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Matrix Metallopeptidase 8(neutrophil collagenase), His-tagged
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Cat.#:MMP8-1132HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP8, None tagged
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Cat.#:MMP8-154HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Matrix Metallopeptidase 8, Catalytic Domain
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Cat.#:MMP8-41HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Matrix Metallopeptidase 8
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Cat.#:MMP8-423HTag:
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human MMP8
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Cat.#:MMP8-446HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human matrix metallopeptidase 8 (neutrophil collagenase), His-tagged
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Cat.#:MMP8-5047HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP8, His-tagged
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Cat.#:MMP8-648HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP8, His tagged
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Cat.#:MmP8-1187MTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse MmP8, None tagged
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Cat.#:Mmp8-523MTag:His
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Mmp8, His-tagged
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Cat.#:Mmp8-610MTag:His
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Mmp8 Protein, His-tagged
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Cat.#:Mmp8-1055RTag:His
Source (Host):NSO CellsSpecies:Rat
Product nameRecombinant Rat Mmp8 Protein, His-tagged
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Cat.#:MMP8-3719RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MMP8 Protein
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Cat.#:Mmp8-750RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp8 protein, His & T7-tagged
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Cat.#:MMP8-409HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Matrix Metallopeptidase 8 (Neutrophil Collagenase)
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Cat.#:MMP8-89HTag:
Source (Host):Species:Human
Product nameNative Human Pro-MMP-8
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Cat.#:MMP8-2054HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP8 cell lysate
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Cat.#:MMP8-001MCLTag:
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse MMP8 cell lysate
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Cat.#:MMP8-2080MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse MMP8 cell lysate
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Involved Pathway

MMP8 involved in several pathways and played different roles in them. We selected most pathways MMP8 participated on our site, such as Activation of Matrix Metalloproteinases, Collagen degradation, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of Matrix Metalloproteinases
MMP15; MMP13; CTSK; TPSAB1; MMP11; CTSG; MMP17; TIMP2A; MMP10; MGC174857
Collagen degradation
MMP13; TLDC2; MMP20; MMP11; MMP8; COL17A1; CTSD; CTSLL; COL15A1B; LOC100686744
Degradation of the extracellular matrix
ADAM8A; CTSG; FURINA; TLDC2; ADAMTS18; CTS7; MMP8; TIMP2B; ACAN; MMP20
Extracellular matrix organization
COL25A1; COL11A1B; CTS7; COL13A1; LOX; COL4A4; P3H2; PCOLCE2B; MATN1; LTBP2
Matrix Metalloproteinases
MMP23B; MMP24; MMP17; TIMP4; MMP26; MMP20; MMP8; MMP19; MMP25; BSG

Protein Function

MMP8 has several biochemical functions, for example, calcium ion binding, metalloendopeptidase activity, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP8 itself. We selected most functions MMP8 had, and list some proteins which have the same functions with MMP8. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein C1rb; CALM2; ACTN2B; SYTL2; SLC25A25; VSNL1; PCDHGB2; EPDR1; JAG2; ANXA5
Function metalloendopeptidase activity
Related Protein MEP1A.2; ADAM18; ADAM30; PAPPAA; ADAM28; ADAMTS1; NPSN; NLN; ADAMTS3; ADAM10A
Function serine-type endopeptidase activity
Related Protein FAP; KLK14; CLPP; HPN; Acr; PRSS22; KLK1B26; PROZ; C1S; MST1
Function zinc ion binding
Related Protein MAN2B2; RLIM; BRF1; GATAD2A; ESR1; MTF2; TRIM35-39; PHF11; CPD; ZDHHC7

MMP8 Related Articles

Oberkofler, CE; Limani, P; et al. Systemic Protection Through Remote Ischemic Preconditioning Is Spread by Platelet-Dependent Signaling in Mice. HEPATOLOGY 60:1409-1417(2014).
Yeo, ASL; Azhar, NA; et al. Lack of Clinical Manifestations in Asymptomatic Dengue Infection Is Attributed to Broad Down-Regulation and Selective Up-Regulation of Host Defence Response Genes. PLOS ONE 9:-(2014).

MMP8 Related Gene Family

MMPs