mmp8
Share
  • Official Full Name
  • matrix metallopeptidase 8 (neutrophil collagenase)
  • Background
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MMP8; matrix metallopeptidase 8 (neutrophil collagenase); HNC; CLG1; MMP-8; PMNL-CL; neutrophil collagenase; PMNL collagenase; matrix metalloproteinase-8; matrix metalloproteinase 8 (neutrophil collagenase); BB138268
Cat.#:MMP8-5437HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MMP8 Protein, GST-tagged
+Inquiry
Cat.#:MMP8-1656HTag:N/A
Source (Host):Human neutrophil granulocytes (Buffy Coat)Species:Human
Product nameRecombinant Human Matrix Metallopeptidase 8 (Neutrophil Collagenase)
+Inquiry
Cat.#:MMP8-2529HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Matrix Metallopeptidase 8(neutrophil collagenase), His-tagged
+Inquiry
Cat.#:MMP8-1132HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP8, None tagged
+Inquiry
Cat.#:MMP8-154HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Matrix Metallopeptidase 8, Catalytic Domain
+Inquiry
Cat.#:MMP8-41HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Matrix Metallopeptidase 8
+Inquiry
Cat.#:MMP8-423HTag:
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human MMP8
+Inquiry
Cat.#:MMP8-446HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human matrix metallopeptidase 8 (neutrophil collagenase), His-tagged
+Inquiry
Cat.#:MMP8-5047HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP8, His-tagged
+Inquiry
Cat.#:MMP8-648HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP8, His tagged
+Inquiry
Cat.#:MmP8-1187MTag:N/A
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse MmP8, None tagged
+Inquiry
Cat.#:Mmp8-523MTag:His
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse Mmp8, His-tagged
+Inquiry
Cat.#:Mmp8-610MTag:His
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Mmp8 Protein, His-tagged
+Inquiry
Cat.#:Mmp8-1055RTag:His
Source (Host):NSO CellsSpecies:Rat
Product nameRecombinant Rat Mmp8 Protein, His-tagged
+Inquiry
Cat.#:MMP8-3719RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MMP8 Protein
+Inquiry
Cat.#:Mmp8-750RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp8 protein, His & T7-tagged
+Inquiry
Cat.#:MMP8-409HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Matrix Metallopeptidase 8 (Neutrophil Collagenase)
+Inquiry
Cat.#:MMP8-89HTag:
Source (Host):Species:Human
Product nameNative Human Pro-MMP-8
+Inquiry
Cat.#:MMP8-2054HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP8 cell lysate
+Inquiry
Cat.#:MMP8-001MCLTag:
Source (Host):CHOSpecies:Mouse
Product nameRecombinant Mouse MMP8 cell lysate
+Inquiry
Cat.#:MMP8-2080MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse MMP8 cell lysate
+Inquiry

Involved Pathway

MMP8 involved in several pathways and played different roles in them. We selected most pathways MMP8 participated on our site, such as Activation of Matrix Metalloproteinases, Collagen degradation, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of Matrix Metalloproteinases
CTRB1; MMP24; TIMP2; MGC174152; MMP11; CTSK; TPSAB1; FURINB; LOC100686744; MGC174155
Collagen degradation
COL15A1B; COL23A1; CTSK; LOC100686744; MGC174155; COL25A1; COL9A3; MMP8; TLDC2; MMP13
Degradation of the extracellular matrix
MMP11; CTRB1; TLDC2; MMP12; TPSAB1; BMP1A; MGC174857; ADAM8; CTSK; COL17A1
Extracellular matrix organization
COL5A1; PCOLCEA; TLL1; FBN2; ADAMTS4; MUSK; COL4A3; COL4A4; MMP11; ICAM4
Matrix Metalloproteinases
MMP11; MMP17; MMP26; TIMP4; MMP24; MMP25; MMP23B; MMP19; MMP27; BSG

Protein Function

MMP8 has several biochemical functions, for example, calcium ion binding, metalloendopeptidase activity, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP8 itself. We selected most functions MMP8 had, and list some proteins which have the same functions with MMP8. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein PCDH1G18; RASGRP2; PCDHA9; MMP8; SVEP1; PCDH1G1; LALBA; MYL12.2; MYO5A; EFCAB10
Function metalloendopeptidase activity
Related Protein ADAMTS2; BMP1; ADAM17; ZMPSTE24; MMP19; ADAMTS3; PAPPAB; ADAM21; MMP2; ADAM2
Function serine-type endopeptidase activity
Related Protein PRSS45; CLPP; PCSK1; CTRC; F9B; MBTPS1; LOC780933; GZMH; TMPRSS2; PRSS37
Function zinc ion binding
Related Protein ZBBX; CXXC4; MBD1; NR6A1; NRD1B; ADAM5; LASP1; CAR6; RARB; TRIM13

MMP8 Related Articles

Oberkofler, CE; Limani, P; et al. Systemic Protection Through Remote Ischemic Preconditioning Is Spread by Platelet-Dependent Signaling in Mice. HEPATOLOGY 60:1409-1417(2014).
Yeo, ASL; Azhar, NA; et al. Lack of Clinical Manifestations in Asymptomatic Dengue Infection Is Attributed to Broad Down-Regulation and Selective Up-Regulation of Host Defence Response Genes. PLOS ONE 9:-(2014).

MMP8 Related Gene Family

MMPs