MMP8
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Official Full Name
matrix metallopeptidase 8 (neutrophil collagenase)
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Overview
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] -
Synonyms
MMP8; matrix metallopeptidase 8 (neutrophil collagenase); HNC; CLG1; MMP-8; PMNL-CL; neutrophil collagenase; PMNL collagenase; matrix metalloproteinase-8; matrix metalloproteinase 8 (neutrophil collagenase); BB138268;
- Recombinant Proteins
- Native Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- Rat
- CHO
- E. coli
- E.coli
- HEK293
- Human Cell
- Human Neutrophil
- In Vitro Cell Free System
- Mammalian Cell
- Mammalian cells
- Neutrophil granulocytes
- Wheat Germ
- GST
- His
- His (Fc)
- Avi
- His|T7
- N/A
- N
- SUMO
- Involved Pathway
- Protein Function
- Interacting Protein
- MMP8 Related Articles
- MMP8 Related Gene Family
MMP8 involved in several pathways and played different roles in them. We selected most pathways MMP8 participated on our site, such as Activation of Matrix Metalloproteinases, Collagen degradation, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of Matrix Metalloproteinases | CTSG;TIMP2B;CMA1;FURINB;ELANE;MMP10;MMP8;LOC100686744;MMP13 |
| Collagen degradation | COL13A1;MMP19;CTS7;COL15A1B;CTSL1;MMP11;MMP13;COL9A1;COL25A1 |
| Degradation of the extracellular matrix | ELANE;BMP1A;CTSK;COL15A1B;CTS7;COL25A1;MMP12;MMP24;COL19A1 |
| Extracellular matrix organization | CRTAP;COL10A1A;COL28A1;VCANB;COL11A1B;ASPN;DDR2;COL5A2;TLL2 |
| Matrix Metalloproteinases | TIMP2;MMP20;BSG;MMP12;MMP15;TIMP4;MMP23B;MMP24;MMP17 |
MMP8 has several biochemical functions, for example, calcium ion binding, metalloendopeptidase activity, serine-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP8 itself. We selected most functions MMP8 had, and list some proteins which have the same functions with MMP8. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | EDIL3;PCDH21;SMOC1;PCDH1A3;PCDH1A6;CAPN2L;PROZ;PCDH1G26;DNER |
| metalloendopeptidase activity | Adam6;ADAM10A;MMP16;FAP;HE2;ADAM7;TLL1;MMP19;ADAMTS15 |
| serine-type endopeptidase activity | TMPRSS4;KLK1B3;TRY;CELA2A;PRSS58;TPSG1;KLK10;HTRA4;PRSS27 |
| zinc ion binding | CDADC1;NEURL3;RNF19B;BRAP;ZDHHC18A;RFWD2;ZDHHC8B;TRIM33;TRIM47 |
MMP8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP8 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP8.
- Q&As
- Reviews
Q&As (6)
Ask a questionThe MMP8 protein interacts with a variety of signaling pathways, including TNF-α, TGF-β, Wnt, and NF-κB.
A number of inhibitors and modulators of MMP8 protein have been developed for the regulation of MMP8 activity and the treatment of related diseases.
The MMP8 protein is involved in the tissue repair and wound healing process, by degrading damaged tissue and supporting the formation of new tissue.
MMP8 protein is involved in regulating the production of inflammation-related molecules and cell infiltration, promoting the occurrence and maintenance of inflammatory response.
MMP8 protein is involved in the inflammatory and remodeling processes of post-traumatic wound healing, contributing to wound repair and tissue regeneration.
MMP8 protein plays an important role in the occurrence and progression of diseases, and studying the regulatory mechanism of MMP8 protein is helpful for the development of new drugs, such as inhibitors targeting MMP8 protein may be applied to the treatment of related diseases
Customer Reviews (3)
Write a reviewThe use of MMP8 as a catalyst can significantly increase the rate and yield of chemical reactions with impressive high catalytic efficiency.
MMP8 is really impressive, the results of every experiment are very consistent, you can see that its production process is very careful.
MMP8 are inexpensive to prepare and cost-effective, making them ideal for our study.
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