MMP7

  • Official Full Name

    matrix metallopeptidase 7 (matrilysin, uterine)

  • Overview

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans, fibronectin, elastin and casein and differs from most MMP family members in that it lacks a conserved C-terminal protein domain. The enzyme is involved in wound healing, and studies in mice suggest that it regulates the activity of defensins in intestinal mucosa. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
  • Synonyms

    MMP7; matrix metallopeptidase 7 (matrilysin, uterine); MMP-7; MPSL1; PUMP-1; matrilysin; matrin; pump-1 protease; uterine matrilysin; uterine metalloproteinase; matrix metalloproteinase-7; matrix metalloproteinase 7 (matrilysin, uterine); MAT;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Chicken
  • Human
  • Mouse
  • Rat
  • 293F
  • CHO
  • E.coli
  • HEK293
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Mouse myeloma cell line NS0
  • Wheat Germ
  • Yeast
  • C
  • His
  • Fc
  • GST
  • His (Fc)
  • Avi
  • His|T7
  • N/A
  • N
  • SUMO
  • TG
  • 8H
  • GGQ
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MMP7-22H Active Recombinant Human MMP7 protein E.coli N/A 173
Human MMP7-01H Active Recombinant Human MMP7 Protein Mouse myeloma cell line NS0
Human MMP7-47H Recombinant Human MMP7 protein, His-tagged E.coli His
Human MMP7-810H Recombinant Human MMP7, Fc tagged Human Cell Fc
Human MMP7-94 Recombinant ProMatrix Metalloproteinase-7 E.coli N/A
Human MMP7-40H Recombinant Human MMP7 E.coli N/A
Human MMP7-2883HCL Recombinant Human MMP7 cell lysate Human Cell N/A
Human MMP7-49H Recombinant Human MMP7 protein, His-tagged 293F His 250
Human MMP7-28205TH Native Human MMP7 N/A
Human MMP7-5435H Recombinant Human MMP7 Protein, GST-tagged Wheat Germ GST
Human MMP7-6280HF Recombinant Full Length Human MMP7 Protein, GST-tagged In Vitro Cell Free System GST 267 amino acids
Human MMP7-395H Recombinant Human MMP7 Protein, GST-tagged E.coli GST 1-100 aa
Human MMP7-48H Recombinant Human MMP7 protein, His-tagged E.coli His 267
Human MMP7-50H Active Recombinant Human MMP7 Protein, TG-8H-GGQ-tagged CHO TG-8H-GGQ
Human MMP7-0504H Active Recombinant Human MMP7 protein, His-tagged HEK293 His Leu18-Lys267
Human MMP7-4565H Recombinant Human MMP7 Protein (Tyr95-Lys267), N-His tagged E.coli N-His Tyr95-Lys267
Human MMP7-221H Active Recombinant Human MMP7 Protein (Tyr95-Lys276), C-His tagged, Animal-free, Carrier-free E.coli C-His Tyr95-Lys276
Human MMP7-001H Recombinant Human MMP7 Protein, His-tagged E.coli His 18-267
Human MMP7-222H Recombinant Human MMP7 Protein (Met1-Lys276), C-His tagged, Animal-free, Carrier-free E.coli C-His Met1-Lys276
Human MMP7-3236H Recombinant Human MMP7 protein, GST-tagged E.coli GST 95-267aa
Human MMP7-2612H Recombinant Human MMP7 protein(18-267 aa), N-SUMO & C-His-tagged E.coli N-SUMO & C-His 18-267 aa
Mouse Mmp7-203M Active Recombinant Mouse Mmp7 Mammalian cells N/A
Mouse Mmp7-748M Recombinant Mouse Mmp7 protein, His-tagged E.coli His Met1~Leu264
Mouse Mmp7-10595M Recombinant Mouse Mmp7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Mmp7-10595M-B Recombinant Mouse Mmp7 Protein Pre-coupled Magnetic Beads HEK293
Rat MMP7-3718R Recombinant Rat MMP7 Protein Mammalian Cell His
Rat Mmp7-749R Recombinant Rat Mmp7 protein, His & T7-tagged E.coli His/T7 Met1~Leu267 (Accession # P50280)
Rat MMP7-659R Recombinant Rat MMP7 Protein (98-267 aa), GST-tagged E.coli GST 98-267 aa
Rat MMP7-1458R Recombinant Rat MMP7 Protein (98-267 aa), His-tagged Yeast His 98-267 aa
Rat MMP7-3374R-B Recombinant Rat MMP7 Protein Pre-coupled Magnetic Beads HEK293
Rat MMP7-3374R Recombinant Rat MMP7 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Cattle MMP7-1126C Recombinant Cattle MMP7 Protein, His&GST-tagged E.coli N-His&GST Asp29-Lys267
Chicken MMP7-1425C Recombinant Chicken MMP7 Mammalian Cell His
Chicken MMP7-1125C Recombinant Chicken MMP7 Protein, His&GST-tagged E.coli N-His&GST Phe22-Ser267
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MMP7 involved in several pathways and played different roles in them. We selected most pathways MMP7 participated on our site, such as Wnt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Wnt signaling pathwayMYCB;FZD7;CCND3;MMP7;INVS;FBXW11A;PRICKLE1A;CUL1B;CAMK2B

MMP7 has several biochemical functions, for example, heparin binding, metalloendopeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP7 itself. We selected most functions MMP7 had, and list some proteins which have the same functions with MMP7. You can find most of the proteins on our site.

Function Related Protein
heparin bindingTHBS4;GM4980;CTGFA;COL5A1;PCSK6;HRG;SMOC2;SERPINC1;SERPINE2
metalloendopeptidase activityMME;MMP12;XRCC6BP1;TLL2;C6AST1;ADAM1B;MMP15;MMP19;PAPPAB
zinc ion bindingBIRC5;ZCCHC4;ZCCHC6;ZDHHC18B;GM757;ZRANB1B;Alb;Ar;BTR02

MMP7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP7 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP7.

ELN; FASLG

Gene Family

MMPs

Research Area

Related articles

Kim, GE; Lee, JS; et al. Expression of matrix metalloproteinases and their inhibitors in different immunohistochemical-based molecular subtypes of breast cancer. BMC CANCER 14:-(2014).
Mitsui, H; Suarez-Farinas, M; et al. Gene Expression Profiling of the Leading Edge of Cutaneous Squamous Cell Carcinoma: IL-24-Driven MMP-7. JOURNAL OF INVESTIGATIVE DERMATOLOGY 134:1418-1427(2014).
  • Reviews
  • Q&As

Customer Reviews (3)

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Reviews
05/01/2023

    This includes rigorous quality control measures to ensure the consistency and purity of the protein, thereby reducing variability in the experimental outcomes.

    05/13/2022

      by utilizing MMP7 protein in trials and collaborating with a supportive manufacturer, researchers can gain access to a versatile tool that can aid in their understanding of angiogenesis and vascular biology.

      05/26/2018

        With expert assistance and reliable product quality, researchers can conduct their experiments with confidence, enabling them to contribute to advancements in the field and potentially improve future therapeutic interventions.

        Q&As (6)

        Ask a question
        What clinical conditions are associated with MMP7 overexpression? 01/31/2023

        MMP7 overexpression has been linked to various diseases, including cancer, inflammatory disorders, and tissue fibrosis.

        In what ways does MMP7 contribute to inflammatory processes? 05/20/2020

        MMP7 is involved in the degradation of extracellular matrix components during inflammation, influencing tissue damage and repair processes.

        How can MMP7 be targeted for therapeutic interventions? 01/20/2020

        Developing specific inhibitors that target MMP7 activity is a potential approach for therapeutic interventions, particularly in diseases where MMP7 plays a detrimental role.

        Are there any inhibitors developed for MMP7? 10/19/2017

        Several MMP inhibitors have been investigated, and some show promise in controlling MMP7 activity. However, their clinical use is still under research.

        How is MMP7 involved in cancer progression? 01/13/2017

        MMP7 facilitates cancer cell invasion and metastasis by degrading the extracellular matrix, allowing cancer cells to invade surrounding tissues and spread to distant organs.

        Can MMP7 be used as a biomarker for cancer diagnosis? 01/09/2016

        Yes, elevated levels of MMP7 have been observed in the serum or tissues of cancer patients, making it a potential biomarker for certain types of cancer.

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