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MMP1

  • Official Full Name

    matrix metallopeptidase 1 (interstitial collagenase)

  • Overview

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
  • Synonyms

    MMP1; matrix metallopeptidase 1 (interstitial collagenase); CLG; CLGN; interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Native Proteins
  • Others
  • Protein Pre-coupled Magnetic Beads
  • Cattle
  • Human
  • Pig
  • Rabbit
  • Rat
  • CHO
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • Human Fibroblasts
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • MBP
  • T7|His
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MMP1-126H Active Recombinant Human MMP1 Protein, His-tagged HEK293 His Phe20-Asn469
Human MMP1-1713H Active Recombinant Human MMP1 E.coli N/A
Human MMP1-149H Recombinant Human Matrix Metallopeptidase 1, Hemopexin-like Domain E.coli N/A
Human MMP1-407H Recombinant Human Matrix Metallopeptidase 1 Mammalian cells N/A
Human MMP1-566H Recombinant Human MMP1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MMP1-91H Recombinant Human MMP1 protein, T7/His-tagged E.coli T7/His
Human MMP1-568H Recombinant Human MMP1 Protein, His-tagged E.coli His
Human MMP1-809H Recombinant Human MMP1 protein, His-tagged HEK293 His Phe20-Asn469
Human MMP1-445H Recombinant Human matrix metallopeptidase 1 (interstitial collagenase), His-tagged E.coli His
Human MMP1-26H Recombinant Human MMP1 protein, His-tagged Insect Cell His
Human MMP1-2884HCL Recombinant Human MMP1 cell lysate Human Cell N/A
Human MMP1-2983H Recombinant Human MMP1 protein, His-tagged E.coli His 428-469 aa
Human MMP1-45H Native Human MMP-1 Human Fibroblasts N/A
Human MMP1-148H Recombinant Human Matrix Metallopeptidase 1, Catalytic Domain E.coli N/A
Human MMP1-5412H Active Recombinant Human MMP1 Protein E.coli N/A
Human MMP1-799H Recombinant Human MMP1 Protein, His-tagged HEK293 His
Human MMP1-5413H Recombinant Human MMP1 Protein, GST-tagged Wheat Germ GST
Human MMP1-6400HF Recombinant Full Length Human MMP1 Protein, GST-tagged In Vitro Cell Free System GST 469 amino acids
Human MMP1-4560H Active Recombinant Human MMP1 protein(Met1-Asn469), His-tagged HEK293 C-His Met1-Asn469
Human MMP1-4450H-B Recombinant Human MMP1 Protein Pre-coupled Magnetic Beads HEK293
Human MMP1-4231H Recombinant Human MMP1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MMP1-238H Recombinant Active Human MMP1 Protein, His-tagged(C-ter) HEK293 His(C-ter) Phe20-Asn469
Human MMP1-4561H Recombinant Human MMP1 Protein (Phe20-Asn469), N-His tagged E.coli N-His Phe20-Asn469
Human MMP1-4450H Recombinant Human MMP1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MMP1-1114H Recombinant Human MMP1 Protein, His-tagged CHO N-His Phe20-Asn469
Human MMP1-2535H Recombinant Human MMP1 protein(111-290 aa), N-MBP & C-His-tagged E.coli N-MBP & C-His 111-290 aa
Human MMP1-2536H Recombinant Human MMP1 protein(20-469 aa), N-MBP & C-His-tagged HEK293 N-MBP & C-His 20-469 aa
Human MMP1-5002H Recombinant Human MMP1 protein(270-469aa), His-tagged E.coli C-His 270-469aa
Rat Mmp1-726R Recombinant Rat Mmp1 protein, His & T7-tagged E.coli His/T7 Asn169~Cys464 (Accession# B5DFD5)
Rabbit MMP1-1115R Recombinant Rabbit MMP1 Protein, His-tagged E.coli N-His Phe99-Pro268
Cattle MMP1-724C Recombinant Cattle MMP1 protein, His & T7-tagged E.coli His/T7 Phe19~Asn469 (Accession# P28053)
Pig MMP1-1116P Recombinant Pig MMP1 Protein, His-tagged E.coli N-His Phe100-Asn469
  • Background
  • Quality Guarantee
  • Case Study
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

What is mmp1 protein?

The MMP1 protein, also known as matrix metalloproteinase 1, is an enzyme that belongs to the matrix metalloproteinase family. It is produced by various cells in the body, including fibroblasts, macrophages, and endothelial cells. MMP1 is involved in the breakdown and remodeling of the extracellular matrix, which is the structural framework of tissues.

The main function of MMP1 is to degrade the collagens present in the extracellular matrix, specifically type I, II, and III collagens. This allows for tissue remodeling during normal physiological processes such as development, wound healing, and tissue repair. MMP1 plays a critical role in maintaining tissue homeostasis by controlling cell migration, tissue morphogenesis, and angiogenesis.

However, overexpression and dysregulation of MMP1 have been associated with various pathological conditions. Excessive MMP1 activity can lead to abnormal tissue remodeling, tissue degradation, and disease progression. It has been implicated in several diseases, including cancer, arthritis, cardiovascular diseases, and chronic lung diseases.

What is the function of mmp1 protein?

MMP1 is secreted as an inactive zymogen and requires activation to become enzymatically active. Once activated, MMP1 can initiate the breakdown of collagen fibers, thereby facilitating tissue remodeling and turnover. It is involved in normal physiological processes such as development, wound healing, and tissue repair. However, excessive MMP1 activity has been associated with pathological conditions such as tissue degradation in arthritis, cancer invasion and metastasis, and fibrosis.

In addition to its role in collagen degradation, MMP1 can also cleave other ECM components, growth factors, cytokines, and cell adhesion molecules, thereby influencing various cellular processes such as cell migration, angiogenesis, and immune response.

Mmp1 related signaling pathway

The signaling pathway related to Mmp1 involves the activation of certain transcription factors such as AP-1 (activator protein 1) and NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells). These transcription factors regulate the expression of Mmp1 gene and promote the production of Mmp1 protein.

Mmp1 Related Diseases

  •  Cancer therapy: MMP1 is a promising target for developing anticancer drugs and blocking tumor growth and metastasis.
  •  Arthritis treatment: Inhibiting MMP1 activity can slow cartilage and bone degradation in arthritis.
  •  Neurodegenerative diseases: MMP1 inhibition could reduce amyloid plaque formation and neuronal damage in Alzheimer's.
  •  Neurodegenerative diseases: MMP1 inhibition could reduce amyloid plaque formation and neuronal damage in Alzheimer's.

Biomedical Application of mmp1 Protein

In terms of biomedical applications, Mmp1 protein and its inhibitors have been explored as potential therapeutic targets for various diseases. In conditions characterized by excessive tissue remodeling, such as fibrosis, the inhibition of Mmp1 activity can prevent the degradation of extracellular matrix and tissue damage. On the other hand, promoting Mmp1 activity can be beneficial in wound healing and tissue regeneration processes.

Furthermore, Mmp1 has been studied as a potential biomarker for certain diseases, particularly in cancer. Elevated levels of Mmp1 have been associated with tumor progression, invasion, and metastasis, making it a potential diagnostic and prognostic marker for cancer.

High Purity

MMP1

Fig1. SDS-PAGE (MMP1-26H)

MMP1

(Joseph B. Addison, 2015)

Fig2. KAP1 and KRAB-ZNFs are overexpressed in breast tumors. Western blot analysis of KAP1 and KRAB-ZNFs in biopsy samples of matched normal(N)–tumor(T) pairs. TLR3 and GAPDH are shown for comparison.

MMP1

(Le Du, 2022)

Fig3. ZNF3 regulates the expressions of EMT-related markers. The mRNA expression levels of EMT-related markers ( Vimentin, TWIST, CK19, MMP1, and ZEB2) were decreased in ZNF3-silenced SW480 cells.

MMP1

(Le Du, 2022)

Fig4. Gene Expression of Fibroblasts Encapsulated in Different Hydrogel Blends. Fold changes in fibroblast ECM related genes when normalized to HA alone gels show that cells respond differently to their microenvironments. One way ANOVA with Tukey's post-hoc test was used to determine differences in gene expression between cells encapsulated in different hydrogel blends.

MMP1 involved in several pathways and played different roles in them. We selected most pathways MMP1 participated on our site, such as PPAR signaling pathway, Pathways in cancer, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
PPAR signaling pathwayAPOA1;CYP7A1A;ACSL4;PLIN1;MMP1;Scd1;PDPK1B;APOA5;RXRB
Pathways in cancerRALB;FIGF;MAPK9;PPARD;F2R;LAMA4;LAMC2;LAMA3;BCL2L1
Bladder cancerARAF;THBS1;RPS6KA5;E2F3;DAPK2;MMP9;TRP53;MMP1;RAF1
Rheumatoid arthritisANGPT1;FLT1;TNFRSF11A;ATP6V0E1;ICAM1;HLA-DRA;Ccl12;CCL20;HLA-DRB5

MMP1 has several biochemical functions, for example, calcium ion binding, endopeptidase activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP1 itself. We selected most functions MMP1 had, and list some proteins which have the same functions with MMP1. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingSPTA1;TNNC1B;EHD1B;ATP2C1;CPNE1;EFHA1;PCDH2G7;PITPNM2;MFGE8B
endopeptidase activityNCSTN;FURIN;MME;CPNE1;ADAM10;SENP5;CD46;PSMA8;CTSH
metalloendopeptidase activityYME1L1B;BMP1B;PAPPA;MMP14B;HE1A;ADAMTS18;MMP2;MEP1A;ADAM25
zinc ion bindingRABGGTB;TRIM5;TRIM38;RNF126;MMP25;RNF38;CBLC;MMP14;PHF23

MMP1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP1 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP1.

F2R; SOX8

Gene Family

MMPs

Research Area

Related articles

Addison, JB; Koontz, C; et al. KAP1 Promotes Proliferation and Metastatic Progression of Breast Cancer Cells. CANCER RESEARCH 75:344-355(2015).
Kumar, D; Moore, RM; et al. Decidual GM-CSF is a critical common intermediate necessary for thrombin and TNF induced in-vitro fetal membrane weakening. PLACENTA 35:1049-1056(2014).
  • Q&As
  • Reviews

Q&As (5)

Ask a question
How does MMP1 relate to wound healing? 02/09/2023

MMP1 is involved in the remodeling of tissue during wound healing by facilitating the breakdown of damaged extracellular matrix components.

Are there therapeutic implications of targeting MMP1 in cancer treatment? 11/11/2022

Inhibiting MMP1 activity is being explored as a potential therapeutic strategy to impede cancer progression and metastasis.

How does MMP1 contribute to tissue remodeling? 05/07/2020

MMP1 plays a key role in tissue remodeling by degrading collagen, a major component of the extracellular matrix, which is essential for processes like wound healing.

In what diseases is MMP1 overexpressed? 08/21/2017

MMP1 overexpression is associated with various diseases, including rheumatoid arthritis, atherosclerosis, and certain types of cancer.

Can MMP1 be a biomarker for prognosis in cancer patients? 02/18/2017

High MMP1 levels have been correlated with poor prognosis in certain cancer types, making it a potential biomarker for predicting disease outcomes.

Customer Reviews (3)

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Reviews
08/26/2021

    The manufacturer can offer technical support and expertise to guide researchers through the experimental process.

    11/09/2020

      The manufacturer can play a vital role in supporting and optimizing the research process.

      07/20/2020

        This guarantees that the protein is reliable, consistent, and suitable for experiments, reducing variability and enhancing the reproducibility of findings.

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