|Official Full Name||matrix metallopeptidase 1 (interstitial collagenase)|
|Background||Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes a secreted enzyme which breaks down the interstitial collagens, types I, II, and III. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]|
|Synonyms||MMP1; matrix metallopeptidase 1 (interstitial collagenase); CLG; CLGN; interstitial collagenase; fibroblast collagenase; matrix metalloprotease 1; matrix metalloproteinase 1|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
mmp1 involved in several pathways and played different roles in them. We selected most pathways mmp1 participated on our site, such as PPAR signaling pathway, Pathways in cancer, Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with mmp1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|PPAR signaling pathway||ACSL1; SCP2A; PDPK1B; PLTP; FABP7A; DBI; SCD; RXRAA; APOA2; ACSBG1|
|Pathways in cancer||GNG2; CBL; GLI1; KRAS; FGF16; ARNT2; LPAR4; FAS; LAMB3; ARNT|
|Bladder cancer||VEGFA; EGF; KRAS; MDM2; SRC; MMP2; HRAS; ARAF; RPS6KA5; CCND1|
|Rheumatoid arthritis||IL-8; CCL5; HLA-DRB3; IL1B; TNFSF11; ATP6V0B; ATP6V0A4; IL23; ATP6V0E1; Ctsl|
mmp1 has several biochemical functions, for example, calcium ion binding, endopeptidase activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by mmp1 itself. We selected most functions mmp1 had, and list some proteins which have the same functions with mmp1. You can find most of the proteins on our site.
|calcium ion binding||MFGE8A; PCDH1G22; VSNL1; SYT5A; PCDH2G8; KCNIP4; EGFL8; FREM2; S100T; TNNC1|
|endopeptidase activity||PCSK6; PSEN2; PSMA8; TRAPPC12; TPP1; KLK1B5; PSMA2; SENP3; PSMB10; FAP|
|metalloendopeptidase activity||TLL2; ADAMTS1; HE1A; MMEL1; MBTPS2; KEL; ADAM10A; MIPEP; NRD1B; ADAMTS8|
|zinc ion binding||ING5; OAS1; RNF11B; ADAMTS8; RFPL4B; TRIML1; LNX2B; BMI1; TRIM35-27; TRAF5|
mmp1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mmp1 here. Most of them are supplied by our site. Hope this information will be useful for your research of mmp1.