MMP17

Official Full Name

matrix metallopeptidase 17 (membrane-inserted)
Overview

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMPs in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. [provided by RefSeq, Jul 2008]
Synonyms

MMP17; matrix metallopeptidase 17 (membrane-inserted); MT4-MMP; matrix metalloproteinase-17; MMP-17; MT4MMP; MTMMP4; MT-MMP 4; membrane-type matrix metalloproteinase 4; membrane-type-4 matrix metalloproteinase; matrix metalloproteinase 17 (membrane-inserted);

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse

Source

E.coli
HEK293
Mammalian Cell
Mammalian cells

Tag

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MMP17-26H	Active Recombinant Human MMP17 protein, His-tagged	Mammalian cells	His	Ala39-Ser531	Inquiry
Human	MMP17-27H	Recombinant Human MMP17 protein	E.coli	Non		Inquiry
Human	MMP17-609H	Recombinant Human MMP17, Catalytic Domain, His-tagged	E.coli	His		Inquiry
Human	MMP17-3489H	Recombinant Human MMP17 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Human	MMP17-3489H-B	Recombinant Human MMP17 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	MMP17-9912M	Recombinant Mouse MMP17 Protein	Mammalian Cell	His		Inquiry
Mouse	MMP17-5601M-B	Recombinant Mouse MMP17 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	MMP17-5601M	Recombinant Mouse MMP17 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

MMP17 involved in several pathways and played different roles in them. We selected most pathways MMP17 participated on our site, such as Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Activation of Matrix Metalloproteinases	FURINB;FURINA;MMP11;TIMP2B;TIMP2A;CMA1;MGC174152;CTSL2;MGC174857
Degradation of the extracellular matrix	ADAM8;MMP20;NID1;CTSLL;MMP17;ACAN;COL17A1;TPSAB1;TLL1
Extracellular matrix organization	PCOLCE2B;LAMB1B;PCOLCEB;FBLN2;PCOLCE2;MFAP2;TIMP2A;MMP8;LAMC3
Matrix Metalloproteinases	TIMP4;MMP12;TIMP2;MMP15;MMP24;MMP17;MMP19;MMP27;MMP11

MMP17 has several biochemical functions, for example, calcium ion binding, enzyme activator activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP17 itself. We selected most functions MMP17 had, and list some proteins which have the same functions with MMP17. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	KCNIP3B;PROCA;SPARC;CDH18;CRTAC1;FAT2;CALM;CAPSL;DST
enzyme activator activity	ARL1;CLPS;MMP15;MMP17;CTAGE5;OGT;PSAPL1;GTF3C4;DBNL
metalloendopeptidase activity	ADAMTS13;ADAMTSL5;ADAM8A;MEP1A.2;PAPLN;ADAMTS7;ASTL;HE1A;ADAM15
zinc ion binding	RXRAA;ADAM21;NAPEPLD;DBF4;TP53I3;DYTN;POLR2I;PHF23B;EWSR1A

MMP17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP17 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP17.

Gene Family

Research Area

Metalloproteases and Regulators

Salz, T; Deng, CW; et al. Histone Methyltransferase hSETD1A Is a Novel Regulator of Metastasis in Breast Cancer. MOLECULAR CANCER RESEARCH 13:461-469(2015).

Wang, Y; Yu, SJ; et al. Expression and clinical significance of matrix metalloproteinase-17 and-25 in gastric cancer. ONCOLOGY LETTERS 9:671-676(2015).