mmp17
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  • Official Full Name
  • matrix metallopeptidase 17 (membrane-inserted)
  • Background
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMPs in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MMP17; matrix metallopeptidase 17 (membrane-inserted); MT4-MMP; matrix metalloproteinase-17; MMP-17; MT4MMP; MTMMP4; MT-MMP 4; membrane-type matrix metalloproteinase 4; membrane-type-4 matrix metalloproteinase; matrix metalloproteinase 17 (membrane-inserted);
Cat.#:MMP17-609HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP17, Catalytic Domain, His-tagged
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Cat.#:MMP17-26HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human MMP17 protein, His-tagged
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Cat.#:MMP17-27HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP17 protein
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Cat.#:MMP17-9912MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MMP17 Protein
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Involved Pathway

MMP17 involved in several pathways and played different roles in them. We selected most pathways MMP17 participated on our site, such as Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of Matrix Metalloproteinases
MMP10; TPSAB1; CTSLL; CTRB1; ELANE; LOC100686744; MMP17; MGC174152; MGC174857; TIMP2
Degradation of the extracellular matrix
ACAN; EMID2; CTSB; TIMP2B; BMP1; LOC100686744; MMP20; COL25A1; MMP19; TIMP2
Extracellular matrix organization
ADAMTS4; BGNA; MFAP3; LAMC3; COL5A1; TIMP2A; MMP12; PTPRS; MFAP5; ADAMTS5
Matrix Metalloproteinases
MMP17; TIMP4; MMP10; MMP19; MMP15; MMP26; MMP12; MMP20; TIMP2; MMP28

Protein Function

MMP17 has several biochemical functions, for example, calcium ion binding, enzyme activator activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP17 itself. We selected most functions MMP17 had, and list some proteins which have the same functions with MMP17. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein RASGRP2; NRXN1; KCNIP3; MATN2; DNASE1L3; MYL1; CALN1; GALNT3; HEG; OCM2
Function enzyme activator activity
Related Protein RICTOR; DAOA; GM1679; SLX4; TAB1; MGST2; GTF3C4; PSAPL1; DCP1A; CTSA
Function metalloendopeptidase activity
Related Protein ECE2; MMP16; MMP14A; HE1B; MBTPS2; THSD4; ADAM22; MMP13; YME1L1B; UQCRC2A
Function zinc ion binding
Related Protein TAB2; PNMA3; CAD; TRIM105; KLF4; ADAM9; RBM10; TRIM3; RNF25; NEURL3

MMP17 Related Articles

Salz, T; Deng, CW; et al. Histone Methyltransferase hSETD1A Is a Novel Regulator of Metastasis in Breast Cancer. MOLECULAR CANCER RESEARCH 13:461-469(2015).
Wang, Y; Yu, SJ; et al. Expression and clinical significance of matrix metalloproteinase-17 and-25 in gastric cancer. ONCOLOGY LETTERS 9:671-676(2015).

MMP17 Related Gene Family

MMPs