MMP17

  • Official Full Name

    matrix metallopeptidase 17 (membrane-inserted)

  • Overview

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene is considered a member of the membrane-type MMP (MT-MMP) subfamily. However, this protein is unique among the MT-MMPs in that it is a GPI-anchored protein rather than a transmembrane protein. The protein activates MMP-2 by cleavage. [provided by RefSeq, Jul 2008]
  • Synonyms

    MMP17; matrix metallopeptidase 17 (membrane-inserted); MT4-MMP; matrix metalloproteinase-17; MMP-17; MT4MMP; MTMMP4; MT-MMP 4; membrane-type matrix metalloproteinase 4; membrane-type-4 matrix metalloproteinase; matrix metalloproteinase 17 (membrane-inserted);

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Mouse
  • E.coli
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • His
  • His (Fc)
  • Avi
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MMP17-26H Active Recombinant Human MMP17 protein, His-tagged Mammalian cells His
Human MMP17-27H Recombinant Human MMP17 protein E.coli N/A
Human MMP17-609H Recombinant Human MMP17, Catalytic Domain, His-tagged E.coli His
Human MMP17-3489H Recombinant Human MMP17 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MMP17-3489H-B Recombinant Human MMP17 Protein Pre-coupled Magnetic Beads HEK293
Mouse MMP17-9912M Recombinant Mouse MMP17 Protein Mammalian Cell His
Mouse MMP17-5601M-B Recombinant Mouse MMP17 Protein Pre-coupled Magnetic Beads HEK293
Mouse MMP17-5601M Recombinant Mouse MMP17 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MMP17 involved in several pathways and played different roles in them. We selected most pathways MMP17 participated on our site, such as Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP17 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of Matrix MetalloproteinasesTPSAB1;CTSK;MMP8;MMP11;MMP24;CTRB1;CTSG;TIMP2;MGC174857
Degradation of the extracellular matrixMMP13;BMP1A;COL15A1B;TLDC2;MMP17;MMP11;ADAMTS18;TPSAB1;MMP20
Extracellular matrix organizationCEACAM8;FBN1;FAM49BA;KLK7;MMP8;BSG;JAM2B;HAPLN1;LOXL1
Matrix MetalloproteinasesMMP27;MMP23B;MMP24;MMP28;MMP12;MMP20;MMP17;BSG;MMP25

MMP17 has several biochemical functions, for example, calcium ion binding, enzyme activator activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP17 itself. We selected most functions MMP17 had, and list some proteins which have the same functions with MMP17. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingCDH9;CAPS;MGMT;PCDH15B;EFCAB3;PCDH21;CBLC;DOC2D;THBS3A
enzyme activator activityARL1;DCP1B;CLPS;LTC4S;GMFG;SFTPBB;GLC8;DAOA;SEC14L2
metalloendopeptidase activityXRCC6BP1;BMP1A;MMP10;ADAM19;MMP24;BMP1;ADAMTS10;ADAM7;OSGEPL1
zinc ion bindingSIAH1;ZMYND11;NR2F6A;CHORDC1;KDM5A;LPP;Car12;ISL2B;UNK

MMP17 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP17 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP17.

Gene Family

MMPs

Research Area

Related articles

Salz, T; Deng, CW; et al. Histone Methyltransferase hSETD1A Is a Novel Regulator of Metastasis in Breast Cancer. MOLECULAR CANCER RESEARCH 13:461-469(2015).
Wang, Y; Yu, SJ; et al. Expression and clinical significance of matrix metalloproteinase-17 and-25 in gastric cancer. ONCOLOGY LETTERS 9:671-676(2015).
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