MMP15

  • Official Full Name

    matrix metallopeptidase 15 (membrane-inserted)

  • Overview

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008]
  • Synonyms

    MMP15; matrix metallopeptidase 15 (membrane-inserted); MTMMP2; SMCP-2; MT2-MMP; matrix metalloproteinase-15; MMP-15; MT2MMP; MT-MMP 2; membrane-type matrix metalloproteinase 2; membrane-type-2 matrix metalloproteinase; matrix metalloproteinase 15 (membrane-inserted);

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Homo sapiens (Human)
  • Human
  • Mouse
  • Mus musculus (Mouse)
  • E.coli
  • E.coli expression system
  • HEK293
  • Mammalian Cell
  • Mammalian cells
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MMP15-608H Active Recombinant Human MMP15 protein, His-tagged Mammalian cells His Glu47-Pro565
Human MMP15-607H Recombinant Human MMP15, Catalytic Domain E.coli N/A
Human MMP15-459H Recombinant Human MMP15 Protein, His/GST-tagged E.coli His/GST Phe280~Asp497
Human MMP15-4278HCL Recombinant Human MMP15 293 Cell Lysate HEK293 N/A
Human MMP15-3488H-B Recombinant Human MMP15 Protein Pre-coupled Magnetic Beads HEK293
Human MMP15-3488H Recombinant Human MMP15 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MMP15-4578H Recombinant Human MMP15 Protein (His410-Leu553), N-His tagged E.coli N-His His410-Leu553
Mouse MMP15-9910M Recombinant Mouse MMP15 Protein Mammalian Cell His
Mouse Mmp15-460M Recombinant Mouse Mmp15 Protein, His-tagged E.coli His Pro336~Arg539
Mouse MMP15-5600M-B Recombinant Mouse MMP15 Protein Pre-coupled Magnetic Beads HEK293
Mouse MMP15-5600M Recombinant Mouse MMP15 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Homo sapiens (Human) RFL19324HF Recombinant Full Length Human Matrix Metalloproteinase-15(Mmp15) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (132-669)
Mus musculus (Mouse) RFL18754MF Recombinant Full Length Mouse Matrix Metalloproteinase-15(Mmp15) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (128-657)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MMP15 involved in several pathways and played different roles in them. We selected most pathways MMP15 participated on our site, such as Activation of Matrix Metalloproteinases, Collagen degradation, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of Matrix MetalloproteinasesMGC174152;MGC174857;MMP10;MGC174155;MMP11;TIMP2A;TIMP2;MMP8;MMP24
Collagen degradationELANE;COL9A3;CTSB;ADAM10;TLDC2;CTSLL;COL19A1;MMP20;CTSL1
Degradation of the extracellular matrixMMP15;TIMP2B;ADAM8;CTSG;TLL1;TIMP2A;CTSD;FURINB;MGC174155
Extracellular matrix organizationCOL6A2;CTSLL;ADAMTS4;CD151;COL6A1;TRAPPC4;COL28A1A;COL13A1;ICAM4
Matrix MetalloproteinasesMMP17;MMP25;MMP20;TIMP2;MMP28;MMP27;MMP15;MMP23B;MMP8

MMP15 has several biochemical functions, for example, calcium ion binding, enzyme activator activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP15 itself. We selected most functions MMP15 had, and list some proteins which have the same functions with MMP15. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingPCDHA6;HPCA;EFEMP2B;RCN1;PLS3;LRP2;CDH6;GRIN1;ITSN2B
enzyme activator activityGM749;APOA5;HSPB2;TAB1;CXCL1;CFLAR;SAE1;CASP9;CLPSL1
metalloendopeptidase activityADAM22;PAPPAA;AFG3L2;ADAM20;ADAM9;PHEX;ADAMTS1;MIPEP;TLL2
protein bindingOLFM2;DYRK1A;CALM1;CD47;PRAME;PSMD7;ARFIP2;DYRK2;ALDH3A1
zinc ion bindingDPF3;TRAF4;WT1;RNF34;LDB3A;BTR30;CPDB;DNPEP;ADAMTS20

MMP15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP15 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP15.

PROC; Gorasp2

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