MMP15
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Official Full Name
matrix metallopeptidase 15 (membrane-inserted)
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Overview
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008] -
Synonyms
MMP15; matrix metallopeptidase 15 (membrane-inserted); MTMMP2; SMCP-2; MT2-MMP; matrix metalloproteinase-15; MMP-15; MT2MMP; MT-MMP 2; membrane-type matrix metalloproteinase 2; membrane-type-2 matrix metalloproteinase; matrix metalloproteinase 15 (membrane-inserted);
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Homo sapiens (Human)
- Human
- Mouse
- Mus musculus (Mouse)
- E.coli
- E.coli expression system
- HEK293
- Mammalian Cell
- Mammalian cells
- His
- His (Fc)
- Avi
- His|GST
- N/A
- N
- Involved Pathway
- Protein Function
- Interacting Protein
- MMP15 Related Gene Family
- MMP15 Related Research Area
MMP15 involved in several pathways and played different roles in them. We selected most pathways MMP15 participated on our site, such as Activation of Matrix Metalloproteinases, Collagen degradation, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of Matrix Metalloproteinases | MGC174155;TIMP2A;MGC174857;LOC100686744;MMP15;TPSAB1;ELANE;CTSK;TIMP2B |
| Collagen degradation | CTSL1;ADAM9;COL13A1;ELANE;MMP11;LOC100686744;MMP8;COL19A1;ADAM10 |
| Degradation of the extracellular matrix | MMP8;ADAMTS5;MMP13;COL9A1;FURINA;MMP19;CTSG;COL23A1;MMP12 |
| Extracellular matrix organization | JAM2B;COL15A1B;PCOLCE2B;MMP24;PTPRS;DDR1;COL10A1A;ADAMTS4;COL28A1D |
| Matrix Metalloproteinases | MMP28;MMP19;MMP17;MMP8;TIMP4;MMP27;MMP12;MMP23B;BSG |
MMP15 has several biochemical functions, for example, calcium ion binding, enzyme activator activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP15 itself. We selected most functions MMP15 had, and list some proteins which have the same functions with MMP15. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | RCN2;CCDC47;MAN1B1;NUCB2B;S100A9;PCDHGA12;RAB11FIP3;FKBP10B;PKD1L3 |
| enzyme activator activity | OGT;PSAP;DNMT3L;ARL1;GM749;DAOA;PPP1R12B;DBNL;PRKCD |
| metalloendopeptidase activity | Adamts19;ADAM2;MMP19;MMP14A;PHEX;OSGEPL1;BMP1;ADAMTS5;ADAM10A |
| protein binding | ROR2;TBX18;CCDC85B;ALDOC;ACHE;DGCR6L;DARS2;ACTR1B;PACSIN2 |
| zinc ion binding | TRIM31;NR1D1;KMT2E;BMI1B;PIAS3;LIMK1;PCGF5;Npepo;BRAP |
MMP15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP15 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP15.
PROC; Gorasp2
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