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Official Full Name matrix metallopeptidase 15 (membrane-inserted)
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. [provided by RefSeq, Jul 2008]
Synonyms MMP15; matrix metallopeptidase 15 (membrane-inserted); MTMMP2; SMCP-2; MT2-MMP; matrix metalloproteinase-15; MMP-15; MT2MMP; MT-MMP 2; membrane-type matrix metalloproteinase 2; membrane-type-2 matrix metalloproteinase; matrix metalloproteinase 15 (membrane-inserted);
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • NS0
    • Tag :
    • His
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MMP15-4278HCL Recombinant Human MMP15 293 Cell Lysate HEK293 N/A
    Human MMP15-459H Recombinant Human MMP15 Protein, His/GST-tagged E.coli His/GST
    Human MMP15-607H Recombinant Human MMP15, Catalytic Domain E.coli N/A
    Human MMP15-608H Recombinant Human MMP15 protein, His-tagged NS0 His
    Mouse Mmp15-460M Recombinant Mouse Mmp15 Protein, His-tagged E.coli His
    Mouse MMP15-9910M Recombinant Mouse MMP15 Protein Mammalian Cell His

    mmp15 involved in several pathways and played different roles in them. We selected most pathways mmp15 participated on our site, such as Activation of Matrix Metalloproteinases, Collagen degradation, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with mmp15 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of Matrix Metalloproteinases FURINB; CTSK; CTRB1; MMP11; TPSAB1; MMP17; TIMP2A; TIMP2B; MMP8; ELANE
    Collagen degradation CTSLL; CTSB; MMP20; COL9A1; TLDC2; MGC174155; MMP12; COL15A1B; ADAM9; COL23A1
    Degradation of the extracellular matrix TPSAB1; MMP24; TLL2; MMP13; CTSLL; MMP20; FAM49BA; CMA1; ADAMTS1; EMID2
    Extracellular matrix organization FBLN1; COL10A1; MUSK; BMP1A; LOXL4; TLL1; LOXL2; LRP4; ADAMTS2; COL25A1
    Matrix Metalloproteinases MMP19; MMP12; MMP26; TIMP2; MMP24; MMP11; BSG; TIMP4; MMP10; MMP27

    mmp15 has several biochemical functions, for example, calcium ion binding, enzyme activator activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by mmp15 itself. We selected most functions mmp15 had, and list some proteins which have the same functions with mmp15. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding ALOX15B; PITPNM2; S100A10B; PCDH1G3; HPCAL4; STIM2; EDEM2; NELL2A; CDH19; MYL6B
    enzyme activator activity OGT; DBF4; RAB3GAP2; MMP17; APOA5; GMFG; TRIM23; ASAP2; TIMP2; ALOX5AP
    metalloendopeptidase activity ADAMTS2; PAPLN; C6AST1; ADAM32; ZMPSTE24; UQCRC1; MIPEP; ADAM20; ADAMTS13; ADAMTS10
    protein binding EPM2AIP1; AHNAK; ZNF625; MAGOHB; MYLIP; TBCA; NFU1; PFN1; CPEB3; ZYX
    zinc ion binding RNF34A; IRGF4; BRF1; ISL1; TRIM35-22; ZSWIM1; GATAD1; S100A3; TRIM47; TRIM35-30

    mmp15 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mmp15 here. Most of them are supplied by our site. Hope this information will be useful for your research of mmp15.

    PROC; Gorasp2

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