MMP2 Protein

MMP2

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MMP2

Official Full Name matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms MMP2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); CLG4; MONA; CLG4A; TBE-1; MMP-II; 72 kDa type IV collagenase; MMP-2; gelatinase A; 72 kDa gelatinase; collagenase type IV-A; neutrophil gelatinase; matrix metalloproteinase-2; matrix metalloproteinase-II
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • E.coli Cells
    • HEK293
    • HEK293F
    • HEK293T
    • Human
    • Human Cell
    • Human Fibroblasts
    • Human Synovial Fibroblasts
    • In Vitro Cell Free System
    • Mammalian Cell
    • Mammalian cells
    • Mouse Fibroblast
    • Sf9 Insect Cell
    • Wheat Germ
    • Yeast
    • Tag :
    • Flag
    • GST
    • His
    • SUMO
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    • N-His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MMP2-150H Active Recombinant Human MMP2 protein Yeast N/A Inquiry
    Human MMP2-201H Active Recombinant Human MMP2 protein E.coli N/A Inquiry
    Human MMP2-808H Active Recombinant Human Matrix Metallopeptidase 2 Sf9 Insect Cell N/A Inquiry
    Human MMP2-1715H Active Recombinant Human Matrix Metallopeptidase 2 (Gelatinase A, 72 KDa Gelatinase, 72 KDa Type IV Collagenase) Human N/A Inquiry
    Human MMP2-151H Recombinant Human Matrix Metallopeptidase 2, Hemopexin-like Domain E.coli N/A Inquiry
    Human MMP2-169H Recombinant Human MMP2 yeast N/A Inquiry
    Human MMP2-1716H Recombinant Human Matrix Metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase) Human N/A Inquiry
    Human MMP2-182H Recombinant Human MMP2 Protein, His-tagged HEK293 His Inquiry
    Human MMP2-244H Recombinant Human MMP2 protein, His-tagged E.coli His Inquiry
    Human MMP2-29435TH Recombinant Human MMP2, His-tagged E.coli His Inquiry
    Human MMP2-408H Recombinant Human MMP2 Mammalian cells N/A Inquiry
    Human Mmp2-416M Recombinant Mouse Mmp2, His-tagged Human Cell His Inquiry
    Human MMP2-450H Recombinant Human matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase), His-tagged E.coli His Inquiry
    Human MMP2-5051H Recombinant Human MMP2, His-tagged E.coli His Inquiry
    Human MMP2-562H Recombinant Human MMP2 Protein, MYC/DDK-tagged HEK293 Myc/DDK Inquiry
    Human MMP2-8392H Recombinant Human MMP2, GST-tagged E.coli GST Inquiry
    Human MMP2-889H Recombinant Human MMP2, None tagged Human Cell N/A Inquiry
    Human MMP2-890H Recombinant Human MMP2 protein, His-tagged HEK293 His Inquiry
    Mouse Mmp2-1019M Recombinant Mouse Mmp2 Protein, His-tagged HEK293 His Inquiry
    Mouse Mmp2-245M Recombinant Mouse Mmp2 protein, His-tagged E.coli His Inquiry
    Mouse Mmp2-415M Recombinant Mouse Matrix Metallopeptidase 2 Mammalian cells N/A Inquiry
    Mouse Mmp2-44M Recombinant Mouse MMP-2/TIMP-2 Complex Mouse Fibroblast N/A Inquiry
    Rat Mmp2-246R Recombinant Rat Mmp2 protein, His-tagged E.coli His Inquiry
    Rat MMP2-28059TR MMP2 protein(Rat) N/A Inquiry
    Rat MMP2-3715R Recombinant Rat MMP2 Protein Mammalian Cell His Inquiry
    Chicken MMP2-5990C Recombinant Chicken MMP2 Mammalian Cell His Inquiry
    Zebrafish MMP2-9789Z Recombinant Zebrafish MMP2 Mammalian Cell His Inquiry
    Human MMP2-2380HCL Recombinant Human MMP2 cell lysate Human Cell N/A Inquiry
    Human MMP2-1120H Recombinant Human MMP2 Protein, His-tagged HEK293F N-His Inquiry
    Human MMP2-1121H Recombinant Human MMP2 Protein, His-tagged HEK293F N-His Inquiry
    Chicken MMP2-1122C Recombinant Chicken MMP2 Protein, His-tagged E.coli N-His Inquiry
    Human MMP2-1611HFL Recombinant Full Length Human MMP2 Protein, C-Flag-tagged Mammalian cells Flag Inquiry
    Mouse Mmp2-1783M Recombinant Mouse Mmp2 Protein, His-tagged E.coli N-His Inquiry
    Mouse Mmp2-1784M Recombinant Mouse Mmp2 Protein, His-tagged E.coli N-His Inquiry
    Mouse Mmp2-1785M Recombinant Mouse Mmp2 Protein, His-tagged E.coli N-His Inquiry
    Rat Mmp2-1786R Recombinant Rat Mmp2 Protein, His-tagged E.coli N-His Inquiry
    Human MMP2-1872H Recombinant Human MMP2 protein, GST-tagged E.coli GST Inquiry
    Rat Mmp2-5467R Recombinant Rat Mmp2 protein, His-tagged Yeast His Inquiry
    Human MMP2-6516HF Recombinant Full Length Human MMP2 Protein, GST-tagged In Vitro Cell Free System GST Inquiry
    Human MMP2-2257H Recombinant Human MMP2 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK Inquiry
    Human MMP2-29475TH Native Human MMP2 N/A Inquiry
    Human MMP2-46H Native Human MMP-2 Human Synovial Fibroblasts N/A Inquiry
    Human MMP2-47H Native Human MMP-2/TIMP-2 Complex Human Fibroblasts N/A Inquiry
    Human MMP2-5425H Recombinant Human MMP2 Protein, GST-tagged Wheat Germ GST Inquiry
    Human MMP2-8392HA Recombinant Human MMP2 protein, GST-tagged, APC labeled E.coli Cells GST Inquiry
    Human MMP2-8392HP Recombinant Human MMP2 protein, GST-tagged, R-PE labeled E.coli Cells GST Inquiry
    Mouse Mmp2-4100M Recombinant Mouse Mmp2 Protein, Myc/DDK-tagged HEK293T Myc/DDK Inquiry
    Mouse MMP2-8455M Native Mouse MMP2 Mouse Fibroblast N/A Inquiry
    Rat MMP2-657R Recombinant Rat MMP2 Protein (110-662 aa), His-SUMO-tagged E.coli His/SUMO Inquiry
    Kit-0320C MMP2 Inhibitor Screening Assay Kit N/A Inquiry

    MMP2 involved in several pathways and played different roles in them. We selected most pathways MMP2 participated on our site, such as Leukocyte transendothelial migration, GnRH signaling pathway, Estrogen signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Leukocyte transendothelial migration ROCK2; PRKCA; RASSF5; JAM3; PTPN11; PLCG1; ACTG1; MYL7; MYL2; NCF4
    GnRH signaling pathway ATF4; CALML5; CAMK2B1; PRKCD; GNA15.4; MAPK1; CAMK2G1; CAMK2D2; MAP2K6; MAP2K4
    Estrogen signaling pathway CALM3; FKBP5; CALM4; CALM2; CALML5; GNAO1; PRKACG; GNAI2; GABBR1; PRKACB
    Pathways in cancer PLCB1; PIK3R5; FGF3; PML; PIK3CB; LAMA4; FLT3; FGFR3; GNG8; TGFA
    Proteoglycans in cancer CAV1; GPC3; PIK3CA; Casp3; ESR1; VAV2; FLNA; RPS6; WNT5B; HOXD10
    Bladder cancer ARAF; TYMP; MMP2; SRC; RPS6KA5; RB1; MMP1; MYC; MAPK3; MAP2K1

    MMP2 has several biochemical functions, for example, metalloendopeptidase activity, metallopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP2 itself. We selected most functions MMP2 had, and list some proteins which have the same functions with MMP2. You can find most of the proteins on our site.

    Function Related Protein
    metalloendopeptidase activity ADAM20; ADAMTSL5; MMP25; MIPEP; MMP15; UQCRC2B; AFG3L2; MBTPS2; ADAM23; PHEX
    metallopeptidase activity CNDP2; TMEM27; MMP14B; ADAM10A; MEP1A.2; ADAM2; ANPEPB; MMP2; XPNPEP2; PAPPAB
    protein binding HDHD2; POSTN; ANXA4; TH; GFI1; BRD3; PRLHR; CLDN2; SYNE1; GIPC1
    serine-type endopeptidase activity PRSS42; HTRA3; KLK1B26; CLPP; CORIN; TPSAB1; PRSS21; PRSS38; CELA3B; PRSS54
    zinc ion binding RNF2; ZDHHC16; MUL1A; APOBEC4; ZFP622; PDLIM5B; ZIM2; TRIM35-30; MMP19; DNMT5

    MMP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP2.

    collagen_i_human; PCSK9; collagen_i_pig; TIMP2; Pcsk9; SCUBE3; USP12; A2M; LDLR; TGFB1; HSP90AA1; BACE1

    Ghosh, A; Pechota, A; et al. Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak/Stat pathway. HUMAN PATHOLOGY 46:284-294(2015).
    Ding, XF; Yang, DR; et al. Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals. MOLECULAR CANCER 14:-(2015).

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