mmp2
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  • Official Full Name
  • matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)
  • Background
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MMP2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); CLG4; MONA; CLG4A; TBE-1; MMP-II; 72 kDa type IV collagenase; MMP-2; gelatinase A; 72 kDa gelatinase; collagenase type IV-A; neutrophil gelatinase; matrix metalloproteinase-2; matrix metalloproteinase-II
Cat.#:MMP2-657RTag:His-SUMO
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat MMP2 Protein (110-662 aa), His-SUMO-tagged
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Cat.#:MMP2-8392HATag:GST
Source (Host):E.coli CellsSpecies:Human
Product nameRecombinant Human MMP2 protein, GST-tagged, APC labeled
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Cat.#:MMP2-8392HPTag:GST
Source (Host):E.coli CellsSpecies:Human
Product nameRecombinant Human MMP2 protein, GST-tagged, R-PE labeled
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Cat.#:MMP2-182HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP2 Protein, His-tagged
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Cat.#:MMP2-5425HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MMP2 Protein, GST-tagged
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Cat.#:MMP2-562HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP2 Protein, MYC/DDK-tagged
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Cat.#:Mmp2-44MTag:
Source (Host):Mouse fibroblastsSpecies:Mouse
Product nameRecombinant Mouse MMP-2/TIMP-2 Complex
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Cat.#:MMP2-169HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human MMP2
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Cat.#:MMP2-28059TRTag:
Source (Host):Species:Rat
Product nameMMP2 protein(Rat)
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Cat.#:MMP2-150HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human MMP2 protein
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Cat.#:MMP2-151HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human Matrix Metallopeptidase 2, Hemopexin-like Domain
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Cat.#:MMP2-201HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP2 protein
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Cat.#:MMP2-244HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP2 protein, His-tagged
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Cat.#:MMP2-29435THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP2, His-tagged
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Cat.#:MMP2-408HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human MMP2
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Cat.#:Mmp2-416MTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Mouse Mmp2, His-tagged
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Cat.#:MMP2-5051HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP2, His-tagged
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Cat.#:MMP2-8392HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP2, GST-tagged
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Cat.#:MMP2-889HTag:N/A
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP2, None tagged
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Cat.#:MMP2-890HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP2 protein, His-tagged
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Cat.#:Mmp2-1019MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Mmp2 Protein, His-tagged
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Cat.#:Mmp2-245MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mmp2 protein, His-tagged
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Cat.#:Mmp2-415MTag:N/A
Source (Host):NS0Species:Mouse
Product nameRecombinant Mouse Matrix Metallopeptidase 2
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Cat.#:Mmp2-246RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp2 protein, His-tagged
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Cat.#:MMP2-3715RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MMP2 Protein
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Cat.#:MMP2-5990CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MMP2
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Cat.#:MMP2-9789ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish MMP2
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Cat.#:MMP2-808HTag:N/A
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human Matrix Metallopeptidase 2
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Cat.#:MMP2-29475THTag:
Source (Host):Species:Human
Product nameNative Human MMP2
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Cat.#:MMP2-46HTag:
Source (Host):Human synovial fibroblastsSpecies:Human
Product nameNative Human MMP-2
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Cat.#:MMP2-47HTag:
Source (Host):Human fibroblastsSpecies:Human
Product nameNative Human MMP-2/TIMP-2 Complex
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Cat.#:MMP2-8455MTag:
Source (Host):Mouse FibroblastSpecies:Mouse
Product nameNative Mouse MMP2
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Cat.#:MMP2-2380HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP2 cell lysate
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Cat.#:Kit-0320CTag:
Source (Host):Species:
Product nameMMP2 Inhibitor Screening Assay Kit
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Involved Pathway

MMP2 involved in several pathways and played different roles in them. We selected most pathways MMP2 participated on our site, such as Leukocyte transendothelial migration, GnRH signaling pathway, Estrogen signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Leukocyte transendothelial migration
CLDN3; NCF1; PLCG2; ESAM; PIK3CG; CLDN6; CLDN7; CLDN8; VAV3; GNAI2
GnRH signaling pathway
CACNA1D; CALM1A; GNAS; MAP2K2; MAP3K2; CAMK2G1; ATF4; MAP2K4; PRKCA; PRKACG
Estrogen signaling pathway
ATF6B; SHC3; KCNJ3; CREB5; GNAQ; MAPK1; HSPA1A; HSPA6; CALML5; CALM3
Pathways in cancer
FOS; STK36; TFG; RALBP1; GNG5; CUL2; TRP53; LPAR2; WNT2B; GNAQ
Proteoglycans in cancer
WNT5B; Casp3; RAF1; ITGA2; WNT11; WNT3A; NANOG; Ctsl; HRAS; IL12B
Bladder cancer
ERBB2; MAPK1; CDK4; NRAS; MAP2K1; E2F1; DAPK1; RB1; CCND1; RAF1

Protein Function

MMP2 has several biochemical functions, for example, metalloendopeptidase activity, metallopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP2 itself. We selected most functions MMP2 had, and list some proteins which have the same functions with MMP2. You can find most of the proteins on our site.
Function
Related Protein
Function metalloendopeptidase activity
Related Protein PAPLN; MMP16; FAP; ZMPSTE24; MEP1A; ADAM1B; ECE2; MMP14B; ADAM10A; ADAMTS13
Function metallopeptidase activity
Related Protein Adamts19; MMP14B; ADAMTS4; CLCA2; ERMP1; ADAM30; CLCA5; MMP23B; ADAM17A; MMP25
Function protein binding
Related Protein ARL13B; APOBEC3H; MAP2K7; CKMT1; NEDD4; PLD1; EHMT1; CDK13; SEC14L4; CYBB
Function serine-type endopeptidase activity
Related Protein PCSK2; TMPRSS12; PRSS1; IMMP1L; GZMM; HTRA1; PROCA; PCSK5; KLK1B3; CELA2B
Function zinc ion binding
Related Protein RNF222; MEP1A; PGLYRP6; SETDB1; MAN2A1; PPARA; ABLIM1; BRCA1; ZDHHC20; RNF151

Interacting Protein

MMP2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP2.
collagen_i_human; PCSK9; collagen_i_pig; TIMP2; Pcsk9; SCUBE3; USP12; A2M; LDLR; TGFB1; HSP90AA1; BACE1

MMP2 Related Articles

Ghosh, A; Pechota, A; et al. Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak/Stat pathway. HUMAN PATHOLOGY 46:284-294(2015).
Ding, XF; Yang, DR; et al. Targeting TR4 nuclear receptor suppresses prostate cancer invasion via reduction of infiltrating macrophages with alteration of the TIMP-1/MMP2/MMP9 signals. MOLECULAR CANCER 14:-(2015).

MMP2 Related Gene Family

MMPs