|Official Full Name||matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase)|
|Background||Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades type IV collagen, the major structural component of basement membranes. The enzyme plays a role in endometrial menstrual breakdown, regulation of vascularization and the inflammatory response. Mutations in this gene have been associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]|
|Synonyms||MMP2; matrix metallopeptidase 2 (gelatinase A, 72kDa gelatinase, 72kDa type IV collagenase); CLG4; MONA; CLG4A; TBE-1; MMP-II; 72 kDa type IV collagenase; MMP-2; gelatinase A; 72 kDa gelatinase; collagenase type IV-A; neutrophil gelatinase; matrix metalloproteinase-2; matrix metalloproteinase-II|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
mmp2 involved in several pathways and played different roles in them. We selected most pathways mmp2 participated on our site, such as Leukocyte transendothelial migration, GnRH signaling pathway, Estrogen signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with mmp2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Leukocyte transendothelial migration||CLDN18; CLDN11; PIK3CB; GNAI3; MYL10; CYBA; PTPN11; CLDN8; ITGAM; MYL7|
|GnRH signaling pathway||PLD2; GNAS; MAP2K7; GNA11B; GNRHR4; MAP2K2A; GNA15.1; CAMK2D; MAPK1; CALML3|
|Estrogen signaling pathway||GNAI1; HSPA6; PLCB3; PIK3CG; SHC2; CALM2; HSP90AA1; MAP2K1; ATF4; ITPR1|
|Pathways in cancer||MAX; CCND1; IKBKB; FZD6; SLC2A1; MAP2K2; MAP2K1; TGFBR2; MAPK1; PML|
|Proteoglycans in cancer||PPP1CA; MAP2K1; WNT3A; PTPN11; HSPB2; VEGFA; ITGA2; CAMK2A; CCND1; WNT11|
|Bladder cancer||MAPK1; E2F2; VEGFA; BRAF; RB1; ARAF; RASSF1; HRAS; RAF1; SRC|
mmp2 has several biochemical functions, for example, metalloendopeptidase activity, metallopeptidase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by mmp2 itself. We selected most functions mmp2 had, and list some proteins which have the same functions with mmp2. You can find most of the proteins on our site.
|metalloendopeptidase activity||MMP23B; MMP16; MMP1; ADAM8A; ADAM17; ADAMTS15; ADAM10B; C6AST4; THSD4; ADAM5P|
|metallopeptidase activity||ADAMTS9; ANPEP; CNDP2; CNDP1; GM12824; PAPPA2; HE2; DNPEP; PAPPA; ECEL1|
|protein binding||PTPRB; MSRB3; WDR4; POLR2L; ADAM8; MCL1; OIP5; MTX2; EFHC1; RCAN3|
|serine-type endopeptidase activity||FURIN; PARLA; TYSND1; TPSG1; PIK3IP1; TMPRSS11E; GZMF; KLK13; PLG; KLK1B26|
|zinc ion binding||RNF114; RNF126; TRAF1; LIN28B; AICDA; LIMK1; MMP12; UBOX5; MYLIP; RABGEF1|
mmp2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mmp2 here. Most of them are supplied by our site. Hope this information will be useful for your research of mmp2.
collagen_i_human; PCSK9; collagen_i_pig; TIMP2; Pcsk9; SCUBE3; USP12; A2M; LDLR; TGFB1; HSP90AA1; BACE1