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MMP25

Official Full Name

matrix metallopeptidase 25
Overview

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]
Synonyms

MMP25; matrix metallopeptidase 25; MMP20; MMPL1; MMP-25; MMP20A; MT6MMP; MTMMP6; MT-MMP6; MT6-MMP; MT-MMP 6; matrix metalloproteinase-25; leukolysin; matrix metalloproteinase 20; matrix metalloproteinase 25; matrix metallopeptidase-like 1; matrix metalloproteinase-like 1; membrane-type 6 matrix metalloproteinase; membrane-type matrix metalloproteinase 6; membrane-type-6 matrix metalloproteinase;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MMP25-1775H	Recombinant Human MMP25 protein, His-tagged	E.coli	His	Tyr108~Ile313	Inquiry
Mouse	MMP25-9921M	Recombinant Mouse MMP25 Protein	Mammalian Cell	His		Inquiry
Mouse	MMP25-5605M	Recombinant Mouse MMP25 Protein, His (Fc)-Avi-tagged	HEK293	His&Fc&Avi		Inquiry
Mouse	MMP25-5605M-B	Recombinant Mouse MMP25 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mus musculus (Mouse)	RFL28219MF	Recombinant Full Length Mouse Matrix Metalloproteinase-25(Mmp25) Protein, His-Tagged	E.coli expression system	His	Full Length of Mature Protein (163-593)	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

MMP25 involved in several pathways and played different roles in them. We selected most pathways MMP25 participated on our site, such as Matrix Metalloproteinases, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Matrix Metalloproteinases	MMP24;TIMP2;MMP10;TIMP4;MMP15;MMP23B;MMP17;MMP26;MMP12

MMP25 has several biochemical functions, for example, calcium ion binding, hydrolase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP25 itself. We selected most functions MMP25 had, and list some proteins which have the same functions with MMP25. You can find most of the proteins on our site.

Function	Related Protein
calcium ion binding	DSC2;C2CD4A;CRB2A;MMP20;CCDC48;EFHB;EFCC1;CDK5R1;PCDHGC5
hydrolase activity	PPM1BB;LIPM;MMP23BB;NUDT21;ATP1A3A;MEIOB;CTSJ;CTSM;Adamts19
metal ion binding	ZNF207A;HDHD1A;OTUD7A;PDE3A;ZDHHC20A;CMTM2A;PRKCBA;ZNF582;ZNF609A
metalloendopeptidase activity	MMP9;ADAM21;MMP24;ADAMTS3;ADAM20;MMP7;MMP25;ADAM33;ADAM10
metallopeptidase activity	ECEL1;HE1B;CLCA1;ADAM20;ADAM10B;MMP14A;AGBL4;HE1A;LNPEP
peptidase activator activity	PCOLCE2;MMP14;CLPX;MMP25;FN1;APP;FBLN1;PCOLCE;PSME4
peptidase activity	HM13;AGBL4;UCHL3;CTSM;KLK1B11;TMPRSS7;APH1C;MMP13A;FURIN
zinc ion binding	ADAM33;KLF7;PHC1;MMP20;ADAMTS10;ZDHHC6;CNBP;ZSWIM4;NR2F2

MMP25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP25 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP25.