MMP25

  • Official Full Name

    matrix metallopeptidase 25

  • Overview

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, attached to the plasma membrane via a glycosylphosphatidyl inositol anchor. In response to bacterial infection or inflammation, the encoded protein is thought to inactivate alpha-1 proteinase inhibitor, a major tissue protectant against proteolytic enzymes released by activated neutrophils, facilitating the transendothelial migration of neutrophils to inflammatory sites. The encoded protein may also play a role in tumor invasion and metastasis through activation of MMP2. The gene has previously been referred to as MMP20 but has been renamed MMP25. [provided by RefSeq, Jul 2008]
  • Synonyms

    MMP25; matrix metallopeptidase 25; MMP20; MMPL1; MMP-25; MMP20A; MT6MMP; MTMMP6; MT-MMP6; MT6-MMP; MT-MMP 6; matrix metalloproteinase-25; leukolysin; matrix metalloproteinase 20; matrix metalloproteinase 25; matrix metallopeptidase-like 1; matrix metalloproteinase-like 1; membrane-type 6 matrix metalloproteinase; membrane-type matrix metalloproteinase 6; membrane-type-6 matrix metalloproteinase;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MMP25-1775H Recombinant Human MMP25 protein, His-tagged E.coli His Tyr108~Ile313
Mouse MMP25-9921M Recombinant Mouse MMP25 Protein Mammalian Cell His
Mouse MMP25-5605M Recombinant Mouse MMP25 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MMP25-5605M-B Recombinant Mouse MMP25 Protein Pre-coupled Magnetic Beads HEK293
Mus musculus (Mouse) RFL28219MF Recombinant Full Length Mouse Matrix Metalloproteinase-25(Mmp25) Protein, His-Tagged E.coli expression system His Full Length of Mature Protein (163-593)
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MMP25 involved in several pathways and played different roles in them. We selected most pathways MMP25 participated on our site, such as Matrix Metalloproteinases, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP25 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Matrix MetalloproteinasesMMP28;MMP23B;MMP24;BSG;MMP15;MMP8;TIMP2;TIMP4;MMP17

MMP25 has several biochemical functions, for example, calcium ion binding, hydrolase activity, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP25 itself. We selected most functions MMP25 had, and list some proteins which have the same functions with MMP25. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingACTN4;PLA2G2F;NCALDA;NRXN1;GUCA1C;PCDHGB4;PNLIPRP2;CLGN;PGS1
hydrolase activityALP3;PNPLA1;MTMR1B;TMPRSS4A;F2RL1.1;WRNIP1;ATP9A;PRSS59.1;ADAMTS12
metal ion bindingRNF145B;ANKZF1;CYP1C2;ZNF277;PRDM5;ECE2;RNF17;NT5DC1;RFESD
metalloendopeptidase activityADAMTS1;MMP26;MMP17;HE2;YME1L1B;ADAMTS2;BMP1A;MEP1A.1;ADAM10B
metallopeptidase activityADAM17;ADAM9;ADAM28;MEP1A.1;ADAM18;ADAM12;AGBL1;AFG3L2;CLCA2
peptidase activator activityFBLN1;APP;CLPX;PINK1;PSME4B;MMP14;PSME4;PCOLCE2;MMP25
peptidase activityADAMTS4;KLK7;PCSK7;USP43A;MMP23BB;HE1B;FURIN;CAPN3A;TMPRSS4B
zinc ion bindingNR2F2;SQSTM1;SIAH2;ZNF3;PDLIM3B;PDLIM3A;TRIM35-1;RFPL4B;RNF146

MMP25 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP25 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP25.

Gene Family

MMPs

Research Area

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