mmp13
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  • Official Full Name
  • matrix metallopeptidase 13 (collagenase 3)
  • Background
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene cleaves type II collagen more efficiently than types I and III. It may be involved in articular cartilage turnover and cartilage pathophysiology associated with osteoarthritis. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MMP13; matrix metallopeptidase 13 (collagenase 3); CLG3; MANDP1; MMP-13; collagenase 3; matrix metalloproteinase 13 (collagenase 3);
Cat.#:MMP13-2045DTag:His-SUMO
Source (Host):E. coliSpecies:Dog
Product nameRecombinant Dog MMP13 Protein (28-478 aa), His-SUMO-tagged
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Cat.#:MMP13-42HTag:N/A
Source (Host):Spodoptera frugiperdaSpecies:Human
Product nameRecombinant Human MMP-13
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Cat.#:MMP13-43HTag:
Source (Host):Spodoptera frugiperdaSpecies:Human
Product nameRecombinant Human MMP-13, activated
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Cat.#:MMP13-5420HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP13 Protein
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Cat.#:MMP13-5421HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MMP13 Protein, GST-tagged
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Cat.#:MMP13-1018HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP13
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Cat.#:MMP13-159HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP13 protein
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Cat.#:MMP13-27HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP13 protein
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Cat.#:MMP13-411HTag:N/A
Source (Host):NS0Species:Human
Product nameRecombinant Human Matrix Metallopeptidase 13 (collagenase 3)
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Cat.#:MMP13-443HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human matrix metallopeptidase 13 (collagenase 3), His-tagged
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Cat.#:MMP13-5044HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP13, His-tagged
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Cat.#:MMP13-729HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP13 protein, His-tagged
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Cat.#:MMP13-810HTag:His
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human MMP13, His-tagged
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Cat.#:MMP13-92HTag:T7/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP13 protein, T7/His-tagged
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Cat.#:Mmp13-1750MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mmp13 protein, His-tagged
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Cat.#:Mmp13-731MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mmp13 protein, His-tagged
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Cat.#:MMP13-9908MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MMP13 Protein
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Cat.#:Mmp13-506RTag:His
Source (Host):HEK293FSpecies:Rat
Product nameRecombinant Rat Mmp13 protein, His-tagged
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Cat.#:Mmp13-734RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp13 protein, His-tagged
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Cat.#:MMP13-5521CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MMP13
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Cat.#:MMP13-736RTag:His
Source (Host):E. coliSpecies:Rabbit
Product nameRecombinant Rabbit MMP13 protein, His-tagged
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Cat.#:MMP13-733PTag:His/T7
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Pig MMP13 protein, His & T7-tagged
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Cat.#:MMP13-4280HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human MMP13 293 Cell Lysate
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Involved Pathway

MMP13 involved in several pathways and played different roles in them. We selected most pathways MMP13 participated on our site, such as AGE/RAGE pathway, Activation of Matrix Metalloproteinases, Assembly of collagen fibrils and other multimeric structures, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP13 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
AGE/RAGE pathway
MAPK14; JAK2; ATF2; LGALS3; JUN; DIAPH1; CHUK; TIRAP; AGER; MMP13
Activation of Matrix Metalloproteinases
CTSLL; TIMP2B; ELANE; TIMP2; FURINA; MGC174155; MGC174857; CTSG; CMA1; LOC100686744
Assembly of collagen fibrils and other multimeric structures
DST; COL10A1A; LOX; COL3A1; COL4A6; COL5A3B; CTSL1; PLEC; BMP1B; COL6A2
Collagen degradation
ELANE; CTSD; MMP19; MMP10; CTSLL; CTSL1; COL15A1B; COL9A3; MGC174152; MMP13
Collagen formation
COL4A4; COL9A1B; PCOLCEA; SERPINH1; LOXL2; COL5A2; COL19A1; COL5A3B; COL23A1; SERPINH1B
Degradation of the extracellular matrix
TIMP2; TIMP2A; COL17A1; TLDC2; TLL2; CTS7; KLK7; ADAMTS4; COL23A1; BMP1A
Endochondral Ossification
CDKN1C; FRZB; RUNX3; SOX9A; COL2A1; SOX5; COL10A1A; RUNX2A; DDR2; SOX6
Extracellular matrix organization
CTS7; CTSLL; MFAP4; ADAM9; MMP8; LOC100514666; LOXL3; ADAMTS5; COL3A1; TIMP2A

Protein Function

MMP13 has several biochemical functions, for example, calcium ion binding, calcium-dependent protein binding, collagen binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP13 itself. We selected most functions MMP13 had, and list some proteins which have the same functions with MMP13. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein PCDHA8; MATN2; CAPN2B; ACTN4; GCA; CSN2; MYLZ3; CAPRIN1A; MAN1C1; CALM2
Function calcium-dependent protein binding
Related Protein ALG2; KOP; CALM1; RAC3; SELP; MASP2; CASQ2; S100A6; SYT8; SNAP25
Function collagen binding
Related Protein ITGA9; MMP13; ITGA1; USH2A; RELL2; GP5; GPR56; CD44; TLL1; MTAP1A
Function fibronectin binding
Related Protein ITGA4; CCDC80; CTSS; SFRP2; ITGAV; CTGF; LPA; VEGFA; FBLN1; IGFBP5
Function low-density lipoprotein particle receptor binding
Related Protein DNAJA1; MMP13; LDLRAP1; APOEB; AP2M1; SYT1; ARRB2; SACS; APOB; CRP
Function metalloendopeptidase activity
Related Protein UQCRC2A; ADAM9; MMP8; MMP17; MMP16; ADAMDEC1; MMP12; ADAM25; MMP23BB; MME
Function zinc ion binding
Related Protein ADAM12; ZDHHC6; GATA1A; TRAF4B; RNF6; BRF2; CHORDC1; ZIM2; NR2F1; ZNRF2B

MMP13 Related Articles

Ma, J; Zhou, D; et al. Keratocytes Create Stromal Spaces to Promote Corneal Neovascularization Via MMP13 Expression. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 55:-(2014).
Jackson, MT; Moradi, B; et al. Activation of Matrix Metalloproteinases 2, 9, and 13 by Activated Protein C in Human Osteoarthritic Cartilage Chondrocytes. ARTHRITIS & RHEUMATOLOGY 66:1525-1536(2014).

MMP13 Related Gene Family

MMPs