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Official Full Name matrix metallopeptidase 12 (macrophage elastase)
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]
Synonyms MMP12; matrix metallopeptidase 12 (macrophage elastase); ME; HME; MME; MMP-12; macrophage metalloelastase; matrix metalloproteinase 12 (macrophage elastase)
    • Species :
    • Human
    • Mouse
    • Rabbit
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Human Cell
    • Mammalian Cell
    • Mammalian cells
    • Mouse myeloma cell line
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MMP12-1134H Recombinant Human MMP12 Protein Mouse myeloma cell line
    Human MMP12-06H Recombinant Human MMP12 protein, His-tagged E.coli His
    Human MMP12-1133H Recombinant Human MMP12, His tagged Human Cell His
    Human MMP12-1283H Recombinant Human MMP12 Protein, His-tagged E.coli His
    Human MMP12-157H Recombinant Human MMP12 E.coli N/A
    Human MMP12-158H Recombinant Human MMP12 E.coli N/A
    Human MMP12-164H Recombinant Human MMP12(Macrophage Elastase), Inactive, Catalytic Domain E.coli N/A
    Human MMP12-28717TH Recombinant Human MMP12, His-tagged E.coli His
    Human MMP12-4281HCL Recombinant Human MMP12 293 Cell Lysate HEK293 N/A
    Human MMP12-5418H Recombinant Human MMP12 Protein, GST-tagged Wheat Germ GST
    Mouse Mmp12-533M Recombinant Mouse Mmp12 protein, His-tagged Human Cell His
    Mouse Mmp12-534M Recombinant Mouse Mmp12 Mammalian cells N/A
    Mouse Mmp12-600M Recombinant Mouse Mmp12 Protein, His-tagged E.coli His
    Mouse MMP12-9907M Recombinant Mouse MMP12 Protein Mammalian Cell His
    Rat MMP12-3712R Recombinant Rat MMP12 Protein Mammalian Cell His
    Rat Mmp12-602R Recombinant Rat Mmp12 Protein, His-tagged E.coli His
    Rat Mmp12-603R Recombinant Rat Mmp12 Protein, His-tagged E.coli His
    Rat Mmp12-604R Recombinant Rat Mmp12 Protein, His-tagged E.coli His
    Rat Mmp12-605R Recombinant Rat Mmp12 Protein, His-tagged E.coli His
    Rabbit MMP12-606R Recombinant Rabbit MMP12 Protein, His-tagged E.coli His

    mmp12 involved in several pathways and played different roles in them. We selected most pathways mmp12 participated on our site, such as Collagen degradation, Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with mmp12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Collagen degradation COL17A1; COL13A1; CTSL1; MGC174155; MMP15; COL25A1; LOC100686744; CTSB; MMP19; MGC174857
    Degradation of the extracellular matrix MMP12; COL9A1; CTSK; BMP1A; ELANE; MMP13; TPSAB1; MMP15; TIMP2B; CTS7
    Extracellular matrix organization COL17A1A; MGC174155; ADAMTS4; DDR1; LRP4; CTSK; LOC100514666; F11R.2; DDR2; MMP17
    Matrix Metalloproteinases MMP17; MMP25; TIMP4; MMP26; MMP19; BSG; MMP8; MMP27; MMP28; TIMP2

    mmp12 has several biochemical functions, for example, calcium ion binding, endopeptidase activity, metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by mmp12 itself. We selected most functions mmp12 had, and list some proteins which have the same functions with mmp12. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding PCDH10; MYLPFA; OCM2; CASQ1A; SLC24A2; GNPTAB; CALR3B; CANT1A; CSN2; BGLAP-RS1
    endopeptidase activity ACE2; MME; CTSH; PSMB5; ELANE; PSEN2; HTRA3; PSMA6B; TMEM59; APH1C
    metalloendopeptidase activity C6AST1; MMP15; ADAM32; ZMPSTE24; ADAMTS1; THOP1; MMP26; ADAM30; ADAM15; ASTL
    zinc ion binding TAF2; RNF122; PHC1; TRIM50; PPARAB; AGBL5; MMP11; TRIM23; TOPORS; TRIM45

    mmp12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mmp12 here. Most of them are supplied by our site. Hope this information will be useful for your research of mmp12.


    Palacios, BS; Estrada-Capetillo, L; et al. Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile. JOURNAL OF PATHOLOGY 235:515-526(2015).
    John-Schuster, G; Hager, K; et al. Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 307:L692-L706(2014).

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