MMP9

  • Official Full Name

    matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase)

  • Overview

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
  • Synonyms

    MMP9; matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); GELB; CLG4B; MMP-9; MANDP2; matrix metalloproteinase-9; 92 kDa gelatinase; type V collagenase; macrophage gelatinase; 92 kDa type IV collagenase; matrix metalloproteinase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase); B/MMP9; AW743869; pro-MMP-9;

  • Recombinant Proteins
  • Native Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Assay Kits
  • Bovine
  • Cattle
  • Chicken
  • Cynomolgus Monkey
  • Dog
  • Human
  • Mouse
  • Pig
  • Rabbit
  • Rat
  • Zebrafish
  • CHO
  • E.coli
  • HEK293
  • HEK293F
  • HEK293T
  • Human
  • Human Blood
  • Human Cell
  • Human Neutrophil
  • In Vitro Cell Free System
  • Insect Cell
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • Yeast
  • Yeast(Pichia pastor)
  • C
  • 6×His
  • His
  • Flag
  • GST
  • His (Fc)
  • Avi
  • His(C
  • ter)
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
  • T7
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MMP9-410H Active Recombinant Human MMP9 protein CHO N/A
Human MMP9-155H Active Recombinant Human MMP9 protein E.coli N/A
Human MMP9-166H Active Recombinant Human MMP9 E.coli N/A
Human MMP9-4893H Active Recombinant Human MMP9 protein, His-tagged HEK293 His
Human MMP9-9810 Active Native Human MMP9 Human Blood N/A
Human MMP9-811H Recombinant Human MMP9, His tagged Human Cell His
Human MMP9-29699TH Recombinant Human MMP9, His-tagged E.coli His
Human MMP9-44H Recombinant Human MMP9, His-tagged E.coli His
Human MMP9-429H Recombinant Human MMP9 protein, His-tagged Yeast(Pichia pastor) His
Human MMP9-774H Recombinant Human MMP9, Catalytic Domain, T7-tagged E.coli T7
Human MMP9-77H Recombinant Human MMP9, His-tagged E.coli His
Human Pro-MMP9-109H Recombinant Human Pro-matrix metallopeptidase 9, His-tagged E.coli His
Human MMP9-661H Active Recombinant Human MMP9 protein(Met1-Asp707) HEK293 N/A
Human MMP9-3829H Recombinant Human MMP9, GST-tagged E.coli GST
Human MMP9-812H Active Recombinant Human MMP9 protein, His-tagged HEK293 His
Human MMP9-560H Recombinant Human MMP9 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human MMP9-105H Recombinant Human matrix metallopeptidase 9, His-tagged E.coli His
Human MMP9-709H Recombinant Human Matrix Metallopeptidase 9 Mammalian cells N/A
Human MMP9-1443H Recombinant Human Matrix Metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase), His-tagged Human His
Human MMP9-2560HCL Recombinant Human MMP9 cell lysate Human Cell N/A
Human MMP9-38H Native Human MMP-9 Human Neutrophil N/A
Human MMP9-3361H Recombinant Human MMP9 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human MMP9-29698TH Native Human MMP9 N/A
Human MMP9-41H Native Human MMP-9/TIMP-1 Complex Human Neutrophil N/A
Human MMP9-40H Native Human MMP-9/Lipocalin/TIMP-1 Complex Human Neutrophil N/A
Human MMP9-005H Active Recombinant Human MMP9 Q279R Protein, His-tagged HEK293 His
Human MMP9-30035TH Native Human MMP9 N/A
Human MMP9-5438H Recombinant Human MMP9 Protein, GST-tagged Wheat Germ GST
Human MMP9-6282HF Recombinant Full Length Human MMP9 Protein, GST-tagged In Vitro Cell Free System GST
Human MMP9-2451H Recombinant Human MMP9 Protein, His-tagged E.coli N-His
Human MMP9-780HB Recombinant Human MMP9 protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
Human MMP9-5469H Recombinant Human MMP9 protein, His-tagged Yeast His
Human MMP9-241H Recombinant Active Human MMP9 (Q279R) Protein, His-tagged(C-ter) HEK293 His(C-ter)
Human MMP9-39H Native Human MMP-9/Lipocalin Complex Human Neutrophil N/A
Human MMP9-780H Recombinant Human MMP9 protein, His-Avi-tagged HEK293 His-Avi
Human MMP9-1403HFL Recombinant Full Length Human MMP9 Protein, C-Flag-tagged Mammalian cells Flag
Human MMP9-801H Recombinant Human MMP9 Protein, His-tagged HEK293 His
Human MMP9-1421H Recombinant Human MMP9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human MMP9-1129H Recombinant Human MMP9 Protein, His-tagged HEK293F N-His
Human MMP9-03H Active Recombinant Pre-activated Human MMP9 Protein HEK293
Human MMP9-4569H Recombinant Human MMP9 Protein (Met94-Asp707), N-His tagged E.coli N-His
Human MMP9-1421H-B Recombinant Human MMP9 Protein Pre-coupled Magnetic Beads HEK293
Human MMP9-4570H Recombinant Human MMP9 Protein (Val217-Asp390), N-His tagged E.coli N-His
Human MMP9-2634H Active Recombinant Human MMP9 protein, His-tagged HEK293 His
Human MMP9-4567H Recombinant Human MMP9 Protein (Met1-Asp707), C-His tagged Mammalian cells C-His
Mouse MMP9-05M Active Recombinant Mouse MMP9 protein, His-tagged Insect Cell His
Mouse Mmp9-1188M Recombinant Mouse MMP9 protein(Met1-Pro730) HEK293 N/A
Mouse Mmp9-2793M Recombinant Mouse Mmp9 protein, His-tagged E.coli His
Mouse Mmp9-431M Recombinant Mouse Mmp9 protein, His-tagged Yeast His
Mouse Mmp9-561M Active Recombinant Mouse Mmp9 Protein, His-tagged HEK293 His
Mouse Mmp9-417M Recombinant Mouse Matrix Metallopeptidase 9 Mammalian cells N/A
Mouse MMP9-2026MCL Recombinant Mouse MMP9 cell lysate Human Cell N/A
Mouse Mmp9-10596M Recombinant Mouse Mmp9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse Mmp9-4101M Recombinant Mouse Mmp9 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse Mmp9-242M Recombinant Mouse MMP9 Protein, His-tagged(C-ter) HEK293 His(C-ter)
Mouse Mmp9-10596M-B Recombinant Mouse Mmp9 Protein Pre-coupled Magnetic Beads HEK293
Mouse Mmp9-1132M Recombinant Mouse Mmp9 Protein, His-tagged HEK293F N-His
Mouse MMP9-1312M Active Recombinant Mouse MMP9 protein, His-tagged HEK293 His
Mouse Mmp9-03M Active Recombinant Mouse Mmp9 Protein (20-730aa), C-His-tagged HEK293 C-His
Mouse Mmp9-1788M Recombinant Mouse Mmp9 Protein, His&GST-tagged E.coli N-His&GST
Mouse MMP9-0495M Recombinant Mouse MMP9 protein, His-tagged HEK293 His
Rat Mmp9-537R Active Recombinant Rat Mmp9, His-tagged Mammalian cells His
Rat Mmp9-2794R Recombinant Rat Mmp9 protein, His-tagged E.coli His
Rat MMP9-3720R Recombinant Rat MMP9 Protein Mammalian Cell His
Rat Mmp9-1195R Recombinant Rat Mmp9, His tagged Human Cell His
Rat Mmp9-436R Recombinant Rat Mmp9 protein, His-tagged Yeast His
Rat MMP9-1940RCL Recombinant Rat MMP9 cell lysate Human Cell N/A
Rat Mmp9-37H Active Recombinant Rat Mmp9 protein (20-708aa), C-6×His-tagged HEK293 C-6×His
Rat Mmp9-3377R-B Recombinant Rat Mmp9 Protein Pre-coupled Magnetic Beads HEK293
Rat Mmp9-3377R Recombinant Rat Mmp9 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat Mmp9-243R Recombinant Active Rat MMP9 Protein, His-tagged(C-ter) HEK293 His(C-ter)
Rabbit MMP9-2795R Recombinant Rabbit MMP9 protein, His & T7-tagged E.coli His/T7
Dog MMP9-5468D Recombinant Dog MMP9 protein, His-tagged Yeast His
Dog MMP9-1128D Recombinant Dog MMP9 Protein, His-tagged E.coli N-His
Bovine MMP9-21B Recombinant Bovine MMP9 protein(107-712aa), His-tagged Yeast C-His
Cattle MMP9-2792C Recombinant Cattle MMP9 protein, His & T7-tagged E.coli His/T7
Cynomolgus Monkey MMP9-13C Active Recombinant Cynomolgus Monkey MMP9 Protein (Ala20-Asp707) CHO
Zebrafish MMP9-12341Z Recombinant Zebrafish MMP9 Mammalian Cell His
Pig MMP9-1130P Recombinant Pig MMP9 Protein, His-tagged E.coli N-His
Pig MMP9-1131P Recombinant Pig MMP9 Protein, His-tagged E.coli N-His
Chicken MMP9-6233C Recombinant Chicken MMP9 Mammalian Cell His
Kit-3100 MMP-9 Fluorimetric Assay Kit N/A
Kit-2130 MMP-9 Inhibitor Screening Kit N/A
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • MMP9 Related Articles

MMP9 involved in several pathways and played different roles in them. We selected most pathways MMP9 participated on our site, such as TNF signaling pathway, Leukocyte transendothelial migration, Estrogen signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP9 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
TNF signaling pathwayCCL2;ICAM1;VEGFC;IL1B;CCL5;CASP10;MAP2K3;CREB5;Casp3
Leukocyte transendothelial migrationVASP;PIK3R3;RAC1;ACTN2;CLDN8;CLDN15;MYL2;CXCR4;CLDN16
Estrogen signaling pathwayATF4;CALM2;GABBR2;Adcy4;PIK3R1;PLCB3;SOS1;HSPA1A;NRAS
Hepatitis BMAPK1;KRAS;HBXIP;Ifna15;PRKCB;IFNA7;Casp3;IFN-a;DDB2
Pathways in cancerGNAI3;FAS;PTGER3;IGF1;WNT5A;Fzd4;WNT4;PTCH1;PTK2
Transcriptional misregulation in cancerHIST2H3C1;TRAF1;MLL1;CD86;Aff1;CEBPE;SIX4;ZEB1;CD40
Proteoglycans in cancerWNT8B;ERBB2;PRKCA;VAV2;HGF;DROSHA;KRAS;PTPN11;ARHGEF1
MicroRNAs in cancerCDC25A;SLC45A3;MDM2;TNXB;PIM1;WNT3;PDGFA;DDIT4;RAF1
Bladder cancerRAF1;CDK4;ARAF;BRAF;HRAS;E2F1;TP53;MMP1A;MMP1

MMP9 has several biochemical functions, for example, collagen binding, endopeptidase activity, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP9 itself. We selected most functions MMP9 had, and list some proteins which have the same functions with MMP9. You can find most of the proteins on our site.

Function Related Protein
collagen bindingSERPINH1A;LRRC15;COMP;RELL2;ITGA3;ACHE;PCOLCE;SMAD3;TLL1
endopeptidase activityPSMB6;PSMB11;PARL;PSMB10;P4HB;SENP3B;PSMB9A;PSMA6A;MMP1A
identical protein bindingNQO1;DPP4;SMAD4;CD74;PIK3AP1;RALYL;ALDH4A1;CLDN11;TRIM8
metalloendopeptidase activityADAM1B;NRD1B;FAP;BMP1;ASTL;ADAMTS5;ADAMTSL4;MEP1A;ECEL1
metallopeptidase activityMEP1A.1;ADAM20;ADAM17A;ADAMTS5;ADAM17;ADAMTS8;PAPPAA;MMP13A;ERMP1
protein bindingUCHL3;XIAP;TMEM194;MT2A;ANKRD49;UBXN2B;CALM1;SHARPIN;HSD17B10
zinc ion bindingRNF39;VPS11;NR4A1;APOBEC3G;NR1D2;TADA2B;ADH8A;RBM14B;VPS8

MMP9 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP9 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP9.

VCAN; MEP1A; MEP1B; TIMP1; SRGN; ELN; SCUBE3; TGFB1; q7cje7_yerpe; ITGA5

Liu, ZK; Dou, CW; et al. RIG-I suppresses the migration and invasion of hepatocellular carcinoma cells by regulating MMY9. INTERNATIONAL JOURNAL OF ONCOLOGY 46:1710-1720(2015).
Muradashvili, N; Benton, RL; et al. Ablation of matrix metalloproteinase-9 gene decreases cerebrovascular permeability and fibrinogen deposition post traumatic brain injury in mice. METABOLIC BRAIN DISEASE 30:411-426(2015).
  • Q&As
  • Reviews

Q&As (5)

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What are the consequences of dysregulated MMP9 expression in cancer progression? 02/13/2022

Dysregulated MMP9 expression is associated with cancer invasion and metastasis, as it enables tumor cells to degrade the extracellular matrix and invade surrounding tissues.

What is the impact of MMP9 polymorphisms on enzyme activity? 09/07/2021

Polymorphisms in the MMP9 gene can influence enzyme activity, potentially affecting the individual's susceptibility to certain diseases and the progression of pathological conditions.

Can you explain the role of MMP9 in tissue remodeling at the molecular level? 01/17/2020

MMP9 facilitates tissue remodeling by cleaving structural proteins in the extracellular matrix, such as collagen and gelatin, leading to changes in tissue architecture.

What is the role of MMP9 in the breakdown of the blood-brain barrier during neurological disorders? 11/14/2019

MMP9 contributes to the breakdown of the blood-brain barrier by degrading tight junction proteins, potentially exacerbating neurological disorders and neuroinflammation.

How does MMP9 contribute to angiogenesis at the molecular level? 06/02/2018

MMP9 plays a role in angiogenesis by promoting the release and activation of growth factors sequestered in the extracellular matrix, facilitating the formation of new blood vessels.

Customer Reviews (3)

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Reviews
05/03/2020

    The superior quality of this recombined protein has significantly enhanced the precision of our research outcomes.

    08/15/2019

      Fast shipping! Ordered this product, and it arrived well-packaged and ready for use in our experiments.

      01/21/2018

        Customer service went above and beyond to accommodate our specific needs, ensuring a smooth purchasing experience.

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