| Cat.No.: | Kit-2213 |
| Product Overview: | The matrix metalloproteinase-3 (MMP-3, stromelysin-1) exhibits a number of activities that would make it a particularly good tumor promoter. Like several other MMPs, MMP-3 was first cloned and later recloned as a cancer-specific gene. In addition to degrading numerous extracellular matrix components, MMP-3 can activate gelatinase B, the collagenases and several serpin-type serine proteinase inhibitors. Moreover, it can release a number of cell surface molecules, including E-cadherin, a known contributor to cancer development. In MMP-3 Assay Kit, MMP-3 hydrolyzes a specific FRET substrate to release the quenched fluorescent group Mca, which can be detected fluorometrically at Ex/Em = 325/393 nm. The kit provides a rapid, simple, sensitive and reliable test which can also be used as a high throughput assay of MMP-3 activity. The assay sensitivity is < 50 µU. This kit can be used with our MMP-3 inhibitor, GM6001 as a control. In addition, we also offer a human recombinant MMP-3 enzyme and a MMP-3 inhibitor Screening Kit, separately. |
| Applications: | The assay sensitivity is < 50 µU. |
| Storage: | -20°C |
| Shipping: | Gel Pack |
| Size: | 100 assays |
| Kit Components: | MMP-3 Assay Buffer; MMP-3 Substrate; Mca Standard (1mM); MMP-3 Positive Control |
| Target Species: | Mammalian |
| Detection method: | Fluorescence (Ex/Em 325/393 nm) |
| Features & Benefits: | Sensitive assays for measuring MMP-3 in various biological samples |
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