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MMP24

Official Full Name

matrix metallopeptidase 24 (membrane-inserted)
Overview

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 by cleavage. The gene has previously been referred to as MMP25 but has been renamed MMP24. [provided by RefSeq, Jul 2008]
Synonyms

MMP24; matrix metallopeptidase 24 (membrane-inserted); MMP25; MMP-24; MT5MMP; MTMMP5; MT-MMP5; MT5-MMP; MT-MMP 5; matrix metalloproteinase-24; membrane-type 5 matrix metalloproteinase; membrane-type matrix metalloproteinase 5; membrane-type-5 matrix metalloproteinase; matrix metalloproteinase 24 (membrane-inserted);

Type

Recombinant Proteins
Protein Pre-coupled Magnetic Beads

Species

Human
Mouse
Rat

Source

E.coli
HEK293
Mammalian Cell

Tag

His
His (Fc)
Avi
His|Myc
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	MMP24-610H	Recombinant Human MMP24, Catalytic Domain, His-tagged	E.coli	His		Inquiry
Human	MMP24-3942H	Recombinant Human MMP24 Protein (Ile429-Gln642), N-His tagged	E.coli	N-His	Ile429-Gln642	Inquiry
Mouse	MMP24-9920M	Recombinant Mouse MMP24 Protein	Mammalian Cell	His		Inquiry
Mouse	MMP24-5604M-B	Recombinant Mouse MMP24 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Mouse	MMP24-2455M	Recombinant Mouse MMP24 Protein (42-575 aa), His-Myc-tagged	E.coli	His/Myc	42-575 aa	Inquiry
Mouse	MMP24-5604M	Recombinant Mouse MMP24 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry
Rat	MMP24-3717R	Recombinant Rat MMP24 Protein	Mammalian Cell	His		Inquiry
Rat	MMP24-3373R-B	Recombinant Rat MMP24 Protein Pre-coupled Magnetic Beads	HEK293			Inquiry
Rat	MMP24-3373R	Recombinant Rat MMP24 Protein, His (Fc)-Avi-tagged	HEK293	His (Fc)-Avi		Inquiry

Involved Pathway
Protein Function
Interacting Protein
MMP24 Related Gene Family
MMP24 Related Research Area

MMP24 involved in several pathways and played different roles in them. We selected most pathways MMP24 participated on our site, such as Activation of Matrix Metalloproteinases, Degradation of the extracellular matrix, Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP24 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Activation of Matrix Metalloproteinases	FURINB;TPSAB1;CTSLL;MMP24;MMP13;MMP8;MMP15;MGC174857;CTSG
Degradation of the extracellular matrix	CTRB1;ADAM8;MMP10;ADAMTS18;TPSAB1;COL9A1;MMP20;LOC100686744;CTSK
Extracellular matrix organization	DMP1;CTSD;COL9A1;EMID2;ADAMTS3;MMP12;COL23A1;COL5A2;MFAP3
Matrix Metalloproteinases	MMP27;MMP10;MMP28;MMP11;MMP15;MMP20;MMP25;TIMP2;MMP26

MMP24 has several biochemical functions, for example, cadherin binding, calcium ion binding, enzyme activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP24 itself. We selected most functions MMP24 had, and list some proteins which have the same functions with MMP24. You can find most of the proteins on our site.

Function	Related Protein
cadherin binding	NEO1;MMP24;CDH13;JUP;FER;Fert2;CTNNA3;NUMB;TBC1D2
calcium ion binding	CAPNS1B;SYT1;EFHC2;CDH5;SYT3;ANXA13;SYT10;SYT9B;EFEMP2
enzyme activator activity	TIMP2;TRIM23;DCP1A;PSAP;DCP1B;GMFG;PPP1R12B;OGT;APOA5
metalloendopeptidase activity	ADAM1B;OSGEPL1;MMP1;MMEL1;C6AST4;ADAM21;ADAMTS5;MMP1A;HE1A
zinc ion binding	XIRP2;ING5B;TXNDC17;XAF1;ADAMTS7;MTA1;WHSC1;ZCCHC8;NR1D2B

MMP24 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP24 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP24.

Gorasp2

Metalloproteases and Regulators