MMP11

  • Official Full Name

    matrix metallopeptidase 11 (stromelysin 3)

  • Overview

    Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMPs, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
  • Synonyms

    MMP11; matrix metallopeptidase 11 (stromelysin 3); ST3; SL-3; STMY3; stromelysin-3; MMP-11; stromelysin III;

  • Recombinant Proteins
  • Native Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • In Vitro Cell Free System
  • Mammalian Cell
  • Wheat Germ
  • GST
  • GST|His
  • His
  • His (Fc)
  • Avi
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human MMP11-160H Recombinant Human MMP11 E.coli N/A
Human MMP11-5245H Recombinant Human MMP11 Protein, GST/His-tagged E.coli GST/His
Human MMP11-830H Recombinant Human MMP11, GST-His E.coli His
Human MMP11-256H Recombinant Human MMP11 Protein, His-tagged E.coli His Ile277~Leu488
Human MMP11-27650TH Recombinant Human MMP11, His-tagged E.coli His
Human MMP11-33H Recombinant Human MMP11, His-tagged HEK293 His
Human MMP11-001H Recombinant Human MMP11 Protein, His-GST-tagged E.coli His/GST 33-488
Human MMP11-27648TH Native Human MMP11 N/A
Human MMP11-5417H Recombinant Human MMP11 Protein, GST-tagged Wheat Germ GST
Human MMP11-4574H Recombinant Human MMP11 Protein (Phe98-Leu488), N-His tagged E.coli N-His Phe98-Leu488
Human MMP11-6409HF Recombinant Full Length Human MMP11 Protein, GST-tagged In Vitro Cell Free System GST 488 amino acids
Mouse MMP11-9906M Recombinant Mouse MMP11 Protein Mammalian Cell His
Mouse Mmp11-257M Recombinant Mouse Mmp11 Protein, His-tagged E.coli His Ala287~Phe491
Mouse MMP11-5596M Recombinant Mouse MMP11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Mouse MMP11-258M Recombinant Mouse MMP11 Protein, his-tagged, Phe102-Arg492 E.coli N-His Phe102-Arg492
Mouse MMP11-5596M-B Recombinant Mouse MMP11 Protein Pre-coupled Magnetic Beads HEK293
Rat MMP11-3711R Recombinant Rat MMP11 Protein Mammalian Cell His
Rat Mmp11-258R Recombinant Rat Mmp11 Protein, His-tagged E.coli His Ala302~Arg458
Rat MMP11-3367R Recombinant Rat MMP11 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat MMP11-3367R-B Recombinant Rat MMP11 Protein Pre-coupled Magnetic Beads HEK293
Chicken MMP11-3322C Recombinant Chicken MMP11 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

MMP11 involved in several pathways and played different roles in them. We selected most pathways MMP11 participated on our site, such as Activation of Matrix Metalloproteinases, Collagen degradation, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Activation of Matrix MetalloproteinasesMMP10;FURINA;MMP13;ELANE;CTRB1;FURINB;MMP17;CTSK;MGC174152
Collagen degradationEMID2;CTSK;MGC174857;MMP19;COL23A1;MMP20;MMP10;COL19A1;LOC100686744
Degradation of the extracellular matrixTIMP2B;FAM49BA;BMP1B;TIMP2;TLDC2;MMP15;COL25A1;ADAMTS5;ADAM15
Extracellular matrix organizationLTBP2;COL1A1;EFEMP1;COL9A3;COL3A1;COL4A4;EMID2;BMP1A;ADAMTS18
Matrix MetalloproteinasesMMP17;MMP12;MMP24;MMP28;MMP23B;MMP8;MMP20;BSG;MMP25

MMP11 has several biochemical functions, for example, calcium ion binding, metalloendopeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP11 itself. We selected most functions MMP11 had, and list some proteins which have the same functions with MMP11. You can find most of the proteins on our site.

Function Related Protein
calcium ion bindingCASQ1B;MYL9;EHD2;CDH5;MGP;PCDH2G10;EMR3;MAN1A2;SVEP1
metalloendopeptidase activityADAMTS4;MMP25;ADAM21;MEP1A;ECE1;PAPLN;MIPEP;YBEY;ADAM22
zinc ion bindingCA2;PJA1;AMFR;CPO;RXRAA;ZDHHC18B;TRIM25;NR2C1;TRIM108

MMP11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP11.

Gene Family

MMPs

Research Area

Related articles

Brunelli, E; Bernabo, I; et al. Remodelling of the skin during metamorphosis in the Italian newt (Lissotriton italicus) (Amphibia, Urodela): localization pattern of keratins, stromelysin-3 (MMP-11), and pan-cadherin. ZOOMORPHOLOGY 134:135-147(2015).
Roscilli, G; Cappelletti, M; et al. Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).
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