mmp11 Protein, matrix metallopeptidase 11 (stromelysin 3)

mmp11

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mmp11

Official Full Name matrix metallopeptidase 11 (stromelysin 3)
Background Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMPs, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
Synonyms MMP11; matrix metallopeptidase 11 (stromelysin 3); ST3; SL-3; STMY3; stromelysin-3; MMP-11; stromelysin III;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • His/GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human MMP11-001H Recombinant Human MMP11 Protein, His-GST-tagged E.coli His/GST
    Human MMP11-160H Recombinant Human MMP11 E.coli N/A
    Human MMP11-256H Recombinant Human MMP11 Protein, His-tagged E.coli His
    Human MMP11-27648TH Native Human MMP11 N/A
    Human MMP11-27650TH Recombinant Human MMP11, His-tagged E.coli His
    Human MMP11-33H Recombinant Human MMP11, His-tagged HEK293 His
    Human MMP11-5245H Recombinant Human MMP11 Protein, GST/His-tagged E.coli GST/His
    Human MMP11-5417H Recombinant Human MMP11 Protein, GST-tagged Wheat Germ GST
    Human MMP11-830H Recombinant Human MMP11, GST-His E.coli His
    Mouse Mmp11-257M Recombinant Mouse Mmp11 Protein, His-tagged E.coli His
    Mouse MMP11-9906M Recombinant Mouse MMP11 Protein Mammalian Cell His
    Rat Mmp11-258R Recombinant Rat Mmp11 Protein, His-tagged E.coli His
    Rat MMP11-3711R Recombinant Rat MMP11 Protein Mammalian Cell His
    Chicken MMP11-3322C Recombinant Chicken MMP11 Mammalian Cell His

    mmp11 involved in several pathways and played different roles in them. We selected most pathways mmp11 participated on our site, such as Activation of Matrix Metalloproteinases, Collagen degradation, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with mmp11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Activation of Matrix Metalloproteinases ELANE; MMP17; MGC174857; CTSK; TIMP2B; TIMP2A; FURINA; MGC174152; MMP8; CTSL2
    Collagen degradation MMP10; CTSL1; COL13A1; MMP19; CTSLL; CTSK; COL9A1; COL23A1; ELANE; MMP20
    Degradation of the extracellular matrix COL25A1; MMP8; ELANE; TPSAB1; MMP24; MMP13; KLK7; CTSLL; CTS7; CTSD
    Extracellular matrix organization ADAMTS18; COL5A1; MMP19; ASPN; SPARC; COL10A1A; F11R.2; MATN3; SERPINH1A; LOXL4
    Matrix Metalloproteinases MMP8; MMP11; MMP26; MMP24; MMP28; MMP20; BSG; MMP27; TIMP2; TIMP4

    mmp11 has several biochemical functions, for example, calcium ion binding, metalloendopeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by mmp11 itself. We selected most functions mmp11 had, and list some proteins which have the same functions with mmp11. You can find most of the proteins on our site.

    Function Related Protein
    calcium ion binding CBLB; DOC2D; MGMT; PLCZ1; RHOT1B; FSTL1B; JAG1; DOC2B; CRB2B; FKBP7
    metalloendopeptidase activity UQCRC2; MEP1A.1; ADAM10; MMP23B; MMP8; ADAM33; MMP3; MMP24; ADAM12; TLL2
    zinc ion binding CNOT4; CRYZ; MGRN1; ADAMTS9; PHF21B; NR3C1; CSRP2; AGTPBP1; PHF10; CPA5

    mmp11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with mmp11 here. Most of them are supplied by our site. Hope this information will be useful for your research of mmp11.

    Brunelli, E; Bernabo, I; et al. Remodelling of the skin during metamorphosis in the Italian newt (Lissotriton italicus) (Amphibia, Urodela): localization pattern of keratins, stromelysin-3 (MMP-11), and pan-cadherin. ZOOMORPHOLOGY 134:135-147(2015).
    Roscilli, G; Cappelletti, M; et al. Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).

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