MMP11
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Official Full Name
matrix metallopeptidase 11 (stromelysin 3)
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Overview
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMPs, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008] -
Synonyms
MMP11; matrix metallopeptidase 11 (stromelysin 3); ST3; SL-3; STMY3; stromelysin-3; MMP-11; stromelysin III;
- Recombinant Proteins
- Native Proteins
- Protein Pre-coupled Magnetic Beads
- Chicken
- Human
- Mouse
- Rat
- E.coli
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- His
- Fc
- Avi
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
MMP11 involved in several pathways and played different roles in them. We selected most pathways MMP11 participated on our site, such as Activation of Matrix Metalloproteinases, Collagen degradation, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Activation of Matrix Metalloproteinases | MMP8;FURINA;MMP13;TIMP2B;TPSAB1;TIMP2;CTSG;CTRB1;TIMP2A |
| Collagen degradation | MGC174155;COL17A1;ADAM10;COL9A1;MMP19;CTSK;MGC174857;MMP11;CTSLL |
| Degradation of the extracellular matrix | ADAM9;ADAMTS8;FURINB;MGC174857;CTRB1;COL23A1;TIMP2B;CTS7;CTSG |
| Extracellular matrix organization | COL4A4;COL5A3A;TTR;VCANB;LOXL3;COL1A1;MATN1;COL9A3;PCOLCE |
| Matrix Metalloproteinases | MMP24;MMP10;BSG;MMP23B;MMP15;MMP12;MMP28;MMP27;MMP25 |
MMP11 has several biochemical functions, for example, calcium ion binding, metalloendopeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP11 itself. We selected most functions MMP11 had, and list some proteins which have the same functions with MMP11. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | PLA2G12A;RHOT1;SYT5B;TPD52;OTOF;RHBDL3;SYTL2;VSNL1A;GRM7 |
| metalloendopeptidase activity | PHEX;BMP1;MMP7;NRD1B;ADAMTS5;ADAM18;ADAMTS9;MMP28;TLL2 |
| zinc ion binding | YAF2;MICALL2B;RNF122;TRIM35-31;DPF3;ARIH2;SF3A2;RABGGTA;MT1A |
MMP11 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP11 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP11.
Gene Family
Research Area
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