mmp11
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  • Official Full Name
  • matrix metallopeptidase 11 (stromelysin 3)
  • Background
  • Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMPs, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008]
  • Synonyms
  • MMP11; matrix metallopeptidase 11 (stromelysin 3); ST3; SL-3; STMY3; stromelysin-3; MMP-11; stromelysin III;
Cat.#:MMP11-5245HTag:GST/His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP11 Protein, GST/His-tagged
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Cat.#:MMP11-5417HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human MMP11 Protein, GST-tagged
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Cat.#:MMP11-160HTag:N/A
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP11
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Cat.#:MMP11-256HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP11 Protein, His-tagged
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Cat.#:MMP11-27650THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP11, His-tagged
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Cat.#:MMP11-33HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human MMP11, His-tagged
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Cat.#:MMP11-830HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human MMP11, GST-His
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Cat.#:Mmp11-257MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Mmp11 Protein, His-tagged
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Cat.#:MMP11-9906MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse MMP11 Protein
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Cat.#:Mmp11-258RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Mmp11 Protein, His-tagged
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Cat.#:MMP11-3711RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat MMP11 Protein
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Cat.#:MMP11-3322CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken MMP11
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Cat.#:MMP11-27648THTag:
Source (Host):Species:Human
Product nameNative Human MMP11
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Involved Pathway

MMP11 involved in several pathways and played different roles in them. We selected most pathways MMP11 participated on our site, such as Activation of Matrix Metalloproteinases, Collagen degradation, Degradation of the extracellular matrix, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP11 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Activation of Matrix Metalloproteinases
CTSLL; CTSL2; MGC174155; MMP8; TIMP2B; LOC100686744; MMP15; CTRB1; TIMP2; MMP24
Collagen degradation
COL9A1; MGC174857; ELANE; COL17A1; ADAM10; MMP15; CTSK; CTSL1; MMP8; LOC100686744
Degradation of the extracellular matrix
MMP12; MGC174152; MGC174155; ACAN; COL15A1B; ADAMTS5; TIMP2A; BMP1; ADAMTS8; TIMP2B
Extracellular matrix organization
LOXL3; COL28A1; SERPINH1B; TPSAB1; MFAP1; MGC174152; LEPREL2; NID2; COL4A6; CD151
Matrix Metalloproteinases
MMP8; MMP24; MMP28; BSG; MMP23B; MMP19; TIMP4; MMP12; MMP17; MMP26

Protein Function

MMP11 has several biochemical functions, for example, calcium ion binding, metalloendopeptidase activity, zinc ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP11 itself. We selected most functions MMP11 had, and list some proteins which have the same functions with MMP11. You can find most of the proteins on our site.
Function
Related Protein
Function calcium ion binding
Related Protein MICU2; MYLPF; BGLAP; REPS1; PCDH2G7; HSP90B1; RASGRP1; CDHR1A; PCDH17; EEF2K
Function metalloendopeptidase activity
Related Protein MMP19; C6AST1; NLN; ADAMTS18; ADAM5; HE1B; MMP11; THSD4; ADAM10; ADAM33
Function zinc ion binding
Related Protein ALPP; ZNF212; ZNRF2B; ZDHHC14; TRIM10; CREBBP; LIN28A; ZDHHC20A; NR1I2; CPM

MMP11 Related Articles

Brunelli, E; Bernabo, I; et al. Remodelling of the skin during metamorphosis in the Italian newt (Lissotriton italicus) (Amphibia, Urodela): localization pattern of keratins, stromelysin-3 (MMP-11), and pan-cadherin. ZOOMORPHOLOGY 134:135-147(2015).
Roscilli, G; Cappelletti, M; et al. Circulating MMP11 and specific antibody immune response in breast and prostate cancer patients. JOURNAL OF TRANSLATIONAL MEDICINE 12:-(2014).

MMP11 Related Gene Family

MMPs