"MMP3" Related Products

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Recombinant Human Matrix Metallopeptidase 3 (Stromelysin 1, Progelatinase), GST-Tagged

Cat. No.: MMP3-1383H
Product Overview: MMP-3 Human Recombinant produced in E.Coli is a single, non-glycosylated, Polypeptide chain fused to a GST tag containing 228 amino acids (251-478) and having a total molecular mass of 51kDa. MMP-3 is purified by proprietary chromatographic techniques.
Description: MMP-3 enzyme is also known as Stromelysin-1or as Transin-1 which hydrolyzes natural collagen at physiological pH and temperature. It dissolves the intervertebral nucleus pulposus and annulus fibrosus of Herniated Lumbar Intervertebral Disk . MMP-3 hydrolyzes components of the extracellular matrix like proteoglycan, laminin, fibronectin, gelatin and collagen types III, IV and IX. It also activates pro-MMP-9 and pro-MMP-8 and superactivates plasmin activated MMP-1. MMP-3 is secreted as a latent proenzyme and is activated by a variety of proteinases, e.g. plasmin, trypsin, chymotrypsin, cathepsin G or human neutrophil elastase. MMP-3 was found to be capable of activating the precursor of IL1-beta.
Source: Human
Host: Escherichia Coli.
Form: MMP-3 is supplied in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol.
Physical Appearance: Sterile Filtered clear solution.
Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles.
Gene Name: MMP3 matrix metallopeptidase 3 (stromelysin 1, progelatinase) [ Homo sapiens ]
Official Symbol: MMP3
Synonyms: MMP3; matrix metallopeptidase 3 (stromelysin 1, progelatinase); SL-1; STMY; STR1; CHDS6; MMP-3; STMY1; MGC126102; MGC126103; MGC126104; stromelysin-1; transin-1; proteoglycanase; OTTHUMP00000045949; matrix metalloproteinase-3; matrix metalloproteinase 3 (stromelysin 1, progelatinase); Stromelysin-1; Matrix metalloproteinase-3; Transin-1; EC 3.4.24
Gene ID: 4314
mRNA Refseq: NM_002422
Protein Refseq: NP_002413
MIM: 185250
UniProt ID: P08254
Chromosome Location: 11q22.3
Pathway: Matrix Metalloproteinases; Rheumatoid arthritis; p75(NTR)-mediated signaling
Function: calcium ion binding; metalloendopeptidase activity; peptidase activity; protein complex binding; zinc ion binding

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Optional requirements on this protein    +Expand
C-fusion    N-fusion   Non-tagged
His    GST   Fc   Others
<1.0 eu/μg    <0.1 eu/μg   <0.01 eu/μg   Not required
Monomer Isolation    Dimer Isolation    Not required
>80% by SDS-PAGE    >90% by SDS-PAGE   >95% by SDS-PAGE   Others

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