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Recombinant Murine Collagen, Type XVIII, Alpha 1

Cat. No.: Col18a1-199M
Product Overview: Recombinant Murinecollagen, type XVIII, alpha 1 was expressed inPichia pastoris.
Description: Endostatin has been identified as a C-terminal fragment of Collagen type 18, a recently identified member of a family of collagen-like proteins referred to as multiplexin familyEndostatin specifically inhibits proliferation of endothelial cells although it does not affect the proliferation of EOMA cells. Endostatin also potently inhibits angiogenesis and tumor growth. Endostatin has an important role in endothelial cell adhesion and cytoskeletal organization. Endostatin can be found in vessel walls (elastic fibers) and basement membranes. Recombinant Endosatin expressed in yeast causes G1 arrest of endothelial cells, and endostatin treatment results in apoptosis of HUVE and HMVE cells.
Source: Pichia pastoris.
Biochem/Physiol Actions: Endostatin is a potent inhibitor of angiogenesis and tumor growth in vitro and in vivo; specifcally inhibits endothelial cell proliferation.
Physical Form: 17 mM citric-phosphate buffer, pH 6.2.
Assay: ≥95% (HPLC).
Concentration: 4 mg/mL (17 mM citric-phosphate buffer, pH 6.2).
Total Impurities: Endotoxin, tested.
Storage Temp: −70°C.
Gene Name: Col18a1 collagen, type XVIII, alpha 1 [ Mus musculus ]
Synonyms: Col18a1; collagen, type XVIII, alpha 1; endostatin
Gene ID: 12822
mRNA Refseq: NM_001109991
Protein Refseq: NP_001103461
UniProt ID: P39061
Chromosome Location: 10 B5-C1; 10 41.3 cM
Function: binding; extracellular matrix structural constituent; metal ion binding; structural molecule activity

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