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Col4a5

  • Official Full Name

    COL4A5 collagen, type IV, alpha 5 [ Homo sapiens ]

  • Overview

    This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. Mutations in this gene are associated with X-linked Alport syndrome, also known as hereditary nephritis. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. Alternatively spliced transcript variants have been identified for this gene.
  • Synonyms

    Arresten; Canstatin; CO4A1_HUMAN; COL4A1; COL4A1 NC1 domain; COL4A2; COL4A3; COL4A4; COL4A5; Collagen Alpha 1(IV) Chain; Collagen Alpha 2(IV) Chain; collagen alpha-1(IV) chain; Collagen IV Alpha 1 Polypeptide; Collagen IV Alpha 2 Polypeptide; Collagen Of Basement Membrane Alpha 1 Chain; Collagen Of Basement Membrane Alpha 2 Chain; Collagen Type IV Alpha 1; Collagen Type IV Alpha 2; Collagen Type IV Alpha 3; Collagen Type IV Alpha 4; Collagen Type IV Alpha 5; DKFZp686I14213; FLJ22259;
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COL4A5-11435H Recombinant Human COL4A5 protein, GST-tagged E.coli GST 423-552 aa
Human COL4A5-332H Recombinant Human COL4A5 Protein, His-tagged E.coli His Gly1461~Thr1685
Human COL4A5-2713H Recombinant Human COL4A5 protein(41-550 aa), C-His-tagged HEK293 C-His 41-550 aa
Zebrafish COL4A5-6638Z Recombinant Zebrafish COL4A5 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Col4a5 Related Articles
  • Col4a5 Related Research Area

Col4a5 involved in several pathways and played different roles in them. We selected most pathways Col4a5 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with Col4a5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AmoebiasisGM-CSF;CXCL1;TNF;ITGAM;COL5A1;PLCB4;RELA;FN1;COL1A2
Assembly of collagen fibrils and other multimeric structuresTLL2;COL3A1;COL4A4;PCOLCE;CTSS;COL10A1A;COL10A1;COL5A2;COL5A1
Axon guidanceKBTBD7;TRIO;CNKSR1;SPNA1;COL6A2;CSK;ITGB3A;SEMA4C;NCK2
Collagen biosynthesis and modifying enzymesSERPINH1;COL13A1;COL25A1;COL1A1;TLDC2;ADAMTS3;ADAMTS2;BMP1A;SERPINH1A
Collagen formationCOL10A1A;COL28A1A;CTSS;COL13A1;PCOLCE;MMP20;BMP1;SERPINH1B;COL9A1
Developmental BiologyFOXD3;COL4A4;CLTB;EPHA4A;JAK3;CSNK2B;ACTR2B;FRS2B;EPHB3A
ECM-receptor interactionCOL27A1B;COL2A1;ITGA2B;CHAD;ITGB6;COL5A1;COL11A1A;COL2A1B;ITGA2
Extracellular matrix organizationMFAP4;PCOLCE2B;LRP4;SERPINH1A;COL5A1;PPIB;LOX;LOC100514666;FURINB

Col4a5 has several biochemical functions, for example, extracellular matrix structural constituent. Some of the functions are cooperated with other proteins, some of the functions could acted by Col4a5 itself. We selected most functions Col4a5 had, and list some proteins which have the same functions with Col4a5. You can find most of the proteins on our site.

Function Related Protein
extracellular matrix structural constituentIMPG2;COL11A2;COL27A1A;KAL1;TINAGL1;COL1A1A;COL5A2;PXDN;COL4A5

Col4a5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Col4a5 here. Most of them are supplied by our site. Hope this information will be useful for your research of Col4a5.

Hashimura, Y; Nozu, K; et al. Milder clinical aspects of X-linked Alport syndrome in men positive for the collagen IV alpha 5 chain. KIDNEY INTERNATIONAL 85:1208-1213(2014).
Olaru, F; Luo, WT; et al. Quaternary Epitopes of alpha 345(IV) Collagen Initiate Alport Post-Transplant Anti-GBM Nephritis. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 24:889-895(2013).
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