COL1A2

  • Official Full Name

    collagen, type I, alpha 2

  • Overview

    This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2;chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis;and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type;VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms;associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1;chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three;transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
  • Synonyms

    COL1A2; collagen, type I, alpha 2; OI4, osteogenesis imperfecta type IV; collagen alpha-2(I) chain; alpha 2(I) collagen; alpha 2 collagen type I; collagen I; alpha 2 polypeptide; collagen of skin; tendon and bone; alpha 2 chain; type I procollagen; alpha;

  • Recombinant Proteins
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Dog
  • Human
  • Mouse
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • His|GST
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COL1A2-116H Recombinant Human COL1A2, His-tagged E.coli His
Human COL1A2-219H Recombinant Human COL1A2 Protein, His-tagged E.coli His
Human COL1A2-115H Recombinant Human COL1A2, GST-tagged Wheat Germ GST
Human COL1A2-01H Recombinant Human COL1A2 protein, His-tagged HEK293 His
Mouse COL1A2-3725M Recombinant Mouse COL1A2 Protein Mammalian Cell His
Mouse Col1a2-220M Recombinant Mouse Col1a2 Protein, His-tagged E.coli His
Mouse COL1A2-1855M-B Recombinant Mouse COL1A2 Protein Pre-coupled Magnetic Beads HEK293
Mouse COL1A2-1855M Recombinant Mouse COL1A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat COL1A2-1518R Recombinant Rat COL1A2 Protein Mammalian Cell His
Rat COL1A2-1175R Recombinant Rat COL1A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rat COL1A2-1175R-B Recombinant Rat COL1A2 Protein Pre-coupled Magnetic Beads HEK293
Rat Col1a2-818R Recombinant Rat Col1a2 Protein, His-tagged E.coli N-His
Dog COL1A2-218D Recombinant Dog COL1A2 Protein, His/GST-tagged E.coli His/GST
Rhesus Macaque COL1A2-960R Recombinant Rhesus monkey COL1A2 Protein, His-tagged Mammalian Cell His
Rhesus Macaque COL1A2-785R Recombinant Rhesus Macaque COL1A2 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque COL1A2-785R-B Recombinant Rhesus Macaque COL1A2 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish COL1A2-9688Z Recombinant Zebrafish COL1A2 Mammalian Cell His
Chicken COL1A2-3548C Recombinant Chicken COL1A2 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • COL1A2 Related Articles
  • COL1A2 Related Research Area

COL1A2 involved in several pathways and played different roles in them. We selected most pathways COL1A2 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Binding and Uptake of Ligands by Scavenger Receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL1A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
AmoebiasisPIK3R5;SERPINB10;C9;CTSG;COL4A1;HSPB1;Casp3;TGFB1;GNA11
Assembly of collagen fibrils and other multimeric structuresCTSS;TLL2;MMP13;TLL1;COL1A2;COL4A6;COL6A2;COL3A1;CTSL1
Binding and Uptake of Ligands by Scavenger ReceptorsCOL1A1;SPARC;NFX1;STAB2;IGKC;SAA1;APOBB.1;HYOU1;HP
C-MYB transcription factor networkGATA1;LECT2;MYF6;PTCRA;YEATS4;ADA;CREBBP;PRTN3;TRIM28
Collagen biosynthesis and modifying enzymesCOL1A2;COL3A1;COL5A1;COL6A2;COL28A1A;COL9A1B;COL5A3A;COL19A1;CRTAP
Collagen formationCOL28A1A;COL19A1;CRTAP;PCOLCE;COL4A6;TLL1;LOX;TLDC2;COL10A1A
ECM-receptor interactionCOL27A1A;ITGA6B;COL11A1A;ITGA8;LAMC2;CD44;TNW;LAMA3;COL4A5
EndothelinsEDNRB;EDN1;EDN2;COL1A2;CYSLTR1;EDNRA;EDN3;COL3A1

COL1A2 has several biochemical functions, for example, SMAD binding, extracellular matrix structural constituent, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL1A2 itself. We selected most functions COL1A2 had, and list some proteins which have the same functions with COL1A2. You can find most of the proteins on our site.

Function Related Protein
SMAD bindingBMP2;TGFBR3;SKI;SKOR1B;SMAD2;COL5A2;HIPK2;SKOR2;TGFBR1
extracellular matrix structural constituentCOL5A2;KAL1;LAMC1;ACAN;COL1A2;COL4A1;MUC5AC;COL2A1A;COL11A1B
identical protein bindingPSMA7;DYNLT1F;CTSC;CLDN2;HOOK3;CRYAA;EIF2AK3;FADD;LCK
metal ion bindingAOX4;LFNG;DGCR8;MOBKL2A;INPP5B;STAMBPA;CTDSPL;CA15C;THAP5
platelet-derived growth factor bindingPDGFB;COL3A1;COL2A1;COL1A2;PDGFRB;COL4A1;PDGFA;COL1A1;PDGFRA
protein bindingSNW1;TP53BP1;SOX1;AGXT;WDTC1;EFHA1;POT1A;THEG;SRM
protein binding, bridgingTRIM5;SPRR1A;FKBP4;NEFL;CUX1;VPS18;NCK1;FLRT1;FBXW7

COL1A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL1A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL1A2.

SGTA; UBQLN1; UBQLN1; ITGA2; q69hr1_cioin; q5yb85_strsg; TFAP2A; ZNF16; LOX; gltX; hemL2; TFAP2C; ZWINT; RAB5A

Jacobsen, CM; Barber, LA; et al. Targeting the LRP5 Pathway Improves Bone Properties in a Mouse Model of Osteogenesis Imperfecta. JOURNAL OF BONE AND MINERAL RESEARCH 29:2297-2306(2014).
Grafel, I; Yang, T; et al. Excessive transforming growth factor-beta signaling is a common mechanism in osteogenesis imperfecta. NATURE MEDICINE 20:670-675(2014).
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