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Official Full Name collagen, type I, alpha 2
Background This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2;chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis;and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type;VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms;associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1;chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three;transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene.
Synonyms COL1A2; collagen, type I, alpha 2; OI4, osteogenesis imperfecta type IV; collagen alpha-2(I) chain; alpha 2(I) collagen; alpha 2 collagen type I; collagen I; alpha 2 polypeptide; collagen of skin; tendon and bone; alpha 2 chain; type I procollagen; alpha
    • Species :
    • Chicken
    • Dog
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Zebrafish
    • Source :
    • E.coli
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COL1A2-115H Recombinant Human COL1A2, GST-tagged Wheat Germ GST
    Human COL1A2-116H Recombinant Human COL1A2, His-tagged E.coli His
    Human COL1A2-219H Recombinant Human COL1A2 Protein, His-tagged E.coli His
    Mouse Col1a2-220M Recombinant Mouse Col1a2 Protein, His-tagged E.coli His
    Mouse COL1A2-3725M Recombinant Mouse COL1A2 Protein Mammalian Cell His
    Rat COL1A2-1518R Recombinant Rat COL1A2 Protein Mammalian Cell His
    Rhesus Macaque COL1A2-960R Recombinant Rhesus monkey COL1A2 Protein, His-tagged Mammalian Cell His
    Dog COL1A2-218D Recombinant Dog COL1A2 Protein, His/GST-tagged E.coli His/GST
    Chicken COL1A2-3548C Recombinant Chicken COL1A2 Mammalian Cell His
    Zebrafish COL1A2-9688Z Recombinant Zebrafish COL1A2 Mammalian Cell His

    col1a2 involved in several pathways and played different roles in them. We selected most pathways col1a2 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Binding and Uptake of Ligands by Scavenger Receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with col1a2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amoebiasis VCL; LAMA2; IL12A; COL2A1; CTSG; PIK3CA; LAMC2; COL4A3; C8B; COL5A1
    Assembly of collagen fibrils and other multimeric structures COL5A1; COL5A3B; COL5A3A; BMP1A; TLL1; PLEC; COL8A2; COL3A1; COL4A5; ABHD1
    Binding and Uptake of Ligands by Scavenger Receptors COL1A1; Alb; STAB2; SCGB3A2; SAA1; HPX; HYOU1; COL1A2; SPARC; APOBB.1
    C-MYB transcription factor network SLC25A3; PRTN3; PPID; LECT2; TRIM28; CREBBP; CDKN1B; GATA1; CSF1R; CDK6
    Collagen biosynthesis and modifying enzymes COL8A1; COL4A6; PCOLCE2B; COL25A1; EMID2; COL6A2; COL5A2; COL4A3; TLL2; COL5A3A
    Collagen formation CTSL2; COL6A2; PPIB; COL19A1; COL9A1; COL10A1; PCOLCEB; CD151; COL6A3; MMP20
    ECM-receptor interaction ITGB3; COL27A1A; GP1BB; TNW; LAMC1; ITGA11A; ITGB3B; FN1; LAMA2; TNR
    Endothelins CYSLTR1; EDN1; EDN2; EDNRA; COL3A1; COL1A2; EDN3; EDNRB

    col1a2 has several biochemical functions, for example, SMAD binding, extracellular matrix structural constituent, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by col1a2 itself. We selected most functions col1a2 had, and list some proteins which have the same functions with col1a2. You can find most of the proteins on our site.

    Function Related Protein
    extracellular matrix structural constituent COL11A2; COL5A1; COL4A4; COL24A1; COL2A1B; COL11A1B; ELN; FBN1; COL5A3B; OPTC
    identical protein binding APLP1; PCM1; MMP9; APPL1; EDC3; VAMP2; SLC22A1; NUP153; CLDN7; CLDN15
    metal ion binding ZNF446; GDPD1; FHL2A; HPDL; SMAD7; COX4I2; COL18A1; NEURL1AA; Fcer2a; PARP12B
    platelet-derived growth factor binding Pdgfa&Pdgfb; COL1A2; PDGFRA; COL1A1; PDGFRB; COL2A1; COL3A1; PDGFA; COL5A1; PDGFB
    protein binding PCGF6; RABEP1; AVPR2; FZD6; PGK1; RPL5; SPON1; MYH11; CLNS1A; CREB5
    protein binding, bridging FSCN2B; CBX5; SLC9A1; RBM14; FGA; TRIM5; SH2D1B; CNTLN; TCAP; BCL3

    col1a2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with col1a2 here. Most of them are supplied by our site. Hope this information will be useful for your research of col1a2.

    SGTA; UBQLN1; UBQLN1; ITGA2; q69hr1_cioin; q5yb85_strsg; TFAP2A; ZNF16; LOX; gltX; hemL2; TFAP2C; ZWINT; RAB5A

    Jacobsen, CM; Barber, LA; et al. Targeting the LRP5 Pathway Improves Bone Properties in a Mouse Model of Osteogenesis Imperfecta. JOURNAL OF BONE AND MINERAL RESEARCH 29:2297-2306(2014).
    Grafel, I; Yang, T; et al. Excessive transforming growth factor-beta signaling is a common mechanism in osteogenesis imperfecta. NATURE MEDICINE 20:670-675(2014).

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