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COL4A2

Official Full Name

collagen, type IV, alpha 2
Overview

This gene encodes one of the six subunits of type IV collagen, the major structural component of basement membranes. The C-terminal portion of the protein, known as canstatin, is an inhibitor of angiogenesis and tumor growth. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
Synonyms

COL4A2; collagen, type IV, alpha 2; collagen alpha-2(IV) chain; canstatin; collagen type IV alpha 2; DKFZp686I14213; FLJ22259; ICH; POREN2;

Type

Recombinant Proteins

Species

Chicken
Human
Mouse

Source

E.coli
Insect Cell
Mammalian Cell
Yeast

Tag

His
His|SUMOstar
N

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	COL4A2-2714H	Recombinant Human COL4A2 protein, His-tagged	E.coli	His	1493-1712aa	Inquiry
Human	COL4A2-335H	Recombinant Human COL4A2 Protein, His-tagged	E.coli	His	Ser1487~Ser1703	Inquiry
Human	COL4A2-1263H	Recombinant Human COL4A2 protein, His-tagged	Insect Cell	His	1261-1712aa	Inquiry
Human	COL4A2-1765H	Recombinant Human COL4A2 Protein (Gly1441-Ala1669), N-His tagged	E.coli	N-His	Gly1441-Ala1669	Inquiry
Mouse	COL4A2-2373M	Recombinant Mouse COL4A2 Protein (1481-1707 aa), His-tagged	E.coli	His	1481-1707 aa	Inquiry
Mouse	COL4A2-2327M	Recombinant Mouse COL4A2 Protein (1481-1707 aa), His-sumostar-tagged	Yeast	His/SUMOstar	1481-1707 aa	Inquiry
Chicken	COL4A2-3965C	Recombinant Chicken COL4A2	Mammalian Cell	His		Inquiry

Involved Pathway
Protein Function
Interacting Protein
COL4A2 Related Articles
COL4A2 Related Research Area

COL4A2 involved in several pathways and played different roles in them. We selected most pathways COL4A2 participated on our site, such as Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL4A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Focal adhesion	ITGA5;CDC42L;PDGFRA;PTEN;ACTB1;PIK3R3;VEGFAB;COL5A2A;ARHGAP5
ECM-receptor interaction	COL6A2;VWF;COL6A1;SV2B;COL4A3;ITGA2;ITGA3B;ITGA4;LAMA1

COL4A2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by COL4A2 itself. We selected most functions COL4A2 had, and list some proteins which have the same functions with COL4A2. You can find most of the proteins on our site.

Function	Related Protein

COL4A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL4A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL4A2.

Seidl, C; Port, M; et al. Differential gene expression triggered by highly cytotoxic alpha-Emitter-immunoconjugates in gastric cancer cells. INVESTIGATIONAL NEW DRUGS 28:49-60(2010).

Poschl, E; Schlotzer-Schrehardt, U; et al. Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development. DEVELOPMENT 131:1619-1628(2004).

Collagens