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Official Full Name collagen, type VII, alpha 1
Background This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen.
Synonyms COL7A1; collagen, type VII, alpha 1; EBD1, EBDCT, EBR1, epidermolysis bullosa, dystrophic, dominant and recessive; collagen alpha-1(VII) chain; collagen VII; alpha 1 polypeptide; LC collagen; long-chain collagen; collagen VII, alpha-1 polypeptide; EBD1
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293T
    • Mammalian Cell
    • Tag :
    • His
    • Myc/DDK
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COL7A1-30HL Recombinant Human COL7A1 Cell Lysate, Myc/DDK-tagged HEK293T Myc/DDK
    Human COL7A1-340H Recombinant Human COL7A1 Protein, His-tagged E.coli His
    Mouse COL7A1-3751M Recombinant Mouse COL7A1 Protein Mammalian Cell His

    COL7A1 involved in several pathways and played different roles in them. We selected most pathways COL7A1 participated on our site, such as Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL7A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Protein digestion and absorption KCNQ1; SLC3A2; MEP1B; SLC3A1; CELA2B; CPA3; PGA4; KCNJ13; COL13A1; ATP1B2

    COL7A1 has several biochemical functions, for example, identical protein binding, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COL7A1 itself. We selected most functions COL7A1 had, and list some proteins which have the same functions with COL7A1. You can find most of the proteins on our site.

    Function Related Protein
    identical protein binding STIM1; TLR3; CLDND; LZTFL1; CBLL1; CLDN20; MNS1; TPRG1L; STK4; SF1
    peptidase inhibitor activity WFDC15A; EPPIN; PTTG2; KAL1B; WFDC13; WFDC6A; STFA2; SPINK13; Cstb; SERPINA3M
    serine-type endopeptidase inhibitor activity COL7A1; SERPINH2; WFDC13; SERPINB6; WFDC6; SERPINB1L2; Serpina1c; SERPINA1D; AGT; CD109

    COL7A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL7A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL7A1.


    Tampoia, M; Bonamonte, D; et al. Prevalence of specific anti-skin autoantibodies in a cohort of patients with inherited epidermolysis bullosa. ORPHANET JOURNAL OF RARE DISEASES 8:-(2013).
    Has, C; et al. Molecular genetic assays for inherited epidermolysis bullosa. CLINICS IN DERMATOLOGY 29:420-426(2011).

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