COL7A1
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Official Full Name
collagen, type VII, alpha 1
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Overview
This gene encodes the alpha chain of type VII collagen. The type VII collagen fibril, composed of three identical alpha collagen chains, is restricted to the basement zone beneath stratified squamous epithelia. It functions as an anchoring fibril between the external epithelia and the underlying stroma. Mutations in this gene are associated with all forms of dystrophic epidermolysis bullosa. In the absence of mutations, however, an acquired form of this disease can result from an autoimmune response made to type VII collagen. -
Synonyms
COL7A1; collagen, type VII, alpha 1; EBD1, EBDCT, EBR1, epidermolysis bullosa, dystrophic, dominant and recessive; collagen alpha-1(VII) chain; collagen VII; alpha 1 polypeptide; LC collagen; long-chain collagen; collagen VII, alpha-1 polypeptide; EBD1;
- Recombinant Proteins
- Protein Pre-coupled Magnetic Beads
- Human
- Mouse
- E.coli
- HEK293
- HEK293T
- Mammalian Cell
- Mammalian cells
- Flag
- His
- His (Fc)
- Avi
- Myc
- DDK
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| Human | COL7A1-1006HFL | Recombinant Full Length Human COL7A1 Protein, C-Flag-tagged | Mammalian cells | Flag |
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| Human | COL7A1-340H | Recombinant Human COL7A1 Protein, His-tagged | E.coli | His | Pro190~Asp472 |
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| Human | COL7A1-638H | Recombinant Human COL7A1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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| Human | COL7A1-30HL | Recombinant Human COL7A1 Cell Lysate, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Human | COL7A1-341H | Recombinant Human COL7A1 Protein, Myc/DDK-tagged | HEK293T | Myc/DDK |
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| Human | COL7A1-638H-B | Recombinant Human COL7A1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | COL7A1-3751M | Recombinant Mouse COL7A1 Protein | Mammalian Cell | His |
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| Mouse | COL7A1-1872M-B | Recombinant Mouse COL7A1 Protein Pre-coupled Magnetic Beads | HEK293 |
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| Mouse | COL7A1-1872M | Recombinant Mouse COL7A1 Protein, His (Fc)-Avi-tagged | HEK293 | His (Fc)-Avi |
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- Involved Pathway
- Protein Function
- Interacting Protein
- COL7A1 Related Articles
COL7A1 involved in several pathways and played different roles in them. We selected most pathways COL7A1 participated on our site, such as Protein digestion and absorption, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL7A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Protein digestion and absorption | SLC3A1;COL7A1;CELA2B;ATP1A4;PGA4;ATP1B2;COL6A4;PRSS3;CPA1 |
COL7A1 has several biochemical functions, for example, identical protein binding, peptidase inhibitor activity, serine-type endopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COL7A1 itself. We selected most functions COL7A1 had, and list some proteins which have the same functions with COL7A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | PRKAB2;SH3GLB1;CRYAA;KCNIP2;CLDN8;PARK7;OAT;SP100;PNMA5 |
| peptidase inhibitor activity | PI15A;COL7A1;SERPINB10;SERPINA3K;MUG1;SSPO;PI15;SERPINA1A;PTTG1 |
| serine-type endopeptidase inhibitor activity | WFDC6B;SERPINA5;SERPINB1L2;APPB;SPINT4;SERPINA1D;PAPLNB;SPINK13;SERPINC1 |
COL7A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL7A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL7A1.
Ywhae
- Q&As
- Reviews
Q&As (6)
Ask a questionIt can be diagnosed through genetic testing and skin biopsies. Genetic testing can detect mutations in the COL7A1 gene, while skin biopsies can observe abnormalities in skin structure.
There is currently no cure for the COL7A1 gene mutation, but there are treatments that can relieve symptoms, such as the use of special dressings, medication, and surgery.
The COL7A1 gene has been implicated in a variety of skin injuries, including burns, trauma, and surgical trauma. These injuries may lead to skin complications in DEB patients.
Mutations in the COL7A1 gene can cause structural abnormalities in the skin, making it fragile and prone to blisters and scarring, which can be accompanied by abnormalities in bones and internal organs.
Certain drugs may have efficacy or side effects on the COL7A1 gene mutation, for example, certain immunosuppressants used to treat other skin conditions may have adverse effects on the skin of DEB patients.
Although there is no conclusive evidence that diet can improve the COL7A1 gene mutation, maintaining a balanced diet with adequate protein, vitamins and minerals is beneficial for overall health.
Customer Reviews (3)
Write a reviewCOL7A1 is less polluting, safe and hygienic, and suitable for long-term use.
It is stable under different temperature and pH conditions.
Their service attitude is very good and always patient to answer our questions.
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