COL4A3

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COL4A3

Official Full Name collagen, type IV, alpha 3 (Goodpasture antigen)
Background Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
Synonyms COL4A3; collagen, type IV, alpha 3 (Goodpasture antigen); collagen alpha-3(IV) chain; tumstatin; collagen IV, alpha-3 polypeptide
    • Species :
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Human Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Fc
    • His
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COL4A3-1369H Recombinant Human COL4A3, His-tagged Sf9 Insect Cell His
    Human COL4A3-179H Recombinant Human COL4A3 Mammalian Cell His
    Human COL4A3-334H Recombinant Human COL4A3 Protein, His/GST-tagged E.coli His/GST
    Mouse COL4A3-3737M Recombinant Mouse COL4A3 Protein Mammalian Cell His
    Rat COL4A3-1219RCL Recombinant Rat COL4A3 cell lysate Human Cell N/A
    Rat Col4a3-8807R Recombinant Rat COL4A3, Fc tagged Human Cell Fc

    COL4A3 involved in several pathways and played different roles in them. We selected most pathways COL4A3 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL4A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Amoebiasis RAB7; LAMA3; ACTN2; GNAQ; FN1; COL4A5; LAMA1; IL12A; GNAS; LAMC1
    Assembly of collagen fibrils and other multimeric structures COL5A3A; COL6A1; COL5A2; COL5A1; COL8A2; LOXL3; COL8A1; LOXL1; BMP1B; PCOLCE
    Axon guidance NTN1A; EPHA4; ABLIM3; MYL12B; SCN8A; ROCK1; DUSP7; ROBO1; NTNG1; SEMA7A
    Collagen biosynthesis and modifying enzymes BMP1B; LEPRE1; PCOLCEB; COL8A1A; COL13A1; PCOLCE2B; COL15A1B; PCOLCEA; COL4A4; COL4A5
    Collagen formation ADAMTS3; LEPREL1; MMP13; COL6A1; COL28A1; COL11A1B; COL25A1; SERPINH1; LOX; TLL1
    Developmental Biology INSM1B; RGMA; EPHB4A; KCNQ2; HELZ2; SPTA1; GDNF; CD24; EFNB1; MYL12A
    ECM-receptor interaction FN1A; LAMB1A; TNC; LAMA3; COL11A1A; COL6A2; ITGB5; ITGAV; ITGB3; LAMB2
    Extracellular matrix organization COL9A1; FN1B; LEPREL2; TRAPPC4; LTBP3; MFAP1; LAMB1B; COL6A3; LOXL2; MMP24

    COL4A3 has several biochemical functions, for example, extracellular matrix structural constituent, integrin binding, metalloendopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COL4A3 itself. We selected most functions COL4A3 had, and list some proteins which have the same functions with COL4A3. You can find most of the proteins on our site.

    Function Related Protein
    extracellular matrix structural constituent COL2A1A; PXDN; COL27A1A; LAMB1; COL4A1; LAMA4; ELNA; COL5A2; CHI3L1; MATN1
    integrin binding CTGFA; GPNMB; ANGPTL3; THBS1; ACTN2; Tcam1; NF2; ITGB1BP1; ADAM23; COL3A1
    metalloendopeptidase inhibitor activity SPOCK3; SPOCK1; TIMP1; RECK; BST2; LXN; TIMP4; WFIKKN2; TIMP2A; TIMP3
    protein binding ARL6IP1; IRS4; COBRA1; IFT46; SNX6; LPXN; FABP3; PPCDC; STRAP; MVP
    structural molecule activity CLDN10; CLDN7; ASPH; KRT13; SNTB2; KRT3; KRTAP3-3; SEPT5; NES; SPRR1B

    COL4A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL4A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL4A3.

    KLK6

    Yao, XD; Chen, X; et al. Challenge in pathologic diagnosis of Alport syndrome: evidence from correction of previous misdiagnosis. ORPHANET JOURNAL OF RARE DISEASES 7:-(2012).
    Abrahamson, DR; Hudson, BG; et al. Cellular Origins of Type IV Collagen Networks in Developing Glomeruli. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 20:1471-1479(2009).

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