• Official Full Name
  • collagen, type IV, alpha 3 (Goodpasture antigen)
  • Background
  • Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
  • Synonyms
  • COL4A3; collagen, type IV, alpha 3 (Goodpasture antigen); collagen alpha-3(IV) chain; tumstatin; collagen IV, alpha-3 polypeptide
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL4A3 Protein, His/GST-tagged
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human COL4A3, His-tagged
Source (Host):Mammalian CellsSpecies:Human
Product nameRecombinant Human COL4A3
Source (Host):Species:Human
Product nameRecombinant Human COL4A3, His-tagged
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COL4A3 Protein
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat COL4A3, Fc tagged
Source (Host):HEK293Species:Rat
Product nameRecombinant Rat COL4A3 cell lysate

COL4A3 Related Articles

Yao, XD; Chen, X; et al. Challenge in pathologic diagnosis of Alport syndrome: evidence from correction of previous misdiagnosis. ORPHANET JOURNAL OF RARE DISEASES 7:-(2012).
Abrahamson, DR; Hudson, BG; et al. Cellular Origins of Type IV Collagen Networks in Developing Glomeruli. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 20:1471-1479(2009).