COL4A3 Protein


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Official Full Name collagen, type IV, alpha 3 (Goodpasture antigen)
Background Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter.
Synonyms COL4A3; collagen, type IV, alpha 3 (Goodpasture antigen); collagen alpha-3(IV) chain; tumstatin; collagen IV, alpha-3 polypeptide
    • Species :
    • Bovine
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • Human Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • Fc
    • His
    • GST
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COL4A3-1369H Recombinant Human COL4A3, His-tagged Sf9 Insect Cell His Inquiry
    Human COL4A3-179H Recombinant Human COL4A3 Mammalian Cell His Inquiry
    Mouse COL4A3-3737M Recombinant Mouse COL4A3 Protein Mammalian Cell His Inquiry
    Rat Col4a3-8807R Recombinant Rat COL4A3, Fc tagged Human Cell Fc Inquiry
    Rat COL4A3-1219RCL Recombinant Rat COL4A3 cell lysate Human Cell N/A Inquiry
    Bovine COL4A3-1132B Recombinant Bovine COL4A3 protein, His-tagged E.coli His Inquiry
    Human COL4A3-2715H Recombinant Human COL4A3 protein, His-tagged E.coli His Inquiry
    Human COL4A3-334H Recombinant Human COL4A3 Protein, His/GST-tagged E.coli His/GST Inquiry

    COL4A3 involved in several pathways and played different roles in them. We selected most pathways COL4A3 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL4A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Assembly of collagen fibrils and other multimeric structures LOXL2; LOXL3; COL4A3; COL3A1; CTSB; COL1A1; ABHD1; BMP1A; BMP1; COL10A1A
    Axon guidance EZRA; ROCK1; NCK1; AKAP9; PAK2; SEMA5A; KCNQ3; NTNG1; CDK5R1B; COL4A5
    Collagen biosynthesis and modifying enzymes COL28A1A; COL28A1D; COL8A1; PCOLCEA; TLDC2; COL10A1A; SERPINH1A; SERPINH1B; PPIB; PCOLCEB
    Collagen formation COL10A1; COL9A1; COL28A1; MMP20; COL6A1; COL23A1; BMP1A; BMP1B; COL3A1; PCOLCE2
    Developmental Biology KALRNB; ADAM23; AP2M1; RHOAE; PAQR3B; HIF3A; ITSN1; LGI1B; RHOB; EFNB1
    ECM-receptor interaction COL5A2; GP1BA; LAMA4; COL4A2; VTNA; COL6A2; ITGA1; ITGA9; SV2A; LAMB1A
    Extracellular matrix organization LOX; ADAMTS3; SPARC; TTR; COL4A4; MMP12; TLL1; ADAM9; NID1; BMP10

    COL4A3 has several biochemical functions, for example, extracellular matrix structural constituent, integrin binding, metalloendopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COL4A3 itself. We selected most functions COL4A3 had, and list some proteins which have the same functions with COL4A3. You can find most of the proteins on our site.

    Function Related Protein
    extracellular matrix structural constituent LAMA4; TFPI2; MATN1; COL4A3; COL11A2; ACAN; IMPG2; CD4; KAL1; COL27A1A
    integrin binding ADAM2; CXADR; VWF; ITGB5; FBLN1; ICAM4; S1PR2; ESM1; SFRP2; WISP2
    metalloendopeptidase inhibitor activity BST2; SPOCK1; TIMP3; TIMP2B; WFIKKN1; TIMP1; NGF; TIMP2A; COL4A3; LXN
    protein binding PIN1; CCNF; MRFAP1L1; GPA33; FBXL19; ERCC1; UTP14A; DPP3; GOLPH3; WIF1
    structural molecule activity CLDN11A; KRT42; LAMA3; EPB41L3A; CLDN1; CLDN6; NUMA1; KRTAP3-3; GNL1; CLDN3

    COL4A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL4A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL4A3.


    Yao, XD; Chen, X; et al. Challenge in pathologic diagnosis of Alport syndrome: evidence from correction of previous misdiagnosis. ORPHANET JOURNAL OF RARE DISEASES 7:-(2012).
    Abrahamson, DR; Hudson, BG; et al. Cellular Origins of Type IV Collagen Networks in Developing Glomeruli. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 20:1471-1479(2009).

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