COL4A3
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Official Full Name
collagen, type IV, alpha 3 (Goodpasture antigen) -
Overview
Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. -
Synonyms
COL4A3;collagen, type IV, alpha 3 (Goodpasture antigen);collagen alpha-3(IV) chain;tumstatin;collagen IV, alpha-3 polypeptide
Recombinant Proteins
- Human
- Mouse
- Rat
- Bovine
- Sf9 Cells
- Mammalian Cells
- HEK293
- Human Cells
- E.coli
- His
- Fc
- Non
- GST
- Avi
- Myc
Involved Pathway
COL4A3 involved in several pathways and played different roles in them. We selected most pathways COL4A3 participated on our site, such as Amoebiasis,Assembly of collagen fibrils and other multimeric structures,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL4A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| ECM-receptor interaction | COL27A1B,ITGB1,ITGA1,CD44,LAMB3,ITGA3,COL4A2,ITGB6,COL2A1B,ITGA3B |
| Developmental Biology | TCF3A,DUSP2,EFNA2,LGI1,MED6,CFC1,NADL1.1,SCN8A,HIF3A,MED20 |
| Axon guidance | AP2A1,CFL1,FGFR1B,ADAM10,PHB,MARK3,SEMA5B,JAK2,ROBO1,JAK3 |
| Amoebiasis | PIK3R2,AASS,TLR2,C8B,SERPINB1C,IL1R1,PRKACG,IFNG,ACTN2,PLCB3 |
| Assembly of collagen fibrils and other multimeric structures | ABHD1,LOXL4,CTSB,CTSL2,BMP1B,COL1A1,COL6A2,COL6A3,COL2A1,COL4A6 |
| Collagen formation | LOXL4,MMP20,LEPREL2,COL6A1,LOXL2,COL9A3,COL28A1A,COL2A1,COL8A2,COL9A1A |
| Extracellular matrix organization | CTSLL,LOXL2,CEACAM1,MFAP5,TPSAB1,PRP,F11R.2,COL5A2,COL4A6,MMP19 |
| Collagen biosynthesis and modifying enzymes | COL9A1B,TLL2,COL25A1,COL5A1,COL1A1,LEPRE1,COL8A1,COL6A2,COL23A1,COL16A1 |
Protein Function
COL4A3 has several biochemical functions, for example, extracellular matrix structural constituent,integrin binding,metalloendopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COL4A3 itself. We selected most functions COL4A3 had, and list some proteins which have the same functions with COL4A3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| integrin binding | WISP1B,WISP2,ADAM15,MMP14,NF2,FN1A,FBLN1,L1CAM,ITGB6,CD151 |
| structural molecule activity | JAG1,SPRR4,CLDN7B,CLDN15LA,PLP1,FGG,KRT73,CLDN2,IFLTD1,CLDN15LB |
| protein binding | MYOCD,PSEN1,ACVR1,ZNF350,NRP1,TRIM54,HADHA,CCDC42,Ar,EXOSC2 |
| metalloendopeptidase inhibitor activity | LXN,TIMP2A,FETUB,RECK,TIMP1,BST2,TIMP4,SPOCK1,NGF,TIMP2B |
| extracellular matrix structural constituent | MEPE,MUC5AC,COL4A4,COL11A1A,OPTC,ELNA,MGP,TFPI2,MATN1,LAMB1 |
Interacting Protein
COL4A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL4A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL4A3.
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References
- Yao, XD; Chen, X; et al. Challenge in pathologic diagnosis of Alport syndrome: evidence from correction of previous misdiagnosis. ORPHANET JOURNAL OF RARE DISEASES 7:-(2012).
- Abrahamson, DR; Hudson, BG; et al. Cellular Origins of Type IV Collagen Networks in Developing Glomeruli. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 20:1471-1479(2009).
