COL4A3 involved in several pathways and played different roles in them. We selected most pathways COL4A3 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL4A3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name |
Pathway Related Protein |
| Amoebiasis |
PLCB2; RAB7A; GNA11; SERPINB4; LAMC2; PLCB1; TGFB1; COL3A1; ACTN3; SERPINB6 |
| Assembly of collagen fibrils and other multimeric structures |
LOXL2; LOXL3; COL4A3; COL3A1; CTSB; COL1A1; ABHD1; BMP1A; BMP1; COL10A1A |
| Axon guidance |
EZRA; ROCK1; NCK1; AKAP9; PAK2; SEMA5A; KCNQ3; NTNG1; CDK5R1B; COL4A5 |
| Collagen biosynthesis and modifying enzymes |
COL28A1A; COL28A1D; COL8A1; PCOLCEA; TLDC2; COL10A1A; SERPINH1A; SERPINH1B; PPIB; PCOLCEB |
| Collagen formation |
COL10A1; COL9A1; COL28A1; MMP20; COL6A1; COL23A1; BMP1A; BMP1B; COL3A1; PCOLCE2 |
| Developmental Biology |
KALRNB; ADAM23; AP2M1; RHOAE; PAQR3B; HIF3A; ITSN1; LGI1B; RHOB; EFNB1 |
| ECM-receptor interaction |
COL5A2; GP1BA; LAMA4; COL4A2; VTNA; COL6A2; ITGA1; ITGA9; SV2A; LAMB1A |
| Extracellular matrix organization |
LOX; ADAMTS3; SPARC; TTR; COL4A4; MMP12; TLL1; ADAM9; NID1; BMP10 |
COL4A3 has several biochemical functions, for example, extracellular matrix structural constituent, integrin binding, metalloendopeptidase inhibitor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by COL4A3 itself. We selected most functions COL4A3 had, and list some proteins which have the same functions with COL4A3. You can find most of the proteins on our site.
| Function |
Related Protein |
| extracellular matrix structural constituent |
LAMA4; TFPI2; MATN1; COL4A3; COL11A2; ACAN; IMPG2; CD4; KAL1; COL27A1A |
| integrin binding |
ADAM2; CXADR; VWF; ITGB5; FBLN1; ICAM4; S1PR2; ESM1; SFRP2; WISP2 |
| metalloendopeptidase inhibitor activity |
BST2; SPOCK1; TIMP3; TIMP2B; WFIKKN1; TIMP1; NGF; TIMP2A; COL4A3; LXN |
| protein binding |
PIN1; CCNF; MRFAP1L1; GPA33; FBXL19; ERCC1; UTP14A; DPP3; GOLPH3; WIF1 |
| structural molecule activity |
CLDN11A; KRT42; LAMA3; EPB41L3A; CLDN1; CLDN6; NUMA1; KRTAP3-3; GNL1; CLDN3 |
COL4A3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL4A3 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL4A3.
KLK6
Yao, XD; Chen, X; et al. Challenge in pathologic diagnosis of Alport syndrome: evidence from correction of previous misdiagnosis. ORPHANET JOURNAL OF RARE DISEASES 7:-(2012).
Abrahamson, DR; Hudson, BG; et al. Cellular Origins of Type IV Collagen Networks in Developing Glomeruli. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 20:1471-1479(2009).
