col4a3bp

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col4a3bp

Official Full Name collagen, type IV, alpha 3 (Goodpasture antigen) binding protein
Background This gene encodes a kinase that specifically phosphorylates the N-terminal region of the non-collagenous domain of the alpha 3 chain of type IV collagen, known as the Goodpasture antigen. Goodpasture disease is the result of an autoimmune response directed at this antigen. One isoform of this protein is also involved in ceramide intracellular transport. Three transcript variants encoding different isoforms have been found for this gene.
Synonyms COL4A3BP; collagen, type IV, alpha 3 (Goodpasture antigen) binding protein; collagen type IV alpha-3-binding protein; ceramide transporter; CERT; GPBP; StAR related lipid transfer (START) domain containing 11; STARD11; hCERT; ceramide transfer protein; li
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COL4A3BP-001HCL Recombinant Human COL4A3BP cell lysate Insect Cell N/A
    Human COL4A3BP-11434H Recombinant Human COL4A3BP, GST-tagged E.coli GST
    Human COL4A3BP-1652H Recombinant Human COL4A3BP Protein, GST-tagged Wheat Germ GST
    Human COL4A3BP-2488H Recombinant Human COL4A3BP, His-tagged E.coli His
    Human COL4A3BP-26193TH Recombinant Human COL4A3BP, His-tagged E.coli His
    Human COL4A3BP-27223TH Recombinant Human COL4A3BP, His-tagged E.coli His
    Human COL4A3BP-3280H Recombinant Human COL4A3BP Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human COL4A3BP-8648H Recombinant Human COL4A3BP, His & GST tagged Insect Cell His/GST
    Mouse COL4A3BP-3738M Recombinant Mouse COL4A3BP Protein Mammalian Cell His

    col4a3bp involved in several pathways and played different roles in them. We selected most pathways col4a3bp participated on our site, such as Metabolism, Metabolism of lipids and lipoproteins, Sphingolipid de novo biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with col4a3bp were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Metabolism GLRX; ESRRA; SLC4A1A; NAT2; ACOT8; LPA; CDIPT; GRHL1; DPYD; SULT2ST2
    Metabolism of lipids and lipoproteins GGTLC1; LBR; LMF1; CYP8B2; MED21; CERS5; TMEM195; SLC27A2; ACOT13; CEPT1A
    Sphingolipid de novo biosynthesis COL4A3BP; GDF1; PPM1L; SPTLC1; FA2H; PPM1LA; CERS5; OSBP; PPM1LB; VAPB
    Sphingolipid metabolism PPAP2B; NEU3.1; SPHK2; SGPP1; GDF1; SGMS1; GAL3ST1; PPM1LB; SPTLC3; SMPD5

    col4a3bp has several biochemical functions, for example, ceramide binding, ceramide transporter activity, phosphatidylinositol-4-phosphate binding. Some of the functions are cooperated with other proteins, some of the functions could acted by col4a3bp itself. We selected most functions col4a3bp had, and list some proteins which have the same functions with col4a3bp. You can find most of the proteins on our site.

    Function Related Protein
    ceramide binding COL4A3BP; PLEKHA8; PRRC2B
    ceramide transporter activity COL4A3BP
    phosphatidylinositol-4-phosphate binding LANCL2; SH3PXD2B; ARFIP1; PLEKHF1; CLSTN2; SNX3; GOLPH3; D6WSU116E; OSBP; SESTD1
    protein binding EIF2AK2; METTL21C; AP2A2; METTL9; POU2F1; USH2A; NUP62L; CIB4; NRF1; KCNA4
    protein kinase activity JAK2B; RPS6KA3; PANK1A; PTK2AB; SGK196; NEK10; ARAF; RPS6KA3B; SBK1; MAP3K12

    col4a3bp has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with col4a3bp here. Most of them are supplied by our site. Hope this information will be useful for your research of col4a3bp.

    CSNK1G2; ITGB3BP; ARL6IP1; ACTL8; PARP2; PRKAR1A; MARK2; RTN3

    Plaisier, E; Borradori, L; et al. Anti-glomerular basement membrane nephritis and bullous pemphigoid caused by distinct anti-alpha 3(IV)NC1 and anti-BP180 antibodies in a patient with Crohn's disease. AMERICAN JOURNAL OF KIDNEY DISEASES 40:649-654(2002).
    Netzer, KO; Leinonen, A; et al. The Goodpasture autoantigen - Mapping the major conformational epitope(s) of alpha 3(IV) collagen to residues 17-31 and 127-141 of the NC1 domain. JOURNAL OF BIOLOGICAL CHEMISTRY 274:11267-11274(1999).

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