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COL25A1

Official Full Name

collagen, type XXV, alpha 1
Overview

This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded;protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer;amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of;over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded;protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different;isoforms have been found for this gene.
Synonyms

COL25A1; collagen, type XXV, alpha 1; collagen alpha-1(XXV) chain; alzheimer disease amyloid-associated protein; collagenous Alzheimer amyloid plaque component; collagen-like Alzheimer amyloid plaque component; AMY; CLAC; CLACP; CLAC-P;

Species	Cat.#	Product name	Source (Host)	Tag	Protein Length	Price
Human	COL25A1-1644H	Recombinant Human COL25A1 Protein, GST-tagged	Wheat Germ	GST		Inquiry
Human	COL25A1-11430H	Recombinant Human COL25A1, His-tagged	E.coli	His	C-term-332a.a.	$319 / 25ug
Human	COL25A1-7377HCL	Recombinant Human COL25A1 293 Cell Lysate	HEK293	N/A		Inquiry
Human	COL25A1-2096HF	Recombinant Full Length Human COL25A1 Protein, GST-tagged	In Vitro Cell Free System	GST	496 amino acids	Inquiry

Involved Pathway
Protein Function
Interacting Protein
Other Resource

COL25A1 involved in several pathways and played different roles in them. We selected most pathways COL25A1 participated on our site, such as Collagen biosynthesis and modifying enzymes, Collagen degradation, Collagen formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL25A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name	Pathway Related Protein
Collagen biosynthesis and modifying enzymes	PCOLCE;TLL1;COL11A1B;LEPREL1;PCOLCE2;COL8A1A;CRTAP;COL1A1;COL23A1
Collagen degradation	MMP19;CTS7;MMP20;CTSL1;COL15A1B;CTSD;MGC174155;COL23A1;ADAM10
Collagen formation	PCOLCE2B;LOXL4;CD151;COL9A1A;EMID2;COL28A1D;COL17A1;LEPREL2;LEPRE1
Degradation of the extracellular matrix	NID1;CTSK;COL15A1B;CTSS;CTSB;COL19A1;CAPNS1;COL23A1;ADAMTS8
Extracellular matrix organization	ADAMTS18;PRP;P3H2;COL8A2;MGC174152;FBLN1;COL10A1;COL4A3;LOXL4

COL25A1 has several biochemical functions, for example, beta-amyloid binding, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL25A1 itself. We selected most functions COL25A1 had, and list some proteins which have the same functions with COL25A1. You can find most of the proteins on our site.

Function	Related Protein
beta-amyloid binding	BACE2;ACHE;COL25A1;LDLRAP1;TM2D1;PION;MAPK8IP2;HSD17B10;LDLRAD3
heparin binding	MPO;THBS4;FGF4;NDNF;UBE4A;ABI3BP;SMOC2;CRISPLD2;PLA2G5

COL25A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL25A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL25A1.