COL25A1 Protein


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Official Full Name collagen, type XXV, alpha 1
Background This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded;protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer;amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of;over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded;protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different;isoforms have been found for this gene.
Synonyms COL25A1; collagen, type XXV, alpha 1; collagen alpha-1(XXV) chain; alzheimer disease amyloid-associated protein; collagenous Alzheimer amyloid plaque component; collagen-like Alzheimer amyloid plaque component; AMY; CLAC; CLACP; CLAC-P
    • Species :
    • Human
    • Source :
    • E.coli
    • HEK293
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COL25A1-11430H Recombinant Human COL25A1, His-tagged E.coli His
    Human COL25A1-1644H Recombinant Human COL25A1 Protein, GST-tagged Wheat Germ GST
    Human COL25A1-7377HCL Recombinant Human COL25A1 293 Cell Lysate HEK293 N/A

    COL25A1 involved in several pathways and played different roles in them. We selected most pathways COL25A1 participated on our site, such as Collagen biosynthesis and modifying enzymes, Collagen degradation, Collagen formation, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL25A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Collagen biosynthesis and modifying enzymes LEPREL1; ADAMTS2; P3H2; COL28A1D; ADAMTS3; SERPINH1A; COL17A1; COL1A1; EMID2; COL2A1
    Collagen degradation COL13A1; EMID2; CTSLL; CTSL1; MMP19; COL15A1B; MMP13; COL9A1; MMP15; COL23A1
    Collagen formation COL10A1; TLL1; COL3A1; LEPRE1; MMP13; CD151; COL9A1; TLL2; COL5A3A; COL9A1B
    Degradation of the extracellular matrix MMP19; TLL2; CMA1; ELANE; MMP8; TLDC2; ADAM8; CAPNS1; TIMP2B; CTRB1
    Extracellular matrix organization TLL2; LRP4; COL28A1; TIMP2B; PCOLCEA; TPSAB1; CEACAM8; EFEMP2; COL15A1B; DST

    COL25A1 has several biochemical functions, for example, beta-amyloid binding, heparin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL25A1 itself. We selected most functions COL25A1 had, and list some proteins which have the same functions with COL25A1. You can find most of the proteins on our site.

    Function Related Protein
    beta-amyloid binding BACE1; CST3; APOE; CHRNA7; FBXO2; HBA-A2; MAPK8IP2; OLFM1; HSD17B10; PION
    heparin binding FN1; PTCH1; NELL2; PLA2G5; WISP1; OGN; PTN; FGFBP1; PCOLCE; CYR61L1

    COL25A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL25A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL25A1.

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