col3a1
Share
  • Official Full Name
  • collagen, type III, alpha 1
  • Background
  • This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
  • Synonyms
  • COL3A1; collagen, type III, alpha 1; EDS4A; collagen alpha-1(III) chain; collagen, fetal; alpha1 (III) collagen; Ehlers-Danlos syndrome type IV, autosomal dominant;
Cat.#:COL3A1-1650HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human COL3A1 Protein, GST-tagged
+Inquiry
Cat.#:COL3A1-3440HTag:His
Source (Host):YeastSpecies:Human
Product nameRecombinant Human COL3A1 Protein, His-tagged
+Inquiry
Cat.#:COL3A1-1957HTag:N/A
Source (Host):YeastSpecies:Human
Product nameRecombinant Human Collagen, Type III, Alpha 1
+Inquiry
Cat.#:COL3A1-19587HTag:
Source (Host):Pichia pastorisSpecies:Human
Product nameRecombinant Human COL3A1 protein
+Inquiry
Cat.#:COL3A1-28012THTag:
Source (Host):Species:Human
Product nameRecombinant Human COL3A1
+Inquiry
Cat.#:COL3A1-604HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human COL3A1, His-tagged
+Inquiry
Cat.#:COL3A1-72HTag:
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL3A1
+Inquiry
Cat.#:COL3A1-73HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human COL3A1 protein, MYC/DDK-tagged
+Inquiry
Cat.#:COL3A1-7927HTag:His/GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human COL3A1 protein, His & GST-tagged
+Inquiry
Cat.#:COL3A1-09MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Col3a1 protein, His-tagged
+Inquiry
Cat.#:COL3A1-3734MTag:His
Source (Host):Mammalian CellsSpecies:Mouse
Product nameRecombinant Mouse COL3A1 Protein
+Inquiry
Cat.#:Col3a1-7928MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Col3a1 protein, His-tagged
+Inquiry
Cat.#:COL3A1-1522RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat COL3A1 Protein
+Inquiry
Cat.#:Col3a1-7929RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Col3a1 protein, His-tagged
+Inquiry
Cat.#:COL3A1-961RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey COL3A1 Protein, His-tagged
+Inquiry
Cat.#:COL3A1-6932CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken COL3A1
+Inquiry

Involved Pathway

COL3A1 involved in several pathways and played different roles in them. We selected most pathways COL3A1 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Binding and Uptake of Ligands by Scavenger Receptors, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL3A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Amoebiasis
LAMA4; GNA14; PIK3CD; TGFB1; ARG1; IL1R1; SERPINB10; PRKACB; TGFB3; ITGAM
Assembly of collagen fibrils and other multimeric structures
TLL2; BMP1B; COL5A1; CD151; COL2A1; CTSL1; COL8A1A; COL5A2; COL4A6; COL6A3
Binding and Uptake of Ligands by Scavenger Receptors
NFX1; COL1A1; LOC479668; APOBB.1; HSPH1; COL1A2; SPARC; SAA1; HPX; COL3A1
Collagen biosynthesis and modifying enzymes
COL10A1; COL1A2; COL8A1A; PRP; COL16A1; BMP1A; BMP1; COL4A3; COL28A1; CRTAP
Collagen formation
COL23A1; COL9A1; COL4A3; COL5A3B; LEPREL1; COL6A3; COL3A1; BMP1B; LOXL2; PCOLCE2B
ECM-receptor interaction
CHAD; CD47; SDC4; FN1A; ITGB4; ITGB1B.2; VTN; LAMA1; LAMC1; ITGA8
Endothelins
EDNRA; EDN3; COL1A2; CYSLTR1; COL3A1; EDNRB; EDN1; EDN2
Extracellular matrix organization
EMID2; LOC100686744; COL10A1A; MGC174152; FN1B; PPIB; MATN1; PCOLCE; ELANE; BMP1B

Protein Function

COL3A1 has several biochemical functions, for example, SMAD binding, extracellular matrix structural constituent, integrin binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL3A1 itself. We selected most functions COL3A1 had, and list some proteins which have the same functions with COL3A1. You can find most of the proteins on our site.
Function
Related Protein
Function SMAD binding
Related Protein SKIL; SNW1; TOB1; COL5A2; SOD3; DAB2; ACVR1; SKOR1A; SKOR2; PURA
Function extracellular matrix structural constituent
Related Protein PXDN; COL4A5; FBN2B; LAMA4; COL8A2; MATN3; MFAP5; COL4A6; ACAN; MATN1
Function integrin binding
Related Protein SRC; PTPN2; TGFBI; SEMA7A; WISP2; ACTN2; TLN1; ACTN4; CD9; ADAM17
Function metal ion binding
Related Protein ZDHHC20A; ZNF292A; TGM1; ZNF286A; RNF26; CHSY3; ZFP488; PRDM9; FLYWCH1; GNA15
Function platelet-derived growth factor binding
Related Protein Pdgfa&Pdgfb; PDGFB; PDGFA; COL1A2; COL6A1; COL5A1; COL3A1; PDGFRB; PDGFRA; COL2A1
Function protein binding
Related Protein DTX3L; PRH2; KLRD1; FTL; COX5B; HIPK4; MALT1; PEX11B; TMEM119; SPSB4

Interacting Protein

COL3A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL3A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL3A1.
all3_aedae; zwf; LOX; ispH; lcrS; pdpD2; q5nfa1_fratt; galT; pbpG; htrE; nagE; opuD; mutTA; thiF; katB; rpoB; q81vw1_bacan; q8ckb2_yerpe; mutY

COL3A1 Related Articles

Vittal, R; Mickler, EA; et al. Type V Collagen Induced Tolerance Suppresses Collagen Deposition, TGF-beta and Associated Transcripts in Pulmonary Fibrosis. PLOS ONE 8:-(2013).
Hung, CF; Rohani, MG; et al. Role of IGF-1 pathway in lung fibroblast activation. RESPIRATORY RESEARCH 14:-(2013).