| Official Full Name | collagen, type II, alpha 1 |
| Background | Type II collagen is the major collagen found in cartilage and is expressed in two forms: IIA and IIB. Type IIA procollagen contains an N-terminal 69 amino acid, cysteine-rich globular domain that is encoded by exon 2. Type IIB procollagen is synthesized by mature chondrocytes in cartilage while Type IIA procollagen is synthesized by chondroprogenitor cells. The Type IIA N-propeptide (PIIANP) has been postulated to play a role in chondrogensis. Type IIA procollagen has been found to be synthesized by osteoarthritic chondrocytes in diseased cartilage and may serve as a specific arthritis biomarker that reflects an attempt by the chondrocytes to repair diseased cartilage. |
| Synonyms | ANFH; AOM; COL11A3; SEDC; alpha-1 type II collagen; cartilage collagen; chondrocalcin; collagen II, alpha-1 polypeptide; collagen alpha-1(II) chain; COL2A1 |
| Species | Cat.# | Product name | Source (Host) | Tag | Protein Length | Price |
|---|
COL2A1 involved in several pathways and played different roles in them. We selected most pathways COL2A1 participated on our site, such as Amoebiasis, Assembly of collagen fibrils and other multimeric structures, Collagen biosynthesis and modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amoebiasis | GNAQ; ACTN2; LAMB2; MUC2; SERPINB1; PLCB3; RELA; SERPINB10; IL1R1; COL24A1 |
| Assembly of collagen fibrils and other multimeric structures | COL1A1; LOXL2; COL6A2; CTSL2; LOXL4; COL4A5; COL4A3; PCOLCE; TLL2; ABHD1 |
| Collagen biosynthesis and modifying enzymes | COL4A4; COL10A1; TLL2; SERPINH1A; COL28A1; COL9A3; COL1A2; COL8A2; SERPINH1B; COL19A1 |
| Collagen formation | CRTAP; COL11A1B; COL13A1; ABHD1; COL15A1B; PCOLCEB; PCOLCE2B; COL9A1; SERPINH1A; TLL1 |
| ECM-receptor interaction | ITGB3B; ITGA5; COL6A5; LAMB3; LAMA1; VTNA; FN1A; ITGA8; COL2A1; COL6A2 |
| Endochondral Ossification | FRZB; PTH; CDKN1C; PTHLHA; SOX5; RUNX3; DDR2; ADAMTS4; PTHLH; CTSL2 |
| Extracellular matrix organization | LOC100514666; BMP1A; TTR; COL4A3; MATN3; TLL1; COL8A2; MMP12; EFEMP2; ITGB3A |
| Focal Adhesion | COL5A2; COL5A2A; ITGAV; COL27A1B; PAK6; RAP1AB; PRKCBB; COL1A1A; ITGB7; PPP1R12B |
COL2A1 has several biochemical functions, for example, extracellular matrix structural constituent conferring tensile strength, identical protein binding, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL2A1 itself. We selected most functions COL2A1 had, and list some proteins which have the same functions with COL2A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| extracellular matrix structural constituent conferring tensile strength | COL2A1; COL9A1; COL9A3 |
| identical protein binding | CDC42; PTS; IIGP1; FBP1; CLDN14; DNMT3A; SORD; RAD51; CPT1A; FZD1 |
| metal ion binding | ARSI; CYB5D1; RPAIN; Car12; TDO2A; ZDHHC13; LTN1; ZFP92; XRCC6BP1; KLK1B3 |
| platelet-derived growth factor binding | COL5A1; COL6A1; COL4A1; PDGFRB; COL3A1; COL2A1; COL1A1; PDGFRA; Pdgfa&Pdgfb; PDGFB |
COL2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL2A1.
COCH; RELA; HYAL1
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