COL2A1

  • Official Full Name

    collagen, type II, alpha 1

  • Overview

    Type II collagen is the major collagen found in cartilage and is expressed in two forms: IIA and IIB. Type IIA procollagen contains an N-terminal 69 amino acid, cysteine-rich globular domain that is encoded by exon 2. Type IIB procollagen is synthesized by mature chondrocytes in cartilage while Type IIA procollagen is synthesized by chondroprogenitor cells. The Type IIA N-propeptide (PIIANP) has been postulated to play a role in chondrogensis. Type IIA procollagen has been found to be synthesized by osteoarthritic chondrocytes in diseased cartilage and may serve as a specific arthritis biomarker that reflects an attempt by the chondrocytes to repair diseased cartilage.

  • Synonyms

    ANFH;AOM;COL11A3;SEDC;alpha-1 type II collagen;cartilage collagen;chondrocalcin;collagen II, alpha-1 polypeptide;collagen alpha-1(II) chain;COL2A1

Recombinant Proteins

  • Human
  • Rat
  • Mouse
  • Chicken
  • Rabbit
  • Bovine
  • HEK293
  • E.coli
  • CHO
  • Mammalian Cells
  • Wheat Germ
  • Human Cells
  • Fetal bovine articular cartilage
  • Chick sternum
  • Human joint
  • Human Nasal Septum
  • In Vitro Cell Free System
  • His
  • GST
  • Non
  • Avi
  • Fc
Cat.# Product name Source (Host) Species Tag Protein Length Price
COL2A1-3929H Recombinant Human COL2A1 protein(Asp1242-Leu1487), His-tagged HEK293 Human His Asp1242-Leu1487
COL2A1-11432H Recombinant Human COL2A1, His-tagged E.coli Human His C-288a.a.
COL2A1-26H Active Recombinant Human COL2A1 protein, His-tagged CHO Human His 26-266;957-1487 a.a.
COL2A1-1521R Recombinant Rat COL2A1 Protein Mammalian Cells Rat His
COL2A1-1649H Recombinant Human COL2A1 Protein, GST-tagged Wheat Germ Human GST
COL2A1-181H Recombinant Human COL2A1 Mammalian Cells Human His
Col2a1-36M Recombinant Mouse Col2a1 protein, His-tagged HEK293 Mouse His
COL2A1-3733M Recombinant Mouse COL2A1 Protein Mammalian Cells Mouse His
COL2A1-5996C Recombinant Chicken COL2A1 Mammalian Cells Chicken His
Col2a1-7924M Recombinant Mouse Col2a1 protein, His-tagged E.coli Mouse His Gly677~Ala817
Col2a1-7925R Recombinant Rat Col2a1 protein, His-tagged E.coli Rat His Lys1226~Tyr1331
COL2A1-7926R Recombinant Rabbit COL2A1 protein, His & GST-tagged E.coli Rabbit GST&His Leu1259~Val1449
COL2A1-2063HCL Recombinant Human COL2A1 cell lysate Human Cells Human Non 1242-1487 a.a.
COL2A1-1178R Recombinant Rat COL2A1 Protein, His (Fc)-Avi-tagged HEK293 Rat Avi&Fc&His
COL2A1-1178R-B Recombinant Rat COL2A1 Protein Pre-coupled Magnetic Beads HEK293 Rat
Col2a1-1278M Recombinant Mouse Col2a1 protein, His-tagged E.coli Mouse His Thr1307~Thr1383
Col2a1-1279M Recombinant Mouse Col2a1 Protein, His-tagged E.coli Mouse His Asp1242-Leu1487
Col2a1-1280M Recombinant Mouse Col2a1 protein, His-tagged HEK293 Mouse His Asp1242~Leu1487
COL2a1-1284H Recombinant Human COL2a1 protein, His-tagged E.coli Human His Gln26~Ala181
COL2A1-13B Native Bovine COL2A1 Protein Fetal bovine articular cartilage Bovine
COL2A1-14B Native Bovine COL2A1 Protein Fetal bovine articular cartilage Bovine
COL2A1-15C Native Chicken COL2A1 Protein Chick sternum Chicken
COL2A1-1647H Native Human COL2A1 Protein Human joint Human Non
COL2A1-1648H Native Human COL2A1 Protein Human Nasal Septum Human Non
COL2A1-16C Native Chicken COL2A1 Protein Chick sternum Chicken
COL2A1-1763H Recombinant Human COL2A1 Protein (Ser1386-Pro1467), N-His tagged E.coli Human His Ser1386-Pro1467
COL2A1-1861M Recombinant Mouse COL2A1 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&Fc&His
COL2A1-1861M-B Recombinant Mouse COL2A1 Protein Pre-coupled Magnetic Beads HEK293 Mouse
COL2A1-2137HF Recombinant Full Length Human COL2A1 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 268 amino acids
COL2A1-2155H Recombinant Human COL2A1 Protein, His-tagged E.coli Human His Trp1337-Leu1487
COL2A1-2156H Recombinant Human COL2A1 Protein, His-tagged E.coli Human His Asp1242-Leu1487
COL2A1-2712H Recombinant Human COL2A1 Protein, His (Fc)-Avi-tagged HEK293 Human Avi&Fc&His
COL2A1-2712H-B Recombinant Human COL2A1 Protein Pre-coupled Magnetic Beads HEK293 Human
COL2a1-3325M Recombinant Mouse COL2a1 protein, His-GST-tagged E.coli Mouse GST&His Gly677~Ala817

    Involved Pathway

    COL2A1 involved in several pathways and played different roles in them. We selected most pathways COL2A1 participated on our site, such as Amoebiasis,Assembly of collagen fibrils and other multimeric structures,Collagen biosynthesis and modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Endochondral Ossification CDKN1C,PTH,PTHLH,MMP13,COL10A1A,NKX3.2,NKX3-2,SERPINH1,FRZB,SOX6
    Assembly of collagen fibrils and other multimeric structures COL5A1,COL10A1,MMP20,DST,LOXL4,COL5A3B,COL6A3,ABHD1,LOXL3,COL11A1B
    Collagen formation ABHD1,CTSL2,MMP20,COL13A1,LOXL2,MMP13,LOXL4,PCOLCE2B,CTSL1,COL10A1
    ECM-receptor interaction COL27A1A,VWF,HMMR,Reln,ITGA3B,CD44,COL11A2,SDC4,COL4A6,ITGB1
    Collagen biosynthesis and modifying enzymes COL13A1,COL4A3,COL8A1A,ADAMTS2,BMP1A,COL9A3,TLL2,COL17A1A,SERPINH1B,PCOLCEA
    Amoebiasis ITGB2L,SERPINB2,IL1B2,PIK3CA,LAMB3,ACTN2,LAMB2,SERPINB3C,GNAL,TNF
    Extracellular matrix organization BGNA,LOXL3,MFAP1B,MATN3B,COL15A1B,PCOLCE2B,CAPNS1,F11R.2,CTSD,COL4A5
    Focal adhesion AKT2,ITGA2B,LAMB2,VTNA,CAPN2,ITGB7,COL24A1,PAK4,COL1A1,PGF

    Protein Function

    COL2A1 has several biochemical functions, for example, extracellular matrix structural constituent conferring tensile strength,identical protein binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL2A1 itself. We selected most functions COL2A1 had, and list some proteins which have the same functions with COL2A1. You can find most of the proteins on our site.

    Function Related Protein
    metal ion binding DTX1,GTPBP8,NRP1,CACNA2D4,CYP2AA9,HBBE1.1,ZNF484,ZNF280D,GH1,HRG
    extracellular matrix structural constituent conferring tensile strength COL9A3,COL9A1
    identical protein binding PRPF19,STIM1,C1S,ANXA4,ESYT2,B2M,COL7A1,SP100,CLDN7,CBX3
    platelet-derived growth factor binding COL1A2,COL1A1,PDGFB,PDGFRA,COL4A1,PDGFRB,Pdgfa&Pdgfb,PDGFA,COL3A1,COL5A1

    Interacting Protein

    COL2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL2A1.

    COCH;RELA;HYAL1

    Resources

    Research Area

    References

    • Tillgren, V; Ho, JCS; et al. The Novel Small Leucine-rich Protein Chondroadherin-like (CHADL) Is Expressed in Cartilage and Modulates Chondrocyte Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 290:918-925(2015).
    • Li, J; Xie, ZG; et al. Calcitonin treatment is associated with less severe osteoarthritis and reduced toll-like receptor levels in a rat model. JOURNAL OF ORTHOPAEDIC SCIENCE 19:1019-1027(2014).

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