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COL9A1

  • Official Full Name

    collagen, type IX, alpha 1

  • Overview

    This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Mutations in this gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, and with Stickler syndrome, a disease characterized by ophthalmic, orofacial, articular, and auditory defects. Two transcript variants that encode different isoforms have been identified for this gene.
  • Synonyms

    COL9A1; collagen, type IX, alpha 1; MED; EDM6; STL4; DJ149L1.1.2;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rat
  • E.coli
  • HEK293
  • HEK293T
  • Human Cell
  • In Vitro Cell Free System
  • Mammalian Cell
  • Mammalian cells
  • Wheat Germ
  • C
  • His
  • mFc
  • Fc
  • Flag
  • GST
  • His (Fc)
  • Avi
  • Myc
  • DDK
  • MYC
  • Myc|DDK
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human COL9A1-265H Recombinant Human COL9A1 protein(Met1-Pro328), mFc-tagged HEK293 C-mFc Met1-Pro328
Human COL9A1-11442H Recombinant Human COL9A1, GST-tagged E.coli GST 20-328a.a.
Human COL9A1-147H Recombinant Human COL9A1, His tagged Human Cell Fc
Human COL9A1-1663H Recombinant Human COL9A1 Protein, GST-tagged Wheat Germ GST
Human COL9A1-758HCL Recombinant Human COL9A1 cell lysate Human Cell N/A
Human COL9A1-796HCL Recombinant Human COL9A1 cell lysate Human Cell N/A
Human COL9A1-5853H Recombinant Human COL9A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human COL9A1-639H-B Recombinant Human COL9A1 Protein Pre-coupled Magnetic Beads HEK293
Human COL9A1-639H Recombinant Human COL9A1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human COL9A1-3298H Recombinant Human COL9A1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human COL9A1-4078H Recombinant Human COL9A1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human COL9A1-2183HF Recombinant Full Length Human COL9A1 Protein, GST-tagged In Vitro Cell Free System GST 328 amino acids
Human COL9A1-729HFL Recombinant Full Length Human COL9A1 Protein, C-Flag-tagged Mammalian cells Flag
Human COL9A1-2324H Recombinant Human COL9A1 protein, His-tagged HEK293 His Met1-Pro328
Human COL9A1-1772H Recombinant Human COL9A1 Protein (Ala24-Pro328), C-His tagged Mammalian cells C-His Ala24-Pro328
Mouse Col9a1-919M Recombinant Mouse Col9a1 Protein, MYC/DDK-tagged HEK293T MYC/DDK
Rat Col9a1-336R Recombinant Rat Col9a1 Protein, His-tagged E.coli N/A Phe24~Leu268
Chicken COL9A1-3731C Recombinant Chicken COL9A1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • COL9A1 Related Research Area

COL9A1 involved in several pathways and played different roles in them. We selected most pathways COL9A1 participated on our site, such as Axon guidance, Collagen biosynthesis and modifying enzymes, Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL9A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Axon guidanceRHOD;FRS2B;PPP3CC;ROCK2;EPHA10;DLG3;EFNA5;PAK2;ARPC5
Collagen biosynthesis and modifying enzymesCOL13A1;COL9A1A;COL4A3;COL28A1;SERPINH1A;COL9A1;PCOLCEA;LEPRE1;TLDC2
Collagen degradationMMP10;COL17A1;MMP19;COL13A1;MGC174155;COL9A3;MMP8;COL23A1;ADAM9
Collagen formationADAMTS3;COL5A3A;PRP;COL3A1;LEPREL1;SERPINH1B;LEPREL2;DST;ADAMTS2
Degradation of the extracellular matrixEMID2;MMP12;CTSL2;ADAM8A;MMP20;TLDC2;CTSS;CMA1;NID1
Developmental BiologyNTN1A;PEA15A;PCSK6;FRS2A;MYL9;SPTBN1;EFNB2;MED25;EPHA10
ECM proteoglycansDMP1;MUSK;COL9A1;SPARC;BGNB;VCANB;ACAN;MATN4;ITGB3A
Extracellular matrix organizationLOXL2;CTSD;COMP;EFEMP1;LTBP4;MFAP1B;CEACAM8;CMA1;LEPRE1

COL9A1 has several biochemical functions, for example, extracellular matrix structural constituent conferring tensile strength, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL9A1 itself. We selected most functions COL9A1 had, and list some proteins which have the same functions with COL9A1. You can find most of the proteins on our site.

Function Related Protein
extracellular matrix structural constituent conferring tensile strengthCOL9A1;COL2A1;COL9A3
metal ion bindingACVR1;RBM4.2;ZFP932;TRIM35-24;CYP2X10.2;ALOX5B.3;EPT1;CYGB2;BMX

COL9A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL9A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL9A1.

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