|Official Full Name||collagen, type IX, alpha 1|
|Background||This gene encodes one of the three alpha chains of type IX collagen, which is a minor (5-20%) collagen component of hyaline cartilage. Type IX collagen is usually found in tissues containing type II collagen, a fibrillar collagen. Studies in knockout mice have shown that synthesis of the alpha 1 chain is essential for assembly of type IX collagen molecules, a heterotrimeric molecule, and that lack of type IX collagen is associated with early onset osteoarthritis. Mutations in this gene are associated with osteoarthritis in humans, with multiple epiphyseal dysplasia, 6, a form of chondrodysplasia, and with Stickler syndrome, a disease characterized by ophthalmic, orofacial, articular, and auditory defects. Two transcript variants that encode different isoforms have been identified for this gene.|
|Synonyms||COL9A1; collagen, type IX, alpha 1; MED; EDM6; STL4; DJ149L1.1.2|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
col9a1 involved in several pathways and played different roles in them. We selected most pathways col9a1 participated on our site, such as Axon guidance, Collagen biosynthesis and modifying enzymes, Collagen degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with col9a1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Axon guidance||NFATC4; NRP2; TRIO; EFNB2A; EFNB3; RND1L; HRAS; SEMA3C; RNF8; PAQR3B|
|Collagen biosynthesis and modifying enzymes||COL6A1; COL11A1B; COL8A1; BMP1; COL5A2; LEPRE1; PPIB; COL9A3; PCOLCE; TLL1|
|Collagen degradation||MMP11; CTSK; TLDC2; CTSB; CTSD; MMP15; LOC100686744; COL19A1; MGC174152; COL25A1|
|Collagen formation||COL23A1; COL3A1; COL4A5; COL9A1B; COL2A1; COL9A3; COL17A1A; CTSL2; MMP20; TLL1|
|Degradation of the extracellular matrix||MMP15; TPSAB1; ADAMTS5; MMP17; COL9A3; ACAN; MMP12; BMP1B; COL25A1; MMP10|
|Developmental Biology||CCNC; RANBP9; FGFR1B; SEMA4D; KBTBD7; DUSP1; EFNA5; EFNA1A; CLTA; DPYSL2|
|ECM proteoglycans||BGNB; ASPN; COL9A3; HAPLN1; MUSK; MATN4; COMP; SPARC; ACAN; DMP1|
|Extracellular matrix organization||TTR; CEACAM1; LEPREL2; TLL1; LOXL4; LEPREL1; ADAMTS18; TIMP2B; HAPLN1; BMP10|
col9a1 has several biochemical functions, for example, extracellular matrix structural constituent conferring tensile strength, metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by col9a1 itself. We selected most functions col9a1 had, and list some proteins which have the same functions with col9a1. You can find most of the proteins on our site.
|extracellular matrix structural constituent conferring tensile strength||COL9A3; COL9A1; COL2A1|
|metal ion binding||GLRX2; ZFP184; RC3H1; WBP7; MARCH9; Car9; ZFP428; SUZ12B; ZNF428; PAPL|
col9a1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with col9a1 here. Most of them are supplied by our site. Hope this information will be useful for your research of col9a1.