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Official Full Name collagen, type XVII, alpha 1
Background This gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.
Synonyms COL17A1; collagen, type XVII, alpha 1; BPAG2; collagen alpha-1(XVII) chain; BP180; alpha 1 type XVII collagen; collagen XVII, alpha-1 polypeptide; 180 kDa bullous pemphigoid antigen 2; bullous pemphigoid antigen 2 (180kD); bA16H23.2 (collagen, type XVII,
    • Species :
    • Human
    • Mouse
    • Source :
    • E.coli
    • HEK293
    • Mammalian Cell
    • Tag :
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COL17A1-329H Recombinant Human COL17A1 Protein, His-tagged E.coli His
    Human COL17A1-7378HCL Recombinant Human COL17A1 293 Cell Lysate HEK293 N/A
    Mouse COL17A1-3721M Recombinant Mouse COL17A1 Protein Mammalian Cell His

    COL17A1 involved in several pathways and played different roles in them. We selected most pathways COL17A1 participated on our site, such as Alpha6-Beta4 Integrin Signaling Pathway, Cell junction organization, Cell-Cell communication, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL17A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Alpha6-Beta4 Integrin Signaling Pathway SMAD3B; DST; DSP; EGFR; NTN1A; CD151; CDKN1A; EIF4EB; PLEC; MST1R
    Cell junction organization CLDN20; CDH9; CDH8; CDH12; CDH17; F11R.2; CLDN7; CLDN3; PVRL2L; FERMT2
    Cell-Cell communication CLDN4; CDH10; KIRREL2; KIRREL3; DSCAML1; CD151; CLDN20; DCC; CDH3; SIRPA
    Collagen biosynthesis and modifying enzymes PRP; SERPINH1; COL5A1; TLDC2; COL9A1; PCOLCE2B; COL19A1; COL23A1; COL5A3B; COL3A1
    Collagen degradation COL19A1; MMP13; MMP19; COL25A1; CTSD; MMP11; COL9A3; COL17A1; LOC100686744; CTSL1
    Collagen formation MMP20; COL17A1; COL10A1; COL1A1; BMP1B; CRTAP; P3H2; ADAMTS2; COL8A1A; PRP
    Degradation of the extracellular matrix FAM49BA; CMA1; ACAN; MMP17; TIMP2; COL9A3; CAPNS1; ADAMTS4; MMP10; BMP1B
    Extracellular matrix organization COL23A1; TLDC2; COL10A1A; FBN1; ADAM8A; BSG; MMP17; MFAP2; LOXL1; FURINB

    COL17A1 has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL17A1 itself. We selected most functions COL17A1 had, and list some proteins which have the same functions with COL17A1. You can find most of the proteins on our site.

    Function Related Protein
    protein binding HIST1H4G; FANCG; FAM127B; DLG3; DPP3; SRMS; ZNF580; POLG; HSPA13; IPO4

    COL17A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL17A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL17A1.

    ssdna_dtdc; EGFR

    Krenacs, T; Kiszner, G; et al. Collagen XVII is expressed in malignant but not in benign melanocytic tumors and it can mediate antibody induced melanoma apoptosis. HISTOCHEMISTRY AND CELL BIOLOGY 138:653-667(2012).
    Levell, NJ; Wingfield, CG; et al. Severe lower limb cellulitis is best diagnosed by dermatologists and managed with shared care between primary and secondary care. BRITISH JOURNAL OF DERMATOLOGY 164:1326-1328(2011).

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