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Official Full Name collagen, type XI, alpha 2
Background This gene encodes one of the two alpha chains of type XI collagen, a minor fibrillar collagen. It is located on chromosome 6 very close to but separate from the gene for retinoid X receptor beta. Type XI collagen is a heterotrimer but the third alpha chain is a post-translationally modified alpha 1 type II chain. Proteolytic processing of this type XI chain produces PARP, a proline/arginine-rich protein that is an amino terminal domain. Mutations in this gene are associated with type III Stickler syndrome, otospondylomegaepiphyseal dysplasia (OSMED syndrome), Weissenbacher-Zweymuller syndrome, autosomal dominant non-syndromic sensorineural type 13 deafness (DFNA13), and autosomal recessive non-syndromic sensorineural type 53 deafness (DFNB53). Alternative splicing results in multiple transcript variants. A related pseudogene is located nearby on chromosome 6.
Synonyms COL11A2; collagen, type XI, alpha 2; DFNA13, DFNB53; collagen alpha-2(XI) chain; HKE5; COBA2_HUMAN; Collagen alpha 2(XI); Collagen type XI alpha 2; DAQB-79P13.8; DFNA13; HGNC:2187; PARP; STL3; pro-a2 chain of collagen type XI; DFNB53
    • Species :
    • Human
    • Zebrafish
    • Source :
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human COL11A2-1635H Recombinant Human COL11A2 Protein, GST-tagged Wheat Germ GST
    Zebrafish COL11A2-4947Z Recombinant Zebrafish COL11A2 Mammalian Cell His

    COL11A2 involved in several pathways and played different roles in them. We selected most pathways COL11A2 participated on our site, such as Focal adhesion, ECM-receptor interaction, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL11A2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Focal adhesion CDC42L2; PARVG; IGF1RB; LAMA2; CHAD; LAMB2; PDPK1B; COL6A1; BIRC2; MYL10
    ECM-receptor interaction ITGA6; THBS3A; COL1A1; TNR; ITGA2B; COL2A1; LAMB2; COL4A3; ITGB4; COL4A5

    COL11A2 has several biochemical functions, for example, extracellular matrix structural constituent. Some of the functions are cooperated with other proteins, some of the functions could acted by COL11A2 itself. We selected most functions COL11A2 had, and list some proteins which have the same functions with COL11A2. You can find most of the proteins on our site.

    Function Related Protein
    extracellular matrix structural constituent MATN1; COL4A4; MUC5AC; COL11A1A; CD4; BGN; CHI3L1; OPTC; MATN3; COL5A1

    COL11A2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL11A2 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL11A2.

    Oh, CD; Maity, SN; et al. Identification of SOX9 Interaction Sites in the Genome of Chondrocytes. PLOS ONE 5:-(2010).
    Lee, HS; Lee, AT; et al. Several regions in the major histocompatibility complex confer risk for anti-CCP-antibody positive rheumatoid arthritis, independent of the DRB1 locus. MOLECULAR MEDICINE 14:293-300(2008).

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