Recombinant Human TRIM16 Protein (A2-P564), His/Strep tagged

• Cat.No.: TRIM16-0415H
• Product Overview: Recombinant Human 8His-StrepII-TEV-(GG)-TRIM16(A2-P564 end) Protein was expressed in Insect cell.

Specification

• Description: E3 ubiquitin ligase that plays an essential role in the organization of autophagic response and ubiquitination upon lysosomal and phagosomal damages. Plays a role in the stress-induced biogenesis and degradation of protein aggresomes by regulating the p62-KEAP1-NRF2 signaling and particularly by modulating the ubiquitination levels and thus stability of NRF2. Acts as a scaffold protein and facilitates autophagic degradation of protein aggregates by interacting with p62/SQSTM, ATG16L1 and LC3B/MAP1LC3B. In turn, protects the cell against oxidative stress-induced cell death as a consequence of endomembrane damage.
• Source: Insect cell
• Species: Human
• Tag: His/Strep
• Form: Liquid
• Protein Length: A2-P564
• Endotoxin: < 0.01 EU per μg of the protein
• Purity: 90%
• Stability: Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
• Storage: Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
• Storage Buffer: Supplied as sterile 50 mM Tris-HCl (pH7.5), 200 mM NaCl, 20% glycerol
• Shipping: It is shipped out with blue ice.

Gene Information

• Gene Name: TRIM16 tripartite motif containing 16 [ Homo sapiens (human) ]
• Official Symbol: TRIM16
• Synonyms: TRIM16; tripartite motif containing 16; tripartite motif-containing protein 16; EBBP; estrogen responsive B box protein; tripartite motif-containing 16; estrogen-responsive B box protein; DKFZp434O1826
• Gene ID: 10626
• mRNA Refseq: NM_006470
• Protein Refseq: NP_006461
• MIM: 609505
• UniProt ID: O95361