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Official Full Name tripartite motif containing 33
Background The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]
Synonyms TRIM33; tripartite motif containing 33; ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA; E3 ubiquitin-protein ligase TRIM33; TIF1-gamma; protein Rfg7; ectodermin homolog; RET-fused gene 7 protein; tripartite motif-containing 33; transcriptional intermediary factor 1 gamma;
    • Species :
    • Human
    • Mouse
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Insect Cells
    • Mammalian Cell
    • Sf9 Insect Cell
    • Tag :
    • DDK
    • Flag
    • GST
    • His
    • Myc/DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TRIM33-110H Recombinant Human TRIM33 Protein, His-tagged Insect Cell His
    Human TRIM33-227H Recombinant Human TRIM33 Protein, GST-tagged E.coli GST
    Human TRIM33-228H Recombinant Human TRIM33 Protein, His-tagged E.coli His
    Human TRIM33-229H Recombinant Human TRIM33 Protein, GST-tagged E.coli GST
    Human TRIM33-230H Recombinant Human TRIM33 Protein, His-tagged E.coli His
    Human TRIM33-336H Recombinant Human TRIM33 Protein, Flag-tagged Insect Cells Flag
    Human TRIM33-506H Recombinant Human TRIM33 Protein, DDK-tagged Sf9 Insect Cell DDK
    Human TRIM33-781HCL Recombinant Human TRIM33 293 Cell Lysate HEK293 N/A
    Human TRIM33-83H Recombinant Human TRIM33, His&FLAG-tagged E.coli His/Flag
    Mouse Trim33-6654M Recombinant Mouse Trim33 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Zebrafish TRIM33-859Z Recombinant Zebrafish TRIM33 Mammalian Cell His

    TRIM33 involved in several pathways and played different roles in them. We selected most pathways TRIM33 participated on our site, such as Downregulation of SMAD2/3:SMAD4 transcriptional activity, Gene Expression, Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Downregulation of SMAD2/3:SMAD4 transcriptional activity TRIM33; SKIB; SKIA; SKI; SMAD3B; RNF111; SKILB; USP9X; USP9; PARP1
    Gene Expression SUZ12; ZNF212; PHF1; ZNF620; RARG; ZNF556; ZFP1; ZNF718; ZNF485; CTGF
    Generic Transcription Pathway LAMTOR1; RARG; MED10; COX8A; ZKSCAN4; ZNF19; RARGA; ZNF707; ZNF480; ZNF75D
    Signal Transduction ADH8A; OPN1SW1; HCAR1-2; TNKS; ARHGEF18; GHRH; FSTL1B; ANXA1C; RGS11; TAAR1
    Signaling by TGF-beta Receptor Complex USP15; USP9; UCHL5; SKIA; TRIM33; SKILB; SKIB; NEDD8L; USP9X; NEDD8
    Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer USP9; USP9X; SKILB; SKIB; TRIM33

    TRIM33 has several biochemical functions, for example, DNA binding, R-SMAD binding, co-SMAD binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM33 itself. We selected most functions TRIM33 had, and list some proteins which have the same functions with TRIM33. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding HOXD13A; MIER1; HIST1H2BH; DMBX1A; EME1; ZNF296; ZFP641; ZFP865; LHX2A; POU3F3A
    R-SMAD binding CTNNB1; ZC3H3; SMAD4; FOXH1; PARP1; C18orf1; SMAD3; TRIM33; JUN; SMURF1
    co-SMAD binding TGIF1; SMAD2; FOXH1; SMAD3; SMAD6; GATA4; TRIM33; SMAD1; USP9X; CITED1
    ligase activity TRIM62; TRIM63; PIAS1; UBE2NA; BIRC3; CCNB1IP1; ZNRF2; SH3RF2; UBR5; RAG1
    protein binding TULP1; PELI1; TMBIM6; PCBD1; CIZ1; FRA10AC1; C12orf43; PLUNC; WDR12; SYN1
    ubiquitin-protein transferase activity RNF41; PDZRN3; UBE2Q2; SMURF2; RNF6; RNF5; UHRF1; ANKIB1A; RNF115; UBE2C
    zinc ion binding SREK1IP1; ZNF385B; LONRF3; NEIL2; ADAM15; NR1D2B; ZDHHC18B; ADH5; TRAF4A; CRIP3

    TRIM33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM33 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM33.

    SMAD4; SMAD2; gata1_human_gene; gata2_human_gene; TAL1; CDK9

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