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Trim63

  • Official Full Name

    tripartite motif containing 63, E3 ubiquitin protein ligase

  • Overview

    This gene encodes a member of the RING zinc finger protein family found in striated muscle and iris. The product of this gene is an E3 ubiquitin ligase that localizes to the Z-line and M-line lattices of myofibrils. This protein plays an important role in the atrophy of skeletal and cardiac muscle and is required for the degradation of myosin heavy chain proteins, myosin light chain, myosin binding protein, and for muscle-type creatine kinase. [provided by RefSeq, Feb 2012]
  • Synonyms

    TRIM63; tripartite motif containing 63, E3 ubiquitin protein ligase; IRF; SMRZ; MURF1; MURF2; RNF28; E3 ubiquitin-protein ligase TRIM63; ring finger protein 28; iris ring finger protein; muscle specific ring finger protein 2; muscle-specific RING finger protein 1; tripartite motif-containing protein 63; striated muscle RING zinc finger protein;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Human
  • Rat
  • Rhesus Macaque
  • Zebrafish
  • E.coli
  • HEK293
  • Mammalian Cell
  • Wheat Germ
  • GST
  • His
  • His (Fc)
  • Avi
  • Myc
  • His|SUMO
  • N/A
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human TRIM63-111H Active Recombinant Human TRIM63, His & SUMO-tagged E.coli His/SUMO
Human TRIM63-30260TH Recombinant Human TRIM63 Wheat Germ N/A 99 amino acids
Human TRIM63-139H Recombinant Human TRIM63 E.coli N/A
Human TRIM63-1833HCL Recombinant Human TRIM63 cell lysate N/A
Human TRIM63-4613H Recombinant Human TRIM63 protein, His&Myc-tagged E.coli His&Myc 1-353aa
Rat TRIM63-6283R Recombinant Rat TRIM63 Protein Mammalian Cell His
Rat Trim63-2164R Recombinant Rat Tripartite Motif-containing 63, GST-tagged E.coli GST
Rat Trim63-5963R Recombinant Rat Trim63 protein, His&Myc-tagged E.coli His&Myc 1-351aa
Rat TRIM63-5940R-B Recombinant Rat TRIM63 Protein Pre-coupled Magnetic Beads HEK293
Rat TRIM63-5940R Recombinant Rat TRIM63 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TRIM63-4973R Recombinant Rhesus monkey TRIM63 Protein, His-tagged Mammalian Cell His
Rhesus Macaque TRIM63-4787R Recombinant Rhesus Macaque TRIM63 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque TRIM63-4787R-B Recombinant Rhesus Macaque TRIM63 Protein Pre-coupled Magnetic Beads HEK293
Zebrafish TRIM63-360Z Recombinant Zebrafish TRIM63 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

Trim63 involved in several pathways and played different roles in them. We selected most pathways Trim63 participated on our site, such as Adaptive Immune System, Antigen processing: Ubiquitination &amp, Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with Trim63 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Adaptive Immune SystemLCP2A;CMTM2A;RNF14;SIGLEC10;CTSC;FBXO27;MKRN1;KLRB1B;DYNC1I1
Antigen processing: Ubiquitination &ampTRIM9;TRIM50;ASB3;ASB13;TRIM63;UBR2;UFL1;STUB1;HUWE1
Proteasome degradationGAN;TRIM39;RNF138;ASB17;ASB2;ASB11;RNF4;RNF41;ASB13
Class I MHC mediated antigen processing &ampHECTD3;UBR2;WWP1;BLMH;UBE2V1;FCGR1B;RNF34;CTSL2;LRRC41
presentationFBXO44;UBE2F;PJA2;MKRN1;CYBA;KLHL21;ASB6;WSB1;VPRBP
Immune SystemRCA2.1;FBXO44;SIRPB1;BAIAP2;KPNA3;EIF4E3;GBP2;NA;EVL
TWEAK Signaling PathwayTRIM63;TNFSF12-TNFSF13

Trim63 has several biochemical functions, for example, ligase activity, protein binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Trim63 itself. We selected most functions Trim63 had, and list some proteins which have the same functions with Trim63. You can find most of the proteins on our site.

Function Related Protein
ligase activityUBR5;UBE2D1A;PCXB;MARCH10;RNF126;UHRF2;MKRN3;IRF2BP1;UBE3B
protein bindingLRRC6;PBX1;SPSB2;PPP1R9A;MARCKSL1;ASCL1;a;C22orf28;TTC3
signal transducer activityGNG3;GNG4;GPR132;TAS2R116;MRGPRB1;GNGT1;MADD;GPR177;STAT1B
titin bindingCAPN3;CALM1;ANKRD2;MYBPC1;SLC14A2;CALM3;OBSCN;TCAP;TRIM63
ubiquitin protein ligase activityTRIM32;MED23;ITCH;TMEM189;RNF19B;HERC6;CCNC;CBLL1;XIAP
zinc ion bindingZFAND5;RXRBB;BAZ2B;TRIM27;MKRN4;GCM1;GATAD2A;ZFAND6;MMP19

Trim63 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Trim63 here. Most of them are supplied by our site. Hope this information will be useful for your research of Trim63.

TTN; EEF1G; CCAR1; MRPL41; GFM1; MYOZ1; NDUFA1; TCAP; NEBL; SNAPIN; ATP5B; TNNT1

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