TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Immune System ARIH2,SEC61B,SOCS3A,KIF2C,CFHL1,NA,CLEC2D,SH3RF1,EVL,LTF
    Antigen processing: Ubiquitination &amp TRIM63,UFL1,RNF111,UBE2L6,RNF41,LRSAM1,FBXO17,VPRBP,SPSB2,HUWE1
    Proteasome degradation ARIH2,VPRBP,SPSB2,UBE2V2,ASB9,KLHL21,UBE2U,ASB8,ATG7,LTN1
    presentation ARIH2,BLMH,FBXO3,FCGR1B,RNF144B,WWP1,STUB1,LTN1,WSB1,KLHL21
    Adaptive Immune System DYNLL2,KLC3,HECTD3,NRG4,FBXO27,KLHL20,UBE2E3,RNF220,SIGLEC8,KLRF1
    Class I MHC mediated antigen processing &amp UBE2J2,TRIM9,UBE2E3,UFL1,ERAP1,FBXO44,HECTD3,ASB7,CTSL1,RNF25

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    protein-glutamic acid ligase activity RNF180,NEURL3,UBE2IB,UBE2IA,NEURL1B,TRIM41,SHRPRBCK1R,MARCH6,SIAH1A,HECW2
    tubulin-glutamic acid ligase activity MARCH5L,SIAH1A,SHRPRBCK1R,UBE2IA,MYLIPA,DTX1,MARCH6,NEURL3,MARCH9,HERC2
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity DTX1,NEURL1B,SIAH2L,RNF144AB,HECW2,RNF169,TRIM71,RNF180,ZNRF2B,ARIH1L
    protein-glycine ligase activity SIAH1A,LTN1,RNF149,ZNRF2B,MARCH6,SIAH2L,ARIH1L,RNF180,MARCH9,G2E3
    tubulin-glycine ligase activity SIAH2L,RNF144AA,G2E3,UBR1,RNF144AB,ZNRF2B,MARCH6,MARCH9,RNF187,SHRPRBCK1R
    protein binding TAGLN2,LIMD1,IMMT,CADPS,NEUROG3,TAF1C,UACA,CD300LH,CTNNBIP1,ARPC5
    coenzyme F420-2 alpha-glutamyl ligase activity SIAH2L,SHRPRBCK1R,MARCH9,MARCH11,NEURL1B,RNF144AB,MARCH4,SIAH1A,ZNRF2B,MYLIPA
    metal ion binding RNF150,ZNF705A,SH3RF3,IMPDH1A,PRPSAP2,ZFP692,HENMT1,ZFP36L3,ZIC5,CYBASC3
    ligase activity TRIM56,HERC6,TRAF7,UBE2KA,UBE2G1B,RNF152,CBLL1,HERC3,NHLRC1,RBX1

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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