TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Immune System LY86,CD300E,ASB2,IFI6,FCN2,IGHM,FBXO17,CLEC2D,EDARADD,ARIH2
    Proteasome degradation UBR2,ASB11,TRIM63,SH3RF1,LTN1,DZIP3,RNF41,ASB18,RNF6,TRIM9
    Antigen processing: Ubiquitination &amp UBR1,UBE2J2,RNF6,KLHL21,LRRC41,FBXO3,RNF4,TRIM9,RNF182,VPRBP
    presentation FBXO27,UBE2U,TPP2,ERAP1,RNF220,FBXO3,HUWE1,ASB4,ASB2,UBE2F
    Class I MHC mediated antigen processing &amp RNF25,TRIM11,DZIP3,CMTM2A,SPSB2,WSB1,RNF34,ARIH2,ASB10,FBXO17
    Adaptive Immune System TRIM41,SIGLEC7,UBE2U,CD200R2,KIF26A,TREML4,MGC174152,AKR1C1,ASB14,AP1G1

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    protein-glutamic acid ligase activity RNF149,TMEM129,ARIH1L,SIAH1A,HECW2,ITCHA,MUL1A,LTN1,UBR1,G2E3
    zinc ion binding ADAM9,MYCBP2,TRIM35-21,SUV39H2,AQPEP,ADAMTS15,LPXN,LMCD1,ZDHHC22,AMFR
    protein binding HPCAL4,DHX36,THOC5,ZFP57,CDC27,ETS1,HDAC2,MSH2,ARR3,RTP4
    protein-glycine ligase activity, elongating MARCH4,MGRN1A,TMEM129,LTN1,SHRPRBCK1R,HERC2,TRIM41,G2E3,RNF180,MYLIPA
    tubulin-glycine ligase activity SIAH2L,RNF169,MARCH11,RNF144AB,MARCH9,SHRPRBCK1R,MARCH6,MYLIPB,MYLIPA,ITCHA
    tubulin-glutamic acid ligase activity MARCH4,TRIM41,RNF180,RNF144AB,RC3H2,RNF169,SIAH1A,HERC2,SIAH2L,TRIM71
    coenzyme F420-0 gamma-glutamyl ligase activity MARCH4,ITCHA,RNF180,MARCH9,G2E3,ZNRF2B,SIAH2L,SHRPRBCK1R,RNF169,MARCH6
    ligase activity PIAS2,SIAH1A,RBBP6,RNF144AA,RNF4,CCNB1IP1,RNF170,CBLB,HERC5,RNF217
    metal ion binding RNF34B,ASPHD2,UBE3A,ZFP36L1B,CSRP1A,UBA2,TOPAZ1,CA15C,CD209,ZNF75A

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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