TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Antigen processing: Ubiquitination &amp RNF14,RNF123,FBXO3,LTN1,ASB17,RNF19B,ASB7,TRIM69,FBXO27,UBE2V2
    presentation RNF6,HUWE1,BLMH,ASB10,RNF14,LRSAM1,UBE2E3,TRIM9,CD207,RNF182
    Class I MHC mediated antigen processing &amp MKRN1,LRR1,NPEPPS,TPP2,SPSB1,GAN,UBE2U,UBE2F,DTX3L,KLHL20
    Immune System CYBB,EVL,RIPK3,CTSD,MB21D1,AP1M2,CD300C,SIGLEC15,LY86,PCBP2
    Adaptive Immune System KIF11,EVL,KIF4A,LILRB2,KIR2DS2,RBCK1,Siglece,SIGLEC11,RAP1GAP2B,ACTR1B
    Proteasome degradation ASB14,TPP2,RNF111,UBE2F,UBR2,CMTM2A,ASB7,PJA1,RNF6,ASB11

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    tubulin-glutamic acid ligase activity RNF144AB,RC3H2,MARCH9,UBE2IA,TMEM129,MARCH11,UBE2IB,NEURL1B,MARCH5L,ZNRF2B
    tubulin-glycine ligase activity MARCH9,ZNRF2B,ZNRF3,ITCHA,RNF180,MGRN1A,NEURL1B,RAG1,FLR,HERC2
    protein-glycine ligase activity HERC2,RNF180,MARCH6,UBR1,UBE2IA,RNF149,RNF187,NEURL1B,MARCH5L,ITCHA
    protein binding LRFN4,NAV2,PGF,CCNB1IP1,CD300LH,CNEP1R1,EIF4A3,NTHL1,COQ9,MAPKAPK3
    protein-glutamic acid ligase activity LTN1,HERC2,ZNRF3,RNF180,DTX1,RAG1,UBR1,HECW2,ITCHA,RNF169
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity RAG1,HERC2,TRIM71,MARCH11,RFWD2,MGRN1A,SHRPRBCK1R,RNF149,RNF180,ZNRF2B
    coenzyme F420-0 gamma-glutamyl ligase activity MYLIPA,SIAH1A,RNF144AB,RNF169,ITCHA,NEURL1B,TRIM71,MARCH4,LTN1,TMEM129
    protein-glycine ligase activity, elongating MARCH4,MGRN1A,HECW2,NEURL1B,RNF187,MARCH11,LTN1,DTX1,RNF144AB,MYLIPA
    ligase activity RNF123,RFWD3,RNF13,EGR2,MID2,UBE2L3B,TRIM32,UNKL,ATG10,DTX4

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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