TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System CD96,PVRL2L,AKR1C1,DCTN2,ITGB1B.1,CTSLL,VPRBP,KLC3,AF251705,LILRB5
    Class I MHC mediated antigen processing &amp ERAP2,CYBA,UFL1,PJA2,ASB4,LRR1,UBE2J2,SPSB1,FBXO44,ARIH2
    Proteasome degradation SPSB1,DTX3L,IWS1,WWP1,RNF14,ASB10,FBXO17,UBA5,RNF111,DZIP3
    presentation RNF4,WSB1,TRIM9,UBE2F,LRR1,ASB4,CD207,LRSAM1,UBA5,HECTD3
    Immune System CLEC2B,EGR1,ALCAMB,ARIH1L,MKRN1,NLRP3,AP1G1,TRIM14,KPNA5,CASPB
    Antigen processing: Ubiquitination &amp TRIM69,ASB3,RNF6,TRIM41,ASB2,SPSB1,CMTM2A,ARIH2,ASB4,UBE2E3

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    coenzyme F420-2 alpha-glutamyl ligase activity ZNRF3,NEURL1B,HERC2,MARCH4,MUL1A,TRIM71,RNF149,ITCHA,MARCH9,HECW2
    tubulin-glycine ligase activity MARCH4,LTN1,SIAH1A,RAG1,ITCHA,MYLIPA,RNF187,RFWD2,FLR,ZNRF2B
    protein-glutamic acid ligase activity TRIM41,UBE2IB,RC3H2,MARCH9,ZNRF2B,NEURL1B,RNF180,ITCHA,MARCH4,G2E3
    protein binding CYSLTR1,ERO1LB,CCS,GPSM1,FAM126B,ZFP2,SNX8,TPRKB,DVL1,LSM7
    protein-glycine ligase activity, elongating RNF149,TRIM71,RNF180,ZNRF2B,ZNRF3,UBE2IA,RAG1,MGRN1A,ITCHA,RC3H2
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity SIAH2L,MGRN1A,UBR1,RAG1,TRIM71,MARCH9,MARCH11,RNF169,SIAH1A,G2E3
    zinc ion binding MUL1,ZKSCAN5,TRAF3,LNX1,ADAMTS13,CXXC4,SP110,XIAP,TRAF1,SUV39H1B
    protein-glycine ligase activity, initiating SIAH1A,SIAH2L,UBE2IB,UBR1,RAG1,RNF144AA,RNF149,RNF180,UBE2IA,MYLIPB
    tubulin-glutamic acid ligase activity HERC2,MYLIPB,ZNRF3,RC3H2,ARIH1L,TMEM129,RNF187,RNF169,MYLIPA,ITCHA

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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