TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Immune System BTR12,KLC3,KLHL21,SIGLEC12,SIGIRR,AP1S3A,WASF3,KPNA3,CD200R2,SIGLEC14
    Adaptive Immune System STIM1B,PTBP3,DYNLL2,TREM1,GRAP2A,RAET1E,UBA5,KIR2DS2,DCTN1,LILRA3
    presentation STUB1,KLHL20,CTSS,ASB2,SEC23A,DTX3L,RNF182,ASB3,SEC61B,FBXO17
    Class I MHC mediated antigen processing &amp UBE2J2,CD207,BLMH,CYBB,TRIM39,CYBA,RNF4,LRR1,NPEPPS,ASB8
    Antigen processing: Ubiquitination &amp ATG7,UFL1,MKRN1,UBR1,RBCK1,HUWE1,SH3RF1,UBE2V2,UBA5,TRAF7
    Proteasome degradation KLHL21,SPSB4,UBE2V2,ASB2,TRIM41,HUWE1,TRIM39,STUB1,GAN,UCHL3

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity RNF31,MUL1,TRIM21,TTLL13,GLULB,KCNG4,UBE2IA,MARCH3,BTRC,LIPT2
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity UBR1,MARCH9,LTN1,DTX1,MUL1A,NEURL3,ZNRF3,MARCH5L,TMEM129,RNF149
    protein-glutamic acid ligase activity MARCH6,RFWD2,RNF180,SIAH2L,TRIM41,ITCHA,SHRPRBCK1R,ZNRF2B,DTX1,NEURL3
    tubulin-glutamic acid ligase activity TRIM41,NEURL3,ITCHA,RC3H2,ARIH1L,MARCH6,UBR1,MARCH4,MARCH5L,MARCH11
    protein-glycine ligase activity, elongating MARCH4,UBE2IA,MYLIPB,HECW2,G2E3,TRIM71,MYLIPA,MARCH11,RAG1,TRIM41
    tubulin-glycine ligase activity G2E3,MUL1A,HERC2,MARCH11,UBE2IA,DTX1,RC3H2,RNF144AA,UBR1,RNF144AB
    metal ion binding ROCK2B,TRIM35-28,CNOT6L,ZKSCAN6,MEP1A.2,ZNF185,CYP2C50,MOB3A,ZSCAN18,TDO2B
    coenzyme F420-0 gamma-glutamyl ligase activity MARCH6,G2E3,RFWD2,ZNRF3,MYLIPA,MYLIPB,TRIM41,RNF149,RNF169,UBE2IA
    protein binding CCNB3,EIF2B1,TMF1,WBP4,HP,PAWR,HSPA2,MAGEB6,POLR2C,GLMN

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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