TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Class I MHC mediated antigen processing &amp KLHL20,TRIM63,CYBB,UBE2F,HUWE1,UBE2U,ASB6,UBE2V2,SPSB1,HECTD3
    presentation KLHL20,ASB7,FCGR1B,TPP2,RNF34,UBE2L6,FBXO27,UFL1,BLMH,TRIM41
    Immune System IFIT12,RNF220,TXNIPA,NOD1,CD180,DHX9,SIGLEC14,ARIH1,TRIM45,ISG20
    Antigen processing: Ubiquitination &amp TRIM63,UBE2F,SH3RF1,SPSB2,UBE2V2,FBXO27,KLHL20,TRIM69,WWP1,PJA2
    Adaptive Immune System MGC174152,HBEGF,OSBPL1A,CYBB,ASB2,LRSAM1,GM11711,CLEC2G,AMICA1,CTLA4
    Proteasome degradation UBE2V1,TRIM9,ASB4,PJA2,SH3RF1,RNF4,STUB1,VPRBP,ARIH2,IWS1

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    protein-glycine ligase activity, elongating G2E3,NEURL3,ZNRF2B,RNF149,LTN1,MARCH6,SIAH1A,MARCH9,MARCH5L,ARIH1L
    coenzyme F420-0 gamma-glutamyl ligase activity ZNRF3,TRIM41,UBR1,NEURL1B,MGRN1A,MARCH5L,MYLIPA,ARIH1L,RNF187,RNF149
    metal ion binding RPE,ZNF609A,OGDH,CNOT8,TRIM35-24,ZNF143,RNF148,PPARAB,ZNF596,TNKS2
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity MYLIPB,MARCH5L,ZNRF3,MARCH6,SHRPRBCK1R,TMEM129,UBE2IA,MARCH9,RNF149,MARCH11
    coenzyme F420-2 alpha-glutamyl ligase activity DTX1,UBR1,HECW2,TMEM129,SIAH2L,NEURL1B,MARCH4,RC3H2,RNF144AB,MARCH6
    protein binding FAM107A,SENP1,C10orf81,BCL2L10,ICAM1,RRAS,E2F6,HTR1A,IL1A,STAG1
    ligase activity MUL1,TRAF3,HUWE1,TRIM11,TRIM32,TRIM27,AMFR,HECW1,FPGS,RNF152
    protein-glycine ligase activity NEURL3,UBR1,RC3H2,TRIM71,UBE2IB,HERC2,SIAH2L,MARCH5L,MUL1A,ZNRF3
    tubulin-glutamic acid ligase activity NEURL1B,MARCH4,UBE2IA,TRIM41,TMEM129,MGRN1A,MYLIPA,DTX1,SIAH1A,RNF169

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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