TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System IGKC,CD200R2,AP2B1,STUB1,CTLA4,SEC61B,DYNC1H1,FGF10B,AP1S1,AP1G1
    Class I MHC mediated antigen processing &amp HUWE1,SEC24A,TRIM11,RNF220,BLMH,ASB3,CTSS,RNF144B,ASB9,RBCK1
    presentation UBE2V1,RNF182,B2ML,PJA1,FBXO3,FCGR1B,RNF6,RNF220,TPP2,UBE2L6
    Immune System S100B,NOD1,KIF11,MICA,POLR3C,WWP1,UNC93B1,FCN2,CFHL3,MAP3K8
    Proteasome degradation CMTM2A,ASB11,UBA5,RNF182,ASB10,PJA2,ASB7,RNF14,UBE2U,PJA1
    Antigen processing: Ubiquitination &amp KLHL20,ASB7,ASB18,UBE2U,ASB8,RNF220,LRSAM1,LTN1,UFL1,TPP2

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    protein binding NFKBIL1,SSX2IP,CDCA4,NDUFAF1,MEF2A,GLDN,LENG1,INTS7,SSBP3,C12orf49
    ligase activity ZSWIM2,RNF6,DTX1,MIB2,TRIM31,PDZRN3,NEDD4,TRIM58,RNF149,ZNRF2B
    protein-glycine ligase activity, initiating MARCH4,TMEM129,RNF169,MGRN1A,MYLIPB,ITCHA,RNF144AA,TRIM71,RC3H2,TTLL3
    protein-glycine ligase activity, elongating ITCHA,TMEM129,NEURL3,HECW2,RNF149,MARCH9,RAG1,RFWD2,SIAH2L,RNF144AB
    protein-glutamic acid ligase activity RAG1,RNF180,RNF149,MARCH9,TRIM41,MYLIPA,SIAH1A,RNF144AA,SIAH2L,RNF187
    ribosomal S6-glutamic acid ligase activity NEURL3,RNF187,UBR1,TRIM41,ZNRF3,MARCH11,MARCH6,TRIM71,RNF144AB,SIAH2L
    zinc ion binding TRIM71,MYNN,PGLYRP4,CA2,TRIM109,ZDHHC22,NEURL1B,ZDHHC5,LIMS1,ING5A
    protein-glycine ligase activity RNF144AB,MARCH5L,G2E3,MARCH4,RNF144AA,ZNRF2B,SHRPRBCK1R,NEURL1B,UBE2IB,ZNRF3
    metal ion binding VAV2,ZFYVE28,RNF44,NRP1A,NAALAD2,CDH15,IKZF2,HAND2,TRIM35-39,MLL5

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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