TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Antigen processing: Ubiquitination &amp DZIP3,UBR2,ATG7,ASB3,DTX3L,KLHL21,LRRC41,RNF138,SH3RF1,RBCK1
    Adaptive Immune System FBXO3,ASB11,THEM4,CTSL1,PDPK1A,KIF3B,KLRB1F,RAP1GAP2,TRIM63,ACTR1A
    Immune System WASF3,ATP6V1G3,RCA2.1,RNF41,RNF220,TRAF7,FBXO44,LGALS9,BFB,TXNIP
    Class I MHC mediated antigen processing &amp ASB3,RNF6,ASB4,CTSL2,TRIM9,ASB9,TRIM41,HECTD3,WSB1,UBE2V1
    Proteasome degradation ASB17,ASB10,KLHL21,GAN,UBE2F,UBE2V2,RBCK1,RNF220,DTX3L,TPP2
    presentation HECTD3,FBXO17,ERAP1,RNF123,ARIH2,CMTM2A,FBXO44,ASB4,RNF19B,SPSB1

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    protein-glutamic acid ligase activity UBR1,ZNRF2B,HERC2,SIAH2L,RFWD2,UBE2IA,MARCH6,SHRPRBCK1R,HECW2,UBE2IB
    metal ion binding ZFP36,RNASEH2A,BCL11B,CYP2J5,CYP51,BTR16,SDHDA,ZNF566,KARS,TNNI1
    protein binding WDR61,EAF2,CUL2,UGP2,PTPN2,PYGO2,RAD50,CGGBP1,PPP2R2A,ANKRD10
    protein-glycine ligase activity, elongating MUL1A,TRIM41,G2E3,MARCH4,MYLIPB,ITCHA,MARCH6,RNF149,RFWD2,UBE2IB
    coenzyme F420-2 alpha-glutamyl ligase activity MARCH4,TRIM41,UBE2IA,MARCH11,RNF149,MARCH9,HECW2,NEURL3,TMEM129,UBE2IB
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity MGRN1A,ARIH1L,UBE2IA,LTN1,MARCH11,RC3H2,SIAH2L,MARCH4,RNF187,RNF144AB
    protein-glycine ligase activity, initiating MGRN1A,RAG1,ZNRF2B,MARCH11,HERC2,RC3H2,MUL1A,RNF169,SHRPRBCK1R,UBE2IA
    coenzyme F420-0 gamma-glutamyl ligase activity RC3H2,NEURL3,SIAH2L,MYLIPA,TRIM41,RNF187,TRIM71,RNF144AA,NEURL1B,G2E3
    ribosomal S6-glutamic acid ligase activity LTN1,RNF149,MYLIPB,MARCH5L,RFWD2,TRIM71,HERC2,UBE2M,MYLIPA,MARCH6

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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