TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    presentation MKRN1,LRR1,RNF34,RNF144B,KLHL20,TRIM41,ASB18,STUB1,SEC23A,HECTD3
    Antigen processing: Ubiquitination &amp LRR1,UBE2V2,UBE2L6,FBXO44,SPSB4,LTN1,TPP2,RNF123,TRAF7,VPRBP
    Class I MHC mediated antigen processing &amp SEC61B,CD207,DTX3L,RNF19B,RNF14,UBE2V1,CYBB,UBE2L6,KLHL20,CTSS
    Proteasome degradation UFL1,CMTM2A,UBE2L6,BLMH,DZIP3,UBR1,UBR2,RNF34,LRSAM1,RNF19B
    Adaptive Immune System DCTN1,KIF5A,CTS7,FGF10B,RAP1GAP2B,RNF220,CTSS,LILRA2,FGF20A,CTSO
    Immune System NCKIPSD,NLRC5,EIF4G2A,ATG7,CMTM2A,SUGT1,ABI1A,TCIRG1,ABI1B,DEFA5

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    protein-glutamic acid ligase activity RNF169,UBR1,NEURL1B,MARCH6,RFWD2,TRIM71,MYLIPA,TMEM129,UBE2IA,MGRN1A
    coenzyme F420-0 gamma-glutamyl ligase activity MYLIPB,RC3H2,G2E3,MGRN1A,RAG1,ZNRF2B,MYLIPA,NEURL3,HERC2,ARIH1L
    protein-glycine ligase activity TRIM41,MARCH9,G2E3,SIAH2L,HERC2,ITCHA,ARIH1L,TTLL3,RFWD2,RNF187
    ribosomal S6-glutamic acid ligase activity SHRPRBCK1R,G2E3,HERC2,UBR1,SIAH2L,RFWD2,TMEM129,MARCH9,RNF149,ARIH1L
    metal ion binding KLK1B3,CUBN,PDP1,TAX1BP1B,ZSCAN4,GATA5,CYP3C1,GDPD3,ZBTB33,DDX11
    protein-glycine ligase activity, initiating ZNRF3,UBE2IA,MARCH6,RFWD2,RNF149,SIAH2L,ZNRF2B,RNF169,MUL1A,NEURL3
    zinc ion binding CAR7,LHX1B,TRIM2,BFAR,LNX2B,SIRT5,PDXK,CA2,ZNF385B,CPZ
    ligase activity RAG1,TMEM129,GLULA,UBE3C,MDM2,HERC2,HACE1,DTX3L,CBLL1,RNF170
    coenzyme F420-2 alpha-glutamyl ligase activity TMEM129,SIAH1A,MARCH9,RAG1,UBR1,NEURL3,G2E3,ITCHA,SHRPRBCK1R,ZNRF3

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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