TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System CTLA4,SPSB4,CRTAM,DYNLL2,OSBPL1A,PVRL2L,IGHM,MOV10,IGKV1-5,AKR1C1
    Antigen processing: Ubiquitination &amp UBE2U,ASB3,FBXO27,TRIM41,DZIP3,ASB10,FBXO44,RNF138,UBE2F,RNF182
    Proteasome degradation ASB8,TRIM41,UBA5,UBE2U,RNF144B,UBE2V2,HECTD3,TRIM9,LTN1,ASB14
    Class I MHC mediated antigen processing &amp KLHL21,TPP2,GAN,BLMH,TRIM69,SPSB1,RNF25,FBXO44,DZIP3,RNF111
    Immune System IFI6,GHRB,PIK3AP1,IGHM,LGALS9,TRIM8,GZMM,TREX1,SIGLEC6,IRF2
    presentation RNF34,UFL1,ASB4,ASB6,BLMH,GAN,UBR1,STUB1,SPSB4,CD207

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    tubulin-glutamic acid ligase activity MARCH5L,ZNRF2B,TMEM129,MUL1A,G2E3,UBR1,TRIM41,RNF149,MGRN1A,UBE2IA
    zinc ion binding ADH5,ZNRD1,RPS29,MT1X,ZDHHC16A,GM757,CRIP1,PDZRN4,ZC3HC1,WHSC1
    tubulin-glycine ligase activity ITCHA,ZNRF2B,RNF187,MARCH6,DTX1,TRIM41,MARCH4,RNF169,SIAH2L,MYLIPB
    metal ion binding ZNF10,GTF3AB,MARCH5L,ZFPL1,ADNP2B,ZNF362A,TNNC1,JAZF1,FOXP4,SUZ12
    protein-glutamic acid ligase activity DTX1,RNF187,ARIH1L,RNF180,RNF169,NEURL3,MARCH4,MYLIPA,HECW2,TRIM71
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity MUL1A,MARCH4,MARCH5L,UBR1,RNF180,RC3H2,SIAH2L,MGRN1A,ITCHA,MARCH11
    ribosomal S6-glutamic acid ligase activity MARCH11,UBE2M,MUL1A,NEURL1B,G2E3,MARCH5L,UBR1,UBE2IB,ZNRF3,HERC2
    ligase activity PARK2,MIB2,RNF144AA,RNF34,COP1,TRIP12,EGR2,HERC3,PCXA,MUL1
    protein-glycine ligase activity RNF187,MARCH9,SIAH1A,SHRPRBCK1R,HERC2,MUL1A,RNF149,UBE2IA,DTX1,NEURL3

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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