TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Adaptive Immune System Mill2,CHUK,CD200R3,ACTR1A,LILRA1,UBE2U,RASGRP1,FAM49BA,KIF5A,SRMS
    Proteasome degradation NPEPPS,ASB14,RNF19B,KLHL21,TPP2,UBE2E3,ASB9,UBE2J2,UBE2V2,RNF34
    Class I MHC mediated antigen processing &amp RNF138,CTSL2,ASB3,UBE2J2,UBE2L6,RNF220,RNF25,FCGR1B,UBR2,DTX3L
    Immune System PANX1,TREML4,CTSD,KIF3C,SIGLEC15,MASP2,ART1,DEFB1,LAIR1,TXNIPB
    Antigen processing: Ubiquitination &amp RNF144B,SPSB2,RNF4,TRAF7,LRRC41,RNF111,ASB9,FBXO17,TRIM11,LRSAM1
    presentation SPSB4,SH3RF1,RNF19B,MKRN1,TRAF7,UBE2J2,UBR1,UBR2,SEC61B,RNF6

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity ZNRF1,RFWD3,KCNG4,MIB1,GLULB,TRIM33,DTX2,TRAIP,RNF138,TRIM2
    protein-glycine ligase activity, initiating SIAH2L,G2E3,HECW2,RNF144AB,UBE2IA,RNF187,ITCHA,ZNRF2B,ZNRF3,TRIM71
    tubulin-glycine ligase activity UBR1,HECW2,G2E3,RNF187,RNF144AB,RC3H2,FLR,MARCH5L,RNF169,MYLIPA
    protein-glutamic acid ligase activity RNF144AA,DTX1,UBE2IA,MGRN1A,TRIM71,MARCH9,SIAH1A,G2E3,RFWD2,RC3H2
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity RFWD2,HERC2,RNF144AB,MYLIPA,SIAH2L,TRIM41,SHRPRBCK1R,UBE2IB,HECW2,ZNRF2B
    tubulin-glutamic acid ligase activity UBR1,RFWD2,SHRPRBCK1R,RNF144AB,RNF180,RNF144AA,MARCH5L,ZNRF3,RAG1,TTLL1
    protein-glycine ligase activity, elongating UBE2IB,G2E3,MARCH4,LTN1,MYLIPB,RNF144AB,RNF180,UBR1,RNF149,ARIH1L
    protein binding TRAPPC6A,RBM25,WHSC1,WASF1,ZMAT3,CHP,CTSD,DYNLRB1,CCT2,FNIP1
    protein-glycine ligase activity UBE2IA,ZNRF3,SIAH1A,ITCHA,RC3H2,NEURL1B,ARIH1L,TMEM129,RNF180,MGRN1A

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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