TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Immune System RNF123,TXNIPA,MASP2,VPRBP,OSBPL1A,PIK3AP1,FAM49BA,PLD4,NLRP4B,DYNC1I1
    Adaptive Immune System CTSL2,KLRF1,CTS7,NRG4,RACGAP1,CD200R3,KIF15,CTSO,MGC174155,CSK
    presentation FCGR1B,ASB4,RNF4,ARIH2,RNF14,CD207,ASB18,FBXO27,UBA5,FBXO3
    Class I MHC mediated antigen processing &amp ASB17,DZIP3,UBE2L6,TRIM9,B2ML,ASB14,SPSB4,RNF25,CTSS,FBXO44
    Proteasome degradation UFL1,LTN1,TRAF7,HUWE1,TRIM63,TRIM39,TRIM9,WWP1,IWS1,FBXO27
    Antigen processing: Ubiquitination &amp KLHL20,UBE2L6,UBE2V2,ASB13,WSB1,LRRC41,ASB2,PJA1,TRIM69,ASB11

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    coenzyme F420-0 gamma-glutamyl ligase activity NEURL1B,LTN1,SHRPRBCK1R,MARCH9,HERC2,MYLIPB,RNF187,MARCH6,TMEM129,ZNRF3
    protein-glycine ligase activity NEURL3,NEURL1B,TMEM129,G2E3,TTLL3,MYLIPA,MARCH11,RAG1,SHRPRBCK1R,SIAH1A
    protein-glycine ligase activity, elongating RNF144AA,RNF144AB,LTN1,ZNRF3,MARCH4,MGRN1A,RNF180,MARCH6,ITCHA,NEURL1B
    tubulin-glutamic acid ligase activity NEURL3,ITCHA,RFWD2,RNF144AA,ARIH1L,UBR1,RNF180,G2E3,MGRN1A,DTX1
    tubulin-glycine ligase activity MARCH9,MGRN1A,RNF180,RFWD2,SHRPRBCK1R,ARIH1L,TMEM129,NEURL1B,HERC2,ZNRF3
    protein-glycine ligase activity, initiating G2E3,SIAH2L,MUL1A,RNF149,RNF144AA,RC3H2,HERC2,HECW2,MARCH6,MARCH5L
    ligase activity IRF2BP1,UBOX5,TRIM69,ACSL1,RFWD2,RNF38,ZNRF3,MUL1,MEX3C,TRIM4
    zinc ion binding ADAMDEC1,GDA,BHMT,MMP7,PDLIM4,RARAB,PRICKLE1B,MME,MID2,ZDHHC15A
    protein-glutamic acid ligase activity ARIH1L,MARCH4,ZNRF2B,RNF144AB,MYLIPB,UBR1,RNF187,RNF169,RAG1,MARCH5L

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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