TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteasome degradation RNF25,RNF138,DTX3L,LRR1,IWS1,ASB10,TRAF7,UBE2V2,RNF123,PJA1
    Immune System MX2,FBXO3,PRLRB,TNIP2,KLC3,TREM1,IFI30,CD200R1,UBE2U,IRF4
    Class I MHC mediated antigen processing &amp LRRC41,PJA2,CYBB,RNF34,UBE2E3,BLMH,KLHL21,FBXO27,LTN1,RNF111
    Antigen processing: Ubiquitination &amp PJA1,RNF19B,RNF144B,RNF4,UFL1,FBXO3,TRIM69,ARIH2,ASB13,RNF111
    Adaptive Immune System FGF8B,KLC3,HUWE1,CD300LF,FAM49BA,MGC174155,CLEC2B,MGC174857,FRS2,AP1S1
    presentation RNF25,ASB14,ASB8,B2ML,ATG7,KLHL21,SPSB2,RNF14,WWP1,UBE2V2

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity UBR1,RC3H2,ZNRF2B,UBE2IB,LTN1,MUL1A,TRIM41,MARCH6,HERC2,RNF149
    ligase activity SIAH2,RANBP2,RNF130,UBE2KA,RING1,RNF149,BRCA1,CBLL1,MARCH5,PELI1
    protein-glycine ligase activity, initiating SHRPRBCK1R,RNF149,MARCH6,RNF180,MUL1A,RFWD2,TMEM129,SIAH1A,SIAH2L,G2E3
    coenzyme F420-2 alpha-glutamyl ligase activity RNF187,RNF144AB,MARCH5L,MARCH4,ZNRF3,NEURL3,TRIM71,MUL1A,NEURL1B,RC3H2
    metal ion binding Fcer2a,ZFP451,HE2,ADAT1,MGRN1A,FBP1,Car2,LACTB2,ZFP507,ZFP12
    zinc ion binding TRIM35-35,MSL2A,KDM5D,SMAD3,ADAM9,RP9,USP45,TRIM2,KDM4B,ZFYVE1
    protein binding PYURF,DACT2,MED26,ESRRG,SPP1,DUSP9,ZNF703,AK3,CHMP4A,MRPL44
    protein-glycine ligase activity RAG1,SIAH2L,RC3H2,NEURL3,ZNRF2B,LTN1,UBE2IA,MARCH4,RNF169,MYLIPB
    ribosomal S6-glutamic acid ligase activity NEURL3,ZNRF2B,NEURL1B,SHRPRBCK1R,MARCH6,SIAH1A,RNF180,UBE2IB,UBE2IA,G2E3

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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