TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proteasome degradation CMTM2A,HECTD3,TRIM41,UBE2L6,UBE2J2,WSB1,RNF4,ASB9,UBE2V2,RNF25
    Immune System IRF9,STUB1,AP1S3A,CTSB,IFITM3,TRIM2,DYNC1H1,RAP1GAP2,USP18,CYLD
    Antigen processing: Ubiquitination &amp SPSB4,UBR1,UBE2V2,LRR1,CMTM2A,PJA1,UBE2E3,HECTD3,ASB3,ASB4
    presentation UBE2L6,ASB13,B2ML,PJA1,ASB6,CTSL1,ATG7,ASB4,ASB3,UBA5
    Class I MHC mediated antigen processing &amp CTSL1,ASB18,ASB17,CTSS,RNF34,UBA5,WSB1,DZIP3,ERAP1,FBXO17
    Adaptive Immune System KLRB1B,CD96,ERAP2,SIGLEC7,ASB10,AGO2,RNF6,VPRBP,CDKN1A,SIGLEC12

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    ligase activity DTX3,TRAF3,ZNRF1,TTC3,HUWE1,CDC34B,LIPT2,HERC4,RNF31,TRIM58
    protein-glutamic acid ligase activity RNF187,RC3H2,SIAH1A,HECW2,SHRPRBCK1R,ARIH1L,RNF180,MGRN1A,G2E3,NEURL1B
    ribosomal S6-glutamic acid ligase activity MARCH9,RNF180,UBE2IB,RC3H2,ITCHA,ZNRF3,RNF149,RAG1,MARCH11,SHRPRBCK1R
    protein-glycine ligase activity, initiating RNF144AA,MGRN1A,RNF144AB,NEURL3,TTLL3,UBE2IA,HERC2,MARCH9,DTX1,UBR1
    protein-glycine ligase activity, elongating RNF187,HERC2,ARIH1L,UBR1,ZNRF2B,ZNRF3,ITCHA,HECW2,MGRN1A,RNF180
    zinc ion binding NR5A1,SLC25A46,LHX5,PDLIM2,DTNB,RNF144B,TTC3,CA15C,RXRA,RNF135
    coenzyme F420-0 gamma-glutamyl ligase activity MGRN1A,NEURL1B,MYLIPB,MYLIPA,RNF169,ZNRF2B,HECW2,DTX1,UBE2IA,RNF149
    tubulin-glycine ligase activity MARCH5L,RAG1,MYLIPB,MARCH9,LTN1,NEURL3,ZNRF3,RNF144AA,RNF149,RNF180
    UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity NEURL3,RNF180,NEURL1B,MARCH6,TRIM41,SHRPRBCK1R,RNF144AA,TRIM71,RC3H2,SIAH1A

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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