TRIM50

  • Official Full Name

    tripartite motif containing 50

  • Synonyms

    TRIM50;tripartite motif containing 50;TRIM50A, tripartite motif containing 50 , tripartite motif containing 50A;E3 ubiquitin-protein ligase TRIM50;FLJ32804;E3 ubiquitin ligase;tripartite motif protein 50;tripartite motif-containing 50;tripartite

Recombinant Proteins

  • Mouse
  • Rat
  • Human
  • Mammalian Cells
  • HEK293
  • E. coli
  • His
  • DDK
  • Myc
  • Avi
  • Fc
  • GST

    Involved Pathway

    TRIM50 involved in several pathways and played different roles in them. We selected most pathways TRIM50 participated on our site, such as Adaptive Immune System,Antigen processing: Ubiquitination &amp,Proteasome degradation, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM50 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Immune System LILRB4,GZMM,TREML1,DHX9,ASB9,CRP,PPIAL4A,CTSK,SUGT1,CD200R2
    Adaptive Immune System UFL1,CD96,LILRB3,AP2S1,PVRL2L,TREML4,KIF2A,PPIAL4A,RNF144B,Siglece
    Class I MHC mediated antigen processing &amp DZIP3,PJA1,WWP1,LRRC41,NPEPPS,FBXO44,RNF41,ATG7,TRIM9,UBE2V2
    Proteasome degradation FBXO44,TRIM41,CMTM2A,NPEPPS,WSB1,UBR1,FBXO27,UBR2,KLHL20,RNF14
    Antigen processing: Ubiquitination &amp RBCK1,RNF14,ARIH2,TRIM41,RNF25,RNF6,RNF144B,KLHL20,TRIM11,RNF182
    presentation ASB8,CD207,RNF4,B2ML,RNF144B,ARIH2,CTSL1,SEC23A,WWP1,RNF41

    Protein Function

    TRIM50 has several biochemical functions, for example, UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity,coenzyme F420-0 gamma-glutamyl ligase activity,coenzyme F420-2 alpha-glutamyl ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM50 itself. We selected most functions TRIM50 had, and list some proteins which have the same functions with TRIM50. You can find most of the proteins on our site.

    Function Related Protein
    coenzyme F420-0 gamma-glutamyl ligase activity NEURL1B,MARCH6,TMEM129,RNF144AA,MARCH5L,MYLIPA,RNF169,MGRN1A,G2E3,ITCHA
    protein-glutamic acid ligase activity RC3H2,RNF144AA,G2E3,MARCH9,ARIH1L,MGRN1A,RNF144AB,UBE2IA,MARCH6,RAG1
    zinc ion binding LHX8A,PNMA3,MEP1A.1,RORAA,ADAMTS20,ZGLP1,PAPLN,NR2F6A,PRICKLE1A,ZCCHC2
    metal ion binding ZDHHC21,BTR12,GCM2,TPH1A,OASL2,ZNHIT6,ACVRL1,TRIM35-31,ZNF460,ZNF45
    tubulin-glutamic acid ligase activity ITCHA,MYLIPB,SIAH1A,RNF144AA,RNF187,DTX1,MGRN1A,UBE2IB,TMEM129,G2E3
    protein-glycine ligase activity, elongating LTN1,ITCHA,SHRPRBCK1R,TMEM129,RNF169,RNF144AB,ZNRF2B,G2E3,SIAH2L,HECW2
    ligase activity DTX3,TTLL9,MARCH1,MARCH5,RNF180,RNF217,CBL,PRPF19,SH3RF2,NHLRC1
    protein-glycine ligase activity SIAH1A,SHRPRBCK1R,RNF187,ZNRF2B,SIAH2L,G2E3,MGRN1A,NEURL1B,RNF144AA,LTN1
    coenzyme F420-2 alpha-glutamyl ligase activity SHRPRBCK1R,MARCH6,TRIM71,MARCH11,MARCH4,RNF169,UBE2IB,MARCH5L,RNF144AA,HERC2

    Interacting Protein

    TRIM50 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM50 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM50.

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