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Official Full Name tripartite motif containing 37
Background This gene encodes a member of the tripartite motif (TRIM) family, whose members are involved in diverse cellular functions such as developmental patterning and oncogenesis. The TRIM motif includes zinc-binding domains, a RING finger region, a B-box motif and a coiled-coil domain. The RING finger and B-box domains chelate zinc and might be involved in protein-protein and/or protein-nucleic acid interactions. The gene mutations are associated with mulibrey (muscle-liver-brain-eye) nanism, an autosomal recessive disorder that involves several tissues of mesodermal origin. Alternatively spliced transcript variants encoding the same protein have been identified.
Synonyms TRIM37; tripartite motif containing 37; MUL, tripartite motif containing 37; E3 ubiquitin-protein ligase TRIM37; KIAA0898; POB1; RING B box coiled coil protein; TEF3; mulibrey nanism protein; RING-B-box-coiled-coil protein; tripartite motif-containing 37
    • Species :
    • Chicken
    • Human
    • Rhesus Macaque
    • Source :
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TRIM37-199H Recombinant Human TRIM37, GST-tagged Sf9 Insect Cell GST
    Human TRIM37-31610TH Recombinant Human TRIM37 Wheat Germ N/A
    Human TRIM37-640H Recombinant Human TRIM37 Protein, GST-tagged, Active Insect Cell GST
    Human TRIM37-780HCL Recombinant Human TRIM37 293 Cell Lysate HEK293 N/A
    Rhesus Macaque TRIM37-4966R Recombinant Rhesus monkey TRIM37 Protein, His-tagged Mammalian Cell His
    Chicken TRIM37-1372C Recombinant Chicken TRIM37 Mammalian Cell His

    trim37 involved in several pathways and played different roles in them. We selected most pathways trim37 participated on our site, such as Ubiquitin mediated proteolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with trim37 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Ubiquitin mediated proteolysis CUL1A; TCEB1B; FBXW8; PIAS4B; UBE2D2; ANAPC2; CDC34A; SOCS3B; TRAF6; TCEB2

    trim37 has several biochemical functions, for example, chromatin binding, ligase activity, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by trim37 itself. We selected most functions trim37 had, and list some proteins which have the same functions with trim37. You can find most of the proteins on our site.

    Function Related Protein
    chromatin binding HINFP; NFKB1; WDHD1; MAZ; SP3; MPO; CBX5; SHMT2; APBB1; KDM8
    ligase activity TRIP12; PCXB; TRIM24; CMTM2A; BRAP; SMURF2; TTLL4; TRIM39; MARCH2; HERC4
    protein binding FAM131C; NR1H2; MRPL23; SNX11; CDKN1B; IRF3; C17orf81; RIPPLY2; SPATA24; PRDM13
    protein homodimerization activity SYNDIG1; PAFAH1B1; ODZ4; RAB11FIP4B; CCL5; ROPN1B; S100B; NPR3; TGFB2; CEP57
    tumor necrosis factor receptor binding TNFSF13B; TNFB; FASLG; TNFSF10L4; CD70; TRAF1; FADD; LTB; TRAF3; ERAP1
    ubiquitin protein ligase activity UBE2S; RNF222; PDZRN3; UBE2N; NEDD4L; HERC6; TRIM24; MED27; UBE2H; SIAH2L
    ubiquitin protein ligase binding CXCR4; TNFRSF14; SKI; LYN; AURKA; SPOP; TRIM28; CUL5A; MC1R; FLJ11011L
    ubiquitin-protein transferase activity FBXO7; RLIM; FBXL6; MARCH1; BIRC5B; FBXO2; MALT1; TRIM68; TRIM36; FBXL14
    zinc ion binding TRIM44; MMP11; CXXC5; NUP153; BBOX1; TAF15; ZCCHC18; RNF112; NR1D2; ADAMTSL1

    trim37 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with trim37 here. Most of them are supplied by our site. Hope this information will be useful for your research of trim37.

    BYSL; ZNF417; MCRS1; PRC1; a8k932_human

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