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Official Full Name tripartite motif containing 21
Background This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined.
Synonyms TRIM21; tripartite motif containing 21; SSA; RO52; SSA1; RNF81; E3 ubiquitin-protein ligase TRIM21; SS-A; ro(SS-A); 52 kDa Ro protein; OTTHUMP00000230775; RING finger protein 81; Sicca syndrome antigen A; tripartite motif-containing 21; sjoegren syndrome type A antigen; tripartite motif-containing protein 21; 52 kDa ribonucleoprotein autoantigen Ro/SS-A; Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro)
    • Species :
    • Cow
    • Human
    • Mouse
    • Rat
    • Rhesus Macaque
    • Source :
    • Bovine Thymus
    • E.coli
    • HEK293
    • HEK293T
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • GST
    • His
    • T7
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human TRIM21-105H Recombinant Human TRIM21, MYC/DDK-tagged HEK293 Myc/DDK
    Human TRIM21-106H Recombinant Human TRIM21, GST-tagged Wheat Germ GST
    Human TRIM21-115H Recombinant Human TRIM21, His-tagged Sf9 Insect Cell His
    Human TRIM21-196H Recombinant Human tripartite motif-containing 21 E.coli N/A
    Human TRIM21-30033TH Recombinant Human TRIM21 Wheat Germ N/A
    Human TRIM21-543H Recombinant Human TRIM21 Protein, His-tagged E.coli His
    Human TRIM21-564H Recombinant Human TRIM21 protein, His-tagged E.coli His
    Human TRIM21-671H Recombinant Human TRIM21 Protein (Met1-Tyr475), His-tagged Insect Cell His
    Human TRIM21-791HCL Recombinant Human TRIM21 293 Cell Lysate HEK293 N/A
    Mouse Trim21-542M Recombinant Mouse TRIM21 Protein, His-tagged E.coli His
    Mouse Trim21-6646M Recombinant Mouse Trim21 Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Rat Trim21-1674R Recombinant Rat Trim21 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque TRIM21-4954R Recombinant Rhesus monkey TRIM21 Protein, His-tagged Mammalian Cell His
    Cow TRIM21-212B Native Cow TRIM21 Bovine Thymus N/A

    TRIM21 involved in several pathways and played different roles in them. We selected most pathways TRIM21 participated on our site, such as Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM21 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Systemic lupus erythematosus C8G; C3; H3F3B; HIST1H4J; HIST3H2A; ACTN4; HIST3H3; FCGR3; CD86; Hc

    TRIM21 has several biochemical functions, for example, DNA binding, RNA binding, identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM21 itself. We selected most functions TRIM21 had, and list some proteins which have the same functions with TRIM21. You can find most of the proteins on our site.

    Function Related Protein
    DNA binding SP5; EEPD1; POLR2C; MLXIPL; POLR2E; HOXA9B; ZNF76; ZNF143B; ZNF784; H2AFB2
    RNA binding EIF2S2; PRAC; IFIT12; EXOSC1; MRPL12; RNASEL; RPL18; DHX36; THOC3; RBM39B
    identical protein binding MRAP2; UBQLN1; LEPR; TRIM39; FZD1; SMAD6; PYCARD; LYZ2; GAPDH; C1QL4
    ligase activity NAPRT1; UBE2NA; MARCH6; RNF180; ADSSL; NEDD4L; UBR1; ZNRF3; RFWD2; RNF139
    protein binding TAS2R16; POLR2A; REL; DDIT3; FBN1; GLRA1; KHDRBS1; HYAL3; ZNF572; MSTN
    ubiquitin-protein transferase activity UHRF1; RBBP6; RNF43; UBE3C; UBE2W; FBXL5; KLHL20; FBXO30A; UBE2D1; TRIM13
    zinc ion binding TLL2; ADAM23; TRIM64C; CTCF; SIRT6; NR4A2B; RBM14A; PTPN1; CCNB1IP1; KNG1

    TRIM21 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM21 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM21.

    TRIM39; 3500; GRAP; UBE2I; TXN2

    Massie, C; Hudson, M; et al. Absence of an association between anti-Ro antibodies and prolonged QTc interval in systemic sclerosis: A multicenter study of 689 patients. SEMINARS IN ARTHRITIS AND RHEUMATISM 44:338-344(2014).
    Rakebrandt, N; Lentes, S; et al. Antibody- and TRIM21-dependent intracellular restriction of Salmonella enterica. PATHOGENS AND DISEASE 72:131-137(2014).

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