TRIM22

  • Official Full Name

    tripartite motif containing 22

  • Overview

    The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferons antiviral effects. Alternative splicing results in multiple transcript variants.

  • Synonyms

    TRIM22;tripartite motif containing 22;E3 ubiquitin-protein ligase TRIM22;GPSTAF50;RNF94;STAF50;50 kDa stimulated trans acting factor;RING finger protein 94;Staf 50;Stimulated trans acting factor (50 kDa);Stimulated Trans Acting Factor (homolog of Mouse Rpt 1 gene);Tripartite binding motif 22;Tripartite motif containing protein 22;staf-50;tripartite motif-containing 22;tripartite motif protein TRIM22;50 kDa-stimulated trans-acting factor;tripartite motif-containing protein 22;stimulated trans-acting factor (50 kDa)
Cat.# Product name Source (Host) Species Tag Protein Length Price
TRIM22-4955R Recombinant Rhesus monkey TRIM22 Protein, His-tagged Mammalian Cells Rhesus macaque His
TRIM22-563H Recombinant Human TRIM22 Protein, GST-His-tagged E.coli Human GST&His
TRIM22-790HCL Recombinant Human TRIM22 293 Cell Lysate HEK293 Human Non
TRIM22-4769R Recombinant Rhesus Macaque TRIM22 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque Avi&Fc&His
TRIM22-4769R-B Recombinant Rhesus Macaque TRIM22 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque

    Involved Pathway

    TRIM22 involved in several pathways and played different roles in them. We selected most pathways TRIM22 participated on our site, such as Cytokine Signaling in Immune system,Immune System,Interferon Signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with TRIM22 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine Signaling in Immune system OSTN,CRKL,TRIM2,CASPB,IFITM2,CSH1,IFITM3,EDARADD,SPTBN1,GBP5
    Immune System LILRA1,SPSB1,MGC174155,FCN3,HECTD3,GRAP2A,RCA2.1,CFHL4,CLEC6A,MGC174152
    Interferon Signaling TRIM38,TRIM3,TRIM68,TRIM29,TRIM45,HERC5,TRIM62,IFITM2,IFIT2,IFIT10
    Interferon gamma signaling TRIM5,TRIM14,TRIM38,TRIM46,TRIM48,GBP5,TRIM6,GBP6,IFI30,TRIM10

    Protein Function

    TRIM22 has several biochemical functions, for example, ligase activity,protein binding,protein binding, bridging. Some of the functions are cooperated with other proteins, some of the functions could acted by TRIM22 itself. We selected most functions TRIM22 had, and list some proteins which have the same functions with TRIM22. You can find most of the proteins on our site.

    Function Related Protein
    protein binding SPG7,SPPL3,RNF182,UBOX5,KPNA4,ZNF131,C20orf195,PDIA2,CTU2,CAMK1
    protein binding, bridging FLRT2,COL8A2,FSCN2A,RBM14,TNNT2A,EVPL,SPRR1B,TCAP,ANK2,TJP2
    zinc ion binding MARCH2,LIMS3,LTA4H,SH3RF3,HNF4A,SCEL,Car2,MORC2A,RNPEPL1,MEX3B
    transcription factor activity, sequence-specific DNA binding POU3F2B,ZNF74,FOXN1,SMAD6,NFYC,HOXA5A,NR2F6B,NKX2-5,TCF7L1A,ZNF583
    protein kinase binding CEP68,TP73,FGR,CCNT2B,CACNB4,CALM,PLK1,TSKS,CEP152,TBL2
    ligase activity RNF126,RNF220,HERC5,SH3RF1,PRP19,HECW1,TRIM21,SMURF2,ZNRF2,UBE2F
    transcription corepressor activity RELB,PIAS1,DNMT3B,ZHX1,SRSF2,ID4,APEX1,SSX1,SFMBT1,TFAP2B

    Interacting Protein

    TRIM22 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TRIM22 here. Most of them are supplied by our site. Hope this information will be useful for your research of TRIM22.

    CASK;q5nes5_fratt;rho;rpoB;glcD3;yezC;USP7;CIC;RERE

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